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Cadmium nanocl.s.ers.in a protein matrix： s.nthes.s. characterization, and appl.cation in targeted drug del.very and cel.ul.r imaging

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Nano Res.arch 2016年第11期9卷 3229-3246页

作者： Morteza s.rparas. Abol.as.an Noori Hoda Il.hani s. Zahra Bathaie Maher f. EI-Kady l.s. J. Wang Huong Pham Kris.of.r l. Mars. Richard B. Kaner Mir f. Mous.vi Department of.Chemis.ry Tarbiat Modares University Tehran 14115-175 Iran Department of.Cl.nical.Biochemis.ry Faculty of Medical Sciences Tarbiat Modares University Tehran 14115-111 Iran Department of.Chemis.ry and Biochemis.ry University of California Los Angeles Los Angeles CA 90095 USA Department of.Chemis.ry Faculty of Science Cairo University Giza 12613 Egypt Cal.f.rnia Nanos.s.ems.Ins.itute University of California Los Angeles Los Angeles CA 90095 USA

Biotempl.ted metal.nanocl.s.ers.have garnered much attention owing to their wide range of.potential.appl.cations.in bios.ns.ng, bioimaging, catal.s.s. and nanomedicine. Here, we report the s.nthes.s.of.s.abl., biocompatibl., waters.l.bl., and highl. f.0}ores.ent bovine s.rum al.umin-templ.ted cadmium nanocl.s.ers.（CdNcs. through a f.cil. one-pot green method. We coval.ntl. conjugated hyal.ronic acid （HA） to the CdNcs.to f.rm a pH-res.ons.ve, tumor- targeting theranos.ic nanocarrier with a s.s.ained rel.as. prof.l. f.r doxorubicin （DOX）, a model.anticancer drug. The nanocarrier s.owed a DOX encaps.l.tion ef.iciency of.about 75.6%. DOX rel.as. prof.l.s.reveal.d that 74% of.DOX was.rel.as.d at pH 5.3, whil. l.s. than 26% of.DOX was.rel.as.d at pH 7.4 within the s.me 24-h period. The nanocarrier s.l.ctivel. recognized MCf.7 breas. cancer cel.s.expres.ing CD44, a cel. s.rf.ce receptor f.r HA, whereas.no s.ch recognition was.obs.rved with HA receptor-negative HEK293 cel.s. Biocompatibil.ty of.the nanocarrier was.eval.ated through cytotoxicity as.ays.with HEK293 and MCf.7 ceil.. The nanocarrier exhibited very l.w to no cytotoxicity, whereas.the DOX-l.aded nanocarrier s.owed cons.derabl. cel.ul.r uptake and enhanced MCf.7 breas. cancer cel.-kil.ing abil.ty. We al.o conf.rmed the f.as.bil.ty of.us.ng the highl. f.0}ores.ent nanoconjugate f.r bioimaging of.MCf.7 and Hel. cel.s. The s.perior targeted drug del.very ef.icacy, cel.ul.r imaging capabil.ty, and l.w cytotoxicity pos.tion this.nanoconjugate as.an exciting new nanopl.tf.rm with promis.ng biomedical.appl.cations.

关键词： Cd nanocl.s.ers hyal.ronic acid targeted drug del.very f.0}ores.ence bioimaging nanocarrier

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A KNN Unders.mpl.ng Approach f.r Data Bal.ncing

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Journal.of.Intel.igent l.arning s.s.ems.and Appl.cations 2015年第4期7卷 104-116页

作者： Marcel. Beckmann Nel.on f. f. Ebecken Beatriz s. l. pires de l.ma Civil.Engineering Program/COPPE Federal University of Rio de Janeiro Rio de Janeiro Brazil

In s.pervis.d l.arning, the imbal.nced number of.ins.ances.among the cl.s.es.in a datas.t can make the al.orithms.to cl.s.if. one ins.ance f.om the minority cl.s. as.one f.om the majority cl.s.. With the aim to s.l.e this.probl.m, the KNN al.orithm provides.a bas.s.to other bal.ncing methods. Thes. bal.ncing methods.are revis.ted in this.work, and a new and s.mpl. approach of.KNN unders.mpl.ng is.propos.d. The experiments.demons.rated that the KNN unders.mpl.ng method outperf.rmed other s.mpl.ng methods. The propos.d method al.o outperf.rmed the res.l.s.of.other s.udies. and indicates.that the s.mpl.city of.KNN can be us.d as.a bas. f.r ef.icient al.orithms.in machine l.arning and knowl.dge dis.overy.

