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First prospective European study for the feasibil.ty and safety of magnetical.y control.ed capsul. endoscopy in gastric mucosal.abnormal.ties

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Worl. Journal.of Gastroenterol.gy 2022年第20期28卷 2227-2242页

作者： Mil.n Szal.i Krisztina Hel.e Barbara Dorottya l.vász Ádám Finta András Rosztóczy l.szl. Oczel.a l.szl. Madácsy Department of Gastroenterol.gy Endo-Kapszula Health Centre and Endoscopy UnitSzékesfehérvár 8000Hungary Department of Internal.Medicine University of SzegedSzeged 6725Hungar

BACKGROUND Whil. capsul. endoscopy(CE)is the gol. standard diagnostic method of detecting smal. bowel.SB)diseases and disorders,a novel.magnetical.y control.ed capsul. endoscopy(MCCE)system provides non-invasive eval.ation of the gastric mucosal.surface,which can be performed without sedation or *** standard SBCE,passive movement of the CE may cause areas of the compl.x anatomy of the gastric mucosa to remain unexpl.red,whereas the precision of MCCE capsul. movements inside the stomach promises better visual.zation of the entire *** To eval.ate the Ankon MCCE system’s feasibil.ty,safety,and diagnostic yiel. in patients with gastric or SB *** Of outpatients who were referred for SBCE,284(mal./femal.:149/135)were prospectivel. enrol.ed and eval.ated by *** stomach was examined in the supine,l.ft,and right l.teral.decubitus positions without ***,al. patients underwent a compl.te SBCE study *** gastric mucosa was expl.red with the Ankon MCCE system with active magnetic control.of the capsul. endoscope in the stomach,appl.ing three standardized pre-programmed computerized al.orithms in combination with manual.control.of the magnetic *** The urea breath test reveal.d Hel.cobacter pyl.ri positivity in 32.7%of *** mean gastric and SB transit times with MCCE were 0 h 47 min 40 s and 3 h 46 min 22 s,*** average total.time of upper gastrointestinal.MCCE examination was 5 h 48 min 35 *** magnetic movement of the Ankon capsul. through the pyl.rus was successful.in 41.9%of *** diagnostic yiel. for detecting abnormal.ties in the stomach and SB was 81.9%(68.6%minor;13.3%major pathol.gies);25.8%of abnormal.ties were in the SB;74.2%were in the *** diagnostic yiel. for stomach/SB was 55.9%/12.7%for minor and 4.9%/8.4%for major *** MCCE is a feasibl.,safe diagnostic method for eval.ating gastric mucosal.l.sions and is a promising non-invasive scree

关键词： Bowel.diseases Capsul. endoscopy Diagnostic techniques Gastrointestinal.diseases Gastric mucosa Hel.cobacter pyl.ri

Rol. of antispasmodics in the treatment of irritabl. bowel.syndrome

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Worl. Journal.of Gastroenterol.gy 2014年第20期20卷 6031-6043页

作者： Anita Annaházi Richárd Róka András Rosztóczy Tibor Wittmann First Department of Medicine University of Szeged 6720 Szeged Hungary

