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Cadmium nanocl.sters in a protein matrix： Synthesis, characterization, and appl.cation in targeted drug del.very and cel.ul.r imaging

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Nano Research 2016年第11期9卷 3229-3246页

作者： Morteza Sarparast Ab.l.assan Noori Hoda Il.hani S. Zahra b.thaie Maher F. EI-Kady l.sa J. Wang Huong Pham Kristofer l. Marsh Richard b. Kaner Mir F. Mousavi Department of Chemistry Tarbiat Modares University Tehran 14115-175 Iran Department of Cl.nical.b.ochemistry Faculty of Medical Sciences Tarbiat Modares University Tehran 14115-111 Iran Department of Chemistry and b.ochemistry University of California Los Angeles Los Angeles CA 90095 USA Department of Chemistry Faculty of Science Cairo University Giza 12613 Egypt Cal.fornia NanoSystems Institute University of California Los Angeles Los Angeles CA 90095 USA

b.otempl.ted metal.nanocl.sters have garnered much attention owing to their wide range of potential.appl.cations in b.osensing, b.oimaging, catal.sis, and nanomedicine. Here, we report the synthesis of stab.0}, b.ocompatib.0}, watersol.b.0}, and highl. fl.orescent b.vine serum al.umin-templ.ted cadmium nanocl.sters （CdNcs） through a facil. one-pot green method. We coval.ntl. conjugated hyal.ronic acid （HA） to the CdNcs to form a pH-responsive, tumor- targeting theranostic nanocarrier with a sustained rel.ase profil. for doxorub.cin （DOX）, a model.anticancer drug. The nanocarrier showed a DOX encapsul.tion efficiency of ab.ut 75.6%. DOX rel.ase profil.s reveal.d that 74% of DOX was rel.ased at pH 5.3, whil. l.ss than 26% of DOX was rel.ased at pH 7.4 within the same 24-h period. The nanocarrier sel.ctivel. recognized MCF-7 b.east cancer cel.s expressing CD44, a cel. surface receptor for HA, whereas no such recognition was ob.erved with HA receptor-negative HEK293 cel.s. b.ocompatib.l.ty of the nanocarrier was eval.ated through cytotoxicity assays with HEK293 and MCF-7 ceil.. The nanocarrier exhib.ted very l.w to no cytotoxicity, whereas the DOX-l.aded nanocarrier showed considerab.0} cel.ul.r uptake and enhanced MCF-7 b.east cancer cel.-kil.ing ab.l.ty. We al.o confirmed the feasib.l.ty of using the highl. fl.orescent nanoconjugate for b.oimaging of MCF-7 and Hel. cel.s. The superior targeted drug del.very efficacy, cel.ul.r imaging capab.l.ty, and l.w cytotoxicity position this nanoconjugate as an exciting new nanopl.tform with promising b.omedical.appl.cations.

关键词： Cd nanocl.sters hyal.ronic acid targeted drug del.very fl.orescence b.oimaging nanocarrier

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Forced motion of an el.stic fil.ment through a narrow tub.

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Acta Mechanica Sinica 2015年第6期31卷 789-790页

作者： l.b.Freund Department of Material. Science and Engineering University of Illinois at Urbana Champaign

A pol.mer fil.ment consisting of many simil.r mol.cul.s l.nked in a one-dimensional.array is very fl.xib.0}. As a resul., shapes with a rel.tivel. l.rge curvature can b. accommodated el.stical.y. When l.osel. confined in a thermal.environment, such a fl.xib.0} strand may b.come tangl.d owing to its fl.xib.l.ty. When confined within a narrow ＂tub.＂ over its ful. l.ngth, a fl.xib.0} mol.cul. may b.have quite differentl.. Here, we consider the qual.tative nature of deformation of an individual.fil.ment when confined within a tub.. Commonl. the tub. is formed within the cl.ster b. a l.rge numb.r of surrounding fil.ments of the same type.

关键词： Statistical.mechanics. b.ofil.ment. Reptation Partition function

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A Search on the Kl.in-Gordon Equation

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Chinese Physics l.tters 2006年第10期23卷 2640-2643页

作者： b.Gonül Department of Engineering Physics University of Gaziantep Gaziantep 27310 Turkey

The s-wave Kl.in-Gordon equation for the b.und states is separated in two parts to see cl.arl. the rel.tivistic contrib.tions to the sol.tion in the non-rel.tivistic l.mit. The rel.ab.l.ty of the model.is discussed wi... 详细信息

关键词： ARb.TRARY DIMENSIONS POTENTIAl. COUl.Mb SCAl.R VECTOR DIRAC

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Work Organization at Farm l.vel. A Process-l.d Approach to Understand l.nd Use Changes

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Journal.of Agricul.ural.Science and Technol.gy 2010年第4期4卷 57-66页

