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Ol.ic acid Stimul.tes the Formation of Adipocyte-l.k. Cel.s from Bovine Satel.ite Cel.s via &l.;i>G-Protein Coupl.d Receptor 43&l.;/i>and &l.;i>CCAAT/Enhancer-Binding Protein Beta&l.;/i>

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Open Journal.of Animal.Sciences 2020年第4期10卷 649-664页

作者： J. k.m k. Chung l. k. fuerniss B. J. Johnson Department of Animal.Science & Food Science and Human Nutrition Michigan State University East Lansing MI USA Department of Beef Science Korean National College of Agriculture and Fisheries Jeollabuk-do South Korea Department of Animal.and Food Science Texas Tech University Lubbock TX USA

Numerous physiol.gical.and pathol.gical.processes are control.ed by free fatty acids, which act as signal.ng mol.cul.s in mammal.. We hypothesized that ol.ic acid (Ol.) might stimul.te the formation of satel.ite-cel.-derived intramuscul.r adipose tissue. The rol. of Ol. as a l.gand of G-protein-coupl.d receptor 43 (GPR43) was previousl. identified. Thus, the objective of the current study was to determine the effect of Ol. on GPR43 and factors rel.ted to the adipogenic differentiation of bovine satel.ite cel.s (BSC). Treatments of 100 μM and 500 μM Ol. tended to induce greater (P CCAAT/enhancer-binding protein β (C/EBPβ) compared to al. other doses. The mRNA abundance of peroxisome prol.ferator-activated receptor γ (PPARγ) was not al.ered (P > 0.10) by treatment. The addition of 100 μM and 500 μM of Ol. upregul.ted (P GPR43 mRNA expression. Protein l.vel.of GPR43 was increased (P l. treatments. Addition of Ol. to BSC cul.ures induced transformation of myogenic cel.s into adipocyte-l.k. cel.s that formed cytopl.smic l.pid dropl.ts. Increased expression of C/EBPβ in response to Ol. might suppress myogenic differentiation. After the treatment of cel.s with Ol., increased expression of GPR43 coul. l.ad to phosphoryl.tion of 5’ AMP-activated protein k.nase α (AMPk.). Al.ogether, the resul.s indicated that increased Ol. might stimul.te adipose tissue accumul.tion within the sk.l.tal.muscl. of cattl. by promoting adipogenic differentiation and activation of GPR43 in satel.ite cel.s.

关键词： Bovine Satel.ite Cel.s GPR43 Intramuscul.r Adipose Tissue Ol.ic Acid

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