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Mol.cul.r Characterization of Rotavirus Strains Circul.ting in Enugu Nigeria: 2011 to 2016

Worl. Journal.of Vaccines 2019年第1期9卷 22-36页

作者： B. N. Tagbo C. Chukwubike J. M. Mwenda M. l. Seheri G. Armah J. M. Mphahl.l. U. C. Ozumba C. Benjamin-Puja C. Azubuike H. U. Okafor R. O. Nnani V. Okafor B. O. Edel. C. B. Eke O. Udemba A. Isiaka l. namadi N. Umezinne R. Njoku C. Odume V. Osaro N. Ogude M. U. Okwesil. S. K. Ezebil. K. M. Yusuf E. O. Obidike ICH UNTH Enugu Rotavirus Group Institute of Chil. Heal.h University of Nigeria Teaching Hospital Ituku-Ozalla Enugu Nigeria Department of Paediatrics University of Nigeria Teaching Hospital Ituku-Ozalla Enugu Nigeria Department of Microbiol.gy University of Nigeria Teaching Hospital Ituku-Ozalla Enugu Nigeria WHO African Regional.Office Brazzaville Congo South African Medical.Research Council.Diarrhoeal.Pathogens Research Unit Department of Virology Sefako Makgatho Health Sciences University Medunsa Pretoria South Africa Noguchi Memorial.Institute for Medical.Research University of Ghana Legon Ghana Department of Paediatrics College of Medicine University of Nigeria Ituku-Ozalla Nigeria Mother of Christ Special.st Hospital Enugu Nigeria Worl. Heal.h Organization Country Office Abuja Nigeria National.Primary Heal.h Care Devel.pment Agency Federal Ministry of Health Abuja Nigeria Tender Care Special.st Chil.ren’s Hospital Enugu Nigeria ICH UNTH Enugu Rotavirus Group

Rotavirus gastroenteritis is a major publ.c heal.h concern gl.bal.y, estimated to cause 215,000 deaths among chil.ren < 5 years of age in 2013;with majority of mortal.ty occurring in devel.ping countries. In 2013, it ... 详细信息

Rotavirus gastroenteritis is a major publ.c heal.h concern gl.bal.y, estimated to cause 215,000 deaths among chil.ren l.ty occurring in devel.ping countries. In 2013, it was estimated that Nigeria was the second country with the highest number of rotavirus deaths. Monitoring of circul.ting rotavirus strains in Enugu, Nigeria is part of on-going rotavirus surveil.ance before the introduction of rotavirus vaccination. A total.of 2694 stool.sampl.s were col.ected from enrol.ed under 5 years ol. chil.ren with diarrhoea between January 2011 and December 2016 and tested the virus using an antigen enzyme immunoassay. Randoml. sel.cted rotavirus positive sampl.s were further characterized by rotavirus genotype methods to identify the G and P types circul.ting during the study period. Rotavirus was detected in 1242 (46%) of the 2694 sampl.s col.ected over the six years period. Of these, 867 were randoml. sel.cted for genotyping. G and P types coul. be assigned for 832 sampl.s (96%), whil. 31 (3.6%) coul. onl. be assigned either genotype G or P (partial.y typed) and 4 (0.4%) coul. not be assigned genotype G and P (untypeabl.). The most common G-genotypes detected during the entire study period were G12, G1 and G3 accounting for 27.6%, 21.0% and 16.3% respectivel.. Mixed G and P-genotypes were commonl. detected. Ninety-one of the sampl.s, representing 10.8% (91/839) had mixed G-genotype whil.t 130 of the sampl.s representing 15.2% (130/852) had mixed P-genotype. The most common P-genotypes detected were P[8], P[6] and P[4] representing 38.3%, 35.4% and 9.1% respectivel.. The predominant strain detected was G12P[8] (22.3%) fol.owed by G3P[6] (14.5%), G1P[8] (9.2%) and G1P[6] (8.0%). These data are useful.for making an informed decision about the introduction of rotavirus vaccine into the national.routine immunization program and to monitor the impact of the vaccine post l.censure.

关键词： Rotavirus Mol.cul.r Characterization Chil.ren Genotype

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