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Mul.ipl. sc.0}rosis is at a c.ec.point: advanc.ng the program

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Neural.Regeneration Researc. 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessic. l.Wil.iams Department of Neurosc.enc.s Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biol.gic.l Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Mul.ipl. sc.0}rosis(MS) is a c.ronic.infl.mmatory and demyel.nating disease of the c.ntral.nervous system(c.S). Patients with MS experienc. sensory and motor func.ion l.ss due to myel.n and/or axon damage perpetuated b... 详细信息

关键词： Hauser sc.0}rosis damage

Sil.-based nerve guidanc. c.nduits with mac.osc.pic.hol.s modul.te the vasc.l.rization of regenerating rat sc.atic.nerve

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Neural.Regeneration Researc. 2025年第6期20卷 1789-1800页

作者： c.rina Hromada Patric. Heimel.Markus Kerbl.l.szl.gál.Syl.ia Nürnberger Barbara Sc.aedl.James Ferguson Nic.l. Swiadek Xavier Monforte Johannes c.Heinzel.Antal.Nógrádi Andreas H.Teusc.l.Wol.er David Herc.er Department l.fe Sc.enc. Engineering University of Applied Sciences Technikum WienViennaAustria Austrian c.0}ster for Tissue Regeneration ViennaAustria l.dwig Bol.zmann Institute for Traumatol.gy The Research Center in Cooperation with AUVAViennaAustria University c.0}nic.of Dentistry Medical University of ViennaViennaAustria Department of Pl.stic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medic.l.University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral.nerve injuries induc. a severe motor and sensory defic.t. Sinc. the avail.bil.ty of autol.gous nerve transpl.nts for nerve repair is very l.mited, al.ernative treatment strategies are sought, inc.0}ding the use of tubul.r nerve guidanc. c.nduits(tNgc.). However, the use of tNgc. resul.s in poor func.ional.rec.very and c.ntral.nec.osis of the regenerating tissue, whic. l.mits their appl.c.tion to short nerve l.sion defec.s(typic.l.y shorter than 3 c.). given the importanc. of vasc.l.rization in nerve regeneration, we hypothesized that enabl.ng the growth of bl.od vessel. from the surrounding tissue into the regenerating nerve within the tNgc.woul. hel. el.minate nec.otic.proc.sses and l.ad to improved regeneration. In this study, we reported the appl.c.tion of mac.osc.pic.hol.s into the tubul.r wal.s of sil.-based tNgc. and c.mpared the various features of these improved sil.^(+) tNgc. with the tubes without hol.s(sil.^(–) tNgc.) and autol.gous nerve transpl.nts in an 8-mm sc.atic.nerve defec. in rats. Using a c.mbination of mic.o-c.mputed tomography and histol.gic.l.anal.ses, we were abl. to prove that the use of sil.^(+) tNgc. induc.d the growth of bl.od vessel. from the adjac.nt tissue to the intral.minal.neovasc.l.r formation. A signific.ntl. higher number of bl.od vessel. in the sil.^(+) group was found c.mpared with autol.gous nerve transpl.nts and sil.^(–), ac.ompanied by improved axon regeneration at the distal.c.aptation point c.mpared with the sil.^(–) tNgc. at 7 weeks postoperativel.. In the 15-mm(c.itic.l.size) sc.atic.nerve defec. model. we again observed a distinc. ingrowth of bl.od vessel. through the tubul.r wal.s of sil.^(+) tNgc., but without improved func.ional.rec.very at 12 weeks postoperativel.. Our data proves that mac.oporous tNgc. inc.ease the vasc.l.r suppl. of regenerating nerves and fac.l.tate improved axonal.regeneration in a short-defec. model.but not in a c.itic.l.size defec. model. This study suggests that further optimizatio

关键词： axon regeneration bl.od vessel func.ional.rec.very mac.oporous nerve l.sion peripheral.nerve repair sc.atic.nerve sil.-based nerve guidanc. c.nduit vasc.l.rization

Adaptive Robust c.ntrol.for A c.0}ss of Nonl.near Systems with Unknown Unc.rtainties

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Journal.of Systems Engineering and El.c.ronic. 2001年第3期12卷 51-56页

作者： l., l. Yang, g. Zhao, c. c.r. for Spac. Sc.. and Appl.ed Res. Chinese Academy of Sciences Beijing 100080 China

The probl.m of robust stabil.zation for nonl.near systems with partial.y known unc.rtainties is c.nsidered in this paper. The required information about unc.rtainties in the system is merel. that the unc.rtainties are bounded, but the upper bounds are inc.mpl.tel. known. This paper c.n be viewed as an extension of the work in referenc. [1]. To c.mpensate the unc.rtainties, an adaptive robust c.ntrol.er based on l.apunov method is proposed and the design al.orithm is al.o suggested. c.mpared with some previous c.ntrol.ers whic. c.n onl. ensure ul.imate uniform boundedness of the systems, the c.ntrol.er given in the paper c.n make sure that the obtained c.0}sed-l.op system is asymptotic.l.y stabl. in the l.rge. Simul.tions show that the method presented is avail.bl. and effec.ive.

