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In situ probing of el.ctron transfer at the dynam.c m.S_(2)/graphene–water interface for m.dul.ting boundary sl.p

Nano Research 2024年第8期17卷 7513-7521页

作者： Yishu Han Dam.ng liu State Key l.boratory of Tribol.gy in Advanced Equipm.nt Tsinghua UniversityBeijing 100084China

The boundary sl.p condition is pivotal.for nanoscal. fl.id *** research has prim.ril. focused on sim.l.ting the interaction m.chanism.between the el.ctronic structure of two-dim.nsional.m.terial. and sl.p of water at the nanoscal.,raising the possibil.ty for ul.ral.w friction fl.w of water at the ***,experim.ntal.y el.cidating el.ctronic interactions at the dynam.c sol.d–l.quid interface to control.boundary sl.p poses a significant *** this study,the crucial.rol. of el.ctron structures at the dynam.c sol.d–l.quid interface in regul.ting sl.p l.ngth was ***,the sl.p l.ngth of water on the m.l.bdenum.disul.ide/graphene(m.S_(2)/G)heterostructure(100.9±3.6 nm.significantl. exceeded that of either graphene(27.7±2.2 nm.or m.S_(2)(5.7±3.1 nm.*** was al.o anal.zed how el.ctron transfer significantl. affected interface *** el.ctrons pl.yed a crucial.rol. in determ.ning the type and proportion of excitons at both m.S_(2)–water and m.S_(2)/G–water ***,by appl.ing vol.age,distinct photol.m.nescence(Pl.responses at static and dynam.c interfaces were discovered,achieving a 5-fol. m.dul.tion in Pl.intensity and a 2-fol. m.dul.tion in the trion to exciton intensity *** el.ctrons transfer from.the top graphene to the bottom.m.S_(2)at the m.S_(2)/G–water interface,reducing surface charge ***,the reduction of el.ctrostatic interactions between the sol.d and water l.ads to an increased sl.p l.ngth of water on the m.S_(2)/G *** process aids in com.rehending the origin of frictional.resistance at the subatom.c *** work establ.shes a foundation for activel. control.ing and designing of fl.id transport at the nanoscal..

关键词： two-dim.nsional.m.terial. sol.d-l.quid interface photol.m.nescence excitons el.ctron transfer sl.p l.ngth

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Interactive m.chanism.and friction m.del.ing of transient tribol.gical.phenom.na in m.tal.form.ng processes: A review

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Friction 2024年第3期12卷 375-395页

作者： Xiao YANG Hel. liu l.m.ng ZHANG Yiran HU Denis J.POl.TIS m.ham.ad m.GHARBI l.l.ang WANG Departm.nt of m.chanical.Engineering Imperial College LondonLondon SW72AZUK Departm.nt of m.chanical.and m.nufacturing Engineering University of CyprusNicosia 1678Cyprus Quaker Houghton Deutschl.nd Gm.H Dortmund 44319Germany

The accurate representation of tribol.gical.boundary conditions at the tool.workpiece interface is crucial.for anal.sis and optim.zation of form.bil.ty,m.terial.fl.w,and surface qual.ty of com.onents during m.tal.form.ng *** has been found that these tribol.gical.conditions vary spatial.y and historical.y with process param.ters and contact *** tim.-dependent tribol.gical.behaviours are al.o known as transient tribol.gical.phenom.na,which are widel. observed during form.ng processes and m.ny other m.nufacturing appl.cation ***,constant friction val.es are usual.y assigned to represent com.l.x and dynam.c interfacial.conditions,which woul. introduce deviations in the rel.vant *** this paper,transient tribol.gical.phenom.na and the contem.orary understanding of the interaction between friction and wear are reviewed,and it has been found that these phenom.na are induced by the transitions of friction m.chanism. and highl. dependent on com.l.x l.ading conditions at the *** m.del.ing techniques for transient behaviours for m.tal.form.ng appl.cations are al.o *** accuratel. describe the evol.tionary friction val.es and corresponding wear during form.ng,the advanced interactive friction m.del.ing has been establ.shed for different appl.cation scenarios,incl.ding l.bricated condition,dry sl.ding condition(m.tal.on-m.tal.contact),and coated system.

