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Response Eval.ation Using c.ntrast-Enhanc.d Ul.rasound f.r Unresec.abl. Advanc.d hepatoc.l.ul.r c.rc.noma Treated With Tyrosine Kinase Inhibitors Pl.s Anti-PD-1 Antibody Therapy

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f.st ef.ic.ent photon dec.l.ration in pl.smas by using two l.ser pul.es at dif.erent f.equenc.es

Ul.rasound in Medic.ne and Biol.gy 2024年第1期50卷 142-149页

作者： Zhao c.-K. Guan x. Pu Y.-Y. Zhou B.-Y. wang l.-f. Sun Y.-K. Yin h.-h. xia h.-S. wang x. han h. xu h.-x. Department of.Ul.rasound Zhongshan Hospital Institute of Ultrasound in Medicine and Engineering Fudan University Shanghai China Shanghai Institute of.Medic.l.Imaging Shanghai China c.ntral.l.boratory and Department of.Medic.l.Ul.rasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China

Objec.ive: The aim of.the work desc.ibed here was to eval.ate the rol. of.c.ntrast-enhanc.d ul.rasound (c.US) in response eval.ation f.r unresec.abl. advanc.d hepatoc.l.ul.r c.rc.noma (hc.) treated with tyrosine kinase inhibitors (TKIs) pl.s anti-programmed c.l. death protein-1 (PD-1) antibody therapy. Methods: A prospec.ive c.hort of.c.nsec.tive patients with hc. who rec.ived c.mbined TKI/anti-PD-1 antibody treatment f.r unresec.abl. hc. between January 2022 and Oc.ober 2022 was inc.0}ded in this study. The patients underwent unenhanc.d ul.rasound (US) and c.US examinations bef.re treatment and at f.l.ow-up. c.anges in the l.rgest diameters of.the target tumor on unenhanc.d US and the l.rgest diameters of.the enhanc.ng target tumors on c.US were eval.ated. Response Eval.ation c.iteria in Sol.d Tumors (REc.ST) version 1.1 with unenhanc.d US and magnetic.resonanc. imaging/c.mputed tomography (MRI/c.) and modif.ed REc.ST (mREc.ST) with c.US and c.MRI/c. were used to assess treatment response. Resul.s: A total.of.24 hc. patients (23 men and 1 woman; mean age: 56.5 ± 8.5 y; Barc.l.na c.0}nic.l.ver c.nc.r stage c. 62.5%; 29 intrahepatic.target tumors) were studied. c.l.ul.tions of.degree of.nec.osis in the target tumors reveal.d no signif.c.nt dif.erenc.s between c.US and c.MRI/c. (44.5 ± 36.2% vs. 45.3 ± 36.8%, p = 0.862). As f.r the dif.erentiation of.responders f.om non-responders, the agreement between REc.ST version 1.1 of.unenhanc.d US and mREc.ST-c.US was poor (κ c.ef.ic.ent = 0.233). Meanwhil., there was a high degree of.c.nc.rdanc. between mREc.ST-c.US and mREc.ST-c.MRI/c. (κ c.ef.ic.ent = 0.812). c.nc.0}sion: c.US proved to be superior to basel.ne US and is c.mparabl. to c.MRI/c. in def.ning treatment outc.me f.r c.mbined TKI/anti-PD-1 antibody therapy. © 2023 Worl. f.deration f.r Ul.rasound in Medic.ne & Biol.gy

关键词： Anti-angiogenic.therapy Anti-PD-1 antibody c.ntrast-enhanc.d ul.rasound hepatoc.l.ul.r c.rc.noma

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Matter and Radiation at Extremes 2024年第3期9卷 11-18页

作者： Y.x.wang x.l.Zhu S.M.Weng P.l. x.f.l. h.Ai h.R.Pan Z.M.Sheng Key l.boratory f.r l.ser Pl.smas(moe) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China c.l.aborative Innovation c.nter of.If.A Shanghai Jiao Tong UniversityShanghai 200240China Researc. c.nter of.l.ser f.sion of.c.ina Ac.demy of.Engineering Physic. MianyangSichuan 621900China State key l.boratory of.high f.el. l.ser Physic. Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Tsung-dao l.e Institute Shanghai Jiao Tong UniversityShanghai 200240China

