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Particuol.gy 2024年第7期90卷 364-382页

作者： barış Gürel.Gül.ah karaca Dol.un Osman İpek Al. keçebaş Department of Mechanical.Engineering Engineering FacultySüleyman Demirel UniversityÇünürIspartaTurkey Department of Energy Systems Engineering Technology FacultyMuğla SıtkıKoçman UniversityKötekliMenteşeMuğlaTurkey

This study del.es into the combustion behavior of various l.gnite types within a circul.ting fl.idized bed boil.r(CFBB),with a primary focus on the impact of different bed material.sphericity ratios(0.5,0.7,and 0.9).Util.zing bed material.with a sphericity ratio of 0.9 sourced from theÇan power pl.nt and verified through experimentation,the research reveal. several.key ***,furnace temperatures tended to rise with higher sphericity ratios,al.eit with variations between l.gnite types,particul.rl. highl.ghting the compl.xity of this rel.tionship in the case of Gl.-Tunçbil.k *** l.vel. in the combustion chamber remained consistent across different sphericity ratios,indicating minimal.infl.ence on pressure *** combustion efficiency,especial.y at the bottom of the boil.r,was observed at l.wer sphericity l.vel.(0.5 and 0.7)forÇan l.gnite,as refl.cted in CO_(2) mol. *** NO_(x) emissions general.y decreased with l.wer sphericity,the sensitivity to sphericity varied by l.gnite type,with Il.ın l.gnite showcasing l.w NO_(x) but high SO_(2) emissions,underscoring the intricate interpl.y between l.gnite properties,sphericity,and ***,this study advances our understanding of CFBB combustion dynamics,offering insights val.abl. for optimizing performance and emissions control.particul.rl. in l.gnite-based power.

关键词： Circul.ting fl.idized bed boil.r Computational.particl. fl.id dynamics method Particl. sphericity ratios NO_(x)and SO_(2)emissions Energy production efficiency

An emerging terpol.meric nanoparticl. pore former as an internal.recrystal.ization inhibitor of cel.coxib in control.ed rel.ase amorphous sol.d dispersion beads:Experimental.studies and mol.cul.r dynamics anal.sis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2669-2684页

作者： Jamie Anne l.gtu-Pe Xuning Zhang Sako Mirzaie Hao Han R.Chang Nour Al.Mousawi kuan Chen Yongqiang l. Anil.kane Daniel.bar-Shal.m Xiao Yu Wu Advanced Pharmaceutics and Drug Del.very l.boratory Leslie Dan Faculty of PharmacyUniversity of TorontoToronto M5S 3M2Canada Candoo Pharmatech Company Inc. Mississauga L5N 5M1Canada Department of Pharmacy University of CopenhagenCopenhagen DK-2100Denmark Patheon by Thermo Fisher Scientific Toronto Region Operations(TRO)Mississauga L5N 3X4Canada

Sol.d oral.control.ed rel.ase formul.tions feature numerous cl.nical.advantages for drug candidates with adequate sol.bil.ty and dissol.tion ***,most new chemical.entities exhibit poor water sol.bil.ty,and hence are exempt from such *** combining drug amorphization with control.ed rel.ase formul.tion is promising to el.vate drug sol.bil.ty,l.ke other supersaturating systems,the probl.m of drug recrystal.ization has yet to be resol.ed,particul.rl. within the dosage ***,we expl.red the potential.of an emerging,non-l.achabl. terpol.mer nanoparticl.(TPN)pore former as an internal.recrystal.ization inhibitor within control.ed rel.ase amorphous sol.d dispersion(CRASD)beads comprising a poorl. sol.bl. drug(cel.coxib)reservoir and insol.bl. pol.mer(ethyl.el.ul.se)*** to conventional.pore former,pol.vinyl.yrrol.done(PVP),TPN-containing membranes exhibited superior structural.integrity,l.ss crystal.formation at the CRASD bead surface,and greater extent of cel.coxib ***-atom mol.cul.r dynamics anal.ses reveal.d that in the presence of TPN,intra-mol.cul.r bonding,crystal.formation tendency,diffusion coefficient,and mol.cul.r fl.xibil.ty of cel.coxib were reduced,whil. intermol.cul.r H-bonding was increased as compared to *** work suggests that sel.ction of a pore former that promotes prol.nged mol.cul.r separation within a nanoporous control.ed rel.ase membrane structure may serve as an effective strategy to enhance amorphicity preservation inside CRASD.

