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Food Bioscience 2022年第4期48卷 559-567页

作者： P.J.Gonzalez-Ramírez l.I.pascual-Mathey R.V.García-Rodríguez ,M.Jimenez C.I.Beristain A.Sanchez-Medina l.a.pascual-pineda Instituto de Química Aplicada Universidad VeracruzanaAv.Dr.Luis Castelazo Ayala s/nCol.Industrial-AnimasC.P.91190XalapaVeracruzMexico Facultad de Química Farmaceutica Biologica Universidad VeracruzanaXalapaVeracruzMexico Centro de Investigacion y Desarrollo en Alimentos(CIDEA) Universidad VeracruzanaXalapaVeracruz91190Mexico

Fresh garlic(FG)was processed at five different relative humidities(RH)at 55◦C for 40 *** moisture content,aw,browning intensity and DPPH scavenging capacity were determined during processing under controlled *** processing,sensory acceptance and metabolite differences were analyzed using ***,a chemometric analysis was performed using both the 1H-NMR chemical profiles and the sensory evaluation of the 40-day black garlic(BG)*** increase in the antioxidant capacity at higher browning rate was *** variability for twenty-five compounds showed main changes in amino and organic acids,sugars,organosulfur compounds,ethanol,methanol GABA,choline and *** acceptance values on the sensory evaluation were for BG processed at 58 and 71%RH,indicating that intermediates RH results in a better sensory *** OPlS-DA chemometric analysis showed that sugars,formic acid,5-HMF,amino acids,ethanol,and choline were the main contributors.

关键词： Black garlic processing Antioxidant activity Chemical profile Sensory evaluation Chemometrics OPlS

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Generating oligodendroglia from adult mesenchymal cells for transplantation:cell reprogramming or direct lineage conversion?

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Neural Regeneration Research 2023年第7期18卷 1493-1494页

作者： Jorge pascual-Guerra JoséA.Rodríguez-Navarro Carlos l.Paíno Service of Neurobiology-Research Ramón y Cajal University Hospital-IRYCISMadridSpain Department of Cellular Biology Complutense UniversityMadridSpain

Cell replacement therapy has long been proposed as a treatment for the damaged nervous *** of the most challenging aspects of such a strategy,however,is finding sources of donor cells for *** neural cells are rarely an option as every cell in the nervous system has a defined function that would be lost if that cell was to be *** possibility would be sourcing precursor or differentiated cells from fetal tissues;however,aside from ethical issues,heterologous cells are at risk of immunological rejection in the long *** improvements over the past 15 years have led to the possibility that autologous non-neural cells could be used for cell transplantation through their conversion into neural derivatives.

关键词： neural programming removed

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Combining spatial and economic criteria in tree-level harvest planning

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Forest Ecosystems 2020年第2期7卷 234-246页

作者： Petteri Packalen Timo Pukkala Adrián pascual School of Forest Sciences University of Eastern FinlandPO Box 11180101 JoensuuFinland Forest Research Center School of AgricultureUniversity of LisbonTapada da Ajuda1349-017 LisboaPortugal

Background:Modern remote sensing methods enable the prediction of tree-level forest resource ***,the benefits of using tree-level data in forest or harvest planning is not clear given a relative paucity of *** particular,there is a need for tree-level methods that simultaneously account for the spatial distribution of trees and other *** this study,we developed a spatial tree selection method that considers tree-level(relative value increment),neighborhood related(proximity of cut trees)and global objectives(total harvest).Methods:We partitioned the whole surface area of the stand to trees,with the assumption that a large tree occupies a larger area than a small *** was implemented using a power *** also utilized spatially explicit tree-level growth models that accounted for competition by neighboring *** was conducted with a variant of cellular *** proposed method was tested in stone pine(Pinus pinea l.)stands in Spain where we implemented basic individual tree detection with airborne laser scanning ***:We showed how to mimic four different spatial distributions of cut trees using alternative weightings of objective *** Non-spatial selection did not aim at a particular spatial layout,the Single-tree selection dispersed the trees to be cut,and the Tree group and Clearcut selections clustered harvested trees at different ***:The proposed method can be used to control the spatial layout of trees while extracting trees that are the most economically mature.

关键词： Spatial optimization Tree selection Cellular automata Remote sensing Airborne laser scanning

Ventilation during cardiopulmonary resuscitation in children: a survey on clinical practice

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World Journal of Pediatrics 2017年第6期13卷 544-550页

作者： Rafael González lázaro pascual Alexandra Sava Sara Tolón Javier Urbano Jesus lópez-Herce Pediatric Intensive Care Department Gregorio Mara(n)ón General University HospitalSchool of MedicineComplutense University of MadridMadridSpain

Background:This study aimed to investigate the ventilation practice during cardiopulmonary resuscitation (CPR) and after return of spontaneous circulation (ROSC) in ***:An online survey of CPR practices was designed and sent to healthcare professionals treating ***:A total of 477 healthcare professionals from 46 countries responded to this survey;92.7% were physicians and 64.2% worked in pediatric intensive care *** CPR guidelines were used by 97.7% of *** respiratory rate most frequently used for children over 12 months was 13 to 20 respirations per minute (rpm) (46% in intubated and 41.8% in non-intubated).For infants under 12 months,the most frequently used respiratory rate was 21 to 30 rpm in intubated patients (37.3%):in non-intubated infants,13 to 20 rpm (26.5%) and 21 to 30 rpm (26.5%) were used with the same *** North America,the respiratory rate most widely used was 7 to 12 rpm;higher rates (13 to 20 rpm and 21 to 30 rpm) were used in Europe and latin America (Plthcare professionals had a target oxygen saturation below 94%;more than 10% used a target arterial PCO2 below 35 mmHg and more than 13% above 45 ***:There is considerable variation in the management of ventilation of children in cardiac arrest,and international recommendations are not being followed in a high percentage of cases.

关键词： cardiopulmonary resuscitation resuscitation ventilation

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang Dong liang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie Dang Jia Guo Hanghang Zhou Xuewei lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

A socioeconomic approach to the profile of microcredit holders from the Hispanic minority in the USA

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Financial Innovation 2023年第1期9卷 484-508页

作者： Salvador Cruz Rambaud Joaquín lópez pascual Emilio M.Santandreu Departamento de Economía y Empresa Universidad de Almería04120 AlmeríaSpain Departamento de Economía de la Empresa Universidad Rey Juan Carlos28032 VicálvaroMadridSpain OUR Microlending llC MiamiFL 33145USA

The subject of this study is the microcredit market in the USA,more specifically in *** justification for choosing this specific state is the massive presence of the Hispanic *** will facilitate a generalization of the obtained results to the microcredit market in latin American ***,the objective of this study is to analyze the profile of microcredit holders and their companies from socioeconomic and financial points of *** our data also consider the degree of repayment of the microloans included in the sample,the clients’profile is related to the punctuality or default of their corresponding loan repayments using the methodology of multi-nomial logit *** variables used in this study refer to personal information concerning borrowers(gender,age,education level,and marital status),the economic situation of their respective companies(closeness to the lender,number of workers,and revenues),and the characteristics of granted loans(principal,term,and purpose).However,the results of the regression show that only two variables are significant at the 5%significance level:the borrower’s age,which has a positive effect on repay-ment punctuality,and the loan term,which exhibits a negative *** findings of this study have clear implications,as they can help lenders design suitable microloans adjusted to customer ***,future research should include other demograph-ics and characteristics of affected companies.

关键词： Microcredit Customer profile Socioeconomic factors Multinomial logit regression Repayment Microentrepreneurship