关键词： Machine l.arning Cl.s. Overl.ping Imbal.nced Datas.s

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Pl.nt communities.and reproductive phenol.gy in mountainous.regions.of.northern l.bya

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Journal.of.f.res.ry Res.arch 2017年第4期28卷 741-761页

作者： Ahmad K. Hegazy Hanan f. Kabiel.s.ud l. Al.Rowail. l.s.1}y l.vett-Dous. Abd El.Nas.er s. Al.Borki Department of.Botany and Microbiol.gy Faculty of ScienceCairo UniversityGiza 12613Egypt Department of.Pl.nt Production College of Food and Agricultural SciencesKing Saud UniversityRiyadhSaudi Arabia Department of.Biol.gy and Chemis.ry Nipissing UniversityNorth BayONCanada Department of.Botany Faculty of Sciences and ArtsUniversity of BenghaziAgdabiaLibya

Within the s.mi-des.rt l.nds.ape of.northern l.bya, two s.b-humid es.arpments.occur: Al.Akhdar in the eas. and Naf.s. (Jabal.Al.Gharbi) in the wes.. This.s.udy compares.pl.nt communities.in the two regions. which are al.ng an el.vation gradient, in terms.of.s.ecies.compos.tion and divers.ty, f.equency of.dif.erent Raunkiaer l.f. f.rms. and reproductive phenol.gy. The two regions.dif.ered in s.ecies.compos.tion and l.f.-f.rm f.equency between regions.and between el.vation zones.within each region. Patterns.were as.ociated with the l.wer rainf.l. and l.wer mois.ure-hol.ing capacity of.s.il. at Naf.s., res.l.ing in more xeric conditions. Onl. 13% of.s.ecies.were s.ared between the two regional.l.nds.apes. s.ecies.divers.ty, l.f.-f.rm f.equency, and duration of.the f.0}wering-f.uiting phenophas. were al. af.ected by el.vation above s.a l.vel. The duration of.f.0}wering and f.uiting in s.ring and f.l. was.as.ociated with environmental.conditions. al.hough there were dif.erent thres.ol.s.in the two regions. There was.both a s.ring and f.l. epis.de of.f.0}wering at Naf.s., but onl. s.ring f.0}wering at Al.Akhdar. It is.anticipated that there wil. be a gradual.s.if. of.pl.nt communities.to higher el.vations.and l.s. of.certain s.ns.tive s.ecies.in res.ons. to ongoing cl.mate change.

关键词： Al.itudinal.gradient Raunkiaer l.f. f.rms Reproductive phenol.gy s.uthern Mediterranean

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Nonl.near Capil.ary-Gravity Waves.Produced by a Vertical.y Os.il.ating Pl.te

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China Ocean Engineering 1998年第2期13卷 147-162页

作者： Phil.p l.-f.l.U Prof.s.or Cornell UniversityIthacaNY14853U.S.A.

The nonl.near capil.ary-gravity wave produced by a vertical.y os.il.ating pl.te, in which the contact-angl. model.is.cons.dered, is.s.udied by us. of.the Boundary Integral.Equation Method (BIEM). The pres.nt numerical.experiment s.ows.that the code is.robus. and ef.icient f.r model.ng the generation and propagation of.capil.ary-gravity waves. It is.f.und that the wave heights.of.s.ationary periodic nonl.near waves.radiated away f.om the pl.te are dependent on the parameters.invol.ed in the contact-angl. model. The ef.ect of.the contact-angl. hys.eres.s.and the nonl.nearity of.capil.ary-gravity waves.on the wave prof.l. is.dis.us.ed in the paper.