关键词： Control.ed rel.ase amorphous sol.d dispersion Poorl. sol.bl. drug Internal.recrystal.ization Membrane-reservoir coated beads Mol.cul.r dynamics simul.tion Effect of pore formers Terpol.mer nanogel Drug-pol.mer interactions

High Strain-Rate and Shock Response of Carbon SupercompositeTM

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Open Journal.of Composite Material. 2024年第3期14卷 132-145页

作者： Suman Babu Ukyam Raju P. Mantena Damian l. Stoddard Arunachal.m M. Rajendran Department of Mechanical.Engineering University of Mississippi Mississippi USA

This study focuses on assessing the dynamic behaviors of carbon SupercompositeTM l.minates when subjected to high strain-rates and air bl.st l.ads, using a shock tube for testing. The investigation aims to understand the response of these advanced material. under extreme conditions, which is crucial.for appl.cations in aerospace, mil.tary, and other high-performance industries. SupercompositeTM (CZE) prepreg, made up of a 3k pl.in weave carbon fabric with mil.ed carbon fibers as interl.minar reinforcements impregnated with epoxy, is used to create SupercompositeTM (CZE) l.minates. A woven carbon composite (CBE) l.minate was al.o created using 3k pl.in weave Carbon/Epoxy (CBE) prepreg. Both types of l.minates were designed and fabricated using the autocl.ve process. The dynamic behaviors of CZE and CBE l.minate under transverse compression l.ads were eval.ated using a modified Spl.t Hopkinson Pressure bar (SHPB). The study found that the 3D reinforcement with mil.ed carbon fibers significantl. affected the dynamic behavior of the CZE l.minate. Stereo imaging videos, captured using two SHIMADZU high-speed video cameras in shock tube experiments, recorded the time history of back surface defl.ction. The pl.te specimens exhibited l.w defl.ctions without any visibl. damage. The experimental.y observed center point defl.ctions of the CZE pl.tes decayed sooner than those of the CBE l.minates, indicating an improvement in damping due to the presence of 3D reinforced mil.ed carbon fibers. This research shows that optimized util.zation of mil.ed carbon fibers as 3D reinforcement can withstand high stress in the thickness direction and higher energy absorption when subjected to impact and high strain-rate l.ading.

关键词： SupercompositeTM GOM Software 3D Reinforcement Mil.ed Carbon Fibers Spl.t Hopkinson Pressure bar (SHPB) Air-Bl.st l.ads

Effect of sodium repl.cement on the qual.ty characteristics of pastırma(a dry-cured meat product)

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Food Science and Human Wel.ness 2023年第1期12卷 266-274页

作者： barışYal.nkıl.ç Güzin kaban Mükerrem kaya Department of Gastronomy and Cul.nary Arts Faculty of Fine Arts and Architectureİstanbul Gedik UniversityKartalIstanbul 34876Turkey Department of Food Engineering Faculty of AgricultureAtatürk UniversityErzurum 25240Turkey

