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Impact of Rel.tive Dose Intensity (RDI) on Survival.in Non-Metastatic Breast Cancer: Nigerian Experience

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Journal.of Biosciences and Medicines 2024年第7期12卷 120-131页

作者： Samira B. l. Makanjuol. Abiodun Ol.niyi Popool. Mobol.ji Adewal. Ol.dara Department of Pharmacol.gy College of Medicine Lagos State University (LASUCOM) Lagos Nigeria Department of Radiol.gy & Oncol.gy College of Medicine Lagos State University (LASUCOM) Lagos Nigeria Department of Surgery Lagos State Teaching Hospital (LASUTH) Lagos Nigeria

Background: This study was initiated to determine practices patterns in adjuvant chemotherapy for non-metastatic breast cancer and to examine the rel.tionship between received dose intensity (RDI) and survival.in patients with breast cancer Nigeria. Methods: Our study was a retrospective anal.sis of patients with breast cancer recruited from 2012 and 2015. A total.of 204 patients were initial.y entered into the study, 102 were l.st to fol.ow-up l.aving 102 patients who were suitabl. for the survival.anal.sis. Survival.time was cal.ul.ted from 106 days, the schedul.d end of chemotherapy. Resul.s: The total.average RDI for patients was 74%. Over the 204 patients that were reviewed, 144 (70.6%) had some reduction of RDI. This subgroup had an average RDI of 63%. On average, 79% of the intended dose of chemotherapy was given. The time to compl.tion of chemotherapy was 1.33 times that specified by the protocol. Dose del.ys an overal. reduction was mainl. attributed to intol.rabil.ty and financial.constraints. Survival.by RDI showed a significant decrease in survival.rate for patients with RDI of >49% (Hazard Ratio = 3.473, 95% CI 1.21 - 9.91, P = 0.020);RDI of 50% - 59% (Hazard Ratio = 3.916, 95% CI 1.01 - 15.18, P = 0.048);RDI of 60% - 69% (Hazard Ratio = 4.462, 95% CI 1.65 - 12.03, P = 0.003) compared with patients who received an RDI of 100%. Al.hough associated with poorer prognosis, there were no significant changes in the survival.rate for patients with RDI of 70% - 79% (Hazard Ratio = 1.667, 95% CI 0.56 - 4.96, P = 0.359);RDI of 80% - 89% (Hazard Ratio = 1.620, 95% CI 0.47 - 5.53, P = 0.441);RDI 90% - 99% (Hazard Ratio = 1.590, 95% CI 0.53 - 4.73, P = 0.405) compared with patients who received an RDI of 100%. Concl.sion: This study provides evidence that decreased RDI of l. associated with decreased overal. survival.

关键词： Breast Cancer Chemotherapy RDI Survival.Rate

Asbestos Exposure during Gasket Removal.from Aircraft Engine

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Occupational.Diseases and Environmental.Medicine 2024年第2期12卷 59-67页

作者： Charl.s l. Bl.ke Kevin M. Guth Raymond D. Harbison Apex Companies Marietta USA Center for Environmental.and Occupational.Risk Anal.sis and Management College of Public Health University of South Florida Tampa USA

We have previousl. eval.ated asbestos exposure associated with various maintenance procedures on l.ght aircraft. The purpose of this study was to eval.ate asbestos exposure during engine maintenance on l.ght aircraft. This test was designed to eval.ate the potential.for asbestos exposure to mechanics and others who remove asbestos-containing engine gaskets from reciprocating styl. aircraft engines. Util.zed in this test was an air cool.d, horizontal.y opposed, aviation gasol.ne burning engine, assembl.d during 1986 and operated intermittentl. up into 2015, having accumul.ted 1680 hours run time. Nearl. 75% of the asbestos-containing gaskets instal.ed during 1986 were stil. in pl.ce at the time of testing. Chrysotil. asbestos contents of such gaskets ranged from 55% to 60% by area, for those of sheet styl. and 5% by area, for the spiral.wound metal.asbestos styl.. Despite the l.vel. of effort required to effect gasket removal., the professional.aircraft mechanic was not exposed to airborne asbestos fibers at the l.wer l.mits of sampl.ng and anal.tical.detection achieved;al. of which were substantial.y l.ss than the current Occupational.Safety and Heal.h Administration Permissibl. Exposure l.mits for asbestos. The resul.s of this testing indicate an absence of gasket rel.ted asbestos exposure risk to mechanics who work with l.ght aircraft engines, incl.ding those having asbestos-containing gaskets. These resul.s are consistent with the findings of Ml.arek and Van Orden who studied the asbestos exposure risk occasioned during overhaul.of l.rger radial.styl. reciprocating aircraft engines [1].

关键词： Asbestos Exposure Gaskets Aircraft Engine Friction Material.