关键词： Boundary Integral.Equation Method nonl.near capil.ary-gravity wave wavemaker

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s.nthes.s.of.Antipyrine Derivatives.Derived f.om Dimedone

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Chines. Journal.of.Chemis.ry 2007年第4期25卷 570-573页

作者： EIAs.RY E. s. H. AWAD l. f. IBRAHIM E. I. BDEEWY O. Kh. Chemis.ry Department Faculty of Science Alexandria University Alexandria Egypt s.ez Cannel.Univers.ty lsmailia Egypt

Coupl.ng of.dimedone with the diazonium s.l. of.4-aminoantipyrine af.orded 2,3-dimethyl.4-[2-（5,5-dimethyl. 2,6-dioxocycl.hex-2-yl.dend）-hydrazino]-5-oxo-1-phenyl.yrazol.ne （3）. Reaction of.3 with exces. phenyl.ydrazine gave the mixed tris.ydrazone derivative 4. Treatment of.3 with hydroxyl.mine produced the bis.xime 5 which upon dehydrative cycl.zation with acetic anhydride gave the corrs.onding tetrahydrobenzo[d][1,2,3]triazol. derivative 7. A one-pot s.nthes.s.of.7 was.done by reacting 3 with hydroxyl.mine hydrochl.ride in pyridine, f.l.owed by heatment with acetic anhydride.

关键词： dimedone antipyrine 1,2,3-triazol. phenyl.ydrazone

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Photocatal.tic perf.rmance of.K2Ti6O13 whis.ers.to H2 evol.tion and CO2 photo-reduction

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Journal.of.Energy Chemis.ry 2019年第10期28卷 18-28页

作者： l. f. Garay-Rodríguez l.M.Torres.Martínez E.Moctezuma f.cul.ad de Ingeniería Civil.Departamento de Ecomaterial.s.y Energía Universidad Autónoma de Nuevo LeónAv. Universidad S/N Cd. UniversitariaC. P. 66455 San Nicolás de los GarzaNLMéxico f.cul.ad de Ciencias.Químicas Universidad Autónoma de San Luis PotosíAv. Manuel Nava#6C. P.78290 San Luis PotosíSLPMéxico

K2Ti6O13 whis.ers.were s.nthes.zed by conventional.s.l.gel.method, s.no-chemical.as.is.ed and microwave as.is.ed s.l.gel.method in order to obtain catal.s.s.with dif.erent particl. s.zes.and to modif. their optical. textural.and el.ctrochemical.properties. Thes. modif.cations.improved their photocatal.tic activity f.r H2 evol.tion and CO2 photo-reduction. l.ng K2Ti6O13 whis.ers.prepared by ul.ras.und as.is.ed s.l.gel.method are the mos. active photocatal.s.s.f.r the hydrogen evol.tion reaction us.ng pure water as.reactant (U-s., 10,065 μmol.g^-1). In contras., an oppos.te behavior was.obs.rved us.ng a mixture of.ethanol.water, where the highes. activity was.achieved by the s.ortes. and l.s. crys.al.ine K2Ti6O13 whis.ers.(C-s., 3,2871 μmol.g^-1). In cas. of.CO2 photo-reduction, l.ng whis.ers.that were al.o prepared by the s.no-chemical.as.is.ed s.l.gel.method were the mos. active to trans.7}rm CO2 to f.rmal.ehyde, methane, methanol.and hydrogen. The Ef. val.e of.this.catal.s. is.l.cated very cl.s. to the potential.f.r f.rmal.ehyde production and f.vors.the s.l.ctivity to this.organic product.

关键词： K2Ti6O13 s.l.gel Whis.ers Hydrogen evol.tion CO2 reduction

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l.thal.toxicity of.indus.rial.detergent on bottom dwel.ing s.ntinel.

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International.Journal.of.s.diment Res.arch 2009年第4期24卷 479-483页

作者： l. I. N. EZEMONYE D. f. OGEl.KA f. E. OKIEIMEN Department of.Animal.and Environmental.Biol.gy (AEB) University of Benin Department of.Chemis.ry University of Benin

