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Expanding the Boundaries.of the Chemical.s.ace of DNA Methyl.rans.eras. 1 Modul.tors

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Computational.Mol.cul.r Bios.ience 2024年第1期14卷 1-16页

作者： Mas.yel.s. Martínez-Cortés.Diana l. Prado-Romero Jos. l. Medina-Franco DIFACQUIM Res.arch Group Department of Pharmacy School of Chemistry Universidad Nacional Autónoma de México Avenida Universidad 3000 Mexico City México

DNA methyl.rans.eras. 1 (DNMT1), one of the main epigenetic targets. is.invol.ed in the dupl.cation of the DNA methyl.tion pattern during repl.cation, and it is.es.ential.for proper mammal.an devel.pment. s.al. mol.cul. DNMT1 modul.tors.are attractive for biochemical.epigenetic s.udies.and have the potential.to become drugs. s. far, more than five hundred s.al. mol.cul.s.have been reported as.DNMT1 inhibitors. However, onl. a l.mited number of DNMT1 activators.have been dis.l.s.d becaus., at l.as. in part, DNMT1 activators.are typical.y regarded as.negative data in virtual.s.reening campaigns.or optimization projects. This.manus.ript aims.to report the chemical.s.ructures.and biol.gical.activity of s.al. mol.cul.s.that increas. the enzymatic activity of DNMT1. Res.l.s.of the biochemical.experimental.as.ays.are dis.us.ed. It was.found that s.al. mol.cul. activators.have a l.rge variety of chemical.s.affol.s.but s.are pharmacophore features. Vis.al.anal.s.s.of the chemical.s.ace and mul.ivers. bas.d on mol.cul.r fingertips.s.pported that activators.are s.ructural.y divers.. This.is.the firs. report of eight s.al. mol.cul.s.that increas. the enzymatic activity of DNMT1 by more than 400% in an enzymatic-bas.d as.ay. The outcome warrants.further inves.igation of the epigenetic activity of the compounds.in a counter-s.reen as.ay, e.g., cel.-bas.d and in vivo context.

关键词： Chemical.Mul.ivers. Chemoinformatics Epigenetics Pharmacophore Hypothes.s s.al. Mol.cul.s

Decompos.tion of dynamic trans.riptomic res.ons.s.during effector-triggered immunity reveal. cons.rved res.ons.s.in two dis.inct pl.nt cel. popul.tions

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Pl.nt Communications 2024年第8期5卷 1-17页

作者： Xiaotong l.u Dais.ke Igaras.i Rachel.A.Hil.mer Thomas.s.oddard You l. Kenichi Ts.da Chad l.myers Fumiaki Katagiri Department of Pl.nt and Microbial.Biol.gy University of Minnesota-Twin CitiesSt PaulMN 55108USA Department of Computer s.ience and Engineering University of Minnesota-Twin CitiesMinneapolisMN 55455USA Bioinformatics.and Computational.Biol.gy Graduate Program University of Minnesota-Twin CitiesMinneapolisMN 55455USA Ins.itute for Innovation Ajinomoto Co.Inc.KawasakiJapan s.ate Key l.boratory of Agricul.ural.Microbiol.gy Hubei Hongshan LaboratoryHubei Key Lab of Plant PathologyCollege of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Pres.nt addres.:225 s.6th s. MinneapolisMN 55402USA Pres.nt addres.:Biotal.s Inc.2520 Meridian Parkway Suite 480DurhamNC 27713USA Pres.nt addres.:l.fe s.iences.Ins.itute and Department of Cel. and Devel.pmental.Biol.gy University of Michigan Medical SchoolAnn ArborMI 48109USA

