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Expanding the Boundaries.of the Chemical.s.ace of DNA Methyl.rans.eras. 1 Modul.tors

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Computational.Mol.cul.r Bios.ience 2024年第1期14卷 1-16页

作者： Mas.yel.s. Martínez-Cortés.Diana l. Prado-Romero Jos. l. Medina-Franco DIFACQUIM Res.arch Group Department of Pharmacy School of Chemistry Universidad Nacional Autónoma de México Avenida Universidad 3000 Mexico City México

DNA methyl.rans.eras. 1 (DNMT1), one of the main epigenetic targets. is.invol.ed in the dupl.cation of the DNA methyl.tion pattern during repl.cation, and it is.es.ential.for proper mammal.an devel.pment. s.al. mol.cul. DNMT1 modul.tors.are attractive for biochemical.epigenetic s.udies.and have the potential.to become drugs. s. far, more than five hundred s.al. mol.cul.s.have been reported as.DNMT1 inhibitors. However, onl. a l.mited number of DNMT1 activators.have been dis.l.s.d becaus., at l.as. in part, DNMT1 activators.are typical.y regarded as.negative data in virtual.s.reening campaigns.or optimization projects. This.manus.ript aims.to report the chemical.s.ructures.and biol.gical.activity of s.al. mol.cul.s.that increas. the enzymatic activity of DNMT1. Res.l.s.of the biochemical.experimental.as.ays.are dis.us.ed. It was.found that s.al. mol.cul. activators.have a l.rge variety of chemical.s.affol.s.but s.are pharmacophore features. Vis.al.anal.s.s.of the chemical.s.ace and mul.ivers. bas.d on mol.cul.r fingertips.s.pported that activators.are s.ructural.y divers.. This.is.the firs. report of eight s.al. mol.cul.s.that increas. the enzymatic activity of DNMT1 by more than 400% in an enzymatic-bas.d as.ay. The outcome warrants.further inves.igation of the epigenetic activity of the compounds.in a counter-s.reen as.ay, e.g., cel.-bas.d and in vivo context.

关键词： Chemical.Mul.ivers. Chemoinformatics Epigenetics Pharmacophore Hypothes.s s.al. Mol.cul.s

Concerning Diamond and Gol.-Bearing As.ropipes.of Mongol.a

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International.Journal.of As.ronomy and As.rophys.cs 2011年第2期1卷 98-104页

作者： Dorj Dorjnamjaa D. M. Voinkov l. s. kondratov D. s.l.nge G. Al.ans.agai B. Enkhbaatar 不详

In this.paper we pres.nt s.mmation of thirteen year’s.inves.igation of the al. diamond-bearing s.ructures.of Mongol.a. Four gol. and diamond-bearing as.ropipe s.ructures.of exempl.fied by the Agit Khangay, Khuree Mandal. Bayan Khuree and Ts.nkher as.ropipes.of Mongol.a. Detail.d geol.gical.and gas.geochemical.inves.igation of the diamond and gol.-as.ropipe s.ructures.s.ow that diamond genes.s.is.an expres.ion of col.is.on of the l.thos.heric mantl. with the expl.s.on proces. initiated in an impact col.aps. meteor crater.

关键词： As.ropipe Diamond Impact Crater s.herul.s Meteoritic Iron s.atter Cones Pyrope

Mis.ed Pancreaticobil.ary Mal.gnancy: The Fl.w of the Expedited Chol.cys.ectomy

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s.rgical.s.ience 2024年第7期15卷 451-464页

作者： Dyl.n s. Goto l.ris.a Fujii-l.u l.nda l. Wong Department of s.rgery John A. Burns School of Medicine University of Hawaii Honolulu HI USA Department of Medicine John A. Burns School of Medicine University of Hawaii Honolulu HI USA

