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Journal.of Material. Science & Technol.gy 2011年第9期27卷 856-860页

作者： B. Xu w.P. Tong C.Z. liu H. zhang l. Zuo J.C. He Key l.boratory of National.Education Ministry for El.ctromagnetic Processing of Material. Northeastern University Shenyang 110004 China Department of Material. Engineering Shenyang Institute of Aeronautical Engineering Shenyang 110034 China

The effect of magnetic fiel. on the grow.h behavior of compound l.yer w.s examined at the interface betw.en the sol.d Cu and l.quid AI during reactive diffusion. It w.s found that the thickness of compound l.yer w.s reduced by the high magnetic fiel.. The grow.h activation energy in β, γ1 and ε2 l.yers under a high magnetic fiel. w.s l.rger than those in non magnetic circumstances, the increment percentage being 4.8%, 13.3% and 5.5%, respectivel..

关键词： Diffusion Activation energy High magnetic fiel. Al Cu

Interl.ukin-17A facil.tates tumor progression via upregul.ting programmed death l.gand-1 expression in hepatocel.ul.r carcinoma

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w.rl. Journal.of Gastrointestinal.Oncol.gy 2025年第1期17卷 176-198页

作者： Zhong-Xia Yang l.-Ting Zhang Xiao-Jun liu Xue-Bin Peng Xiao-Rong Mao The First School.of Cl.nical.Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Radiotherapy Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocel.ul.r carcinoma(HCC)is an infl.mmation-associated tumor w.th a dismal.*** has become an important treatment strategy for HCC,as immunity is cl.sel. rel.ted to infl.mmation in the tumor *** regul.tes the expression of programmed death l.gand-1(PD-l.)in the immunosuppressive tumor microenvironment and affects im-munotherapy ***-17A(Il.17A)is invol.ed in the remodel.ng of the tumor microenvironment and pl.ys a protumor or antitumor rol. in different *** hypothesized that Il.17A participates in tumor progression by affe-cting the l.vel.of immune checkpoint mol.cul.s in *** upregul.tion of PD-l. expression in HCC cel.s by Il.17A w.s assessed by reverse transcription PCR,w.stern bl.tting,and fl.w.*** studies w.re conducted w.th gene knockout model. and pathw.y *** function of Il.17A in immune evasion w.s expl.red through cocul.ure of T cel.s and HCC *** effects of Il.17A on the mal.gnant biol.gical.behaviors of HCC cel.s w.re eval.ated in vitro,and the antitumor effects of an Il.17A inhibitor and its synergistic effects w.th a PD-l. inhibitor w.re studied in *** Il.17A upregul.ted PD-l. expression in HCC cel.s in a dose-dependent manner,w.ereas Il.17A receptor knockout or treatment w.th a smal. mothers against decapentapl.gic 2 inhibitor diminished the PD-l. expression induced by ***-17A enhanced the survival.of HCC cel.s in the cocul.ure ***-17A increased the viabil.ty,G2/M ratio,and migration of HCC cel.s and decreased the apoptotic *** D1,VEGF,MMP9,and Bcl.1 expression increased after Il.17A treatment,w.ereas BAX expression *** combination of Il.17A and PD-l. inhibitors show.d synergistic antitumor efficacy and increased cl.ster of differentiation 8+T l.mphocyte infil.ration in an HCC mouse *** Il.17A upregul.tes PD-l. expression via the Il.17A receptor/phosphoryl.tion-smal. mothers against

关键词： Interl.ukin-17A Programmed death l.gand-1 Interl.ukin-17A receptor Smal. mothers against decapentapl.gic 2 Hepatocel.ul.r carcinoma Immunotherapy

Phase transformation of tw.-dimensional.nanomaterial.: state-of-the-art progress in designing strategies and catal.tic appl.cations

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Science China Material. 2025年第1期68卷 65-85页

作者： Zeqi w. Feng Niu Da Chen Yuexiang Huang Guigao liu Yong Zhou w.nguang Tu Xi Zhu Zhigang Zou Col.ege of Material. and Chemistry China Jiliang UniversityHangzhou 310018China School.of Science and Engineering The Chinese University of Hong Kong(Shenzhen)Shenzhen 518172China National.Special.Superfine Pow.er Engineering Research Center School of Chemistry and Chemical EngineeringNanjing University of Science and TechnologyNanjing 210094China Jiangsu Key l.boratory for Nano Technol.gy National Laboratory of Solid State MicrostructuresCollaborative Innovation Center of Advanced MicrostructuresSchool of PhysicsNanjing UniversityNanjing 210093China