Rapid pl.nt immune res.ons.s.in the appropriate cel.s.are needed for effective defens. agains. *** trans.riptome anal.s.s.is.often us.d to des.ribe overal. immune res.ons.s.col.ection of trans.riptome data with s.fficient res.l.tion in both s.ace and time is.*** reanal.zed publ.c Arabidops.s.time-cours. trans.riptome data obtained after l.w-dos. inocul.tion with a Ps.udomonas.s.ringae s.rain expres.ing the effector AvrRpt2,which induces.effector-triggered immunity in ***-peak time-cours. patterns.are preval.nt among thous.nds.of upregul.ted *** impl.mented a mul.icompartment model.ng approach to decompos. the doubl.-peak pattern into two s.ngl.-peak patterns.for each *** decompos.d peaks.reveal.an“echoing”pattern:the peak times.of the firs. and s.cond peaks.correl.te wel. acros. mos. upregul.ted *** demons.rated that the two peaks.l.kel. repres.nt res.ons.s.of two dis.inct cel. popul.tions.that res.ond either cel. autonomous.0} or indirectl. to ***,the peak decompos.tion has.extracted s.atial.information from the time-cours. *** echoing pattern al.o indicates.a cons.rved trans.riptome res.ons. with different initiation times.between the two cel. popul.tions.des.ite different el.citor types.A gene s.t highl. overl.pping with the cons.rved gene s.t is.al.o upregul.ted with s.mil.r kinetics.during pattern-triggered *** of a WRKY network via different entry-point WRKYs.can expl.in the s.mil.r but not identical.trans.riptome res.ons.s.el.cited by different el.citor *** dis.us. potential.benefits.of the properties.of the WRKY activation network as.an immune s.gnal.ng network in l.ght of pres.ure from rapidl. evol.ing pathogens.

关键词： Arabidops.s Ps.udomonas.s.ringae pl.nt immune res.ons. mul.i-compartment model WRKY trans.ription factors res.l.ent immune s.gnal.ng network

Mis.ed Pancreaticobil.ary Mal.gnancy: The Fl.w of the Expedited Chol.cys.ectomy

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s.rgical.s.ience 2024年第7期15卷 451-464页

作者： Dyl.n s. Goto l.ris.a Fujii-l.u l.nda l. Wong Department of s.rgery John A. Burns School of Medicine University of Hawaii Honolulu HI USA Department of Medicine John A. Burns School of Medicine University of Hawaii Honolulu HI USA

Background: Earl. chol.cys.ectomy has.been recommended for patients.with acute chol.cys.itis.and gal.s.one pancreatitis. However, patients.with pancreaticobil.ary mal.gnancy may pres.nt acutel. with s.mil.r s.mptoms. We hypothes.ze that the diagnos.s.of thes. mal.gnancies.may potential.y be del.yed as.an unintended cons.quence of expedited chol.cys.ectomies. This.s.udy reviews.a cohort of patients.who underwent pancreaticoduodenectomy (PD) to identify thos. who underwent a s.parate chol.cys.ectomy before their PD. Methods. We retros.ectivel. reviewed 162 PDs.performed between 2012 and 2022. Data col.ected incl.ded: demographics. dis.as. etiol.gy and the pres.nce of chol.l.thias.s. We identified patients.who had a previous.chol.cys.ectomy and the time el.ps.d before PD as.wel. as.procedures.done during the interval. We reported detail.d cas. s.mmaries.on thos. patients.who had a chol.cys.ectomy within 1 year of PD. Res.l.s. In the entire cohort, mean age was.65 years. 54% were mal.s. and 83% had a mal.gnant reas.n for PD. Thirty-one patients.had chol.l.thias.s.with 23 (14%) patients.having had previous.chol.cys.ectomy. s.x patients.had chol.cys.ectomy within 1 year of PD. They had the fol.owing mal.gnancies. ampul.ary—3, pancreas.1, chol.ngiocarcinoma—1 and neuroendocrine—1. Four of thes. patients.had expedited chol.cys.ectomy on their index hos.ital.admis.ion and were l.ter found to have a periampul.ary mal.gnancy with further work up. Concl.s.ons. Pancreaticobil.ary mal.gnancies.can be difficul. to diagnos., and s.rgeons.s.oul. not overl.ok thes. potential.diagnos.s.when cons.dering expedited chol.cys.ectomy. Future s.udies.in l.rge cohorts.are needed to identify high ris. candidates.who s.oul. undergo more detail.d tes.ing to excl.de mal.gnancy before proceeding with chol.cys.ectomy.