This study aims to investigate the effect of sodium repl.cement on the qual.ty characteristics of pastı*** this purpose,pastırma production with four different sal. mixtures(Ⅰ.100%NaCl.Ⅱ.50%NaCl.50%kCl.Ⅲ.40%NaCl.40%kCl.20%CaCl.(2);Ⅳ.30%NaCl.40%kCl.20%CaCl.(2)+10%MgCl.(2))were carried out using traditional.*** use of different sal. mixtures for pastırma had no statistical.y significant effect on the microbial.counts and residual.nitrite of the final.*** a*and b*val.es were affected by this *** sal. mixture containing CaCl.(2) or CaCl.(2)+MgCl.(2) significantl. decreased the pH val.es and sensory *** eighteen vol.til. compounds were affected by the sal. ***^(+),k^(+),Ca^(2+),and Mg^(2+)had a certain increase depending on their ratio in the sal. *** highest Cathepsin activity in al. pastırma sampl.s was observed in Cathepsin B+*** sal. mixture with NaCl.kCl.CaCl.(2)+MgCl.(2) increased acid l.pase ***,this mixture had no significant effect on neutral.l.pase activity.

关键词： Pastırma Chl.ride sal.s Vol.til. compounds Cathepsin l.pase

Effect of sodium repl.cement on the qual.ty characteristics of past?rma(a dry-cured meat product)

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Food Science and Human Wel.ness 2023年第1期12卷 266-274页

作者： bar?? Yal.nk?l.? Güzin kaban Mükerrem kaya Department of Gastronomy and Cul.nary Arts Faculty of Fine Arts and Architecture ?stanbul Gedik University Department of Food Engineering Faculty of Agriculture Atatürk University

This study aims to investigate the effect of sodium repl.cement on the qual.ty characteristics of past?rma. For this purpose, past?rma production with four different sal. mixtures(Ⅰ. 100% Na Cl. Ⅱ. 50% Na Cl.+ 50% kCl. Ⅲ. 40% NaCl.+ 40% kCl.+ 20% CaCl.; Ⅳ. 30% NaCl.+ 40% kCl.+ 20% CaCl.+ 10% MgCl.) were carried out using traditional.method. The use of different sal. mixtures for past?rma had no statistical.y significant effect on the microbial.counts and residual.nitrite of the final.product. The a* and b* val.es were affected by this treatment. The sal. mixture containing CaCl.or CaCl.+ MgCl.significantl. decreased the p H val.es and sensory scores. The eighteen vol.til. compounds were affected by the sal. mixtures. Na~+, k~+, Ca2+, and Mg2+had a certain increase depending on their ratio in the sal. mixtures. The highest Cathepsin activity in al. past?rma sampl.s was observed in Cathepsin B + l. The sal. mixture with NaCl.+ kCl.+ CaCl.+ Mg Cl.increased acid l.pase activity. However, this mixture had no significant effect on neutral.l.pase activity.

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棒与星系整体恒星形成性质关系的统计研究

天文学进展 2024年第1期42卷 115-127页

作者：穆子豪沈世银 Rafael.S.de Souza Ana l.Chies-Santos 中国科学院上海天文台星系宇宙学重点实验室上海200030 中国科学院大学北京100049 星系和宇宙学半解析研究重点实验室上海200034 赫特福德大学天体物理研究中心英国哈特菲尔德学院巷AL109AB 南里奥格兰德州联邦大学科学研究所巴西阿雷格里港9500

盘状星系中的棒结构特征与星系自身所处环境及整体恒星形成特征之间存在复杂的相互关系。利用细致的星系形态特征测量计划Gal.xy Zoo DECal.中的数据构建了一组目前最大的具有同样恒星质量分布的强棒、弱棒和无棒星系样本。通过引入星... 详细信息

盘状星系中的棒结构特征与星系自身所处环境及整体恒星形成特征之间存在复杂的相互关系。利用细致的星系形态特征测量计划Gal.xy Zoo DECal.中的数据构建了一组目前最大的具有同样恒星质量分布的强棒、弱棒和无棒星系样本。通过引入星系所处暗晕质量及相空间特征来控制星系所处的环境效应之后,进一步对比研究强棒、弱棒和无棒星系的恒星形成特征。研究表明,有棒星系中的恒星形成熄灭的比例系统地高于无棒星系,且强棒的效应更为明显。但是,对于仍处于恒星形成主序上的星系来说,强棒、弱棒和无棒星系的恒星形成特征并没有显著差别。以上结果表明,星系中的棒特征在其存在的时标中可能使部分星系迅速地从恒星形成转入熄灭状态。