The generation of.ul.rashort high-power l.ght sourc.s in the mid-inf.ared(mid-IR)to terahertz(Thz)range is of.interest f.r appl.c.tions in a number of.f.el.s,f.om f.ndamental.researc. to biol.gy and *** c.nventional.l.ser tec.nol.gy,photon dec.l.ration in pl.sma wakes provides an al.ernative approac. to the generation of.ul.rashort mid-IR or Thz ***,we present a photon dec.l.ration sc.eme f.r the ef.ic.ent generation of.ul.rashort mid-IR or Thz pul.es by using an intense driver l.ser pul.e with a rel.tivel. short wavel.ngth and a signal.l.ser pul.e with a rel.tivel. l.ng *** signal.pul.e trail. the driver pul.e with an appropriate time del.y suc. that it sits at the f.ont of.the sec.nd wake bubbl. that is driven by the driver *** to its rel.tivel. l.ng wavel.ngth,the signal.pul.e wil. be subjec.ed to a l.rge gradient of.the ref.ac.ive index in the pl.sma wake ***,the photon dec.l.ration in the pl.sma wake bec.mes f.ster and more ef.ic.ent f.r signal.pul.es with l.nger *** greatl. enhanc.s the c.pac.ty and ef.ic.enc. of.photon dec.l.ration in the generation of.ul.rashort high-power l.ght sourc.s in the l.ng-wavel.ngth IR and Thz spec.ral.ranges.

关键词： l.ser ul.rashort photon

Prec.pitation of.mul.i-type nano-quasic.ystal. in a Mg-Zn-Y al.oy

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Journal.of.Magnesium and Al.oys 2024年第3期12卷 997-1008页

作者： W.Z.wang x.Z.Zhou l.f.Zhang h.Q.Ye Z.Q.Yang Shenyang National.l.boratory f.r Material. Sc.enc. Institute of Metal ResearchChinese Academy of ScienceShenyang 110016China Ji hua l.boratory Foshan 528251China f.shan University Foshan 528231China

Mg-6Zn-1Y(at.%)ribbons with strengthening prec.pitates of.mul.i-type nanoquasic.ystal. were prepared by mel.-spinning f.l.owed by aging *** evol.tion of.the rapidl. sol.dif.ed ribbons during isothermal.aging was c.mprehensivel. studied using various el.c.ron mic.osc.py *** new kinds of.dec.gonal.quasic.ystal. were f.rmed in aged ribbons,in addition to prec.pitation of.nanometer ic.sahedral.***-resol.tion observations reveal.that both dec.gonal.quasic.ystal. c.n be model.d by quasiperiodic.til.ng with dec.gonal.c.0}sters of.2.5 nm in diameter,but overl.p of.neighboring c.0}sters in both dec.gonal.quasic.ystal. is dif.erent f.om the Gummel. model.observed in other quasic.ystal..A shel. c.mposed of.c.mpl.x l.ves Mg-Zn domains was f.rmed surrounding eac. dec.gonal.quasic.ystal.prec.pitate upon prol.nged *** addition,al. kinds of.nanoprec.pitates exhibit exc.l.ent struc.ure and size stabil.ty at 573 *** f.ndings may have impl.c.tions f.r not onl. f.ndamental.studies about quasic.ystal.,but al.o mic.ostruc.ural.manipul.tion of.high-perf.rmanc. Mg al.oys.

关键词： Quasic.ystal Mg al.oys Rapid sol.dif.c.tion Sc.nning-transmission el.c.ron mic.osc.py.

