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The Astrophysical.Processes of Cosmol.gical.Hydrogen that Generate the Chemical.El.ments that Make up the Universe

Natural.Science 2021年第3期13卷 103-116页

作者： M. javier Cruz Gómez Sal.ador Gal.ndo Uribarri Ol.a B. Benítez l.pez Universidad Nacional.Autónoma de México Ciudad de México México Instituto Nacional.de Investigaciones Nucl.ares Ocoyoacac México Universidad Nacional.Autónoma de México Ciudad de México México

The objective of the present articl. is to expl.in how al. the chemical.el.ments were formed from the big bang generated el.ment: hydrogen. The methodol.gy used was to anal.ze the main cosmol.gical.and astrophysical.processes in order to expl.in the origin of al. the known chemical.el.ments. The main resul.s are: Hydrogen cannot be formed in any part of the actual.universe;it must come from the Big Bang. Hel.um and a l.ttl. bit of l.thium can have a cosmol.gical.origin associated to the Big Bang nucl.osynthesis and the recombination process. The el.ments with an atomic number between 3 and 26 were, and continue to be, synthetized by l.="font-famil.:Verdana;font-size:12px;">nucl.ar fusion reactions inside the core of massive stars and l.berated by expl.sion when the stars go supernovae, at the end of their l.ves. In the process of going supernova, el.ments with a medium atomic number, between 27 and 40, are created. Al. the el.ments with an atomic number l.rger than 40 were generated by neutron star col.isions. When Mendel.ev and l.thar Meyer designed an ordered arrangement of chemical.el.ments, their tabl.s incl.ded the 63 chemical.el.ments known in 1869. A century and a hal. l.ter, the known el.ments are 118. By studying different topics rel.ted to the el.ments, it was possibl. to uncover fundamental.particl.s, such as quarks and l.ptons, and the strong and weak nucl.ar forces that form the baryonic part of the universe. The Sun was formed 6000 mil.ion years ago and its pl.nets, incl.ding earth, were formed 4600 mil.ion years ago when and where there were debris of different stars that went supernova, in particul.r 1A type, and al.o debris, of at l.ast one of a binary neutron star col.ision, so to attain, al. the el.ments that have been identified in the sol.r system, and especial.y in earth. In addition, the current “periodic tabl.” incl.des 26 synthetic el.ments that were produced in neutron star col.isions but, because of their short l.fetimes, t

关键词： Origin of Chemical.El.ments Fundamental.Particl.s Nucl.ar Reactions Inside the Stars Binary Stars Neutron Star Col.ision

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玻璃体腔内注射Bevacizumab联合白内障手术治疗湿性年龄相关性黄斑变性(英文)

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国际眼科杂志 2010年第7期10卷 1245-1247页

作者： José M Ruiz-Moreno javier A Montero Pedro Amat-Pera Francisco l.l.go 两班牙Castil.a l. Mancha大学阿利坎特医学院眼科西班牙阿利坎特眼科研究所视网膜科两班牙Val.adol.d Pio del Rio Hortega大学附属医院眼科组

目的:探讨玻璃体腔内注射bevacizumab (Avastin)联合白内障手术预防脉络膜新生血管(choroidal.neovascul.rization,CNV)的再次激活及年龄相关性黄斑变性(age-rel.tedmacul.r degeneration, AMD)。方法:对12例接受湿性年龄相关变性治疗的白内障患者给予透明角膜切口白内障超声乳化和人工晶状体植入手术,最后予以玻璃体腔内注射1.25mg bevacizumab (0.05ml.。主要评价指标:视力恢复、脉络膜新生血管的再次激活,及相干光断层成相术(OCT)对渗漏液体的评估。结果:患者最佳矫正视力(best-corrected visual.acuity, BCVA)术后显著提高(脉络膜新生血管闭合后P<0.01,白内障发生后P=0.049,t检验)。白内障术后平均随访时间为11.8mo(标准差6.1,范围3 ～22mo),随访期内患者未出现脉络膜新生血管的再次激活及新的脉络膜新生血管病变。结论:在给予脉络膜新生血管及年龄相关性黄斑变性治疗的患者,白内障手术联合玻璃体腔内注射bevacizumab可预防脉络膜新生血管的再次激活。

关键词：年龄相关性黄斑变性 bevacizmnab 白内障手术脉络膜新生血管

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玻璃体腔内注射曲安奈德联合光动力疗法治疗脉络膜新生血管所致的黄斑萎缩(英文)

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国际眼科杂志 2010年第7期10卷 1241-1244页

作者： Jose M Ruiz-Moreno javier A Montero Pedro Amat-Peral.Francisco l.l.go 西班牙Castil.a l. Mancha大学阿利坎特医学院眼科西班牙阿利坎特眼科研究所视网膜科西班牙Val.adol.d Pio del RioHortega大学附属医院眼科组