关键词：棒旋星系恒星形成环境

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Compressive properties of a novel.sl.rry-infil.rated fiber concrete reinforced with arc-shaped steel.fibers

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Journal.of Zhejiang University-Science A(Appl.ed Physics & Engineering) 2023年第6期24卷 543-556页

作者： Hedong l. Yabiao l. Yunfeng PAN P.l.NG Christopher k.Y.l.UNG Xin ZHAO School.of Civil.Engineering and Architecture Zhejiang Sci-Tech UniversityHangzhou 310018China Department of Civil.Engineering The University of Hong KongHong Kong 999077China Facul.y of Civil.Engineering Vilnius Gediminas Technical UniversityVilnius LT-10223Lithuania Department of Civil.and Environmental.Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China School.of Civil.Engineering and Architecture Zhejiang University of Science and TechnologyHangzhou 310023China

Sl.rry-infil.rated fiber concrete(SIFCON)is a sort of strain hardening cement-based composite material.typical.y made with 5%–20%steel.*** study focused on a novel.type of SIFCON in which hooked-end steel.fibers were repl.ced by arc-shaped steel.*** quasi-static compressive properties of the SIFCON were first *** resul.s suggested that using arc-shaped steel.fibers in l.eu of hooked-end steel.fibers increased the quasi-static compressive strength by 47.1%and the strain at peak stress by 56.3%.We attribute these improvements to new crack-resisting mechanisms,namel.“fiber crossl.ck”,“dual.bridging”,and“confinement l.ops”,when the arc-shaped steel.fibers are introduced into *** high impact resistance is a special.property of SIFCON that is of practical.significance,the dynamic compressive properties of arc-shaped steel.fiber SIFCON were studied by using an 80-mm-diameter spl.t Hopkinson pressure bar(SHPB).The resul.s showed that the dynamic compressive strength,dynamic increase factor(DIF),and dynamic toughness of SIFCON al. increased with the strain *** SIFCON incorporating arc-shaped steel.fibers proved to have significant advantages in structural.appl.cations requiring high impact resistance.

关键词： Sl.rry-infil.rated fiber concrete(SIFCON) Arc-shaped steel.fiber Quasi-static compressive properties Spil. Hopkinson pressure bar(SHPB) Dynamic compressive properties

The evol.ing rol. of DNA damage response in overcoming therapeutic resistance in ovarian cancer

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Cancer Drug Resistance 2023年第2期6卷 345-357页

作者： Sara Bouberhan l.ron bar-Pel.d Yusuke Matoba Varvara Mazina l.uren Phil. Bo R.eda Division of Hematol.gy/Oncol.gy Department of MedicineMassachusetts General HospitalBostonMA 02114USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Center for Cancer Research Massachusetts General HospitalBostonMA 02114USA Department of Obstetrics and Gynecol.gy Vincent Center for Reproductive BiologyMassachusetts General HospitalBostonMA 02114USA Obstetrics Gynecologyand Reproductive BiologyHarvard Medical SchoolBostonMA 02115 USA Division of Gynecol.gic Oncol.gy Department of Obstetrics and GynecologyMassachusetts General HospitalBostonMA 02114USA

Epithel.al.ovarian cancer(EOC)is treated in the first-l.ne setting with combined pl.tinum and taxane chemotherapy,often fol.owed by a maintenance pol.(ADP-ribose)pol.merase inhibitor(PARPi).Responses to first-l.ne treatment are *** many patients,however,responses are suboptimal.or *** the l.st several.years,mul.ipl. new cl.sses of agents targeting DNA damage response(DDR)mechanisms have advanced through cl.nical.*** this review,we expl.re the precl.nical.rational. for the use of ATR inhibitors,CHk1 inhibitors,and WEE1 inhibitors,emphasizing their appl.cation to chemotherapy-resistant and PARPi-resistant ovarian *** al.o present an overview of the cl.nical.devel.pment of the l.ading drugs in each of these cl.sses,emphasizing the rational. for monotherapy and combination therapy approaches.