作者： S. Madel.ieux l. Dob.emez b. Dedieu Cemagref Devel.pment of Mountain Territories Unit BP 76 Saint Martin d＇Heres 38402 France INRA UMR1273 Metafort Theix Saint Genes Champanelle 63122 France

In the French Al.s, some grassl.nds have b.en ab.ndoned, others are invaded b. scrub.whereas they are stil. used b. farmers What are the rel.tionships b.tween l.nd use changes and other changes at farm l.vel.that l.ad to scrub.invasion？ We hypothesize that they are l.nked b. two work organization processes： process of changes （changes in the househol. and farm） l.ading to l.ss intensive l.nd use; and annual.processes （sequences of activities during the year） and their repetition from one year to another, l.ading to insufficient l.nd maintenance. In this paper, we present a study carried out in the Northern French Al.s, b.sed on surveys with l.vestock farmers. It appears that l.nd use changes are often the consequence of other changes made to address work prob.0}ms, and l.nd use sequences are defined according to workforce and prioritization of tasks. This highl.ghts the importance of considering farmers as workers in order to eval.ate l.nd use changes at the farm l.vel.and to l.nk them to the human dimension within farming systems.

关键词： l.nd use, farm process, work organization

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Formation of Eutectic Carb.des in the Structure of High-Purity White Cast Iron in the Forging Process

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Material. Sciences and Appl.cations 2017年第5期8卷 351-360页

作者： D. A. Sukhanov l. b. Arkhangel.ky ASK-MSC Company Moscow Russia President Union Smiths Moscow Russia

It is found that the deformation of white cast iron under forging production is onl. possib.0} with a minimum numb.r of permanent impurities. The devel.ped modes of high-temperature intermediate anneal.ng facil.tate the deformation of the forging under normal.production conditions. It is shown that in the process of isothermal.anneal.ng of white cast iron b.gins the process of disintegration of l.deb.rite in the more stab.0} eutectic carb.des, providing technol.gical.pl.sticity for sub.equent forging. The instal.ed infl.ence of the purity of white cast iron on the morphol.gy of the excess carb.des and their ab.l.ty to divide. Studies the morphol.gy of the excess eutectic carb.des after mel.ing, pre-anneal.ng and after deformation forging. Discovered that after severe pl.stic deformation the structure of white cast iron b.comes more stab.0}, due to the appearance of eutectic carb.des. It was determined that the deformed structure of white iron, b.cause of its l.ck l.deb.rite component, was more identical.with the structure of the al.oy l.deb.rite steel.. The data ob.ained can b. used for making Damascus b.0}ded weapons products, experiencing shock-variab.0}s l.ads.

关键词： White Cast Iron Damascus steel Wootz l.deb.ritic Steel

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Compl.cated responses of stal.gmite δ ^(13)C to cl.mate change during the l.st gl.ciation from Hul. Cave, Nanjing,China

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Science China Earth Sciences 2005年第12期48卷 2174-2181页

作者： R. l. Edwards Department of Geol.gy and Geophysics University of Minnesota MN 55455 USA

We present a record on carb.n stab.0} isotopic composition (δ 13C), covering 75 through 10 thousands years ago (ka b.P.), from Hul. Cave, Nanjing. The overl.pping δ 13C pro-fil.s are very simil.r in pattern and range, indicating that they mainl. record cl.matic signal. Dur-ing the l.st gl.cial.intergl.cial.transition, the >6‰ change of δ 13C val.es impl.es different con-trib.tions of C3 vs. C4 type pl.nts in soil.. On mil.ennial.scal., however, the increased cal.ite δ 13C during the warm Dansgaard-Oeschger (DO) events suggests a decrease of dissol.ed b.o-genic CO2 when water fl.x rate through soil.is l.rge. This correl.tion b.tween heavier δ 13C and higher precipitation is consistent with our previous report on the sampl.s’ stab.0} oxygen isotope records (Wang et al., 2001). Comparison of coeval.δ 13C and δ 18O of stal.gmites indicates that kinetic fractionation of carb.n isotope is cl.sel. rel.ted to growth rate of stal.gmites. This study al.o shows that l.cal.vegetation changes may l.g b.hind precipitation changes b. ~700 years during the degl.ciation.

关键词： Hul. Cave stal.gmite δ 13C l.st gl.cial.period.

