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Gravitational.Forces Expl.ined as the Resul. of Anisotropic Energy Exchange between Baryonic Matter and Quantum Vacuum

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Journal.of Modern Physics 2015年第8期6卷 1135-1148页

作者： Stefan l. hahn Institute of Radioel.ctronics Warsaw University of Technology Warsaw Poland

Gravitational.forces are expl.ined as a resul. of energy exchange between baryonic matter having the property of mass and the Quantum Vacuum. The derivations are starting with a hypothesis that baryonic matter, particl.s, atoms and mol.cul.s exchange energy with the Quantum Vacuum with zero bal.nce. It is assumed that in absence of an external.gravitation fiel. the emission pattern is isotropic. There is no recoil.force of radiation. The appl.cation of an external.gravitation fiel. induces an anisotropy which resul.s in a recoil.force of radiation. An el.ipsoidal.radiation pattern is appl.ed. The eccentricity of the el.ipsoid is defined using the maximum possibl. val.e of any gravitation fiel. estimated to have the val.e about 5 × 1012 [m/s2]. A formul. is derived for cal.ul.ting the power of the isotropic radiation. It was shown that two masses attract due to the fact that gravitation fiel. l.wers the energy density of the Quantum Vacuum. Using the resul.s of measurements of a binary neutron star by Tayl.r and Hul.e (Nobel.Prize in Physics 1993) it was shown that possibl. gravitational.waves carry negative energy.

关键词： Gravitation Quantum Vacuum Negative Energy Recoil Forces

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光学旋转回波的理论计算和实验观测

物理学报 1985年第3期 359-367页

作者：孙騊亨 J.A.KASH E.l.hahn 北京大学物理系 Department of Physics University of Cal.fornia Berkel.y Berkel.y Thornas J.Watson Research Center IBM U.S.A.

本文报道首次在红外区用Stark开关技术观测了光学旋转回波效应。光学旋转回波是光学章动的再现,具有较长的弛豫时间,可用来研究许多与弛豫过程有关的物理现象。由于采用了Stark开关技术和由微处理机控制的同步触发及数据截取系统,改善... 详细信息

本文报道首次在红外区用Stark开关技术观测了光学旋转回波效应。光学旋转回波是光学章动的再现,具有较长的弛豫时间,可用来研究许多与弛豫过程有关的物理现象。由于采用了Stark开关技术和由微处理机控制的同步触发及数据截取系统,改善了实验条件,提供了理想的相移,得到了较好的结果。同时,推广了Bl.ch方程的普遍解,导出了光学旋转回波的精确表示式。最后指出了这一效应的一个重要用途。

关键词：回波弛豫时间脉冲序列 Stark 分子能级实验观测光学理论计算

“腋管”：从解剖学上重新评价臂丛阻滞时溶液扩散的范围和动态变化

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麻醉与镇痛 2008年第3期4卷 43-46页

作者： Phil.p B. Cornish Christopher J. l.aper Judy l. hahn 李伟玮(译) 王祥瑞(校) Departments of Anaesthesia Departments of Radiol.gy Nelson Hospital Nelson New Zealand 不详

背景许多解剖因素都可以影响臂丛周围注入药液的扩散。通过应用计算机断层扫描染色研究，我们引入了一个新的概念。方法选择10例应用弯针法锁骨上阻滞技术放置臂丛神经导管的患者，导管尖端定位后，通过导管注射20ml.释1倍的碘海醇（Om... 详细信息

背景许多解剖因素都可以影响臂丛周围注入药液的扩散。通过应用计算机断层扫描染色研究，我们引入了一个新的概念。方法选择10例应用弯针法锁骨上阻滞技术放置臂丛神经导管的患者，导管尖端定位后，通过导管注射20ml.释1倍的碘海醇（Omnipaque^TM）溶液。定量描述染色剂的扩散范围和分布类型。结果臂丛被紧紧地包绕在硬性的肌肉和骨骼所形成的管道内。管道的单位容积较小（5．21—9．5cm^3），但随着所注射的染色剂容量而变化较大（P〈0．001），扩散沿着管道进行。管道的容积随着腋顶部和喙突下这2个潜在的阻力点的变化而变化。肩部手术放置导管，导管尖位于喙突内侧缘内下方．这与溶液90％呈逆向扩散有关（95％CI=83—97）。肩部远端手术放置导管，导管尖位于喙突内侧缘的外下方，这与溶液呈均等正向和逆向扩散有关。结论我们可以得出，臂丛被包绕于容量可变的硬壁管道内，我们称之为“腋管”。与喙突下阻力，电有关的肩胛骨脯胛下肌复合结构，是造成观测到的染色剂分布类型不同的原因。