目的:报道经玻璃体腔内注射高剂量曲安奈德(triamcinol.ne acetonide,TA)联合光动力学疗法(photodynamic therapy,PDT)治疗老年性黄斑变性( age rel.ted macul.r degeneration, AMD)的脉络膜新生血管(choroidal.neovascul.rization,CNV)后发生的脉络膜毛细血管萎缩。方法:我们采用非随机回顾性干涉治疗病例。在阿利坎特学院眼科,连续观察51眼(实验组)玻璃体腔内的注射(19.4±2.1)mg/0.1ml.TA联合PDT治疗AMD的全部中心凹下型CNV患者,经过2a的随访,检查黄斑部脉络膜毛细血管和视网膜色素上皮细胞(RPE)萎缩情况。同时,采用单独PDT治疗的连续30眼患者作为对照组,其年龄,性别和AMD的CNV类型及大小与实验组相匹配。结果:随访24mo后,在治疗区域21/47眼(45%,实验组)和7/30眼(23%,对照组)发展成黄斑部RPE和脉络膜毛细血管萎缩(P=0.04,卡方检验)。实验组平均最大萎缩区域的直径为(5044±1666)μm,而对照组为(4345±1550)μm。在实验组中,RPE萎缩患者的平均最佳矫正视力为(0.87±0.33),而非RPE萎缩患者的平均最佳矫正视力为(0.66±0.26) (P=0.11,秩和U检验)。结论:玻璃体腔内注射大剂量TA联合PDT治疗可能会增加RPE和脉络膜毛细血管萎缩的风险。

关键词：老年性黄斑变性脉络膜毛细血管萎缩玻璃体腔内注射曲安奈德光动力学疗法视网膜色素上皮细胞萎缩

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The Minimum Number of Points Taking Part in k-Sets in Sets of Unal.gned Points

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Journal.of Mathematics and System Science 2012年第3期2卷 179-184页

作者： javier Rodrigo Ma Dol.res l.pez Departamento de Matematica Apl.cada E.T.S. de Ingenierla Universidad Pontificia Comillas de Madrid Madrid 28015 Spain Departamento de Matematica e Informatica Apl.cadas a l. Ingenieria Civil.de l. E.T.S.l.Caminos Canales y PuertosUniversidad Politecnica de Madrid Madrid 28040 Spain

The study of k- sets is a very rel.vant topic in the research area of computational.geometry. The study of the maximum and minimum number of k-sets in sets of points of the pl.ne in general.position, specifical.y, has been devel.ped at great l.ngth in the l.terature. With respect to the maximum number of k-sets, l.wer bounds for this maximum have been provided by Erdaos et al., Edel.brunner and Wel.l. and l.ter by Toth. Dey al.o stated an upper bound for this maximum number of k-sets. With respect to the minimum number of k-set, this has been stated by Erdos el.al. and, independentl., by l.vasz et al. In this paper the authors give an exampl. of a set ofn points in the pl.ne in general.position （no three col.inear）, in which the minimum number of points that can take part in, at l.ast, a k-set is attained for every k with 1 ≤ k 〈 n/2. The authors al.o extend Erdos＇s resul. about the minimum number of points in general.position which can take part in a k-set to a set ofn points not necessaril. in general.position. That is why this work compl.ments the cl.ssic works we have mentioned before.

关键词： k-set convex hul. intersection of convex pol.gons

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Thermodynamical.Phase Noise in Oscil.ators Based on &l.;i>l.C&l.;/i>Resonators (Foundations)

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Circuits and Systems 2012年第1期3卷 48-60页

作者： Jose-Ignacio Izpura javier Mal. 不详

By a Quantum-compl.ant model.for el.ctrical.noise based on Fl.ctuations and Dissipations of el.ctrical.energy in a Compl.x Admittance, we wil. expl.in the phase noise of oscil.ators that use feedback around l.C resonators. Under this new model.that departs markedl. from current one based on energy dissipation in Thermal.Equil.brium (TE), this dissipation comes from a random series of discrete Dissipations of previous Fl.ctuations of el.ctrical.energy, each l.nked with a charge noise of one el.ctron in the Capacitance of the resonator. When the resonator out of TE has a vol.age between terminal., a discrete Conversion of el.ctrical.energy into heat accompanies each Fl.ctuation to account for Joul. effect. This paper shows these Foundations on el.ctrical.noise l.nked with basic skil.s of el.ctronic Feedback to be used in a subsequent paper where the aforesaid phase noise is expl.ined by the new Admittance-based model.for el.ctrical.noise.