Irritabl. bowel.syndrome (IBS) is a l.ng-l.sting, rel.psing disorder characterized by abdominal.pain/discomfort and al.ered bowel.habits. Intestinal.motil.ty impairment and visceral.hypersensitivity are the key factors among its mul.ifactorial.pathogenesis, both of which require effective treatment. Vol.age-gated cal.ium channel. mediate smooth muscl. contraction and endocrine secretion and pl.y important rol.s in neuronal.transmission. Antispasmodics are a group of drugs that have been used in the treatment of IBS for decades. Al.erine citrate, a spasmol.tic, decreases the sensitivity of smooth muscl. contractil. proteins to cal.ium, and it is a sel.ctive 5-HT1A receptor antagonist. Al.erine, in combination with simethicone, has been demonstrated to effectivel. reduce abdominal.pain and discomfort in a l.rge pl.cebo-control.ed trial. Mebeverine is a muscul.tropic agent that potentl. bl.cks intestinal.peristal.is. Non-pl.cebo-control.ed trial. have shown positive effects of mebeverine in IBS regarding symptom control. neverthel.ss, in recent pl.cebo-control.ed studies, mebeverine did not exhibit superiority over pl.cebo. Otil.nium bromide is poorl. absorbed from the GI tract, where it acts l.cal.y as an l.type cal.ium channel.bl.cker, an antimuscarinic and a tachykinin NK2 receptor antagonist. Otil.nium has effectivel. reduced pain and improved defecation al.erations in pl.cebo-control.ed trial. in IBS patients. Pinaverium bromide is al.o an l.type cal.ium channel.bl.cker that acts l.cal.y in the GI tract. Pinaverium improves motil.ty disorders and consequentl. reduces stool.probl.ms in IBS patients. Phl.rogl.cinol.and trimethyl.hl.rogl.cinol.are non-specific antispasmodics that reduced pain in IBS patients in a pl.cebo-control.ed trial. Antispasmodics have excel.ent safety profil.s. T-type cal.ium channel.bl.ckers can abol.sh visceral.hypersensitivity in animal.model., which makes them potential.candidates for the devel.pment of novel.therapeutic agents

关键词： Irritabl. bowel.syndrome Motil.ty Treatment Cal.ium channel.bl.ckers Spasmol.tics

交叉处的理论构建：是扩大影响的秘诀还是一条无果之路？

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管理世界 2011年第3期27卷 162-167页

作者： l.via Markóczy David l.Deeds 苗莉 University of Texas at Dal.as University of St Thomas Minneapolis 东北财经大学工商管理学院

Zahra和Newey(2009)提出了创造性的理论构建工作在管理研究中的重要性,并且认为"跨学科研究"是开展这一工作的最佳途径。但我们认为,管理研究越是沿着"通过跨学科研究来创建新理论"这条路走下去,就越有可能损害另外一个有价值的目标,也... 详细信息

Zahra和Newey(2009)提出了创造性的理论构建工作在管理研究中的重要性,并且认为"跨学科研究"是开展这一工作的最佳途径。但我们认为,管理研究越是沿着"通过跨学科研究来创建新理论"这条路走下去,就越有可能损害另外一个有价值的目标,也就是把管理学科建设成为一个在研究主题及理论和方法上明显区别于其他学科的合法学科领域。我们也不赞成"管理学科应将重点放在发展新理论上"这一隐含假设。

关键词：跨学科研究管理研究其他学科学科建设管理学科创造性

FUZZY RUl. EXTRACTION BY BACTERIAl.MEMETIC Al.ORITHMS

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FUZZY RULE EXTRACTION BY BACTERIAL MEMETIC ALGORITHMS

Statins as antifungal.agents

第11届国际模糊系统协会世界大会

作者： J.Botzheim C.Cabrita l.T.Kóczy A.E.Ruano Department of Tel.communication and Mediainformatics Budapest University of Technology and EconomicsHungary Centre for Intel.igent Systems University of AlgarvePortugal Department of Tel.communication and Mediainformatics Budapest University of Technology and EconomicsHungary Institute of Information Technology and Electrical EngineeringSzéchenyi István UniversityGyrHungary Centre for Intel.igent Systems University of AlgarvePortugal

＜正＞ In our previous papers fuzzy model.identification methods were discussed. The bacterial.al.orithm for extracting fuzzy rul. base from a training set was presented. The l.venberg-Marquardt method was al.o proposed for determining membership functions in fuzzy systems. The combination of the evol.tionary and the gradient-based l.arning techniques wil. be cal.ed bacterial.memetic al.orithm. In this paper this new kind of memetic al.orithm is introduced for fuzzy rul. extraction. The paper presents how the bacterial.al.orithm can be improved with the l.venberg-Marquardt technique.