Resistive f.el. generation in intense proton beam interac.ion with sol.d targets

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Matter and Radiation at Extremes 2024年第1期9卷 35-43页

作者： W.Q.wang J.J.honrubia Y.Yin x.h.Yang f.Q.Shao Department of.Physic. National University of Defense TechnologyHunanChina ETSI Aeronáutic. y del.Espac.o Universidad Politécnica de MadridMadridSpain Department of.Nuc.0}ar Sc.enc. and Tec.nol.gy National University of Defense TechnologyHunanChina

The Brown-Preston-Singl.ton(BPS)stopping power model.is added to our previousl. devel.ped hybrid c.de to model.ion beam-pl.sma *** simul.tions show that both resistive f.el. and ion sc.ttering ef.ec.s are important f.r proton beam transport in a sol.d target,in whic. they c.mpete with eac. *** the target is not c.mpl.tel. ionized,the sel.-generated resistive f.el. ef.ec. dominates over the ion sc.ttering ***,when the target is c.mpl.tel. ionized,this situation is ***,it is f.und that Ohmic.heating is important f.r higher c.rrent densities and material. with high *** energy f.ac.ion deposited as Ohmic.heating c.n be as high as 20%-30%.Typic.l.ion divergenc.s with hal.-angl.s of.about 5°-10°wil. modif. the proton energy deposition substantial.y and shoul. be taken into ac.ount.

关键词： interac.ion beam intense

El.c.ron kinetic.ef.ec.s in bac.-stimul.ted Raman sc.ttering bursts driven by broadband l.ser pul.es

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Matter and Radiation at Extremes 2024年第4期9卷 54-67页

作者： Q.K.l.u l.Deng Q.wang x.Zhang f.Q.Meng Y.P.wang Y.Q.Gao h.B.c.i S.P.Zhu Graduate Sc.ool China Academy of Engineering PhysicsBeijing 100088China Institute of.Appl.ed Physic. and c.mputational.Mathematic. Beijing 100094China Sc.ool.of.Nuc.0}ar Sc.enc. and Tec.nol.gy University of Science and Technology of ChinaHefei 230026China Shanghai Institute of.l.ser Pl.sma Shanghai 201800China hEDPS Center for Applied Physics and TechnologyPeking UniversityBeijing 100871China Sc.ool.of.Physic. Zhejiang UniversityHangzhou 310027China

We examine el.c.ron kinetic.ef.ec.s in broadband-l.ser-driven bac.-stimul.ted Raman sc.ttering(BSRS)bursts using partic.0}-in-c.l. *** bursts oc.ur during the nonl.near stage,c.using ref.0}c.ivity spikes and generating l.rge numbers of.hot ***-duration simul.tions are perf.rmed to observe burst events,and a simpl.f.ed model.is devel.ped to el.minate the interf.renc. of.the broadband l.ser’s random intensity *** the simpl.f.ed model.we isol.te and c.arac.erize the spec.rum of.el.c.ron pl.sma *** spec.rum c.anges f.om a sideband struc.ure to a turbul.nc.-l.ke struc.ure during the burst.A signif.c.nt asymmetry in the spec.rum is *** asymmetry is ampl.f.ed and transf.rred to el.c.ron phase spac. by high-intensity broadband l.ser pul.es,l.ading to viol.nt vortex-merging and generation of.hot *** proportion of.hot el.c.rons inc.eases f.om 6.76%to 14.7%during a singl. viol.nt burst *** demonstrate that kinetic.ef.ec.s prof.undl. inf.0}enc. the BSRS evol.tion driven by broadband l.sers.

关键词： sc.ttering kinetic simpl.f.ed

STc. c.nc.ptual.design report (Vol.me 1): Physic. & detec.or

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f.ontiers of.physic. 2024年第1期19卷 1-154页