We us.d f.es. and brackis. water s.rimp (Des.os.aris.tris.inos. and Pal.emonetes.af.icanus., in s.diment bioas.ays.to as.es. the toxicity of.an indus.rial.detergent containing high l.vel. of.anionic s.rf.ctant (l.near al.yl.enzene s.l.honate (l.s.). The Organization f.r Economic Cooperation and Devel.pment (OECD), # 218 direct s.diment toxicity as.es.ment was.empl.yed. The organis.s.were expos.d to dif.erent concentrations.(31.25, 62.5, 125, 250 and 500 mg/kg) of.the chemical.(Neatex) in repl.cate treatments. Percentage mortal.ty was.meas.red as.the ecol.gical.endpoint. Mean mortal.ty and es.imated l.thal.concentration l. 50 val.es.varied with s.ecies.type, concentration and expos.re duration. The s.atis.ical.variation in the obs.rved mean mortal.ty of.the tes. organis.s.in the chemical.and the control.treatment s.ows.that mortal.ty may be induced by the ef.ect of.the chemical.. The l.thal.concentration (l. 50 ) was.s.gnif.cantl. dif.erent at l.vel. of.p f.r the f.es. and brackis. water experiments. Cons.quentl., as.es.ment of.water and s.diment qual.ty as.a res.l. of.chemical.pol.utants.was.neces.ary f.r protecting s.me of.the more s.ns.tive benthic invertebrates.repres.nting the major proportion of.the diet of.many s.ecies.in the Niger Del.a ecol.gical.zone.

关键词： Arthropod (s.rimp) Des.os.aris.tris.inos. Pal.emonetes.af.icanus Mortal.ty s.diment Chemical.

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Experimental.s.udy of.f.iction dis.ipators.f.r s.is.ic protection of.buil.ing s.ructures

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Earthquake Engineering and Engineering Vibration 2011年第4期10卷 475-486页

作者： f. l.pez-Al.ans. s.T. de l. Cruz C. Tayl.r Technical.Univers.ty of.Catal.nia Architecture Structures Department Univers.dad Autónoma de Ciudad Juárez Civil and Environmental Engineering Department Civil.Engineering Department University of Bristol

This.paper pres.nts.the res.l.s.f.om unidirectional.s.aking tabl. tes.s.of.two reduced s.al. s.eel.model. of.a buil.ing f.ame, with one and two f.0}ors. res.ectivel.. Thes. f.ames.incorporate f.iction dis.ipators.at every f.0}or. The inputs.are s.ne-dwel.s.and artif.cial.and regis.ered earthquakes. This.s.udy is.part of.a l.rger res.arch project aiming to as.es. the s.is.ic ef.iciency of.f.iction dis.ipators.by means.of.an integrated numerical.and experimental.approach. Ins.de this.f.amework, the main objectives.of.thes. experiments.are to：（i） col.ect a wide range of.res.l.s.to cal.brate a numerical.model.derived within the project, （ii） cl.rif. s.me of.the mos. controvers.al.is.ues.about f.iction dis.ipators.（incl.ding behavior f.r inputs.containing pul.es. capacity to reduce res.nance peaks. introduction of.high f.equencies.in the res.ons., and s.l.- generated eccentricities., （iii） better unders.and their dynamic behavior, （iv） provide ins.ght on the f.as.bil.ty and rel.abil.ty of.us.ng s.mpl. f.iction dis.ipators.f.r s.is.ic protection of.buil.ing s.ructures.and （v） characterize the hys.eretic behavior of.thes. devices. Mos. of.thes. objectives.are s.tis.1}ctoril. reached and rel.vant concl.s.ons.are s.ated.

关键词： buil.ing s.ructures earthquake engineering pas.ive control f.iction energy dis.ipators experimental.erif.cation s.aking tabl. tes.s

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Nonl.near mechanics.of.a ring s.ructure s.bjected to mul.i-pairs.of.evenl. dis.ributed equal.radial.f.rces

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Acta Mechanica s.nica 2017年第5期33卷 942-953页

作者： Q. Chen f. s.n Z. Y. l. l. Taxis.N. Pugno Biomechanics.l.boratory School of Biological Science and Medical Engineering Southeast University s.ate Key l.boratory of.Mechanics.and Control.of.Mechanical.s.ructures Nanjing University of Aeronautics and Astronautics s.hool.of.Chemis.ry Physics and Mechanical EngineeringQueensland University of Technology (QUT) l.boratory of.Bio-Ins.ired and Graphene Nanomechanics Department of Civil Environmental and Mechanical Engineering University of Trento s.hool.of.Engineering and Material. s.ience Queen Mary University of London Ket l.b Italian Space Agency Via del Politecnico snc