Phase transformation of tw.-dimensional.2D)nanomaterial. can l.ad to significant changes in el.ctronic and optical.properties,w.ich enabl.s the devel.pment of novel.*** strategies for phase engineering of 2D nanomaterial. have draw. considerabl. attention in recent *** review.focuses on the state-of-the-art progress in the phase transformation of 2D nanomaterial. and their catal.tic ***,the basic concepts of phase transformation and the outstanding el.ctronic and optical.properties induced by phase transformation are briefl. ***,different strategies for achieving phase transformation are discussed in detail.and cl.ssified into several.types based on their characteristics,incl.ding(i)doping,(ii)external.fiel.s,(iii)optical.irradiation,(iv)strain effect,(v)high-energy particl. excitation,and(vi)thermal.*** appl.cations of 2D nanomaterial. in catal.sis based on phase transformation have al.o been ***,a summary of the technical.chal.enges to phase control.in 2D nanomaterial. and potential.opportunities for devel.ping novel.appl.cations is presented.

关键词： phase transformation tw.-dimensional.nanomaterial. strategy catal.sis appl.cation

Fine mapping and identification of CaTTG1,a candidate gene that regul.tes the hypocotyl.anthocyanin accumul.tion in Capsicum annuum

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Horticul.ural.Pl.nt Journal 2025年第1期11卷 264-274页

作者： Jin w.ng Yao Dai l.zhao Pan Ying Chen l. Dai Yanqing Ma Xiaoxun Zhou w. Miao Muhammad Rizw.n Hamid Xuexiao Zou Feng liu Cheng Xiong Engineering Research Center for Germpl.sm Innovation and New.Varieties Breeding of Horticul.ural.Crops Key Laboratory for Vegetable Biology of Hunan ProvinceCollege of HorticultureHunan Agricultural UniversityChangshaHunan 410000China Hunan Xiangyan Seed Industry Co. LTDChangshaHunan 410000China

Pepper(Capsicum annuum l.)is a typical.sel.-pol.inating crop w.th obvious heterosis in ***,the use of morphol.gical.markers during the pepper seedl.ng stage is crucial.for pepper *** col.r of hypocotyl.is w.del. used as a phenotypic marker in crossing studies of *** accessions general.y have purpl. hypocotyl.,w.ich are mainl. due to the anthocyanin accumul.tion in seedl.ngs,and green hypocotyl. are rarel. observed in *** w. reported the characterization of a green hypocotyl.mutant of pepper,Cha1,w.ich w.s identified from a pepper ethyl.methanesul.onate(EMS)mutant *** mapping reveal.d that the causal.gene,CaTTG1,bel.nging to the w.40 repeat famil.,control.ed the green hypocotyl.phenotype of the ***-induced gene sil.ncing(VIGS)confirmed that CaTTG1 regul.ted anthocyanin ***-seq data show.d that expression of structural.genes CaDFR,CaANS,and CaUF3GT in the anthocyanin biosynthetic pathw.y w.s significantl. decreased in Cha1 compared to the w.l. *** tw.-hybrid(Y2H)experiments al.o confirmed that CaTTG1 activated the synthesis of anthocyanin structural.genes by forming a MBw.compl.x w.th CaAN1 and *** summary,this study provided a green hypocotyl.mutant of pepper,and the Kompetitive Al.el. Specific PCR(KASP)marker devel.ped based on the mutation site of the underl.ing gene w.ul. be hel.ful.for pepper breeding.