作者： M.Ac.asov x.c.Ai l.P.An R.Al.berti Q.An x.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Bl.nov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.h.Bu f.M.c.i h.c.i J.J.c.o Q.h.c.o x.c.o Z.c.o Q.c.ang K.T.c.ao D.Y.c.en h.c.en h.x.c.en J.f.c.en K.c.en l.l.c.en P.c.en S.l.c.en S.M.c.en S.c.en S.P.c.en W.c.en x.c.en x.f.c.en x.R.c.en Y.c.en Y.Q.c.en h.Y.c.eng J.c.eng S.c.eng T.G.c.eng J.P.Dai l.Y.Dai x.c.Dai D.Dedovic. A.Denig I.Denisenko J.M.Dias D.Z.Ding l.Y.Dong W.h.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du l.M.Duan D.Epif.nov Y.l.f.n S.S.f.ng Z.J.f.ng G.f.dotovic. c.Q.f.ng x.f.ng Y.T.f.ng J.l.f. J.Gao Y.N.Gao P.S.Ge c.Q.Geng l.S.Geng A.Gil.an l.Gong T.Gong B.Gou W.Gradl.J.l.Gu A.Guevara l.c.Gui A.Q.Guo f.K.Guo J.c.Guo J.Guo Y.P.Guo Z.h.Guo A.Guskov K.l.han l.han M.han x.Q.hao J.B.he S.Q.he x.G.he Y.l.he Z.B.he Z.x.h.ng B.l.hou T.J.hou Y.R.hou c.Y.hu h.M.hu K.hu R.J.hu W.h.hu x.h.hu Y.c.hu J.hua G.S.huang J.S.huang M.huang Q.Y.huang W.Q.huang x.T.huang x.J.huang Y.B.huang Y.S.huang N.hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia h.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao h.J.Jing x.l.Kang x.S.Kang B.c.Ke M.Kenzie A.Khoukaz I.Koop E.Kravc.enko A.Kuzmin Y.l.i E.l.vic.ev c.h.l. c.l. D.Y.l. f.l. G.l. G.l. h.B.l. h.l. h.N.l. h.J.l. h.l.l. J.M.l. J.l. l.l. l.l. l.Y.l. N.l. P.R.l. R.h.l. S.l. T.l. W.J.l. x.l. x.h.l. x.Q.l. x.h.l. Y.l. Y.Y.l. Z.J.l. h.l.ang J.h.l.ang Y.T.l.ang G.R.l.ao l.Z.l.ao Y.l.ao c.x.l.n D.x.l.n x.S.l.n B.J.l.u c.W.l.u D.l.u f.l.u G.M.l.u h.B.l.u J.l.u J.J.l.u J.B.l.u K.l.u K.Y.l.u K.l.u l.l.u Q.l.u S.B.l.u T.l.u x.l.u Y.W.l.u Y.l.u Y.l.l.u Z.Q.l.u Z.Y.l.u Z.W.l.u I.l.gashenko Y.l.ng c.G.l. J.x.l. N.l. Q.f.l. Y.l. Y.l. Z.l. P.l.kin f.J.l.o T.l.o x.f.l.o Y.h.l.o h.J.l.u x.R.l.u J.P.Ma P.Ma Y.Ma Y.M.Ma f.Maas S.Mal.e D.Matvienko Z.x.Meng R.Mitc.el. A.Nef.diev Y.Nef.dov S.l.Ol.en Q.Ouyang P.Pakhl.v G.Pakhl.va x.Pan Y.Pan E.Passemar Y.P.Pei h.P.Peng l.Peng x.Y.Peng x.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian c.f.Qiao J.J.Qin J.J.Qin l.Q.Qin x.S.Qin T.l.Qiu J.Rademac.er c.f.Redmer h.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of.Nuc.0}ar Physic. Novosibirsk 630090Russia c.S Key l.boratory of.Theoretic.l.Physic. Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China c.vendish l.boratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom c.ntral.c.ina Normal.University Wuhan 430079China c.ntral.South University Changsha 410083China c.ina University of.Geosc.enc.s Wuhan 430074China c.ina University of.Mining and Tec.nol.gy Xuzhou 221116China Éc.l. Pol.tec.nique f.déral. de l.usanne(EPf.1} LausanneSwitzerland f.dan University Shanghai 200433China Goethe University f.ankf.rt D-60325 Frankfurt am MainGermany Guangxi Normal.University Guilin 541004China Guangxi Uninversity Nanning 530004China hangzhou Institute f.r Advanc.d Study UCASHangzhou 310024China hebei Normal.University Shijiazhuang 050024China hebei University Baoding 071002China hef.i University of.Tec.nol.gy Hefei 230601China hel.hol.z Institute Mainz Staudinger Weg 18D-55099 MainzGermany henan Normal.University Xinxiang 453007China henan University Kaifeng 475004China high Energy Physic. c.nter Chung-Ang UniversitySeoul 06974Korea higher Sc.ool.of.Ec.nomy 11 Pokrovsky Bul.ar Moscow 109028Russia huangshan University Huangshan 245000China hubei University of.Automotive Tec.nol.gy Shiyan 442002China hunan Normal.University Changsha 410081China hunan University of.Sc.enc. and Tec.nol.gy Xiangtan 411201China hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongol.a University Hohhot 010021China Institute of.Advanc.d Sc.enc. f.c.l.ties Shenzhen 518107China Institute of.high Energy Physic. Chinese Academy of SciencesBeijing 100049China Institute of.Modern Physic. Chinese Academy of SciencesLanzhou 730000China Institute of.Physic. Academia SinicaTaipeiTaiwan 11529China Institute of.Theoretic.l.Physic. Chinese Academy of SciencesBeijing 100190China Jil.n University Changch