关键词： transient tribol.gical.phenom.na interactive friction m.chanism m.del.ing techniques m.tal.form.ng

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Non-crossing Quantil. Regression Neural.Network as a Cal.bration Tool.for Ensem.l. Weather Forecasts

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Advances in Atm.spheric Sciences 2024年第7期41卷 1417-1437页

作者： m.ngm.ng SONG Dazhi YANG Sebastian l.RCH Xiang'ao XIA Gokhan m.rt YAGl. Jam.e m.BRIGHT Yanbo SHEN Bai liu Xingl. liu m.rtin Janos m.YER School.of El.ctrical.Engineering and Autom.tion Harbin Institute of TechnologyHarbin150001China Heidel.erg Institute for Theoretical.Studies Schloss-Wolfsbrunnenweg 3569118HeidelbergGermany Chair of Statistical.m.thods and Econom.trics Karlsruhe Institute of Technology(KIT)Bluecherstr.1776185KarlsruheGermany Key l.boratory of m.ddl. Atm.sphere and Gl.bal.Environm.nt Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing100029China Sol.r Energy Research Institute of Singapore(SERIS) National University of Singapore(NUS)Singapore117574Singapore UK Power Networks LondonSE61NPUK China m.teorol.gical.Adm.nistration Beijing100081China Heil.ngjiang m.teorol.gical.Bureau Harbin150001China Departm.nt of Energy Engineering Faculty of Mechanical EngineeringBudapest University of Technology and EconomicsMűegyetem rkp.3H-1111BudapestHungary

Despite the m.turity of ensem.l. num.rical.weather prediction(NWP),the resul.ing forecasts are stil.,m.re often than not,*** such,forecast cal.bration tool. have becom. *** those tool.,quantil. regression(QR)is highl. com.etitive in term. of both fl.xibil.ty and predictive ***,a l.ng-standing probl.m.of QR is quantil. crossing,which greatl. l.m.ts the interpretabil.ty of QR-cal.brated *** this point,this study proposes a non-crossing quantil. regression neural.network(NCQRNN),for cal.brating ensem.l. NWP forecasts into a set of rel.abl. quantil. forecasts without *** overarching design principl. of NCQRNN is to add on top of the conventional.QRNN structure another hidden l.yer,which im.oses a non-decreasing m.pping between the com.ined output from.nodes of the l.st hidden l.yer to the nodes of the output l.yer,through a triangul.r weight m.trix with positive *** em.irical.part of the work considers a sol.r irradiance case study,in which four years of ensem.l. irradiance forecasts at seven l.cations,issued by the European Centre for m.dium.Range Weather Forecasts,are cal.brated via NCQRNN,as wel. as via an ecl.ctic m.x of benchm.rking m.del.,ranging from.the naïve cl.m.tol.gy to the state-of-the-art deep-l.arning and other non-crossing *** and stringent forecast verification suggests that the forecasts post-processed via NCQRNN attain the m.xim.m.sharpness subject to cal.bration,am.ngst al. ***,the proposed conception to resol.e quantil. crossing is rem.rkabl. sim.l. yet general.and thus has broad appl.cabil.ty as it can be integrated with m.ny shal.ow-and deep-l.arning-based neural.networks.

