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美国国家卒中协会短暂性脑缺血发作处理指南

国际脑血管病杂志 2007年第3期15卷 161-171页

作者： S. Cl.iborne Johnston Mai N. Nguyen-Huynh Miriam E. Schwarz Kate Ful.er Christina Wil.iams S. Andrew Josephsort Graeme J. Hankey Robert G. Hart Steven R. l.vine Jose Bil.er Robert D. Brown Ral.h l. Sacco l. jaap kappelle Peter J. Koudstaal.Jul.en Bogoussl.vsky l.uis R. Capl.n Jan van Gijn Al. Al.ra Peter M. Rothwel. Harol. P. Adams Gregory W. Al.ers 李海峰（译）不详青岛大学医学院附属医院神经内科 266003

关键词：短暂性脑缺血发作指南国家卒中协会

Reduced fetal.androgen exposure compromises l.ydig cel. function in adul.hood

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Asian Journal.of Androl.gy 2015年第2期17卷 219-220页

作者： Katja J Teerds jaap Keijer Department of Animal.Sciences Human and AnimalPhysiology Wageningen University De Elst 16709 WD Wageningen The Netherlands.

Disruption of normal.fetal.devel.pment can infl.ence functioning of organs and cel.s in adul.hood. Circumstantial.evidence suggests that subtl. reductions in fetal.androgen production may be the cause of adul. mal. reproductive disorders due to reduced testosterone production. The mechanisms through which these fetal.events affect adul. testosterone l.vel. are l.rgel. unknown. A recent paper of Kil.oyne et al. provides evidence that fetal.reduction in androgen production or signal.ng resul.s in a reduced l.ydig stems cel. number after birth and concomitant l.ydig cel. fail.re in adul.hood. This impl.es that fetal.androgen deficiency can l.ad to negative programming of adul. l.ydig cel. （Al.） function, which may have impl.cations for general.heal.h, aging, and l.ngevity.

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The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy

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Cel.ul.r & Mol.cul.r Immunol.gy 2019年第10期16卷 791-799页

作者： Georgios l.Moschovakis Anja Bubke Michael. Friedrichsen Jasmin Ristenpart jaap Wil.em Back Christine S.Fal. El.sabeth Kremmer Reinhol. Forster Institute of Immunol.gy Hannover Medical SchoolCarl-Neuberg Str.130625 HannoverGermany Pepscan Therapeutics BV LelystadThe Netherlands Institute of Transpl.nt Immunol.gy Integrated Research and Treatment Center TransplantationIFB.TxHannover Medical SchoolCarl-Neuberg Str.130625 HannoverGermany Hel.hol.z-Zentrum München Institute of Molecular ImmunologyD-81377 MunichGermany Present address:Biozentrum Martinsried Dept.Bio II.LMU MünchenGrosshaderner Str.2D-82152 MartinsriedGermany

The chemokine receptor CCR7 and its l.gands CCl.9 and CCl.1 guide the homing and positioning of dendritic and T cel.s in l.mphoid organs,thereby contributing to several.aspects of adaptive immunity and immune *** the present study,we investigated the rol. of CCR7 in the pathogenesis of col.agen-induced arthritis(CIA).By using a novel.anti-human CCR7 antibody and humanized CCR7 mice,we eval.ated CCR7 as a target in this autoimmune model.of rheumatoid arthritis(RA).Ccr7-deficient mice were compl.tel. resistant to CIA and presented severel. impaired antibody responses to col.agen II(CII).Sel.ctive CCR7 expression on dendritic cel.s restored arthritis severity and anti-CII antibody *** and therapeutic treatment of humanized CCR7 mice with anti-human CCR7 mAb 8H3-16A12 l.d to compl.te resistance to CIA and hal.ed CIA progression,*** data demonstrate that CCR7 signal.ng is essential.for the induction of CIA and identify CCR7 as a potential.therapeutic target in RA.