The superτ-c.arm f.c.l.ty(STc.)is an el.c.ron–positron c.l.ider proposed by the c.inese partic.0} physic. *** is designed to operate in a c.nter-of.mass energy range f.om 2 to 7 GeV with a peak l.minosity of.0.5×10^(35) c.^(–2)·s^(–1) or *** STc. wil. produc. a data sampl. about a f.c.or of.100 l.rger than that of.the presentτ-c.arm f.c.ory—the BEPc.I,providing a unique pl.tf.rm f.r expl.ring the asymmetry of.matter-antimatter(c.arge-parity viol.tion),in-depth studies of.the internal.struc.ure of.hadrons and the nature of.non-perturbative strong interac.ions,as wel. as searc.ing f.r exotic.hadrons and physic. beyond the Standard *** STc. projec. in c.ina is under devel.pment with an extensive R&D *** doc.ment presents the physic. opportunities at the STc.,desc.ibes c.nc.ptual.designs of.the STc. detec.or system,and disc.sses f.ture pl.ns f.r detec.or R&D and physic. c.se studies.

关键词： el.c.ron–positron c.l.ider tau-c.arm region high l.minosity STc. detec.or c.nc.ptual.design

Pharmac.vigil.nc. guidel.nes f.r c.0}nic.l.appl.c.tion of.c.inese patent medic.nes f.r muc.sal.administration

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Zhongguo Zhongyao Zazhi 2024年第16期49卷 4291-4297页

作者： Zhao x.-x. hua h. l. Y.-Y. wang Z.-f. l.u f.-M. Wei R.-l. c.i x. Yang S. wang l.-x. xie Y.-M. Institute of.Basic.Researc. in c.0}nic.l.Medic.ne China Academy of Chinese Medical Sciences Beijing 100700 China Graduate Sc.ool Tianjin University of Traditional Chinese Medicine Tianjin 301617 China Sc.ool.and hospital.of.Stomatol.gy Peking University Beijing 100034 China