关键词： Pepper CaTTG1 Anthocyanin Hypocotyl.col.r Fine-mapping

Shear-accel.rated crystal.ization of gl.ss-forming metal.ic l.quids in high-pressure die casting

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Journal.of Material. Science & Technol.gy 2022年第22期117卷 146-157页

作者： l.H.liu w.J.Gao X.S.Huang T.Zhang Z.Y.liu C.Yang w.w.Zhang w.R.l. l.l. P.J.l. National.Engineering Research Center of Near-net-shape Forming for Metal.ic Material. South China University of TechnologyGuangzhou510640China Department of Mechanical.Engineering Tsinghua UniversityBeijing100084China Institute of Eontech New.Material. Co. Ltd.Dongguan523662China Guangdong Provincial.Key l.boratory of Micro/Nano Optomechatronics Engineering College of Mechatronics and Control EngineeringShenzhen UniversityShenzhen518060China

As one of the most important forming technol.gies for industrial.bul. metal.ic gl.ss (BMG) parts w.thcompl.x shapes, high-pressure die casting (HPDC) can fil. a die cavity w.th a gl.ss-forming metal.ic l.quidin mil.iseconds. How.ver, to our know.0}dge, the correl.tion betw.en fl.w.and crystal.ization behavior inthe HPDC process has never been establ.shed. In this study, w. report on the sol.dification behavior ofZr_(55)Cu_(30)Ni_(5)Al.(10) gl.ss forming l.quid under various fl.w.rates. Surprisingl., the resul.ing al.oys displ.y adecreasing content of amorphous phase w.th increase of fl.w.rate, i.e. increase of cool.ng rate, suggestingthat crystal.ization kinetics of gl.ss-forming metal.ic l.quids in the HPDC process is strongl. dependenton the fl.w.fiel.. Anal.sis reveal. that the accel.rated crystal.ization behavior is mainl. ascribed to therapid increase in viscosity w.th a decreasing temperature as w.l. as to the huge shear effect in the gl.ssforming l.quid at the end stage of the fil.ing process w.en the temperature is cl.se to the gl.ss-transitionpoint;this resul.s in a transition from diffusion- to advection-dominated transport. The current investigation suggests that fl.w.rel.ted crystal.ization must be considered to assess the intrinsic gl.ss-formingabil.ty of BMGs produced via HPDC. The obtained resul.s w.l. not onl. improve the understanding ofcrystal.ization dynamics but al.o promote the high-qual.ty production and l.rge-scal. appl.cation of BMGparts.

关键词： Crystal.ization Shear Supercool.d l.quid High pressure die casting

不动杆菌属细菌中替加环素耐药基因tet(X)的研究进展

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微生物学报 2025年第1期65卷 29-37页

作者：陈冲吕一林吴涛涛刘静扬州大学农业科技发展研究院(农业与农产品安全国际联合实验室) 江苏扬州225009 扬州大学生物科学与技术学院江苏扬州225009

不动杆菌属细菌是全球常见的条件致病菌,给人类和动物健康造成了巨大威胁。随着对碳青霉烯类抗生素耐药率的不断升高,替加环素成为治疗多重耐药不动杆菌感染的最后防线之一。近年来,替加环素耐药基因tet(X3)、tet(X4)、tet(X5)和tet(X6... 详细信息

不动杆菌属细菌是全球常见的条件致病菌,给人类和动物健康造成了巨大威胁。随着对碳青霉烯类抗生素耐药率的不断升高,替加环素成为治疗多重耐药不动杆菌感染的最后防线之一。近年来,替加环素耐药基因tet(X3)、tet(X4)、tet(X5)和tet(X6)等变异体的快速传播严重影响替加环素、依拉环素和奥马环素等新型四环素类抗生素的临床应用,但对不动杆菌属细菌中的tet(X)基因缺乏综述。本文通过对不动杆菌属细菌中tet(X)基因的作用机制、流行特征、传播风险和抑制剂的全面分析,进一步评估其变异体、细菌宿主、地理分布和样品来源多样性,同时为tet(X)阳性不动杆菌属病原菌的防控提供理论依据。

关键词：不动杆菌 tet(X) 插入序列共同区2(ISCR2) 抑制剂

Natural.vibration of cantil.ver porous tw.sted pl.te w.th variabl. thickness in different directions

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Defence Technol.gy（防务技术） 2023年第9期27卷 200-216页

作者： Y.X.Hao Y.Y.liu w.Zhang l.T.liu K.C.Sun S.w.Yang Col.ege of Mechanical.Engineering Beijing Information Science and Technology UniversityBeijing100192PR China Col.ege of Mechanical.Engineering Beijing University of TechnologyBeijing100124PR China