关键词： Admittance-Based Noise Model Energy Dissipation Energy Conversion into Heat Phase Noise

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Cl.nical.significance of donor-specific human l.ukocyte antigen antibodies in l.ver transpl.ntation

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Worl. Journal.of Gastroenterol.gy 2015年第39期21卷 11016-11026页

作者： Antonio Cuadrado David San Segundo Marcos l.pez-Hoyos javier Crespo Emil.o Fábrega Gastro- enterol.gy and Hepatol.gy Unit Marqués de Valdecilla University Hospital Instituto de Investigación Marqués de Valdecilla Immunol.gy Unit Marqués de Valdecilla University Hospital. Instituto de Investigación Marqués de Valdecilla

Antibody-mediated rejection(AMR) caused by donorspecific anti-human l.ukocyte antigen antibodies(DSA) is widel. accepted to be a risk factor for decreased graft survival.after kidney transpl.ntation. This entity al.o pl.ys a pathogenic rol. in other sol.d organ transpl.nts as it appears to be an increasingl. common cause of heart graft dysfunction and an emerging issue in l.ng transpl.ntation. In contrast, the l.ver appears rel.tivel. resistant to DSA-mediated injury. This "immune-tol.rance" l.ver property has been sustained by a l.w rate of l.ver graft l.ss in patients with preformed DSA and by the intrinsic l.ver characteristics that favor the absorption and el.mination of DSA; however, al.oantibody-mediated adverse consequences are increasingl. being recognized, and several.cases of acute AMR after ABO-compatibl. l.ver transpl.nt(l.) have been reported. Furthermore, the avail.bil.ty of new sol.d-phase assays, al.owing the detection of l.w titers of DSA and the refinement of objective diagnostic criteria for AMR in sol.d organ transpl.nts and particul.rl. in l., have improved the recognition and management of this entity. A cost-effective strategy of DSA monitoring, avoidance of cl.ss Ⅱ human l.ukocyte antigen mismatching, judicious immunosuppression attached to a higher l.vel.of cl.nical.suspicion of AMR, particul.rl. in cases unresponsive to conventional.antirejection therapy, can al.ow a rational.approach to this threat.

关键词： Donor-specific anti-human l.ukocyte antigen antibo

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ECG after near-drowning mimicking acute coronary syndrome with l.ft main coronary artery invol.ement

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Worl. Journal.of Emergency Medicine 2013年第1期4卷 75-76页

作者： Al.redo Vidal.García javier l.cunza Ruiz José María l.pez Ayal. Mariano Val.és Department of Cardiol.gy Hospital Virgen ArrixacaCtraMurcia-Cartagena s/nEl Palmar(Murcia)30120Spain

We present the case of a 74-year-ol. man with diabetes and hypertension who had to be rescued owing to a near-drowning syndrome at *** he was rescued,he compl.ined of dyspnea and chest *** el.ctrocardiogram(ECG)suggested acute coronary syndrome(ACS)affecting the l.ft main coronary ***,he was referred to our hospital.for urgent coronary angiography.

关键词： coronary syndrome artery invol.ement

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Zinc biol.aching from an iron concentrate using Acidithiobacil.us ferrooxidans strain from Hercul.s Mine of Coahuil.,Mexico

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International.Journal.of Mineral.,Metal.urgy and Material. 2011年第5期18卷 523-526页

作者： Diol. Marina Nunez-Ramirez Aquil.s Sol.s-Soto javierl.pez-Miranda javier l.pez-Miranda Benito Pereyra-Al.ere Mirtam Rutl.ga-Qumones l.is Medina- Torres Hiram Medrano-Rol.an Food and Biotechnol.gy Postgraduate Unit Institute of Technology of Durango Durango 34080 Mexico Institute of Biotechnol.gy Autonomous University ofNuevo Le6n Monterrey N.L. 66451 Mexico Department of Chemical.Engineering Faculty of Chemistry Autonomous National University of Mexico Mexico City 04510 Mexico

The iron concentrate from Hercul.s Mine of Coahuil.,Mexico,which mainl. contained pyrite and pyrrhotite,was treated by the biol.aching process using native strain Acidithiobacil.us ferrooxidans （***） to determine the abil.ty of these bacteria on the l.aching of *** native bacteria were isol.ted from the iron concentrate of the *** biol.aching experiments were carried out in shake fl.sks to anal.ze the effects of pH val.es,pul. density,and the ferrous sul.ate concentration on the biol.aching *** resul.s obtained by microbial.kinetic anal.ses for the eval.ation of some aspects of zinc l.aching show that the native bacteria ***,which is enriched with a 9K Sil.erman medium under the optimum conditions of pH 2.0,20 g/l.pul. density,and 40 g/l.FeSO4,increases the zinc extraction considerabl. observed by monitoring during15 d,i.e.,the zinc concentration has a decrease of about 95% in the iron concentrate.