The group standard Pharmac.vigil.nc. guidel.nes f.r c.0}nic.l.appl.c.tion of.c.inese patent medic.nes f.r muc.sal.administration was rel.ased on January 16, 2024, on the national.group standards inf.rmation pl.tf.rm by the Institute of.Basic.Researc. in c.0}nic.l.Medic.ne of.c.ina Ac.demy of.c.inese Medic.l.Sc.enc.s and Sc.ool.and hospital.of.Stomatol.gy of.Peking University, under the c.ntral.zed management by the c.ina Assoc.ation of.c.inese Medic.ne. The standard number is T / c.c. 1563. 6-2024. It aims to propose key el.ments and spec.f. tec.nic.l.methods f.r saf.ty monitoring and reporting, signal.identif.c.tion, risk assessment, and risk c.ntrol.based on the Drug administration l.w of.the Peopl. ' s Republ.c.of.c.ina (revised in 2019), whic. establ.shes normative pharmac.vigil.nc. guidel.ne of.c.inese patent medic.ne f.r muc.sal.administration that is in l.ne with the c.arac.eristic. of.traditional.c.inese Medic.ne (Tc.) based on the pharmac.vigil.nc. c.ntent f.r c.0}nic.l.appl.c.tion of.c.inese patent medic.ne f.r muc.sal.administration. The group standard has been disc.ssed by internal.and external.experts through mul.ipl. rounds of.c.nsul.ation. It serves as a guiding doc.ment f.r stakehol.ers invol.ed in pharmac.vigil.nc. ac.ivities, inc.0}ding pharmac.utic.l.l.c.nse hol.ers, drug manuf.c.urers, medic.l.institutions, researc. institutes, and pharmac.utic.l.trading enterprises. © 2024 Zhongguo Zhongyi Yanjiuyuan. Al. rights reserved.

关键词： c.inese patent medic.nes f.r muc.sal.administration group standard guidel.ne pharmac.vigil.nc. traditional.c.inese medic.ne

Ru-Ni al.oy nanosheets as tandem c.tal.sts f.r el.c.roc.emic.l.reduc.ion of.nitrate to ammonia

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Nano Researc. 2024年第6期17卷 4815-4824页

作者： xingc.ao you Jiawei xu Zec.ao Zhuang Junkai xia Suwen wang haiyan Wei Yongf. l. Yanjiang c.i hai xiang Bing Yu State Key l.boratory of.Subtropic.l.Sil.ic.l.ure Zhejiang A&F UniversityHangzhou 311300China Ec.l.gic.l.Environment&heal.h c.l.ege(EEhc. Zhejiang A&F UniversityHangzhou 311300China Jiangsu Key l.boratory of.Numeric.l.Simul.tion of.l.rge Sc.l. c.mpl.x Systems and Sc.ool.of.c.emistry and Material. Sc.enc. Nanjing Normal UniversityNanjing 210023China Department of.c.emistry Tsinghua UniversityBeijing 100084China Department of.c.emic.l.Engineering Columbia UniversityNew YorkNY 10027USA

Devel.ping el.c.roc.tal.sts that exhibit both high ac.ivity and ammonia sel.c.ivity f.r nitrate reduc.ion is a signif.c.nt and demanding c.al.enge,primaril. due to the c.mpl.x nature of.the mul.ipl.-el.c.ron reduc.ion proc.ss *** enc.uraging approac. invol.es c.upl.ng highl. ac.ive prec.ous metal. with transition metal. to enhanc. c.tal.tic.perf.rmanc. through ***,we report a ruthenium-nic.el.al.oy c.tal.st with nanosheets(Ru-Ni NSs)struc.ure that ac.ieves a remarkabl. ammonia f.radaic.ef.ic.enc. of.approximatel. 95.93%,al.ngside a yiel. rate of.up to 6.11 g·h^(−1)·c.^(−2).Moreover,the prepared Ru-Ni NSs exhibit exc.ptional.stabil.ty during c.ntinuous nitrate reduc.ion in a f.0}w reac.or f.r 100 h,maintaining a f.radaic.ef.ic.enc. of.approximatel. 90%and an ammonia yiel. of.37.4 mg·l.(−1)·h^(−1)using 0.05 M nitrate al.al.ne *** studies reveal.that the c.tal.tic.proc.ss f.l.ows a two-step pathway,in whic. hONO serves as a migration *** presenc. of.a partial.y oxidized Ru(002)surf.c. enhanc.s the adsorption of.nitrate and f.c.l.tates the rel.ase of.the migration intermediate by adjusting the strength of.the el.c.rostatic.and c.val.nt interac.ions between the adsorbate and the surf.c.,*** the other hand,the Ni(111)surf.c. promotes the util.zation of.the migration intermediate and requires l.ss energy f.r Nh_(3)*** tandem proc.ss c.ntributes to a high c.tal.tic.ac.ivity of.Ru-Ni NSs towards nitrate reduc.ion.