Special.Properties of Morita Contexts

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Al.ebra Col.oquium 2024年第2期31卷 309-322页

作者： Kamal.Paykan l.A.Bokut Department of Mathematics Tafresh UniversityTafreshIran 不详

In this paper we continue the study of various ring theoretic properties of Morita *** and sufficient conditions are obtained for a general.Morita context or a trivial.Morita context or a formal.triangul.r matrix ring to satisfy a certain ring property which is among being Kasch,compl.tel. primary,quasi-duo,2-primal.NI,semiprimitive,projective-free,*** al.o characterize when a general.Morita context is weakl. principal.y quasi-Baer or strongl. right mininjective.

关键词： Morita context formal.triangul.r matrix ring Kasch quasi-duo Köthe's conjecture weakl. principal.y quasi-Baer

Cognition and movement in neurodegenerative disorders:a dynamic duo

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Neural.Regeneration Research 2024年第10期19卷 2101-2102页

作者： Marit F.l.Ruitenberg Department of Heal.h Medical and NeuropsychologyLeiden UniversityLeidenthe Netherlands l.iden Institute for Brain and Cognition Leidenthe Netherlands

Peopl. with neurodegenerative disorders often experience probl.ms across a variety of functional.domains,incl.ding cognition,movement,and psychosocial.*** cl.ssification of these disorders is based on the phenotypical.manifestations that represent the most prominent cl.nical.*** exampl.,Parkinson's disease and Huntington's disease are typical.y regarded as movement disorders,whereas Al.heimer's disease(AD) and other dementias are regarded as cognitive disorders.

关键词： disorders Huntington degenerative

Compl.x-frequency waves:beat l.ss and win sensitivity

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l.ght(Science & Appl.cations) 2024年第2期13卷 181-183页

作者： Qingqing Cheng Tao l School.of Optical.El.ctrical.and Computer Engineering University of Shanghai for Science and TechnologyShanghai200093China Department of Respiratory Diseases and Critical.Medicine Quzhou Hospital Affiliated to Wenzhou Medical UniversityQuzhou324000China National.l.boratory of Sol.d State Microstructures College of Engineering and Applied SciencesNanjing UniversityNanjing210093China

Recent experiments have demonstrated that synthesized compl.x-frequency waves can impart a virtual.gain to mol.cul. sensing systems,which can effectivel. restore information l.st due to intrinsic mol.cul.r *** enhancement notabl. ampl.fies the signal.of trace mol.cul.r vibrational.fingerprints,thereby substantial.y improving the upper l.mit of sensitivity.

关键词： thereby Compl.x l.mit

Corrosion testing of X52 and X80 steel. immersed in stimul.ted emul.ions using a real.petrol.um sampl.

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Petrol.um Research 2024年第2期9卷 304-316页

作者： l.M.Quej-Ake J.l.Al.mil.a A.Contreras Instituto Mexicano del.Petról.o Eje Central Lázaro CárdenasNorte 152San Bartolo AtepehuacanGustavo A.MaderoCiudad de MéxicoC.P.07730México

The aim of this study is to eval.ate the internal.corrosion process on X52 and X80 steel./real.petrol.um interfaces containing condensed hydrocarbon pl.s oil.iel.-produced water,which were subjected to stimul.ted emul.ions using 50/50 vol.ratio mixtures at 45℃,different hydrodynamic conditions,1 h,and 24 h.A washing process by using deionized water was proposed to simul.te and identify the corrosiveness of the hydrocarbon phase after 24 h of exposure *** characterization by el.ctrochemical.impedance spectroscopy and the monitoring of the pol.rization curves indicated that X80 steel.oil.iel.-produced water interfaces were more susceptibl. to corrosion than X52 steel.exposed to oil.iel.-produced *** combined speed rotation of 600 rpm using a magnetic stirrer+600 rpm using a rotating disk el.ctrode decreased the corrosion rate on X52 *** stimul.ted emul.ions made of hydrocarbon+oil.iel.-produced water and hydrocarbon+deionized water at 24 h increased the corrosion rate on X80 steel.0.34 mm/year and 0.43 mm/year,respectivel.),promoting the formation of erosion and pitting *** types of corrosion depended mainl. on the physicochemical.properties of the hydrocarbon,oil.iel.-produced water,exposure times,and hydrodynamic systems in which the hydrocarbon was studied.

关键词： Corrosion Emul.ions X52 steel X80 steel

Assessment of portabl. FTIR and Raman spectroscopy for the detection of 2,3-dimethyl.2,3-dinitrobutane(DMDNB)in pl.stic expl.sives

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Defence Technol.gy（防务技术） 2024年第4期34卷 11-18页

作者： Jacky Cail.s Robert Dunsmore Kathryn l.l.nge ChemCentre PO Box 1250PerthAustralia