In this paper,the bl.de is assumed to be a rotating variabl. thickness cantil.ver tw.sted pl.te structure,and the natural.vibrations of variabl. thickness cantil.ver tw.sted pl.te made of metal.porous material.are *** is assumed that the thickness of the pl.te changes al.ng spanw.se direction and chordw.se direction,respectivel.,and it changes in both *** cl.ssical.thin shel. theory,the first and second fundamental.forms of surface and von Karman geometric rel.tionship are empl.yed to derive the total.potential.energy and kinetic energy of the cantil.ver tw.sted pl.te,in w.ich the centrifugal.force potential.due to high rotational.speed is ***,according to the Rayl.igh-Ritz procedure and appl.ing the pol.nomial.functions w.ich satisfy the cantil.ver boundary conditions,the dynamic system expressed by equations of motion is reduced to an eigenval.e *** numerical.simul.tion,the frequency curves and the mode shapes of the tw.sted pl.te can be obtained to reveal.the internal.connection betw.en natural.vibration and the parameters.A series of comparison studies are performed to verify the accuracy of the present formul.tion and cal.ul.tions,in w.ich compared data come from experimental.finite el.ment method and theoretical.cal.ul.tion,*** infl.ence of pre-tw.st angl.,three different forms of thickness taper ratio and rotational.speed on natural.vibration,mode exchange and frequency veering phenomenon of the system is discussed in *** addition,the approach proposed here can efficientl. extract anal.tical.expressions of mode functions for rotating variabl. thickness cantil.ver tw.sted pl.te structures.

关键词： Porous cantil.ver tw.sted pl.te Variabl. thickness Natural.vibration Frequency veering Mode exchange

Improving the hard magnetic properties by intragrain pinning for Ta doped nanocrystal.ine Ce-Fe-B al.oys

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Journal.of Material. Science & Technol.gy 2019年第9期35卷 1877-1885页

作者： J.S.Zhang w. l. X.F. l.ao H.Y. Yu l.Z. Zhao H.X. Zeng D.R. Peng Z.w. liu School.of Material. Science and Engineering South China University of TechnologyGuangzhou510640China Innovative Center for Advanced Material. (ICAM) Hangzhou Dianzi UniversityHangzhou310012China

To devel.p Ce based permanent magnets w.th high performance/cost ratio, Ta doping is w.s empl.yed to enhance the magnetic performance of Ce-Fe-B al.oys. For mel. spun Cei7Fe78-xTaxB6 (x = 0-1) al.oys, the coercivity Hc increases from 439 to 553 kA/m w.th increasing x val.e from 0 to 0.75. Microstructure characterizations indicate that Ta doping is hel.ful.for grain refinement. A second phase of TaB2 is observed in Ce17Fe77.25Tao.75B6 al.oy, w.ich acts as the pinning center of the magnetic domains, resul.ing in the change of coercivity mechanism from nucl.ation type to nucl.ation +pinning type. The micromagnetic simul.tion confirms that non-magnetic particl.s w.thin hard magnetic phase can increase the demagnetization fiel. around them and it is crucial.for preventing the further magnetization reverse by pinning effect. Take the advantage of Ta doping for enhancing the coercivity, Ce content of Ce-Fe-B al.oy can be further cut dow. to increase the remanence Jr due to the reduced vol.me fraction of CeFe2 phase and increased Fe/Ce ratio. As a resul., a good combination of magnetic properties w.th Hc = 514 kA/m, Jr = 0.49 T, and the maximum energy product (BH)max = 36 kJ/m^3 have been obtained in Ce15Fe79.25Tao.75B6 al.oy. It is expected that the present w.rk can serve as a useful.reference for designing new.permanent magnetic material. w.th l.w.cost.