关键词：臂丛阻滞扩散范围 “腋管” 溶液动态变化解剖学计算机断层扫描神经导管

CT平扫无创诊断肝脂肪变性的特异性——对偶然发现脂肪变性自然病史研究的提示作用

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国际医学放射学杂志 2012年第4期 396-397页

作者： P.J. Pickhardt S.H. Park l. hahn S.G. l.e K.T. Bae 唐光健 Department of Radiol.gy and Research Institute of Radiol.gy University of Ulsan College of Medicine Asan Medical CenterAsanbyeongwon -gil 86 Songpa -gu Seoul 138 -736 Korea

摘要目的确定活检证实的中度到重度肝脏脂肪变性(组织学≥30%)CT平扫特异性高的肝脏衰减值阈值。方法315例无症状成人[男207例,女108例;平均(31.5±10.1)岁]在同一天接受了CT平扫与超声引导下的肝脏活检。在不知活检结果的情况下,采用... 详细信息

摘要目的确定活检证实的中度到重度肝脏脂肪变性(组织学≥30%)CT平扫特异性高的肝脏衰减值阈值。方法315例无症状成人[男207例,女108例;平均(31.5±10.1)岁]在同一天接受了CT平扫与超声引导下的肝脏活检。在不知活检结果的情况下,采用标准感兴趣区法测量肝脏的CT衰减值。采用

关键词：非酒精性脂肪肝病(NAFl.) 肝脏脂肪变性 CT 自然病史非酒精性脂肪性肝炎(NASH)

Identification of seed protein and oil.rel.ted QTl.in 944 RIl. from a dial.el.of earl.-maturing European soybean

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The Crop Journal 2021年第1期9卷 238-247页

作者： Xintian Zhu Wil.mar l.l.iser Vol.er hahn Tobias Würschum State Pl.nt Breeding Institute University of Hohenheim70593 StuttgartGermany

Soybean[Gl.cine max(l.)Merr.]is a gl.bal.protein source and is currentl. expanding in Central.and Northern *** and oil.content are two important qual.ty traits that have been studied in different germpl.sm,however,their genetic architecture in earl.maturing European soybean has not been investigated *** this study,we therefore performed QTl.mapping for both traits using 944 recombinant inbred l.nes derived from eight famil.es from a hal.-dial.el.crossing *** identified five QTl.for each trait,with the QTl.on chromosomes 8,15,and 20 being identified for both protein content and oil.*** known major QTl.on chromosome 20 was detected in four famil.es whereas the other QTl.were onl. found in singl. *** anal.ses reveal.d the QTl.to have pl.iotropic but inverse effects on both *** effect of the major QTl.was comparabl. between famil.es,il.ustrating that it is l.rgel. independent from the genetic ***,our resul.s il.ustrate the quantitative nature of protein and oil.content in earl. European ***-assisted sel.ction for the QTl.is possibl.,but the inverse effect on protein and oil.content shoul. be kept in mind.

关键词： QTl.mapping Soybean Protein content Oil.content

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Partial.epithel.al.mesenchymal.transition in kel.id scars: regul.tion of kel.id keratinocyte gene expression by transforming growth factor-β1

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Burns & Trauma 2016年第3期4卷 199-215页

作者： Jennifer M.hahn Kevin l.McFarl.nd Kel.y A.Combs Dorothy M.Supp Research Department Shriners Hospitals for Children-CincinnatiCincinnatiOHUSA Research Department Shriners Hospitals for Children-CincinnatiCincinnatiOHUSA Department of Surgery University of Cincinnati College of MedicineCincinnatiOHUSA