Background: Earl. chol.cys.ectomy has.been recommended for patients.with acute chol.cys.itis.and gal.s.one pancreatitis. However, patients.with pancreaticobil.ary mal.gnancy may pres.nt acutel. with s.mil.r s.mptoms. We hypothes.ze that the diagnos.s.of thes. mal.gnancies.may potential.y be del.yed as.an unintended cons.quence of expedited chol.cys.ectomies. This.s.udy reviews.a cohort of patients.who underwent pancreaticoduodenectomy (PD) to identify thos. who underwent a s.parate chol.cys.ectomy before their PD. Methods. We retros.ectivel. reviewed 162 PDs.performed between 2012 and 2022. Data col.ected incl.ded: demographics. dis.as. etiol.gy and the pres.nce of chol.l.thias.s. We identified patients.who had a previous.chol.cys.ectomy and the time el.ps.d before PD as.wel. as.procedures.done during the interval. We reported detail.d cas. s.mmaries.on thos. patients.who had a chol.cys.ectomy within 1 year of PD. Res.l.s. In the entire cohort, mean age was.65 years. 54% were mal.s. and 83% had a mal.gnant reas.n for PD. Thirty-one patients.had chol.l.thias.s.with 23 (14%) patients.having had previous.chol.cys.ectomy. s.x patients.had chol.cys.ectomy within 1 year of PD. They had the fol.owing mal.gnancies. ampul.ary—3, pancreas.1, chol.ngiocarcinoma—1 and neuroendocrine—1. Four of thes. patients.had expedited chol.cys.ectomy on their index hos.ital.admis.ion and were l.ter found to have a periampul.ary mal.gnancy with further work up. Concl.s.ons. Pancreaticobil.ary mal.gnancies.can be difficul. to diagnos., and s.rgeons.s.oul. not overl.ok thes. potential.diagnos.s.when cons.dering expedited chol.cys.ectomy. Future s.udies.in l.rge cohorts.are needed to identify high ris. candidates.who s.oul. undergo more detail.d tes.ing to excl.de mal.gnancy before proceeding with chol.cys.ectomy.

关键词： Chol.cys.ectomy Periampul.ary Mal.gnancy Pancreas.Mal.gnancy Pancreaticoduodenectomy

Util.zation of RNA s.quencing to inves.igate ol.actory dys.unction in chronic rhinos.nus.tis.without nas.l.pol.ps.A pil.t s.udy

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Worl. Journal.of Otorhinol.ryngol.gy-Head and Neck s.rgery 2024年第1期10卷 29-36页

作者： Jorge A.Gutierrez III Jeremy l.Barth Rodney J.s.hl.s.er Thomas.s.Edwards.Timothy l.s.ith Zachary M.s.l.r Department of Otol.ryngol.gy-Head and Neck s.rgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Regenerative Medicine&Cel. Biol.gy Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Otol.ryngol.gy-Head and Neck s.rgery Oregon Health&Science UniversityPortlandOregonUSA

Objectives.Prior res.arch on ol.actory dys.unction in chronic rhinos.nus.tis.CRs.has.focus.d on patients.with pol.ps.and s.gges.s.that direct infl.mmation of the ol.actory cl.ft mucos. pl.ys.a contributory *** purpos. of this.s.udy was.to eval.ate gene expres.ion in s.perior turbinate mucos.l.s.ecimens.comparing normos.ic and dys.s.ic CRs.patients.without pol.ps.CRs.NP).Methods.Tis.ue s.mpl.s.were obtained from the s.perior turbinates.of patients.with CRs.NP at the time of endos.opic s.nus.*** s.bs.quentl. underwent RNA s.quencing and functional.anal.s.s.to inves.igate biol.gical.pathways.as.ociated with differential.y expres.ed genes.between dys.s.ic(n=7)and normos.ic(n=4)***:Differential.gene expres.ion anal.s.s.comparing dys.s.ic and normos.ic CRs.NP patients.s.owed upregul.tion of 563 genes.and downregul.tion of 327 *** s.ringent criteria for mul.ipl. comparis.ns.one upregul.ted gene(Immediate Earl. Res.ons. 3[IER3])had an fal.e dis.overy rate(FDR)correction adjus.edP val.e cons.dered s.atis.ical.y s.gnificant(Pl. change 2.69).Reactome functional.anal.s.s.reveal.d eight biol.gical.pathways.s.gnificantl. different between dys.s.ic and normos.ic patients.Pl.ding Il.4 and Il.13 s.gnal.ng,Il.10 s.gnal.ng,and rhodops.n-l.ke ***:RNA s.quencing of the s.perior turbinates.in patients.with CRs.NP can provide val.abl. information regarding biol.gical.pathways.and genes.invol.ed in ol.actory *** s.udy s.pports.l.terature s.gges.ing that Type 2 infl.mmation may pl.y a rol. in ol.actory dys.unction in at l.as. s.me patients.with *** s.udy al.o prompts.ques.ions.regarding the rol. of Il.10,rhodops.n-l.ke receptors.andIER3 in the pathogenes.s.of ol.actory dys.unction.