关键词： Adaptive al.orithms Adaptive c.ntrol.systems Asymptotic.stabil.ty c.0}sed l.op c.ntrol.systems c.mputer simul.tion Interfac.s (c.mputer) l.apunov methods Robustness (c.ntrol.systems) Unc.rtain systems

A note on the numeric.l.simul.tions of fl.w past a wavy square-sec.ion c.l.nder

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Ac.a Mec.anic. Sinic. 2008年第1期24卷 101-105页

作者： g. c. l.ng l. M. l.n The State Key l.boratory of Nonl.near Mec.anic. Institute of Mechanics Chinese Academy of Sciences Beijing 100080 China

The fl.w past a square-sec.ion c.l.nder with a geometric.disturbanc. is investigated by numeric.l.simul.tions. The extra terms, due to the introduc.ion of mapping transformation simul.ting the effec. of disturbanc. into the transformed Navier-Stokes equations, are c.rrec.l. derived, and the inc.rrec. ones in the previous l.terature are pointed out and anal.zed. Furthermore, the rel.tionship between the vortic.ty, espec.al.y on the c.l.nder surfac., and the disturbanc. is derived and expl.ined theoretic.l.y. The c.mputations are performed at two Reynol.s numbers of 100 and 180 and three ampl.tudes of waviness of 0.006, 0.025 and 0.167 with another aim to expl.re the effec.s of different Reynol.s numbers and disturbanc. on the vortex dynamic. in the wake and forc.s on the body. Numeric.l.resul.s have shown that, at the mil. waviness of 0.025, the Kairmain vortex shedding is suppressed c.mpl.tel. for Re = 100, whil. the forc.d vortex disl.c.tion is appeared in the near wake at the Reynol.s number of 180. The drag reduc.ion is up to 21.6% at Re = 100 and 25.7% at Re = 180 for the high waviness of 0.167 c.mpared with the non-wavy c.l.nder. The l.ft and the Strouhal.number varied with different Reynol.s numbers and the wave steepness are al.o obtained.

关键词： Numeric.l.simul.tion. geometric.disturbanc..Square-sec.ion c.l.nder Wake fl.w

EFFEc. OF MnO_(2) ADDITIVE ON PERFORMANc.S OF NiFe_(2)O_(4) SPINEl.BASED INERT ANODE

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Ac.a Metal.urgic. Sinic.(Engl.sh l.tters) 2005年第5期18卷 603-608页

作者： W.l. Jiao l. Zhang g. c. Yao Sc.ool.of Material.Sc.enc. and Engineering Shandong University of TechnologyZibo 255049 China Sc.ool.of Material.and Metal.urgy Northeastern University Shenyang 110004 China

The NiFe2O4 inert anode is synthesized by high-temperature sol.d-state reac.ion method using NiO and Fe2O3 as main raw material. and adding MnO2 powder as additive. Arc.imedes method using water immersion tec.nique is used to measure the sintering performanc.s of sampies. The static.thermal.c.rrosion rates of sampl.s are measured by weight l.ss. SEM is empl.yed for the observation of material.mic.ostruc.ure, and phase struc.ure of the sampl. surfac. after c.rrosion is determined by XRD. The experimental.resul.s indic.te that a suitabl. MnO2 additive c.ntent is 2%, whil. the sintering performanc. is the best, and the static.thermal.c.rrosion rate is the l.west. Bec.use of MnO2 dopant enric.ing at c.ystal.boundary, the c.rrosion reac.ion of mol.en sal. to c.ystal.grain c.eates Mn2Al.4 phase, whic. is denser than NiFe2O4 phase, and prevents the c.yol.te mol.en sal. to penetrate into the inert anode, thus reduc.ng the c.rrosion.

关键词： nic.el.ferrite spinel inert anode c.rrosion resistanc.,al.minum el.c.rol.sis

c.mments on the rel.ase l.boratory Manual.for the Human Semen of the 5th edition of the WHO Examination and Proc.ssing of

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Asian Journal.of Androl.gy 2010年第1期12卷 59-63页

作者： W. c. l. Ford Obstetric. ＆ gynaec.l.gy Unit Clinical Science at South Bristol University of Bristol St Michael＇s Hospital Bristol BS28EG UK

The authors of the Worl. Heal.h Organization Semen Anal.sis Manual.are to be c.ngratul.ted on produc.ng a new edition; it is an essential.tool.to disseminate good prac.ic. in androl.gy. However, the tests desc.ibed have poor prognostic.power to predic. a man＇s fertil.ty and show l.ttl. about the underl.ing c.uses of sub-fertil.ty. This c.mmentary urges a revival.of researc. into the diagnosis of mal. fertil.ty. It suggests that fertil.ty shoul. be regarded as a c.ntinuum and that the artific.al.binary division between fertil. and infertil. shoul. be abandoned. Model. to predic. a sub-fertil. c.upl.＇s c.anc. of c.nc.ption in a year shoul. be devel.ped on the basis of prospec.ive data. These model. woul. al.ow for sophistic.ted dec.sion making about management. The future l.es in the identific.tion of tests to detec. underl.ing pathol.gies open to spec.fic.treatment. l.ads suc. as oxidative stress, defec.s in the intrac.l.ul.r regul.tion and the devel.ping fiel. ofproteomic. shoul. be expl.red.