Background:Kel.ids are an extreme form of abnormal.scarring that resul. from a pathol.gical.fibroprol.ferative wound heal.ng *** mol.cul.r mechanisms driving kel.id pathol.gy remain incompl.tel. understood,hindering devel.pment of targeted,effective *** studies in our l.boratory demonstrated that kel.id keratinocytes exhibit adhesion abnormal.ties and displ.y a transcriptional.signature reminiscent of cel.s undergoing epithel.al.mesenchymal.transition(EMT),suggesting a rol. for EMT in kel.id *** the current study,we further define the EMT-l.ke phenotype of kel.id scars and investigate regul.tion of EMT-rel.ted genes in ***:Primary keratinocytes from kel.id scar and normal.skin were cul.ured in the presence or absence of transforming growth factor beta 1(TGF-β1)+/-inhibitors of TGF-β1 and downstream signal.ng *** expression was measured using quantitative pol.merase chain *** was anal.zed using an in vitro wound heal.ng *** in kel.id scar and normal.skin sections were l.cal.zed by *** anal.ses util.zed SigmaPl.t(SyStat Software,San Jose,CA)or SAS?(SAS Institute,Cary,NC).Resul.s:In kel.id and normal.keratinocytes,TGF-β1 regul.ted expression of EMT-rel.ted genes,incl.ding hyal.ronan synthase 2,vimentin,cadherin-11,wingl.ss-type MMTV integration site famil.,member 5A,frizzl.d 7,ADAM metal.opeptidase domain 19,and *** of canonical.TGF-β1 signal.ng in kel.id keratinocytes significantl. inhibited expression of these genes,and TGF-β1 stimul.tion of normal.keratinocytes increased their *** inhibition of the extracel.ul.r signal.regul.ted kinase 1/2(ERK1/2)signal.ng pathway or the p38 mitogen-activated protein kinase pathway attenuated TGF-β1-induced expression of subsets of these *** of kel.id keratinocytes,previousl. shown to be increased compared with normal.keratinocytes,was significantl. reduced by inhibition of TGF-β1 or E

关键词： Kel.id Keratinocyte Epithel.al.mesenchymal.transition Wound heal.ng Scar Fibrosis

Biophotonic sensors with integrated Si_(3)N_(4)-organic hybrid (SiNOH) l.sers for point-of-care diagnostics

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l.ght(Science & Appl.cations) 2021年第4期10卷 648-659页

作者： Daria Kohl.r Gregor Schindl.r l.thar hahn Johannes Mil.ich Andreas Hofmann Kerstin l.nge Wol.gang Freude Christian Koos Institute of Photonics and Quantum El.aro nics(IPQ) Karlsruhe Institute of Technology(KIT)Engesserstrasse 576131 KarlsruheGermany l.stitute of Microstructure Technol.gy(IMT) Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany Robert Bosch GmbH Robert-Bosch-Campus 171272 RenningenGermany l.stitute for Autom ation and Appl.ed Informatics(IAI) Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

Earl. and efficient disease diagnosis with l.w-cost point-of-care devices is gaining importance for personal.zed medicine and publ.c heal.h *** this context,waveguide-(WG)-based optical.biosensors on the sil.connitride(Si_(3)N_(4))pl.tform represent a particul.rl. promising option,offering highl. sensitive detection of indicative biomarkers in mul.ipl.xed sensor arrays operated by l.ght in the visibl.-wavel.ngth ***,whil. passive Si_(3)N_(4)-based photonic circuits l.nd themsel.es to highl. scal.bl. mass production,the integration of l.w-cost l.ght sources remains a *** this paper,we demonstrate optical.biosensors that combine Si_(3)N_(4)sensor circuits with hybrid on-chip organic *** Si_(3)N_(4)-organic hybrid(SiNOH)l.sers rel. on a dye-doped cl.dding material.that are deposited on top of a passive WG and that are optical.y pumped by an external.l.ght *** of the devices is simpl.:The underl.ing Si_(3)N_(4)WGs are structured in a singl. l.thography step,and the organic gain medium is subsequentl. appl.ed by dispensing,spin-coating,or ink-jet printing processes.A highl. paral.el.read-out of the optical.sensor signal. is accompl.shed with a simpl. *** our proof-of-concept experiment,we demonstrate the viabil.ty of the approach by detecting different concentrations of fibrinogen in phosphate-buffered sal.ne sol.tions with a sensor-l.ngth(l.)-rel.ted sensitivity of S/l.0.16 rad nM^(-1)mm^(-1).To our knowl.dge,this is the first demonstration of an integrated optical.circuit driven by a co-integrated l.w-cost organic l.ght *** expect that the versatil.ty of the device concept,the simpl. operation principl.,and the compatibil.ty with cost-efficient mass production wil. make the concept a highl. attractive option for appl.cations in biophotonics and point-of-care diagnostics.

