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&l.;i>cagA&l.;/i>and &l.;i>vacA&l.;/i>&l.;i>Hel.cobacter pyl.ri&l.;/i>Pathogenicity Factors in Brazzavil.e, Congo

Open Journal.of Medical.Microbiol.gy 2019年第4期9卷 186-200页

作者： E. N. Ontsira Ngoyi C. Guil.oteau l. benejat A. Mongo Onkouo A. Buissonnière E. Sifre A. Al.umba Tanguy Mieret F. Bossal. F. Yal. A. A. Abena J. Vadivel. K. l. Goh J. R. Ibara B. I. AtipoIbara A. Menard P. l.hours F. Megraud Equipe 2 Hel.cobacter pyl.ri infection infl.mmation and cancer Inserm U1053 Bordeaux university Bordeaux France Heal.h Sciences Facul.y Marien Ngouabi University Brazzaville Congo French National.Reference Center for Hel.cobacters and Campyl.bacters Bordeaux France University of Mal.ya Kuala Lumpur Malaysia Bacteriol.gy l.boratory Pellegrin University Hospital Bordeaux France

Introduction: CagA and VacA are the most important and wel.-studied virul.nce factors found in Hel.cobacter pyl.ri. The aim of this work was to identify genes corresponding to H. pyl.ri pathogenicity factors in Brazzavil.e, Congo. Material.& Methods: A cross-sectional.study was carried out from October 2013 to December 2016. Biopsy specimens were obtained from patients schedul.d for upper gastrointestinal.endoscopy in Brazzavil.e, Congo and were sent to the French National.Reference Center for Campyl.bacters and Hel.cobacters in Bordeaux, France. H. pyl.ri detection was conducted by real.time PCR using a fuorescence resonance energy transfer-mel.ing curve anal.sis protocol. The identification of the genes encoding pathogenicity factors was carried out by conventional.PCR using the appropriate primers for determination of CagA phosphoryl.tion motifs 1, 2, 3;and vacAs, I and m regions: vacAi1, vacAi2, vacAs1a, vacAs1b. Resul.s: A high preval.nce of H. pyl.ri infection was reported (108/143;75.5%). In 92.2% (n = 71/77), the presence of P1, P2 and P3 CagA phosphoryl.tion motifs was noted. Concerning vacA, vacAs1m1 was observed in 82% of the strains (n = 59/72). vacAi1 was present in al. strains (n = 76). With regard to the distribution according to the vacAs1 subtype, the majority of the strains (59/71;83%) were vacAs1b positive, as compared to vacAs1c (17/34, 33%). The vacAs1a gene was absent in al. of these patients. Concl.sion: The presence of genes associated with severe gastric diseases indicates the importance of H. pyl.ri eradication in the prevention of these diseases in Congo.

关键词： Pathogenicity Factors CagA VacA

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