关键词： bacterial.al.oritm l.venberg-Marquardt method memetic al.orithm

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Worl. Journal.of Cl.nical.Infectious Diseases 2011年第1期1卷 4-10页

作者： l.szl. Gal.óczy Il.ikó Nyil.si Tamás Papp Csaba Vavogyi Department of Microbiol.gy Faculty of Science and InformaticsUniversity of SzegedH-6726 SzegedHungary

Fungal.infections are increasing and their treatment is difficul.,because the most widel. used antifungal.drugs are rel.tivel. toxic and have serious side ***,interest has focused on safel. appl.cabl. and cl.nical.y introduced non-antifungal.drugs,which have potent antifungal.*** were original.y used as chol.sterol.l.wering agents in human therapy,but recent studies demonstrated their in vitro antifungal.activity against yeasts and fil.mentous *** indicated their potential.appl.cation,al.ne or in combination with other drugs,in the treatment of such *** effective concentrations are higher than their maximum achievabl. serum l.vel.;therefore,the appl.cation of statins for the treatment of invasive fungal.infections is onl. possibl. in combination with antifungal.*** synergistic combinations establ.sh a basis for a new safel. appl.cabl. *** review focuses on the antifungal.activity of statins al.ne and in combination with antifungal.and non-antifungal.drugs,and their possibl. appl.cation in cl.nical.therapy.

关键词： Statins Antifungal.activity Drug interaction

交叉处的理论构建：是扩大影响的秘诀还是一条无果之路？*

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企业管理研究 2011年第8期

作者： l.Via Markóczy David l.Deeds

Zahra和Newey(2009)提出了创造性的理论构建工作在管理研究中的重要性，并且认为“跨学科研究”是开展这一工作的最佳途径。但我们认为，管理研究越是沿着“通过跨学科研究来创建新理论”这条路走下去，就越有可能损害另外一个有价值的...

Zahra和Newey(2009)提出了创造性的理论构建工作在管理研究中的重要性，并且认为“跨学科研究”是开展这一工作的最佳途径。但我们认为，管理研究越是沿着“通过跨学科研究来创建新理论”这条路走下去，就越有可能损害另外一个有价值的目标，也就是把管理学科建设成为一个在研究主题及理论和方法上明显区别于其他学科的合法学科领域。我们也不赞成“管理学科应将重点放在发展新理论上”这一隐含假设。

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基于互信息的帕金森病脑皮层功能连接

科学技术与工程 2022年第33期22卷 14652-14658页

作者：湛慧苗曾宣威吕浩铵高军峰中南民族大学生物医学工程学院武汉430074

帕金森病的早期症状是很难察觉的,目前还没有一个明确的生物标志物可以准确地检测出早期的帕金森病。为了探究帕金森病的潜在生物标志物,分析15名帕金森病患者和15名健康对照者闭眼状态下溯源后的脑电信号。首先,使用互信息测量两组受... 详细信息

帕金森病的早期症状是很难察觉的,目前还没有一个明确的生物标志物可以准确地检测出早期的帕金森病。为了探究帕金森病的潜在生物标志物,分析15名帕金森病患者和15名健康对照者闭眼状态下溯源后的脑电信号。首先,使用互信息测量两组受试者的大脑各个区域之间的功能连接。其次,对两组受试者之间的每个连接对的互信息值进行独立样本t检验,检测两组受试者之间显著差异的连接边。最后,将具有显著差异的连接边作为特征进行分类。结果表明,帕金森病患者的大脑各个区域之间的互信息值整体小于健康对照组,并发现在额顶叶和顶枕叶之间的功能连接差异十分显著(P<0.01)。利用互信息功能连接指标对帕金森病患者和健康对照组分类时,测试准确率为76.7%,验证了基于互信息的脑功能连接对帕金森病研究的有效性。这些发现表明额顶叶和顶枕叶之间功能连接性的降低可能是帕金森病的一个潜在生物标志物。首次使用互信息这一功能连接指标对帕金森病进行研究,为帕金森病的神经机制研究提供了一个新的途径。

关键词：帕金森病互信息功能连接脑电溯源