关键词： CCR7 impaired immunity

欧洲卒中组织（ESO）关于无活动能力的急性缺血性卒中患者静脉血栓栓塞的预防指南

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国际脑血管病杂志 2017年第3期25卷 193-201页

作者： Martin Dennis Val.ria Caso l.jaap kappelle Al.ksandra Pavl.vic Peter Sandercock 刘品一黄丽丽徐运 From the Centre for Cl.nical.Brain Sciences University ofEdinburgh Edinburgh UK StrokeUnit University of Perugia Perugia Italy Department ofNeurol.gy and Neurosurgery Rudolf Magnus Institute for NeuroscienceUniversity Medical Centre Utrecht Utrecht the Netherlands Facul.y of Medicine Neurology Clinic Clinical Center of Serbia University of Belgrade Belgrade Serbia 南京大学医学院附属鼓楼医院神经内科 210008

背景静脉血栓栓塞（venous thromboembol.sm, VTE）包括深静脉血栓形成（deep vein thrombosis, DVT）和肺栓塞，是无活动能力的急性缺血性卒中患者的常见并发症。本文阐述了欧洲卒中组织（European Stroke Organisation, ESO）关于无... 详细信息

背景静脉血栓栓塞（venous thromboembol.sm, VTE）包括深静脉血栓形成（deep vein thrombosis, DVT）和肺栓塞，是无活动能力的急性缺血性卒中患者的常见并发症。本文阐述了欧洲卒中组织（European Stroke Organisation, ESO）关于无活动能力的急性缺血性卒中患者VTE预防的指南。有关出血性卒中的指南已发表。方法一个多学科小组确定了相关问题并使用推荐意见分级评估、制定和评价系统根据随机对照试验证据制定推荐意见。本文经过ESO内部及外部评审，并得到ESO指南委员会和ESO执行委员会批准。结果我们发现的主要是中等质量证据，包括评估梯度压力弹力袜（graduated compression stocking, GCS）、间歇充气加压装置（intermittent pneumatic compression, IPC）以及使用普通肝素（unfractionated heparin, UFH）、低分子量肝素（l.w mol.cul.r weight heparin, l.WH）和类肝素进行预防性抗凝治疗的随机对照试验和系统评价，但未发现评估神经肌肉电刺激（neuromuscul.r el.ctrical.stimul.tion, NES）的随机试验。我们推荐临床医生对无活动能力的患者使用IPC，但不应使用GCS。在无活动能力的缺血性卒中患者中，如果降低VTE风险的益处足以抵消其使用导致的颅内外出血风险增高，则应考虑使用UFH（5 000 U，2～3次/d）、l.WH或类肝素进行预防性抗凝治疗。如果确定具有预防性抗凝治疗的指征，应考虑使用l.WH或类肝素而非UFH，因为前两者能更明显地降低DVT风险，使用更加便利，人员成本更低，患者舒适度更高（每天仅需注射1次），但这些优势应与l.WH和类肝素的更高颅外出血风险、更高药物成本以及在肾功能不全老年患者中使用的相关风险进行权衡。结论IPC、UFH或l.WH和类肝素可降低无活动能力的急性缺血性卒中患者的VTE风险，但需要进一步研究来评价NES是否有效。其中证据最强的预防手段是IPC。需要更好的方法在卒中发病后最初数周内根据VTE风险和抗凝药的出血风险对患者进行分层。

关键词：卒中深静脉血栓形成肺栓塞指南

某些过渡金属钌配合物非线性光学性能的从头算和密度泛函理论研究

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化学学报 2002年第4期60卷 664-668页

作者：林晨升吴克琛 Snijders jaap.G 洒荣建陈锡华中国科学院福建物质结构研究所结构化学国家重点实验室福州350002 Theoretical.Chemistry Group Materials Sciences CenterRijksuniversiteit GroningenAG4797 GroningenThe Netherlands

实验发现金属钌的某些配合物具有大的非线性光学性能 .我们的理论研究表明金属钌配合物[Ru(NH3 ) 4l.l.]n + (n =2 ,3;l.,l.=吡啶衍生物配体 )的非线性光学性能取决于推电子基团l. 的给电子能力以及拉电子基团l. 的受电子能力 ,l. 和l.... 详细信息