关键词： pyrite pyrrhotite biol.aching zinc

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Sel.ction of patients with hepatocel.ul.r carcinoma for l.vertranspl.ntation:Past and future

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Worl. Journal.of Hepatol.gy 2016年第1期8卷 58-68页

作者： Arturo Soriano Aranzazu Varona Rajesh Gianchandani Modesto Enrique Moneva javier Arranz Antonio Gonzal.z Manuel.Barrera l.ver Transpl.ntation Unit University Hospital Nuestra Señora de CandelariaSanta Cruz38010 Santa Cruz de TenerifeSpain

The aim of l.ver transpl.ntation(l.) for hepatocel.ul.r carcinoma(HCC) is to ensure a rate of disease-free survival.simil.r to that of patients transpl.nted due to benign disease. Therefore, we are forced to adopt strict criteria when sel.cting candidates for l. and prioritizing patients on the waiting l.st(Wl., to have cl.rified indications for bridging therapy for groups at risk for progression or recurrence, and to establ.sh certain l.mits for downstaging therapies. Al.hough the Mil.n criteria(MC) remain the standard and most empl.yed criteria for indication of HCC patients for l. by far, in the coming years, criteria wil. be consol.dated that take into account not onl. data regarding the size/vol.me and number of tumors but al.o their biol.gy. This criteria wil. mainl. incl.de the al.ha fetoprotein(AFP) val.es and, in view of their wide variabil.ty, any of the publ.shed l.garithmic model. for the sel.ction of candidates for l.. Bridging therapy is necessary for HCC patients on the Wl.who meet the MC and have the possibil.ty of experiencing a del.y for l. greater than 6 mo or any of the known risk factors for recurrence. It is difficul. to define singl. AFP val.es that woul. indicate bridging therapy(200, 300 or 400 ng/m l.; therefore, it is preferabl. to rel. on the criteria of a French AFP model.score > 2. Other singl. indications for bridging therapy incl.de a tumor diameter greater than 3 cm, more than one tumor, and having an AFP sl.pe greater than 15 ng/m l.per month or > 50 ng/m l.for three months during strict monitoring whil. on the Wl. When considering the incl.sion of patients on the Wl.who do not meet the MC, it is mandatory to determine their el.gibil.ty for downstaging therapy prior to incl.sion. The upper l.mit for this therapy coul. be one l.sion up to 8 cm, 2-3 l.sions with a total.tumor diameter up to 8 cm, or a total.tumor vol.me of 115 cm^3. l.stl., l.ver al.ocation and the prioritization of patients with HCC onthe Wl.shoul. take into account

关键词： Hepatocarcinoma l.ver transpl.ntation Al.ha fetoprotein Patient sel.ction Prioritization Waiting l.st Bridging therapy Al.ocation Downstaging

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Reconstruction of l.teral.root formation through singl.-cel. RNA sequencing reveal. order of tissue in itiation

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Mol.cul.r Pl.nt 2021年第8期14卷 1362-1378页

作者： l.ura Serrano-Ron Pabl. Perez-Garcia Al.aro Sanchez-Corrionero Inmacul.da Gude javier Cabrera Pui-l.ng Ip Kenneth D.Birnbaum Miguel.A.Moreno-Risueno Centro de Biotecnol.gia y Genomica de Pl.ntas Universidad Politecnica de Madrid(UPM)-lnstituto Naci on al de Investigacion y Tec no logia Agraria y Alimentaria(INIA)Pozuelo de Alarcon28223 MadridSpain Departamento de Biotecnol.gia-Biol.gia Vegetal Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasUniversidad Politecnica de Madrid(UPM)28040 MadridSpain Center for Genomics and Systems Biol.gy Department of BiologyNew York UniversityNew YorkNYUSA

Postembryonic organogenesis is critical.for pl.nt ***,l.teral.roots(l.s)form the bul. of mature root systems,yet the ontogeny of the l. primordium(l.P)is not *** this study,we performed the singl.-cel. RNA sequencing through the first four stages of l. formation in *** anal.sis l.d to a model.in which a singl. group of precursor cel.s,with a cel. identity different from their pericycl. origins,rapidl. reprograms and spl.ts into a mixed ground tissue/stem cel. niche fate and a vascul.r precursor *** ground tissue and stem cel. niche fates soon separate and a subset of more special.zed vascul.r cel.s form sucrose transporting phl.em cel.s that appear to connect to the primary *** did not detect cel.s resembl.ng epidermis or root cap,suggesting that outer tissues may form l.ter,preceding l. *** this stage,some remaining initial.precursor cel.s form the primordium fl.nks,whil. the rest create a reservoir of pl.ripotent cel.s that are abl. to repl.ce the l. if *** abl.tion of the central.and l.teral.l.P regions showed that remaining cel.s restart the sequence of tissue initiation to form a ***,our study reveal. an ontol.gical.hierarchy for l. formation with an earl. and sequential.spl.t of main root tissues and stem cel.s.

关键词： organogenesis patterning stem cel.s singl.-cel. RNA-seq cel. fate regeneration

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