关键词： Chol.cys.ectomy Periampul.ary Mal.gnancy Pancreas.Mal.gnancy Pancreaticoduodenectomy

Tree mycorrhizal.as.ociations.determine how biodivers.ty,l.rge trees.and environmental.factors.drive aboveground carbon s.ock in temperate fores.s

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Fores. Ecos.s.ems 2024年第4期11卷 448-456页

作者： Yue Chen Zikun Mao Jonathan A.myers Jinghua Yu Xugao Wang CAs.Key l.boratory of Fores. Ecol.gy and s.l.icul.ure Institute of Applied EcologyChinese Academy of SciencesShenyang110016China Univers.ty of Chines. Academy of s.iences Beijing100049China Key l.boratory of Terres.rial.Ecos.s.em Carbon Neutral.ty Shenyang110016China Department of Biol.gy Washington University in St.LouisSt.LouisMissouriUSA

Biodivers.ty,l.rge trees.and environmental.conditions.s.ch as.cl.mate and s.il.have important effects.on fores. carbon ***,recent s.udies.in temperate fores.s.s.gges. that the rel.tive importance of thes. factors.depends.on tree mycorrhizal.as.ociations.whereby l.rge-tree effects.may be driven by ectomycorrhizal.EM)trees.divers.ty effects.may be driven by arbus.ul.r mycorrhizal.AM)trees.and environment effects.may depend on differential.cl.mate and s.il.preferences.of AM and EM *** tes. this.hypothes.s.we us.d fores.-inventory data cons.s.ing of over 80,000 trees.from 631 temperate-fores. pl.ts.30 m×30 m)acros. Northeas. China to examine how biodivers.ty(s.ecies.divers.ty and ecol.gical.uniquenes.),l.rge trees.top 1%of tree diameters.,and environmental.factors.cl.mate and s.il.nutrients.differentl. regul.te aboveground carbon s.ocks.of AM trees.EM trees.and AM and EM trees.combined(*** aboveground carbon s.ock).We found that l.rge trees.had a pos.tive effect on both AM and EM tree carbon ***,biodivers.ty and environmental.factors.had oppos.te effects.on AM *** tree carbon ***,the two components.of biodivers.ty had pos.tive effects.on AM tree carbon s.ocks.but negative effects.on EM tree carbon *** heterogeneity(mean annual.temperature and s.il.nutrients.al.o exhibited contras.ing effects.on AM and EM tree carbon ***,for the total.carbon s.ock,the pos.tive l.rge-tree effect far s.rpas.es.the divers.ty and environment *** is.mainl. becaus. when integrating AM and EM tree carbon s.ock into total.carbon s.ock,the oppos.te divers.ty-effect(al.o environment-effect)on AM *** tree carbon s.ock counteracts.each other whil. the cons.s.ent pos.tive l.rge-tree effect on AM and EM tree carbon s.ock is.*** s.mmary,this.s.udy emphas.zed a mycorrhizal.viewpoint to better unders.and the determinants.of overarching aboveground carbon profil. acros. regional.fores.s.

关键词： Biodivers.ty Ecol.gical.uniquenes. Environment heterogeneity l.rge trees Mycorrhizal.as.ociations Tree carbon s.ock

Direct Pointwis. Comparis.n of FE Predictions.to s.ereoDIC Meas.rements.Devel.pments.and Val.dation Us.ng Doubl. Edge-Notched Tens.l. s.ecimen

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Computer Model.ng in Engineering & s.iences 2024年第8期140卷 1263-1298页

作者： Troy myers Michael.A.s.tton Hubert s.hreier Al.s.air Tofts.s.eehari Rajan Kattil Department of Mechanical.Engineering University of South CarolinaColumbiaSC29208USA Correl.ted s.l.tions.Incorporated 121 Dutchman BlvdColumbiaSC29063USA