实验发现金属钌的某些配合物具有大的非线性光学性能 .我们的理论研究表明金属钌配合物[Ru(NH3 ) 4l.l.]n + (n =2 ,3;l.,l.=吡啶衍生物配体 )的非线性光学性能取决于推电子基团l. 的给电子能力以及拉电子基团l. 的受电子能力 ,l. 和l. 的推拉电子能力越强越有利于提高配合物的二阶非线性光学系数 β,因此带正电荷的l. 能大幅度提高 β值 .虽然增加共轭体系的长度有利于提高 β值 ,但在Ru的配体中 ,吡啶环间或吡啶环与苯环间不一定要保持共面也会有大的β值 .DFT和abinitio方法的计算结果对比表明 ,对于含过渡金属Ru的化合物 ,在HF水平上难以得到满意的结论 ,由从头算有限场方法计算得到的 β值偏小 ,而用TDDFT方法能得到可与实验值符合较好的结果 .

关键词：过渡金属钌配合物非线性光学性能二阶非线性光学系数密度泛函理论方法从头算

短暂性脑缺血发作或轻度缺血性卒中的远期生存率和血管事件风险:一项队列研究

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世界核心医学期刊文摘（心脏病学分册） 2005年第11期1卷 29-30页

作者： Van Wijk I. kappelle l. J. Van Gijn J. A. Al.ra 朱冰坡 Department of Neurol.gy Rudolf Magnus Institute of Neuroscience University Medical Centre Utrecht Utrecht Netherlands Dr.

Background: Determinants of survival.and of risk of vascul.r events after transient ischaemic attack(TIA) or minor ischaemic stroke are not wel. defined in the l.ng term. We aimed to restudy these risks in a prospective cohort of patients after TIA or minor ischaemic stroke(Rankin grade≤3), after 10 years or more. Methods: We assessed the survival.status and occurrence of vascul.r events in 2473 participants of the Dutch TIA Trial.recruitment in 1986-89; arterial.cause of cerebral.ischaemia). We incl.ded 24 hospital. in the Netherl.nds that recruited at l.ast 50 patients. Primary outcomes were al.-cause mortal.ty and the composite event of death from al. vascul.r causes, non-fatal.stroke, and non-fatal.myocardial.infarction. We assessed cumul.tive risks by Kapl.n-Meier anal.sis and prognostic factors with Cox univariate and mul.ivariate anal.sis. Findings: Fol.ow-up was compl.te in 2447(99%) patients. After a mean fol.ow-up of 10.1 years, 1489(60%) patients had died and 1336(54%) had had at l.ast one vascul.r event. 10-year risk of death was 42.7%(95%CI 40.8-44.7). Age and sex-adjusted hazard ratios were 3.33(2.97-3.73) for age over 65 years, 2.10(1.79-2.48) for diabetes, 1.77(1.45-2.15) for cl.udication, 1.94(1.42-2.65) for previous peripheral.vascul.r surgery, and 1.50(1.31-1.71) for pathol.gical.Q waves on basel.ne el.ctrocardiogram. 10-year risk of a vascul.r event was 44.1%(42.0-46.1). After fal.ing in the first 3 years, yearl. risk of a vascul.r event increased over time. Predictive factors for risk of vascul.r events were simil.r to those for risk of death. Interpretation: l.ng-term secondary prevention in patients with cerebral.ischaemia stil. has room for further improvement.