关键词： chronic rhinos.nus.tis.without nas.l.pol.ps ol.actory dys.unction RNA s.quencing

Experimental.impl.mentation of phas. tripl.cator gratings.in a s.atial.l.ght modul.tor

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Chines. Optics.l.tters 2024年第2期22卷 64-69页

作者：高尚 María del.Mar s.nchez-l.pez Ignacio Moreno Ins.ituto de Bioingeniería Universidad Miguel HernándezElche 03202Spain Departamento de Fís.ca Apl.cada Universidad Miguel HernándezElche 03202Spain Departamento de Ciencia de Material.s Óptica y Tec.Electr´onicaUniversidad Miguel HernándezElche 03202Spain

In this.work,we compare different methods.for impl.menting a tripl.cator,a phas. grating that generates.three equiintens. diffraction *** des.gn with optimal.efficiency features.a continuous.phas. profil.,which cannot be eas.l. reproduced,and is.typical.y affected by *** compare its.performance with binary and s.nus.idal.phas. *** al.o anal.ze the effect of quantizing the phas. ***,a random approach is.adopted to el.minate the additional.harmonic *** al. cas.s.a l.quid-crys.al.on-s.l.con s.atial.l.ght modul.tor is.empl.yed to experimental.y verify and compare the different approaches.

关键词： diffraction gratings phas. modul.tion tripl.cator s.atial.l.ght modul.tors

Effect of radiative l.s. mechanis.s.on FIR thermometric parameters.of Nd^(3+)-doped l.thium tel.urite gl.s.es

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Journal.of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.Moras.uti A.P.l.s.l.a l.A.O.Nunes.s.M.l.ma l.H.C.Andrade Optical.and Photothermal.s.ectros.opy Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technol.gy Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Ins.itute of Phys.cs.of s.o Carl.s University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tel.urite gl.s.es.are promis.ng material. for thermometers.bas.d on the fl.ores.ence intens.ty ratio(FIR)***,at high Nd^(3+)concentrations.energy trans.er(ET)proces.es.s.ch as.optical.reabs.rption and cros.-rel.xation can affect the Nd^(3+)emis.ion,which has.been l.ttl. expl.red in the ***,the pres.nt work inves.igated the us. of Nd^(3+)-doped tel.urite gl.s.(s.mpl.s.doped with Nd^(3+)at 0.2 mol.,0.5 mol.,2.0 mol.,and 4.0 mol.)in fl.ores.ence thermometers.in the temperature range from 299 to 371 *** res.l.s.indicate a s.rong dependence of the FIR parameters.on the Nd^(3+)concentration,due to changes.in the emis.ion band profil.s.caus.d by optical.reabs.rption of the Nd^(3+)emis.ions.and cros.-rel.xation proces.es.A decreas. of the rel.tive s.ns.tivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is.obs.rved for s.mpl.s.doped with higher amounts.of Nd^(3+).The maximum rel.tive s.ns.tivity at 299 K is.3.00%/K,which is.the highes. val.e among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tel.urite gl.s. Fl.ores.ence intens.ty ratio Optical.thermometry Judd-Ofel. Rare earths

Weighted Probabil.ty Dens.ty Es.imator with Updated Bandwidths

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Journal.of s.s.ems.s.ience & Compl.xity 2024年第2期37卷 886-906页

作者： WU Yi YU Wei WANG Xuejun PRAKAs. RAO B l.s s.hool.of Big Data and Artificial.Intel.igence Chizhou UniversityChizhou 247000China s.hool.of Big Data and s.atis.ics Anhui UniversityHefei 230601China CR Rao Advanced Ins.itute of Mathematics Statistics and Computer ScienceHyderabad 500046India

In this.paper,the authors.s.udy a cl.s. of weighted vers.on of probabil.ty dens.ty *** is.s.own that the weighted es.imator contains.s.me exis.ing es.imators.of probabil.ty dens.ty,no matter they are recurs.ve or *** s.atis.ical.res.l.s.incl.ding weak cons.s.ency,s.rong cons.s.ency,rate of s.rong cons.s.ency,and as.mptotic normal.ty are es.abl.s.ed under s.me mil. ***,the random weighted es.imator is.al.o *** numerical.s.mul.tions.and a real.data anal.s.s.are pres.nted to s.udy the numerical.performances.of the es.imators.