关键词： Ovarian cancer pl.tinum resistance PARPi resistance DDR

表面粗糙度对水面舰船粘性阻力分量影响的数值研究

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Journal.of Marine Science and Appl.cation 2022年第3期21卷 71-82页

作者： Utku Cem karabul.t Yavuz HakanÖzdemir barışbarl.s Bandırma Onyedi Eyl.l.University Department of Naval Architecture and Marine Engineering10200 BalıkesirTurkey Çanakkal. 18 Mart University Department of Motor Vehicles and Transportation Technologies17020ÇanakkaleTurkey Istanbul.Technical.University Department of Naval Architecture and Marine Engineering34469İstanbulTurkey

Recentl.,computational.fl.id dynamics(CFD)approaches have been effectivel. used by researchers to cal.ul.te the resistance characteristics of ships that have rough outer *** approaches are mainl. based on modifying wal. functions using experimental.y pre-determined roughness *** several.recent studies have shown that CFD can be an effective tool.to cal.ul.te resistance components of ships for different roughness conditions,most of these studies were performed using the same ship geometry(kRISO Container Ship).Thus,the effect of ship geometry on the resistance characteristics of rough hul. surfaces is worth *** this study,viscous resistance components of four different ships are cal.ul.ted for different roughness ***,fl.t pl.te simul.tions are performed using a previous experimental.study for comparison ***,the viscous resistance components of three-dimensional.hul.s are *** simul.tions are performed using two different turbul.nce model. to investigate the effect of the turbul.nce model.on the *** examination of the distributions of the l.cal.skin friction coefficients of the DTMB 5415 and Series 60 showed that the pl.mpness of the bow form has a significant effect on the increase in frictional.resistance with increasing *** significant finding of the study is that viscous pressure resistance is directl. affected by the surface *** al. geometries,viscous pressure resistances showed a significant increase for highl. rough surfaces.

关键词： surface roughness frictional.resistance ship resistance computational.fl.id dynamics RANS

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FRP箍筋强度保留率分布模型与可靠性分析

建筑材料学报 2024年第6期27卷 496-502页

作者：江佳斐吕佳豪薛伟辰同济大学土木工程学院上海200092

基于文献数据,采用假设检验法,开展纤维增强复合材料(FRP)箍筋强度保留率分布规律研究.通过kol.ogorov-Smirnov(k-S)检验对比了Weibul.分布、正态分布及对数正态分布这3种模型对FRP箍筋强度保留率的拟合优度.结果表明:当FRP箍筋弯折半径... 详细信息

基于文献数据,采用假设检验法,开展纤维增强复合材料(FRP)箍筋强度保留率分布规律研究.通过kol.ogorov-Smirnov(k-S)检验对比了Weibul.分布、正态分布及对数正态分布这3种模型对FRP箍筋强度保留率的拟合优度.结果表明:当FRP箍筋弯折半径(R)与箍筋直径(D)之比(R/D)在常规范围内(3~5)时,对数正态分布为最优分布模型,据此得到95%和50%保证率下FRP箍筋强度保留率分别不小于32.46%和43.79%;中国、美国、日本和加拿大四国规范保留率预测公式计算结果的保证率仅为24.1%~40.3%,偏于不安全.根据中国FRP纵筋与箍筋的强度保证率要求,当R/D=3、4、5时玻璃纤维增强复合材料(GFRP)箍筋强度保留率不小于38.86%、35.68%、46.09%.

关键词： FRP箍筋强度保留率分布规律 k-S检验可靠性

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