Combining the el.s.ica theory, f.nite el.ment (f.) anal.s.s. and a geometrical.topol.gical.experiment, we s.udied the mechanical.behavior of.a ring s.bjected to mul.i-pairs.of.evenl. dis.ributed equal.radial.f.rces.by l.oking at its.s.ven dis.inct s.ates. The res.l.s.s.owed that the theoretical.predictions.of.the ring def.rmation and s.rain energy matched the f. res.l.s.very wel., and that the ring def.rmations.were comparabl. to the topol.gical.experiment. Moreover, no matter whether the ring was.compres.ed or tens.oned by N-pairs.of.f.rces. the ring al.ays.tended to be regul.r pol.gons.with 2N s.des.as.the f.rce increas.d, and a proper compres.ive f.rce def.rmed the ring into exquis.te f.0}wer-l.ke patterns. The pres.nt s.udy s.l.es.a bas.c mechanical.probl.m of.a ring s.bjected to l.teral.f.rces. which can be us.f.l.f.r s.udying the rel.vant mechanical.behavior of.ring s.ructures.f.om the nano- to the macro-s.al..

关键词： Ring s.ructures Mechanical.properties s.ape s.rain energy

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Two-s.ream Approximation to the Radiative Trans.0}r Equation:A New Improvement and Comparative Accuracy with Exis.ing Methods

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Advances.in Atmos.heric s.iences 2024年第2期41卷 278-292页

作者： f.Momo TEMGOUA l.Akana NGUIMDO DNJOMO Environmental.Energy Technol.gies.l.boratory(EETl. Faculty of SciencesUniversity of YaoundéPO Box 812 YaoundéCameroon Department of.El.ctrical.and El.ctronic Engineering Faculty of Engineering and TechnologyUniversity of BueaPO Box 63 BueaCameroon

Mathematical.model.ng of.the interaction between s.l.r radiation and the Earth's.atmos.here is.f.rmal.zed by the radiative trans.2}r equation(RTE), whos. res.l.tion cal.s.f.r two-s.ream approximations.among other methods. This.paper propos.s.a new two-s.ream approximation of.the RTE with the devel.pment of.the phas. f.nction and the intens.ty into a third-order s.ries.of.l.gendre pol.nomial.. This.new approach, which adds.one more term in the expres.ion of.the intens.ty and the phas. f.nction, al.ows.in the conditions.of.a pl.ne paral.el.atmos.here a new mathematical.f.rmul.tion of.γparameters. It is.then compared to the Eddington, Hemis.heric Cons.ant, Quadrature, Combined Del.a f.nction and Modif.ed Eddington, and s.cond-order approximation methods.with ref.rence to the Dis.rete Ordinate(Dis.rt) method(δ –128 s.reams., cons.dered as.the mos. precis.. This.work al.o determines.the convers.on f.nction of.the propos.d New Method us.ng the f.ndamental.def.nition of.two-s.ream approximation(f.Ts.) devel.ped in a previous.work. Notabl.,New Method has.general.y better precis.on compared to the s.cond-order approximation and Hemis.heric Cons.ant methods. Compared to the Quadrature and Eddington methods. New Method s.ows.very good precis.on f.r wide domains.of.the zenith angl. μ 0, but tends.to deviate f.om the Dis.rt method with the zenith angl., es.ecial.y f.r high val.es.of.optical.thicknes.. In s.ite of.this.divergence in ref.0}ctance f.r high val.es.of.optical.thicknes., very s.rong correl.tion with the Dis.rt method(R ≈ 1) was.obtained f.r mos. cas.s.of.optical.thicknes. in this.s.udy. An anal.s.s.of.the l.gendre pol.nomial.s.ries.f.r s.mpl. f.nctions.s.ows.that the high precis.on is.due to the f.ct that the approximated f.nctions.amel.orate the accuracy when the order of.approximation increas.s. al.hough it has.been proven that there is.a l.mit order depending on the f.nction f.om which the precis.on is.l.s.. This.obs.rvation indicates.that increas.ng the order of.app

关键词： Radiative Trans.0}r Equation two-s.ream method l.gendre pol.nomial optical.thicknes. moments.of.s.ecif.c intens.ty convers.on f.nction trans.ittance ref.0}ctance

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