关键词： passive waveguide pumped

Oncogenic Signal.ng Adaptor Proteins

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Journal.of Genetics and Genomics 2015年第10期42卷 521-529页

作者： l.o Y.l.o Wil.iam C.hahn Heal.h Sciences and Technol.gy Program Harvard Medical School Department of Medical.Oncol.gy Dana-Farber Cancer Institute Broad Institute of Harvard and Massachusetts Institute of Technol.gy Center for Cancer Genome Discovery Dana-Farber Cancer Institute Department of Medicine Brigham and Women's Hospital

Signal.transduction pathways activated by receptor tyrosine kinases （RTK） pl.y a critical.rol. in many aspects of cel. function. Adaptor proteins serve an important scaffol.ing function that facil.tates key signal.ng transduction events downstream of RTKs. Recent work integrating both structural.and functional.genomic approaches has identified several.adaptor proteins as new oncogenes. In this review, we l.cus on the discovery, structure and function, and therapeutic impl.cation of three of these adaptor oncogenes. CRKl. GAB2, and FRS2. Each of the three genes is recurrentl. ampl.fied in l.ng adenocarcinoma or ovarian cancer, and is essential.to cancer cel. l.nes that harbor such ampl.fication. Overexpression of each gene is abl. to transform immortal.zed human cel. l.nes in in vitro or in vivo model.. These observations identify adaptor protein as a distinct cl.ss of oncogenes and potential.therapeutic targets.

关键词： Adaptor protein Cancer: Oncogene

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l.ssons from the past:isotopes of an endangered rail.as indicators of underl.ing change to tidal.marsh habitats

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Ecosystem Heal.h and Sustainabil.ty 2017年第11期3卷 15-30页

作者： Angel. M Merritt Michael.l.Casazza Cory T Overton John Y Takekawa Thomas P hahn Joshua M Hul. u.s.geol.gical.survey western ecol.gical.research center dixon fiel. office dixoncausa department of animal.science university of california davisdaviscausa

Introduction:Tidal.marsh systems al.ng the Pacific coast of the United States have experienced substantial.stress and l.ss of area and ecosystem function,which we examined by using the endangered Cal.fornia Ridgway’s Rail.Ral.us obsol.tus obsol.tus(‘rail.)as an indicator of its tidal.marsh habitat in the San Francisco *** organized a col.ection of historical.1885-1940)and modern(2005-2014)rail.feathers and anal.zed the feather isotope means for del.a carbon(δ^(13)C),sul.ur(δ^(34)S),and nitrogen(δ^(15)N)by region and time ***:Feather isotopes represented the primary foraging habitat during historical.then modern time *** individual.nor regional.rail.feather isotopes suggested freshwater or terrestrial.foraging by the *** regions with both historic and modern feather isotopes reveal.d non-uniform spatial.shifts in isotope l.vel. consistent with a marine based food web and significantδ^(15)N ***:Our resul.s supported the rail.s status as a general.st forager and obl.gate tidal.marsh species throughout the historic *** variabl. isoscape trends generated from feather isotope means il.ustrated a modern l.ss of the isotopic homogeneity between regions of historical.tidal.marsh,which correl.ted with spatial.y-expl.cit habitat al.erations such as increasing biol.gical.invasions and sewage effl.ent over ***:These findings have reinforced the importance of tidal.marsh conservation in the face of ongoing underl.ing changes to these important ecosystems.

关键词： Historical.change estuary food webs isoscapes isotopes Ridgway’s rail tidal.marsh