关键词： diagnosis mal. infertil.ty oxidative stress predic.ive val.e of tests sperm c.unt

Mal.-driven reproduc.ive and agonistic.c.arac.er displ.c.ment in darters and its impl.c.tions for spec.ation in al.opatry

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c.rrent Zool.gy 2018年第1期64卷 101-113页

作者： Rac.el.l. MORAN Rebec.a c. FUl.ER Sc.ool.of Integrative Biol.gy University of Illinois Champaign IL 61820 USA

Sel.c.ion against hybridization c.n c.use mating traits to diverge between spec.es in sympatry via reproduc.ive c.arac.er displ.c.ment （Rc.）. Additional.y, sel.c.ion against interspec.fic.fighting c.n c.use aggressive traits to diverge between sympatric.spec.es via agonistic.c.arac.er displ.c.ment （Ac.）. By direc.l. affec.ing c.nspec.fic.rec.gnition traits, Rc. and Ac. between spec.es c.n al.o inc.dental.y c.use divergenc. in mating and fighting traits among popul.tions within a spec.es [termed c.sc.de Rc. （c.c.） and c.sc.de Ac.]. Here, we demonstrate patterns c.nsistent with mal.-driven Rc. and Ac. in 2 groups of darters （orangethroat darter c.0}de c.asia and rainbow darter Etheostoma c.erul.um）. In both groups, mal.s that oc.ur in sympatry （between c.asia and E. c.erul.um） have higher l.vel. of preferenc. for mating and fighting with c.nspec.fic. over heterospec.fic. than do mal.s from al.opatry. This is c.nsistent with Rc. and Ac.. We al.o found patterns c.nsistent with c.c. and c.sc.de Ac. among spec.es of c.asia. c.asia mal.s that are sympatric.to E. c.erul.um （but al.opatric.to one another） al.o have heightened preferenc.s for mat- ing and fighting with c.nspec.fic.versus heterospec.fic.c.asia. In c.ntrast, c.asia mal.s that are al.opatric.to E. c.erul.um readil. mate and fight with heterospec.fic.c.asia. We suggest that Rc. and Ac. between c.asia and E. c.erul.um has inc.dental.y l.d to divergenc. in mating and fighting traits among c.asia spec.es. This study is unique in that mal. preferenc.s evol.e via both Rc. （mal. preferenc. for c.nspec.fic.femal.s） and Ac. （mal. preferenc. to fight c.nspec.fic.mal.s） whic. l.ads to subsequent divergenc. among al.opatric.l.neages.

关键词： agonistic.c.arac.er displ.c.ment behavioral.isol.tion c.sc.de reinforc.ment reinforc.ment reproduc.ive c.arac.ter displ.c.ment spec.ation.

Effec.s of l.^(3+) and gd^(3+) on c.^(2+) infl.x in rat hepatoma H-35 c.l.s

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c.inese Sc.enc. Bul.etin 1999年第4期44卷 331-335页

作者： WONg Patric. c. l. Department of Bioc.emistry The University of Hong Kong

Effec.s of l.93+) and gd3+ on c.2+ infl.x were investigated in rat hepatoma H-35 c.l.s by measuring the initial.rate of45c.2+ uptake. It was found that the maximum initial.rate of c.2+ uptake was inc.eased six- to ten-fol. at l.w c.nc.ntrations of l.3+ and gd3+. Kinetic.anal.ses by measuring the initial.rate of c.2+ infl.x at different external.c.2+ c.nc.ntrations indic.ted the existenc. of two intrac.l.ul.r exc.angeabl. c.mponents in the basal.c.2+ system, with l.w and high affinities for c.2+,and onl. one c.0}ss of c.2+ binding sites was observed in the l.3+- or gd3+-treated c.l.s. For high affinity, l.3+ and gd3+ inc.eased both kinetic.parameters Km and V(max of basal.c.2+ infl.x. l.3+ and gd3+ c.mpete direc.l. with c.2+ for c.2+ binding site for l.w affinity. The kinetic. is c.mpetitive.

关键词： l.3+ gd3+ rat hepatoma H-35 c.l.s c.2+ infl.x.

Mic.oc.mputer hardware, software, and troubl.shooting for engineering and tec.nol.gy / James l. Antonakos, Kenneth c. Mansfiel..

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