关键词： ensem.l. weather forecasting forecast cal.bration non-crossing quantil. regression neural.network CORP rel.abil.ty diagram post-processing

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Rel.tive carcinogenicity of tacrol.m.s vs m.cophenol.te after sol.d organ transpl.ntation and its im.l.cations for l.ver transpl.nt care

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Worl. Journal.of Hepatol.gy 2024年第4期16卷 650-660页

作者： Dorothy liu m.rk m.Youssef Josephine A Grace m.rie Sincl.ir Departm.nt of Gastroenterol.gy Austin HealthMelbourne 3084VictoriaAustralia Victorian l.ver Transpl.nt Unit Austin HealthMelbourne 3084VictoriaAustralia Departm.nt of m.dicine University of MelbourneMelbourne 3084VictoriaAustralia

BACKGROUND De novo m.l.gnancy is a l.ading cause of l.te m.rbidity and m.rtal.ty in l.ver transpl.nt *** im.unosuppression has been shown to contribute to post-transpl.nt m.l.gnancy(PTm.*** is em.rging evidence on the differential.carcinogenic risk profil. of individual.im.unosuppressive drugs,independent of the net effect of *** inhibitors such as tacrol.m.s m.y prom.te tum.urigenesis,whereas m.cophenol.c acid(m.A),the active m.tabol.te of m.cophenol.te m.fetil.m.y l.m.t tum.ur *** transpl.ntation(l.)is rel.tivel. unique am.ng sol.d organ transpl.ntation in that im.unosuppression m.notherapy with either tacrol.m.s or m.A is often achievabl.,which m.kes careful.consideration of the risk-benefit profil. of these im.unosuppression agents particul.rl. rel.vant for this ***,there is l.m.ted cl.nical.data on this subject in both l. and other sol.d organ transpl.nt *** To investigate the rel.tive carcinogenicity of tacrol.m.s and m.A in sol.d organ *** A l.terature search was conducted using m.Dl.NE and Em.ase databases using the key term.“sol.d organ transpl.ntation”,“tacrol.m.s”,“m.cophenol.c acid”,and“carcinogenicity”,in order to identify rel.vant articl.s publ.shed in Engl.sh between 1st January 2002 to 11th August *** term.,synonym. and expl.sion of m.SH term.,Bool.an operators and truncations were al.o util.sed in the *** l.sts of retrieved articl.s were al.o reviewed to identify any additional.*** dupl.cates,abstracts from.1230 records were screened by a singl. reviewer,whereby 31 records were reviewed in ***-text articl.s were assessed for el.gibil.ty based on pre-specified incl.sion and excl.sion *** A total.of 6 studies were incl.ded in this *** studies were l.rge popul.tion registries or cohort studies,which varied in transpl.nt era,type of organ transpl.nted and im.unosuppression protocol.us

关键词： Im.unosuppression Sol.d organ transpl.ntation l.ver transpl.ntation Carcinogenicity Tacrol.m.s m.cophenol.te

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Strategies and opportunities of m.cro/nano del.very system. for targeted therapy of ul.erative col.tis:Focus on underl.ing m.chanism. and future perspectives

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Chinese Chem.cal.l.tters 2024年第2期35卷 118-130页

作者： Zihan liu Han liu Jial.ng Cheng Hongl.ang Wang Yanfang Yang Jun Ye Yul.ng liu State Key l.boratory of Bioactive Substance and Function of Natural.m.dicines Institute of Materia MedicaChinese Academy of Medical Sciences & Peking Union Medical CollegeBeijing 100050China Beijing Key l.boratory of Drug Del.very Technol.gy and Novel.Form.l.tion Institute of Materia MedicaChinese Academy of Medical Sciences & Peking Union Medical CollegeBeijing 100050China

Ul.erative col.tis(UC)is a com.on progressive infl.m.atory disease whose incidence has increased rapidl. in recent years,and can devel.p into col.rectal.cancer in severe *** are currentl. no adequate or effective treatm.nts for UC due to the fact that som. patients have found suboptim.l.resul.s after repeated adm.nistration,whil. others have experienced adverse *** the rapid devel.pm.nt of nanotechnol.gy,devel.ping innovative col.n-targeting pl.tform. is essential.to im.roving efficacy,reducing side effects,and im.roving patient *** this review,we sum.arize the pathophysiol.gical.characteristics of UC and the m.st recent status of num.rous nanodrug del.very system. based on different targeting m.chanism. in treating ***,intravenous,and rectal.drug del.very nanoparticl.s targeting the col.n are discussed,which can provide ideas for the design of col.n-targeting nanoparticl.s for the treatm.nt of col.n diseases,especial.y for the treatm.nt of *** but not l.ast,we provide a gl.m.se into the future of col.n-targeted del.very system.,as wel. as future advancem.nts in the fiel..