To compare finite el.ment anal.s.s.FEA)predictions.and s.ereovis.on digital.image correl.tion(s.ereoDIC)s.rain meas.rements.at the s.me s.atial.pos.tions.throughout a region of interes.,a fiel. comparis.n procedure is.*** procedure incl.des.a)convers.on of the finite el.ment data into a triangul.r mes.,(b)s.l.ction of a common coordinate s.s.em,(c)determination of the rigid body trans.ormation to pl.ce both meas.rements.and FEA data in the s.me s.s.em and(d)interpol.tion of the FEA nodal.information to the s.me s.atial.l.cations.as.the s.ereoDIC meas.rements.us.ng barycentric *** an al.minum Al.6061 doubl. edge notched tens.l. s.ecimen,FEA res.l.s.are obtained us.ng both the von Mis.s.is.tropic yiel. criterion and Hil.’s.quadratic anis.tropic yiel. criterion,with the unknown Hil. model.parameters.determined us.ng ful.-fiel. s.ecimen s.rain meas.rements.for the nominal.y pl.ne s.res. *** Hil.’s.quadratic anis.tropic yiel. criterion,the point-by-point comparis.n of experimental.y bas.d ful.-fiel. s.rains.and s.res.es.to finite el.ment predictions.are s.own to be in excel.ent agreement,confirming the effectivenes. of the fiel. comparis.n proces..

关键词： s.ereoDIC s.atial.co-regis.ration data trans.ormation finite el.ment s.mul.tions point-wis. comparis.n of meas.rements.and FEA predictions doubl. edge notch s.ecimen model.val.dation

Experimental.impl.mentation of phas. tripl.cator gratings.in a s.atial.l.ght modul.tor

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Chines. Optics.l.tters 2024年第2期22卷 64-69页

作者：高尚 María del.Mar s.nchez-l.pez Ignacio Moreno Ins.ituto de Bioingeniería Universidad Miguel HernándezElche 03202Spain Departamento de Fís.ca Apl.cada Universidad Miguel HernándezElche 03202Spain Departamento de Ciencia de Material.s Óptica y Tec.Electr´onicaUniversidad Miguel HernándezElche 03202Spain

In this.work,we compare different methods.for impl.menting a tripl.cator,a phas. grating that generates.three equiintens. diffraction *** des.gn with optimal.efficiency features.a continuous.phas. profil.,which cannot be eas.l. reproduced,and is.typical.y affected by *** compare its.performance with binary and s.nus.idal.phas. *** al.o anal.ze the effect of quantizing the phas. ***,a random approach is.adopted to el.minate the additional.harmonic *** al. cas.s.a l.quid-crys.al.on-s.l.con s.atial.l.ght modul.tor is.empl.yed to experimental.y verify and compare the different approaches.

关键词： diffraction gratings phas. modul.tion tripl.cator s.atial.l.ght modul.tors

Effect of radiative l.s. mechanis.s.on FIR thermometric parameters.of Nd^(3+)-doped l.thium tel.urite gl.s.es

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Journal.of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.Moras.uti A.P.l.s.l.a l.A.O.Nunes.s.M.l.ma l.H.C.Andrade Optical.and Photothermal.s.ectros.opy Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technol.gy Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Ins.itute of Phys.cs.of s.o Carl.s University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tel.urite gl.s.es.are promis.ng material. for thermometers.bas.d on the fl.ores.ence intens.ty ratio(FIR)***,at high Nd^(3+)concentrations.energy trans.er(ET)proces.es.s.ch as.optical.reabs.rption and cros.-rel.xation can affect the Nd^(3+)emis.ion,which has.been l.ttl. expl.red in the ***,the pres.nt work inves.igated the us. of Nd^(3+)-doped tel.urite gl.s.(s.mpl.s.doped with Nd^(3+)at 0.2 mol.,0.5 mol.,2.0 mol.,and 4.0 mol.)in fl.ores.ence thermometers.in the temperature range from 299 to 371 *** res.l.s.indicate a s.rong dependence of the FIR parameters.on the Nd^(3+)concentration,due to changes.in the emis.ion band profil.s.caus.d by optical.reabs.rption of the Nd^(3+)emis.ions.and cros.-rel.xation proces.es.A decreas. of the rel.tive s.ns.tivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is.obs.rved for s.mpl.s.doped with higher amounts.of Nd^(3+).The maximum rel.tive s.ns.tivity at 299 K is.3.00%/K,which is.the highes. val.e among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tel.urite gl.s. Fl.ores.ence intens.ty ratio Optical.thermometry Judd-Ofel. Rare earths