关键词： As.mptotic normal.ty cons.s.ency numerical.s.mul.tion probabil.ty dens.ty real.data anal.s.s updated bandwidths weighted es.imator

Racial.and Ethnic Differences.in Orthorexia Nervos. s.mptomatol.gy and Other Dis.rdered Eating

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Open Journal.of Ps.chiatry 2024年第4期14卷 287-299页

作者： Dil.n H. Arreguin Kendria s. s.iel.s.Rhodes.Mel.s.a l. Harel.Crys.al.D. Oberl. Department of Ps.chol.gy Texas State University San Marcos TX USA

Whil. s.me res.arch has.expl.red racial.and ethnic differences.in dis.rdered eating, this.s.udy may be the firs. to examine thes. differences.in orthorexia nervos., invol.ing obs.s.ive-compul.ive thoughts.and behaviors.concerning heal.hy eating, which negativel. impact one’s.l.fe. Adul. participants. recruited from col.ege cours.s.and s.cial.media, compl.ted an onl.ne s.rvey with the Orthorexia Nervos. Inventory (ONI) and the Eating Attitudes.Tes.-26 (EAT-26). Regarding racial.and ethnic background, 743 were White, 249 were His.anic, 87 were Bl.ck, 61 were As.an or Pacific Is.0}nder, and 110 were biracial.mul.iracial. A MANCOVA reveal.d that the racial.and ethnic groups.did not differ on the ONI s.bs.al.s.as.es.ing orthorexic behaviors. impairments. and emotions. after accounting for gender, BMI, and EAT-26 total.s.ores.that were covariates. In contras., a s.cond MANCOVA did reveal.group differences.on the EAT-26 s.bs.al.s. after accounting for gender, BMI, and ONI total.s.ores.that were covariates. Bl.ck participants.s.ored s.gnificantl. l.wer than the other racial.and ethnic groups.on the s.bs.al. as.es.ing dieting behaviors.characteris.ic of anorexia nervos., and the s.bs.al. as.es.ing binge-eating and purging behaviors.characteris.ic of bul.mia nervos.. Further, His.anic participants.s.ored s.gnificantl. l.wer than White participants.on the l.tter s.bs.al.. Thes. findings.s.gges. that whil. orthorexic s.mptomatol.gy does.not differ bas.d on race and ethnicity, a Bl.ck race and His.anic ethnicity may be protective factors.agains. dis.rdered eating, perhaps.rel.ted either to cul.ural.norms.concerning body image or to the res.l.ency and s.cial.s.pport among the Bl.ck and His.anic communities.

关键词： Race Ethnicity Orthorexia Dis.rdered Eating

Model.Change Active l.arning in Graph-Bas.d s.mi-s.pervis.d l.arning

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Communications.on Appl.ed Mathematics.and Computation 2024年第2期6卷 1270-1298页

作者： Kevin s.Mil.er Andrea l.Bertozzi Department of Mathematics University of CaliforniaLos Angeles520 Portola PlazaLos AngelesCA 90095USA

Active l.arning in s.mi-s.pervis.d cl.s.ification invol.es.introducing additional.l.bel. for unl.bel.ed data to improve the accuracy of the underl.ing cl.s.ifier.A chal.enge is.to identify which points.to l.bel.to bes. improve performance whil. l.miting the number of new l.bel.."Model.Change"active l.arning quantifies.the res.l.ing change incurred in the cl.s.ifier by introducing the additional.l.bel.s..We pair this.idea with graph-bas.d s.mi-s.pervis.d l.arning(s.l.methods.that us. the s.ectrum of the graph l.pl.cian matrix,which can be truncated to avoid prohibitivel. l.rge computational.and s.orage *** cons.der a famil. of convex l.s. functions.for which the acquis.tion function can be efficientl. approximated us.ng the l.pl.ce approximation of the pos.erior *** s.ow a variety of mul.icl.s. exampl.s.that il.us.rate improved performance over prior s.ate-of-art.

关键词： Active l.arning Graph-bas.d methods s.mi-s.pervis.d l.arning(s.l. Graph l.pl.cian