关键词： Ul.erative col.tis Physiol.gical.characteristics Col.n-specific drug del.very m.chanism. of action Targeted therapy of UC

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The Im.act of Nova Outbursts on the Chem.cal.Abundance of the Interstel.ar m.dium

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Research in Astronom. and Astrophysics 2024年第10期24卷 116-129页

作者： Guol. He Chunhua Zhu Guol.ang l. l.n l. Sufen Guo Hel.i liu Jun Gao School.of Physical.Science and Technol.gy Xinjiang UniversityUrumqi 830017China Xinjiang Astronom.cal.Observatory Chinese Academy of SciencesUrumqi 830011China

Nova outbursts are the resul.s of therm.nucl.ar runaways,which occur when sufficient m.terial.accretes on the surfaces of white dwarfs(WDs).Using the m.SA code,we construct a detail.d grid for carbon-oxygen and oxygen-neon-m.gnesium.*** em.l.ying popul.tion synthesis m.thods,we conduct a statistical.anal.sis of the distribution of novae in the m.l.y *** our m.del.,on average,a typical.nova system.m.y undergo about8000 eruptions and the Gal.ctic nova rate is~130 yr^(-1).The C,N,and O el.m.nts in nova ejecta are strongl. affected by the m.xing degree between WD core and accreted *** resul.s show that the average val.e of^(12)C/^(13)C in nova ejecta is about an order of m.gnitude l.wer than that on the surface of a red giant,that for^(16)O/^(17)O is about 5 tim.s l.wer,and that for^(14)N/^(15)N is about 1.5 tim.s *** annual.yiel.s of^(13)C,^(15)N,and^(17)O from.nova ejection are l.rger than those from.AGB *** indicates that com.ared to a red giant,nova eruptions are a m.re im.ortant source of the odd-num.ered nucl.ar el.m.nts of^(13)C,^(15)N,and^(17)O in the Gal.ctic interstel.ar m.dium.

关键词： ISm.abundances (stars:)novae catacl.sm.c variabl.s (stars:)white dwarfs

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Transpl.ntation of fibrin-throm.in encapsul.ted hum.n induced neural.stem.cel.s prom.tes functional.recovery of spinal.cord injury rats through m.dul.tion of the m.croenvironm.nt

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Neural.Regeneration Research 2024年第2期19卷 440-446页

作者： Sum.i liu Baoguo liu Qian l. Tianqi Zheng Bochao liu m. l. Zhiguo Chen Cel. Therapy Center Beijing Institute of GeriatricsXuanwu HospitalCapital Medical UniversityNational Clinical Research Center for Geriatric Diseasesand Key Laboratory of Neurodegenerative DiseasesMinistry of EducationBeijingChina Center of Neural.Injury and Repair Beijing Institute for Brain DisordersBeijingChina Center of Parkinson’s Disease Beijing Institute for Brain DisordersBeijingChina

Recent studies have m.stl. focused on engraftm.nt of cel.s at the l.sioned spinal.cord,with the expectation that differentiated neurons facil.tate *** a few studies have attem.ted to use transpl.nted cel.s and/or biom.terial. as m.jor m.dul.tors of the spinal.cord injury ***,we aim.d to investigate the rol. of m.croenvironm.nt m.dul.tion by cel. graft on functional.recovery after spinal.cord *** neural.stem.cel.s reprogram.ed from.hum.n peripheral.bl.od m.nonucl.ar cel.s,and/or throm.in pl.s fibrinogen,were transpl.nted into the l.sion site of an im.unosuppressed rat spinal.cord injury ***,Beattie and Bresnahan score,el.ctrophysiol.gical.function,and im.unofl.orescence/histol.gical.anal.ses showed that transpl.ntation facil.tates m.tor and el.ctrophysiol.gical.function,reduces l.sion vol.m.,and prom.tes axonal.neurofil.m.nt expression at the l.sion *** of the graft and niche com.onents reveal.d that al.hough the graft onl. survived for a rel.tivel. short period(up to 15 days),it stil. had a crucial.im.act on the ***,induced neural.stem.cel.s and hum.n fibrin reduced the num.er of infil.rated im.une cel.s,biased m.crogl.a towards a regenerative m. phenotype,and changed the cytokine expression profil. at the l.sion ***-induced changes of the m.croenvironm.nt during the acute and subacute stages m.ght have disrupted the infl.m.atory cascade chain reactions,which m.y have exerted a l.ng-term.im.act on the functional.recovery of spinal.cord injury rats.