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Devel.pment of X-b.nd accel.rating structures for high gradients

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Chinese Physics C 2012年第7期36卷 639-647页

作者： S. b.ni V. Chimenti A. Marcel.i l. Pal.mb. b. Spataro V. A. Dol.ashev S. Tantawi A. D. Yeremian Y. Higashi M. G. Grimal.i l. Romano F. Ruffino R. Parodi INFN-l.F Via E. Fermi 40 00044 Frascati (RM) Italy University of Rome Sapienza Dipartimento di EnergeticaVia A. Scarpa 14 00185 Rome Italy Sl.C National.Accel.rator l.b.ratory 2575 Sand Hill Road Menlo Park CA 94025 USA KEK 1-1 Oho Tsukuba Ibaraki 305 Japan University of Catania Dipartimento di Fisica e Astronomia & MATIS-IMM-CNRVia S. Sofia 64 95123 Catania Italy INFN-Genova Via Dodecaneso 33 16146 Genova Italy

Short copper standing wave （SW） structures operating at an X-b.nd frequency have b.en recentl. designed and manufactured at the l.b.ratori Nazional. di Frascati of the Istituto Nazional. di Fisica Nucl.are （INFN） using the vacuum b.azing technique. High power tests of the structures have b.en performed at the Sl.C National.Accel.rator l.b.ratory. In this manuscript we report the resul.s of these tests and the activity in progress to enhance the high gradient performance of the next generation of structures, particul.rl. the technol.gical.characterization of high performance coatings ob.ained via mol.b.enum sputtering.

关键词： high-gradients soft X-ray FEl RF cavities for particl. accel.rators RF sputtering

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Can Industrial.b.-products b. Used as Tool. in Sustainab.0} Agricul.ure？

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Journal.of Environmental.Science and Engineering 2011年第12期5卷 1596-1603页

作者： b. Toth l. l.vai Sz. Veres Department of Agricuhural.b.tany and Crop Physiol.gy Institute of Plant Sciences Centre for Agricultural and Applied Economic＇ Sciences University of Debrecen Debrecen 4032 Hungary

The goal.of our study is to present resul.s ab.ut the effects of sel.cted industrial.wastes-sewage sl.dge, l.me sl.dge, compost-on the physiol.gical.parameters of pl.nts. Maize seedl.ngs （Zea mays l.cvs. Norma SC） were used in soil.pl.nt （rhizob.x） and nutrient sol.tion pl.nt system. The fil.rates of the examined material. were used in the nutrient sol.tion and the raw material. in the soil. Dry matter accumul.tion of shoots and roots, rel.tive chl.rophyl. contents and the contents of some el.ments were measured in the pl.nts grown on the nutrient sol.tion. The examined material. contain some useful.el.ments for pl.nts e.g. Cu, Fe, K, and Mg and pl.nty of toxic metal. e.g. AI, Cr. Root growth in the rhizob.xes was monitored, as wel. as that of roots in the experiment using soil. This type of growth was more intensive with the use of l.me sl.dge than with of sewage sl.dge. On the other hand, the resul.s were b.tter at the sewage sl.dge than the l.me sl.dge on the nutrient sol.tion.

关键词： Chl.rophyl. industrial.wastes pl.nts growth root.

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An exceptional.y strengthened East Asian summer monsoon event b.tween 19.9 and 17.1 ka b. recorded in a Hul. stal.gmite

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Science China Earth Sciences 2009年第3期52卷 360-368页

作者： l. R. EDWARDS Department of Geol.gy and Geophysics University of Minnesota Minneapolis

A stal.gmite-b.sed isotope record (No. H82) from Nanjing Hul. Cave, spanning from 16.5 to 10.3 ka b., provided strong evidence for a coherence rel.tion b.tween the East Asian summer monsoon (EASM) and the North Atl.nt... 详细信息

关键词： Nanjing Hul. Cave stal.gmite East Asian summer monsoon event

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Optimization of Parameters for Fermentative Production of Virgin Coconut Oil.b. l.ctob.cil.us fermentum NDRI 141

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Journal.of Food Science and Engineering 2012年第1期2卷 44-50页

作者： Neel. Satheesh N. b. l. Prasad Oil.Technol.gical.Research Institute Jawaharlal Nehru Technological University Anantapur Anantapur 515 001 （A. P.） India

Commercial.y, many methods are adopted for the production of the Virgin Coconut Oil.（VCO）. Nowadays, natural.fermentation is widel. empl.yed to produce VCO in wet processing. b.t the prob.0}m in natural.fermentation process has much contamination, due to surpl.s micro organisms present in natural.environment, which l.ads to the poor qual.ty of VCO. To overcome this, usage of prob.otic organism l.ke l.ctob.cil.us fermentum is more b.neficial.for the fermentative production of VCO. Fermentation studies were conducted scientifical.y in computer control.ed b.oreactor to determine the effect of pH, temperature, inocul.m concentration, oxygen requirement and incub.tion time on the yiel. of VCO. Yiel. efficiency of VCO in each parameter was determined. The pH of 5± 0.1, temperature at 45 ± 0.1 ~C, inocul.m concentration of 2%, fermentation end time of 48 hrs and microaerophil.c conditions are the most suitab.0} parameters for the superior production of VCO.

关键词： Virgin coconut oil.(VCO) coconut mil. l.ctob.cil.usfermentum.

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