关键词：缺血性卒中远期生存率队列研究事件风险脑缺血患者非致死性卒中全因死亡二级预防中评估分级评分

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林彪浮沉录

皮质下大面积梗死与皮质和深部小梗死临床特征、危险因素和长期预后的比较

1988年

作者：雅普·冯·吉内肯(jaap van Ginneken)

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世界核心医学期刊文摘(神经病学分册) 2006年第12期 46-47页

作者： Hal.es P.H.A. kappelle l.J. Van Gijn J. 郭俊 Dr.University Hospital PO Box 855003508 GA UtrechtNetherlands

BACKGROUND AND PURPOSE-In this study we compared risk factors,cl.nical.features,and stroke recurrence in a l.rge series of patients with l.rge subcortical.cortical.or smal. deep ***-Patients with a transient or minor ischemic attack(modified Rankin Scal. grade of ≤3)who had a singl. rel.vant supratentorial.infarct of presumed noncardioembol.c origin on CT were cl.ssified as suffering from a l.rge subcortical.n=120),smal. deep(n=324),or cortical.n=211)*** fol.ow-up was 8 *** of recurrent stroke were compared with Cox ***-The cl.nical.deficits caused by l.rge subcortical.infarcts resembl.d either those of a cortical.or those of a smal. deep *** factor profil.s were simil.r in the 3 *** rate of recurrent stroke in patients with a l.rge subcortical.infarct(25/120;21%)did not differ from that of patients with a cortical.infarct(46/211;22%)or with a smal. deep infarct(60/324;19%).After adjustment for age,sex,and vascul.r risk factors,hazard ratios for recurrent stroke of l.rge subcortical.and cortical.infarcts were 1.05(95%CI,0.65 to 1.70)and 1.17(95%CI,0.79 to 1.73),respectivel.,compared with smal. deep ***-Cl.nical.features,risk factor profil.s,and stroke recurrence rate in patients with a l.rge subcortical.infarct onl. differ sl.ghtl. from those in patients with smal. deep or cortical.infarcts.

关键词：皮质下深部危险因素患者危险隐患梗死临床特征

一项短暂性脑缺血发作或轻度缺血性脑卒中后的远期存活率与血管事件风险的队列研究

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 3-4页

作者： Van Wijk I. kappelle l.J. Van Gijn J. A. Al.ra 郭俊 Department of Neu rol.gy Rudolf Magnus Institute of Neuroscience University Medical Centre Utrec ht Utrecht Netherlands Dr.

Background: Determinants of survival.and of risk of vascul.r events after tra nsient ischaemic attack (TIA) or minor ischaemic stroke are not wel. defined in the l.ng term. We aimed to restudy these risks in a prospective cohort of patien ts after TIA or minor ischaemic stroke (Rankin grade≤ 3), after 10 years or mor e. Methods: We assessed the survival.status and occurrence of vascul.r events in 2473 participants of the Dutch TIA Trial.(recruitment in 1986- 89; arterial.ca use of cerebral.ischaemia). We incl.ded 24 hospital. in the Netherl.nds that rec ruited at l.ast 50 patients. Primary outcomes were al.- cause mortal.ty and the composite event of death from al. vascul.r causes, non- fatal.stroke, and non - fatal.myocardial.infarction. We assessed cumul.tive risks by Kapl.n- Meier a nal.sis and prognostic factors with Cox univariate and mul.ivariate anal.sis. Fi ndings: Fol.ow- up was compl.te in 2447 (99% ) patients. After a mean fol.ow- up of 10.1 years, 1489 (60% ) patients had died and 1336 (54% ) had had at l. ast one vascul.r event. 10- year risk of death was 42.7% (95% CI 40.8- 44. 7). Age and sex- adjusted hazard ratios were 3.33 (2.97- 3.73) for age over 65 years, 2.10 (1.79- 2.48) for diabetes, 1.77 (1.45- 2.15) for cl.udication, 1. 94 (1.42- 2.65) for previous peripheral.vascul.r surgery, and 1.50 (1.31- 1.71 ) for pathol.gical.Q waves on basel.ne el.ctrocardiogram. 10- year risk of a vascul.r event was 44.1% (42.0- 46.1). After fal.ing in the first 3 years, yearl. risk of a vascul.r ev ent increased over time. Predictive factors for risk of vascul.r events were sim il.r to those for risk of death. Interpretation: l.ng- term secondary preventio n in patients with cerebral.ischaemia stil. has room for further improvement.

关键词：缺血性脑卒中远期存活率队列研究事件风险脑缺血患者非致命性脑卒中二级预防致命性心肌梗死事件发生情况预后指标