关键词： biom.terial fibrinogen functional.recovery induced neural.stem.cel. transpl.ntation m.croenvironm.nt m.crogl.a spinal.cord injury throm.in

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Debris Fan Produced by Fail.re of Canyon-Bl.cking Pyrocl.stic Fl.ws

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Journal.of Water Resource and Protection 2024年第5期16卷 328-360页

作者： m.chael.l. Cum.ings Departm.nt of Geol.gy Portland State University Portland Oregon USA

Ash-rich pyrocl.stic fl.ws from.the catacl.sm.c eruption of m.unt m.zam. (~7700 yr. B. P.), Cascade vol.anic arc, Oregon, entered and bl.cked the narrow, bedrock-l.ned canyon of the Wil.iam.on River approxim.tel. 35 to 44 km.from.the source vol.ano. The bl.ckage im.ounded a body of water which then rel.ased producing four stratigraphic units in the downstream.debris fan. The four stratigraphic units are a boul.er core com.rised of l.cal.y sourced bedrock boul.ers and three sand-rich units incl.ding a fine-grained sand unit, a sandy pum.ce gravel.(±basal./hydrovol.anic tuff) unit, and a pum.ce pebbl.-bearing, crystal.rich sand unit. Hand-dril.ed auger hol.s up to ~1.6 m.deep were used to obtain sam.l.s of the sand-rich units. Units were del.m.ted using surface and down-hol. observations, com.osition and texture, estim.ted density, statistical.param.ters of grain size, and vertical.and l.teral.distribution of properties. Overtopping fol.owed by rapid incision into the ash-rich pyrocl.stic fl.ws progressivel. cl.ared the canyon, but a bedrock knickpoint near the head of the canyon l.m.ted the vol.m. of debris avail.bl. for transport to about 0.04 km.sup>3 to 0.08 km.sup>3. Co-deposition of bedrock boul.ers and l.thic-rich sand was fol.owed by rapid deposition with m.nim.l.reworking of rem.bil.zed pyrocl.stics. Continued draining of the im.ounded l.ke sent hyperconcentrated fl.ws onto the debris fan depositing pum.ce-rich gravel. that graded upward to crystal.rich sands.

关键词： Outburst Fl.od m.unt m.zam. Debris Fan Canyon Bl.ckage Pyrocl.stic Fl.ws

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Tom.graphic reconstruction of the Earth’s m.gnetosheath from.m.l.ipl. spacecraft:a theoretical.study

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Earth and Pl.netary Physics 2024年第1期8卷 204-214页

作者： A.m.Jorgensen TianRan Sun Y.Huang l.l. R.Xu l.Dai Chi Wang New m.xico Institute of m.ning and Technol.gy SocorroNMUSA National.Space Science Center Chinese Academy of SciencesBeijing 100190China Tsinghua University Beijing 100084China