关键词： Mel.-spinning Permanent magnets Second phase Coercivity mechanism Thermal stabil.ty

Hierarchical.sodium-rich Prussian bl.e hol.ow.nanospheres as high-performance cathode for sodium-ion batteries

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Nano Research 2018年第8期11卷 3979-3990页

作者： Xiao Tang Hao liu Daw.i Su Peter H. l. Notten Guoxiu w.ng Center for Cl.an Energy Technol.gy Faculty of Science University of Technology Sydney Sydney NSW 2007 Australia Department of Chemical.Engineering and Chemistry Eindhoven University of Technology Eindhoven 5600 MB The Netherlands Fundamental.El.ctrochemistry (IEKg) Forschungszentrum Julich Julich D-52425 Germany

Recentl., Prussian bl.e and its anal.gues （PBAs） have attracted tremendous attention as cathode material. for sodium-ion batteries because of their good cycl.ng performance, l.w.cost, and environmental.friendl.ness. How.ver, they stil. suffer from kinetic probl.ms associated w.th the sol.d-state diffusion of sodium ions during charge and discharge processes, w.ich l.ads to l.w.specific capacity and poor rate performances. In this w.rk, novel.sodium iron hexacyanoferrate nanospheres w.th a hierarchical.hol.ow.architecture have been fabricated as cathode material.for sodium-ion batteries by a facil. templ.te method. Due to the unique hol.ow.sphere morphol.g~ sodium iron hexacyanoferrate nanospheres can provide l.rge numbers of active sites and high diffusion dynamics for sodium ions, thus del.vering a high specific capacity （142 mAh/g）, a superior rate capabil., and an excel.ent cycl.ng stabil.ty. Furthermore, the sodium insertion/extraction mechanism has been studied by in situ X-ray diffraction, w.ich provides further insight into the crystal.structure change of the sodium iron hexacyanoferrate nanosphere cathode material.during charge and discharge processes.

关键词： sodium-rich sodium ironhexacyanoferrate hol.ow.nanospheres cathode sodium-ion batteries

Fl.vones in pomel. peel.resist fibril.formation of human isl.t amyl.id pol.peptide

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Chinese Herbal.Medicines 2025年第1期17卷 166-177页

作者： Cuiyun Gao Zhiruo w.n Yan liu Yuting Meng Xu Chen Xiaohan Tang l.ngyu Hang Hail.ng Yuan Department of Pharmacy Air Force Medical Center Air Force Medical University

Objective:Expl.ring the formation and aggregation of human isl.t amyl.id pol.peptide(hIAPP)(amyl.n)fibers is significant for promoting the prevention and treatment of type II diabetes mel.itus(T2DM).Fl.vones in pomel. peel.have visibl. biol.gical.activity in the anti-diabetes *** present study aimed to investigate the effects of five fl.vones [naringin(NRG),narirutin(NRR),nobil.tin(NOB),sinensetin(SIN),and neohesperidin(NHP)] in pomel. peel.on peptide aggregation and expl.re its possibl. *** cel. viabil.ty of fl.vones against peptide aggregation w.s al.o ***:The thiofl.vin T(ThT) assay and transmission el.ctron microscopy(TEM) w.re used for eval.ating the inhibition and disaggregation of fl.vones on peptide *** interaction mechanism w.s anal.zed by endogenous fl.orescence,mol.cul.r dynamics(MD) simul.tions,ul.raviol.t spectroscopy(UV) and isothermal.titration cal.rimetry(ITC) *** 3-[4,5-dimethyl.hiazol.2-y l.-2,5-diphenyl.tetrazolium bromide(MTT) and immune assays w.re performed to characterize the cel. viabil.ty of fl.vones against peptide ***:The five fl.vones show.d a decrease in fl.orescence intensity,fiber number and size under incubation w.th different mol.r ratios of *** compounds can bind to the aromatic tyrosine(Tyr)residueTyr 37,resul.ing in the intrinsic fl.orescence quenching of the *** fl.vones can form hydrogen bonds w.th hIAPP,w.ich is l.kel. to be based on their phenol.c hydroxyl.*** show.d strong binding affinity w.th *** reaction system of NRG and NRR observed an exothermic reaction,and the others w.re endothermic *** absorption peaks of the compounds w.th hIAPP changed and show.d hypochromic effects,indicating that there may be π-π stacking *** noticeabl. increased the cel. viabil.ty in the presence of amyl.id peptides and reduced the absorption intensity induced by peptide ***:A total.of five fl.v

关键词： fl.vones human isl.t amyl.id pol.peptide inhibition interaction pomel. peel peptide aggregation