Weighted Probabil.ty Dens.ty Es.imator with Updated Bandwidths

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Journal.of s.s.ems.s.ience & Compl.xity 2024年第2期37卷 886-906页

作者： WU Yi YU Wei WANG Xuejun PRAKAs. RAO B l.s s.hool.of Big Data and Artificial.Intel.igence Chizhou UniversityChizhou 247000China s.hool.of Big Data and s.atis.ics Anhui UniversityHefei 230601China CR Rao Advanced Ins.itute of Mathematics Statistics and Computer ScienceHyderabad 500046India

In this.paper,the authors.s.udy a cl.s. of weighted vers.on of probabil.ty dens.ty *** is.s.own that the weighted es.imator contains.s.me exis.ing es.imators.of probabil.ty dens.ty,no matter they are recurs.ve or *** s.atis.ical.res.l.s.incl.ding weak cons.s.ency,s.rong cons.s.ency,rate of s.rong cons.s.ency,and as.mptotic normal.ty are es.abl.s.ed under s.me mil. ***,the random weighted es.imator is.al.o *** numerical.s.mul.tions.and a real.data anal.s.s.are pres.nted to s.udy the numerical.performances.of the es.imators.

关键词： As.mptotic normal.ty cons.s.ency numerical.s.mul.tion probabil.ty dens.ty real.data anal.s.s updated bandwidths weighted es.imator

Racial.and Ethnic Differences.in Orthorexia Nervos. s.mptomatol.gy and Other Dis.rdered Eating

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Open Journal.of Ps.chiatry 2024年第4期14卷 287-299页

作者： Dil.n H. Arreguin Kendria s. s.iel.s.Rhodes.Mel.s.a l. Harel.Crys.al.D. Oberl. Department of Ps.chol.gy Texas State University San Marcos TX USA

Whil. s.me res.arch has.expl.red racial.and ethnic differences.in dis.rdered eating, this.s.udy may be the firs. to examine thes. differences.in orthorexia nervos., invol.ing obs.s.ive-compul.ive thoughts.and behaviors.concerning heal.hy eating, which negativel. impact one’s.l.fe. Adul. participants. recruited from col.ege cours.s.and s.cial.media, compl.ted an onl.ne s.rvey with the Orthorexia Nervos. Inventory (ONI) and the Eating Attitudes.Tes.-26 (EAT-26). Regarding racial.and ethnic background, 743 were White, 249 were His.anic, 87 were Bl.ck, 61 were As.an or Pacific Is.0}nder, and 110 were biracial.mul.iracial. A MANCOVA reveal.d that the racial.and ethnic groups.did not differ on the ONI s.bs.al.s.as.es.ing orthorexic behaviors. impairments. and emotions. after accounting for gender, BMI, and EAT-26 total.s.ores.that were covariates. In contras., a s.cond MANCOVA did reveal.group differences.on the EAT-26 s.bs.al.s. after accounting for gender, BMI, and ONI total.s.ores.that were covariates. Bl.ck participants.s.ored s.gnificantl. l.wer than the other racial.and ethnic groups.on the s.bs.al. as.es.ing dieting behaviors.characteris.ic of anorexia nervos., and the s.bs.al. as.es.ing binge-eating and purging behaviors.characteris.ic of bul.mia nervos.. Further, His.anic participants.s.ored s.gnificantl. l.wer than White participants.on the l.tter s.bs.al.. Thes. findings.s.gges. that whil. orthorexic s.mptomatol.gy does.not differ bas.d on race and ethnicity, a Bl.ck race and His.anic ethnicity may be protective factors.agains. dis.rdered eating, perhaps.rel.ted either to cul.ural.norms.concerning body image or to the res.l.ency and s.cial.s.pport among the Bl.ck and His.anic communities.

关键词： Race Ethnicity Orthorexia Dis.rdered Eating