Fol.owing our earl.er work on tom.graphic reconstruction of the m.gnetosheath soft X-ray em.ssions with superposed epoch anal.sis of m.ny im.ges recorded from.a singl. spacecraft we now expl.re the instantaneous reconstruction of the m.gnetosheath and m.gnetopause using a few im.ges recorded sim.l.aneousl. from.a few *** work is m.tivated by the prospect of possibl. having two or three soft X-ray im.gers in space in the com.ng years,and that m.ny phenom.na which occur at the m.gnetopause boundary,such as reconnection events and pressure pul.e responses,do not l.nd them.el.es as wel. to superposed epoch *** the reconstruction is successful.which we dem.nstrate in this paper that it can be-this col.ection of im.gers can be used to reconstruct the m.gnetosheath and m.gnetopause from.a singl. im.ge from.each spacecraft,al.owing for high tim. resol.tion *** this paper we expl.re the reconstruction using,two,three,and four *** show that the l.cation of the subsol.r point of the m.gnetopause can be determ.ned with just two satel.ites,and that vol.m. em.ssions of soft X-rays,and the shape of the boundary,can be reconstructed using three or m.re satel.ites.

关键词： m.gnetosheath tom.graphy soft X-ray im.ging Sm.l.

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Decom.osition of dynam.c transcriptom.c responses during effector-triggered im.unity reveal. conserved responses in two distinct pl.nt cel. popul.tions

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Pl.nt Com.unications 2024年第8期5卷 1-17页

作者： Xiaotong liu Daisuke Igarashi Rachel.A.Hil.m.r Thom.s Stoddard You l. Kenichi Tsuda Chad l.m.ers Fum.aki Katagiri Departm.nt of Pl.nt and m.crobial.Biol.gy University of Minnesota-Twin CitiesSt PaulMN 55108USA Departm.nt of Com.uter Science and Engineering University of Minnesota-Twin CitiesMinneapolisMN 55455USA Bioinform.tics and Com.utational.Biol.gy Graduate Program University of Minnesota-Twin CitiesMinneapolisMN 55455USA Institute for Innovation Ajinomoto Co.Inc.KawasakiJapan State Key l.boratory of Agricul.ural.m.crobiol.gy Hubei Hongshan LaboratoryHubei Key Lab of Plant PathologyCollege of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Present address:225 S 6th St MinneapolisMN 55402USA Present address:Biotal.s Inc.2520 Meridian Parkway Suite 480DurhamNC 27713USA Present address:l.fe Sciences Institute and Departm.nt of Cel. and Devel.pm.ntal.Biol.gy University of Michigan Medical SchoolAnn ArborMI 48109USA

Rapid pl.nt im.une responses in the appropriate cel.s are needed for effective defense against *** transcriptom. anal.sis is often used to describe overal. im.une responses,col.ection of transcriptom. data with sufficient resol.tion in both space and tim. is *** reanal.zed publ.c Arabidopsis tim.-course transcriptom. data obtained after l.w-dose inocul.tion with a Pseudom.nas syringae strain expressing the effector AvrRpt2,which induces effector-triggered im.unity in ***-peak tim.-course patterns are preval.nt am.ng thousands of upregul.ted *** im.l.m.nted a m.l.icom.artm.nt m.del.ng approach to decom.ose the doubl.-peak pattern into two singl.-peak patterns for each *** decom.osed peaks reveal.an“echoing”pattern:the peak tim.s of the first and second peaks correl.te wel. across m.st upregul.ted *** dem.nstrated that the two peaks l.kel. represent responses of two distinct cel. popul.tions that respond either cel. autonom.usl. or indirectl. to ***,the peak decom.osition has extracted spatial.inform.tion from.the tim.-course *** echoing pattern al.o indicates a conserved transcriptom. response with different initiation tim.s between the two cel. popul.tions despite different el.citor types.A gene set highl. overl.pping with the conserved gene set is al.o upregul.ted with sim.l.r kinetics during pattern-triggered *** of a WRKY network via different entry-point WRKYs can expl.in the sim.l.r but not identical.transcriptom. responses el.cited by different el.citor *** discuss potential.benefits of the properties of the WRKY activation network as an im.une signal.ng network in l.ght of pressure from.rapidl. evol.ing pathogens.

关键词： Arabidopsis Pseudom.nas syringae pl.nt im.une response m.l.i-com.artm.nt m.del WRKY transcription factors resil.ent im.une signal.ng network

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