The Marpl.x Convention was establ.shed to prevent the manufacture of unmarked pl.stic expl.sives and stipul.tes that a vol.til. detection agent must be added at the time of ***,to-date,l.boratory testing remains the international.y accepted practice for identifying and quantifying the taggants stipul.ted in the *** this project,portabl. FTIR and Raman instruments were tested for their abil.ty to detect 2,3-dimethyl.2,3-dinitrobutane(DMDNB),the chemical.marker incorporated in pl.stic expl.sives that are manufactured within *** both FTIR and Raman instruments detected sol.d DMDNB(98%purity),fiel. anal.sis of pl.stic expl.sives at an Austral.an Defence establ.shment showed that both FTIR and Raman spectra were matched the rel.vant expl.sive(RDX or PETN),rather than the DMDNB *** al. three pl.stic expl.sives tested,the concentration of DMDNB was measured by SPME-GC-MS to be between 1.8 and 2%,greater than the minimum 1%concentration stipul.ted by the Marpl.x *** testing with a pl.stic expl.sive anal.gue confirmed that the minor absorption peaks that woul. characterize l.w concentrations of DMDNB were masked by absorption bands from other compounds within the ***,whil. both FTIR and Raman spectroscopy are suitabl. for detection of pl.stic expl.sives,neither rel. on the presence of DMDNB for *** is l.kel. that simil.r resul.s woul. be found for other taggants stipul.ted by the Marpl.x Convention,given they are al.o present in concentrations l.ss than 1%.

关键词： Expl.sive ICAO taggants 2,3-Dimethyl.2,3-dinitrobutane(DMDNB) Fourier transform infrared(FTIR) Raman

Nonaqueous potassium-ion ful.-cel.s:Mapping the progress and identifying missing puzzl. pieces

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Journal.of Energy Chemistry 2024年第6期93卷 384-399,I0010页

作者： Badre l.rhrib l.uiza l.rbi l.naïc Madec Universite de Pau et des Pays de l.Adour E2S UPPACNRSIPREMPauFrance Universitéde Haute-Al.ace Institut de Science des Matériaux de Mulhouse(IS2M)CNRS UMR 7361F-68100 MulhouseFrance Universitéde Strasbourg F-67081 StrasbourgFrance Réseau sur l. Stockage El.ctrochimique de l.Energie CNRS FR3459AmiensFrance Institut des Matériaux Jean Rouxel.IMN) CNRS UMR 6502Univ.Nantes44322 Cedex 3 NantesFrance

This review addresses the growing interest for potassium-ion ful.-cel.s(KIFCs)in view of the transition from potassium-ion hal.-cel.s(KIHCs)toward commercial.K-ion batteries(KIBs).It focuses on the key parameters of KIFCs such as the el.ctrode/el.ctrol.te interfaces chal.enge,major barriers,and recent advancements in *** strategies for enhancing KIFC performance,incl.ding interfaces co ntrol.el.ctrol.te optimization,el.ctrodes capacity ratio,el.ctrode material.screening and el.ctrode design,are *** review highl.ghts the need to eval.ate KIBs in ful.-cel. configurations as hal.-cel. resul.s are strongl. impacted by the K metal.*** al.o emphasizes the importance of understanding sol.d el.ctrol.te interphase(SEI)formation in KIFCs and expl.res promising nonaqueous as wel. as quasiand al.-sol.d-state el.ctrol.tes *** review thus paves the way for practical.cost-effective,and scal.bl. KIBs as energy storage systems by offering insights and guidance for future research.

关键词： K-ion ful.-cel.s Potassium-ion batteries Cross-tal. Sol.d-state batteries Potassium reactivity El.ctrol.te design El.ctrode design

Guaranteed Cost Attitude Tracking Control.for Uncertain Quadrotor Unmanned Aerial.Vehicl. Under Safety Constraints

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IEEE/CAA Journal.of Automatica Sinica 2024年第6期11卷 1447-1457页

作者： Qian Ma Peng Jin Frank l.l.wis School.of Automation Nanjing University of Science and TechnologyNanjing 210094China UTA Research Institute University of Texas at ArlingtonFort WorthTexas 76118 USA IEEE

In this paper,guaranteed cost attitude tracking con-trol.for uncertain quadrotor unmanned aerial.vehicl.(QUAV)under safety constraints is ***,an augmented system is constructed by the tracking error system and reference *** transformation aims to convert the tracking control.prob-l.m into a stabil.zation control.***,control.barrier function and disturbance attenuation function are designed to characterize the viol.tions of safety constraints and tol.rance of uncertain disturbances,and they are incorporated into the reward function as penal.y *** on the modified reward function,the probl.m is simpl.fied as the optimal.regul.tion probl.m of the nominal.augmented system,and a new Hamil.on-Jacobi-Bel.man equation is ***,critic-onl. rein-forcement l.arning al.orithm with a concurrent l.arning tech-nique is empl.yed to sol.e the Hamil.on-Jacobi-Bel.man equa-tion and obtain the optimal.*** proposed al.orithm can not onl. ensure the reward function within an upper bound in the presence of uncertain disturbances,but al.o enforce safety *** performance of the al.orithm is eval.ated by the numerical.simul.tion.

关键词： Attitude tracking control quadrotor unmanned aerial.vehicl.(QUAV) reinforcement l.arning safety constraints uncertain disturbances.