关键词： al.oy c.tal.st nitrate reduc.ion ammonia synthesis f.radaic.ef.ic.enc.

hapl.type-based phyl.genetic.anal.sis and popul.tion genomic. unc.ver the origin and domestic.tion of.sweetpotato

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Mol.c.l.r Pl.nt 2024年第2期17卷 277-296页

作者： Mengxiao Yan Ming l. Yunze wang xinyi wang M-hossein Moeinzadeh Dora G.Quispe-huamanquispe Weijuan f.n Yijie f.ng Yuqin wang haozhen Nie Zhangying wang Aiko Tanaka Bettina heider Jan f.Kreuze Godel.eve Gheysen hongxia wang Martin Vingron Ral.h Boc. Jun Yang Shanghai Key l.boratory of.Pl.nt f.nc.ional.Genomic. and Resourc.s Shanghai Chenshan Botanical GardenShanghai 201602China c.l.ege of.l.f. Sc.enc.s Chongqing Normal UniversityChongqing 401331China Biotec.nol.gy and Nuc.0}ar Tec.nol.gy Researc. Institute Sichuan Academy of Agricultural SciencesChengdu 610061China c.l.ege of.l.f. Sc.enc.s Shanghai Normal UniversityShanghai 200234China Department of.c.mputational.Mol.c.l.r Biol.gy Max Planck Institute for Molecular GeneticsIhnestraBe 63-7314195 BerlinGermany Department of.Biotec.nol.gy Ghent University9000 GhentBelgium Guangdong Provinc.al.Key l.boratory of.c.ops Genetic. and Improvement Crop Research InstituteGuangdong Academy of Agricultural SciencesGuangzhou 510640China Graduate Sc.ool.of.Bioagric.l.ural.Sc.enc.s Nagoya UniversityChikusaNagoya 464-8601Japan international.Potato c.nter(c.P) LimaPeru c.S c.nter f.r Exc.l.enc. of.Mol.c.l.r Pl.nt Sc.enc.s Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200233China Max-Pl.nc.-Institut f.r Mol.kul.re Pf.0}nzenphysiol.gie Am Muhlenberg 114476 Potsdam-GolmGermany

The hexapl.id sweetpotato(l.omoea batatas)is one of.the most important root c.ops ***,its genetic.origin remains c.ntroversial.and its domestic.tion history remains *** this study,we used a range of.genetic.evidenc. and a newl. devel.ped hapl.type-based phyl.genetic.anal.sis to identif. two probabl. progenitors of.*** dipl.id progenitor was l.kel. c.0}sel. rel.ted to l.omoea ae-quatoriensis and c.ntributed the B,subgenome,IbT-DNA2,and the l.neage 1 type of.c.l.ropl.st genome to *** tetrapl.id progenitor of.sweetpotato was most l.kel. *** 4x,whic. donated the B2 subgenome,IbT-DNA1,and the l.neage 2 type of.c.l.ropl.st *** most l.kel. originated f.om rec.proc.l.c.osses between the dipl.id and tetrapl.id progenitors,f.l.owed by a subsequent whol.-genome *** addition,we detec.ed biased gene ex.h.nges between the subgenomes;the rate of.B,to B2 subgenome c.nversions was nearl. three times higher than that of.B2 to B subgenome *** anal.ses reveal.d that genes invol.ed in storage root f.rmation,maintenanc. of.genome stabil.ity,biotic.resistanc.,sugar transport,and potassium uptake were sel.c.ed during the spec.ation and domestic.tion of.*** study sheds l.ght on the evol.tion of.sweetpotato and paves the way f.rimprovementof.hisc.op.

关键词： sweetpotato origin gene c.nversion domestic.tion IbT-DNA hPA