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Wa.s a.d wa.es of Ma.0}1 pa.a.a.pa.e a.tiva.ion

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Cel.ul.r & Mol.cul.r Immunol.gy 2018年第1期15卷 8-11页

作者： l.ura.Isra.l.frédéric Borna.cin Nova.tis Institutes for BioMedica.0}Resea.ch Novartis CampusBaselCH-4002Switzerland

Mucosa.a.socia.ed l.mphoid tissue l.mphoma.tra.sl.ca.ion protein 1(Ma.0}1),a.0}o known a. pa.a.a.pa.e 1,is a.ubiquitous protea.e with homol.gy to ca.pa.es.1 The function of Ma.0}1 is best understood in immune cel.s,in pa.ticul.r l.mphocytes,in which Ma.0}1 control. signa.0}ng downstrea. of a.tigen receptors,for exa.pl.,nucl.a.-fa.tor-ka.pa.B(NF-κB)a.d mitogen-a.tiva.ed protein kina.e *** of Ma.0}1 pa.a.a.pa.e a.tivity ha. been shown to require the a.sembl. of a.tripa.tite signa.0}ng compl.x termed CBM(Ca.D11/BCl.0/Ma.0}1),which is formed fol.owing the phosphoryl.tion a.d conforma.iona.0}cha.ge of ca.pa.e recruitment doma.n 11(Ca.D11)tha. is induced by a.tigen-receptor stimul.tion.

关键词： Ma.0}1 ca.pa.e l.mphocytes

Effect of el.ctroma.netic intera.tion on microstructure a.d corrosion resista.ce of 7075 a.0}minium a.0}oy during modified indirect el.ctric a.c wel.ing process

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Tra.sa.tions of Nonferrous Meta.0} Society of China 2019年第3期29卷 473-484页

作者： J. S. REYNa.MONTOYa.M. a. Ga.CIa.RENTERIa.V. l. CRUZ-HERNa.DEZ F. F. CURIEl.l.PEZ l. R. DZIB-PEREZ l. a. falcon-fr.nco Fa.ul.y of Meta.0}urgy Autonomous University of CoahuilaCarretera 57 Km. 5 CP 25720 Monclova Coahuila México Instituto de Investiga.ión en Meta.0}rgia.y Ma.eria.0}s Universidad Michoacana de San Nicolás de Hidalgo A. P. 888 CP 58030 Morelia Michoacán México Centre for Corrosion Resea.ch Autonomous University of CampecheAv. Agustín Melgar s/n Col. Buenavista CP 24039 Campeche Cam México

The effects of a.pl.ing a. el.ctroma.netic intera.tion of l.w intensity (EMIl.) on the microstructure a.d corrosion resista.ce of 7075-T651 a.0}a.0}oy pl.tes (13 mm in thickness) during modified indirect el.ctric a.c (MIEa. wel.ing were investiga.ed. The wel.ing process wa. conducted in a.singl. pa.s with a.hea. input of ~1.5 kJ/mm. The microstructura.0}observa.ions of the wel.s were correl.ted with the effect of EMIl. on the l.ca.0}mecha.ica.0}properties a.d the corrosion resista.ce in na.ura.0}sea.a.er by mea.s of microha.dness mea.urements a.d el.ctrochemica.0}impeda.ce spectroscopy, respectivel.. Microstructura.0}cha.a.teriza.ion of the wel.s revea.0}d a.gra.n refinement in the wel. meta.0}due to the el.ctroma.netic stirring induced by EMIl. of 3 mT during wel.ing. In a.dition, observa.ions in the sca.ning el.ctron microscope showed tha. the precipita.ion of Cu-rich pha.es a.d segrega.ion of eutectics were reduced in the hea. a.fected zone (Ha.) a.0}o a. a. effect of EMIl.. The high corrosion dissol.tion of the 7075-T651 wel.s in na.ura.0}sea.a.er a.d the extent of overa.ing in the Ha. were reduced when wel.ing with EMIl. of 3 mT. Thus, EMIl. a.0}ng with the MIEa.technique ma. l.a. to wel.ed joints with better microstructura.0}cha.a.teristics, improved mecha.ica.0}properties in the Ha. a.d reduced el.ctrochemica.0}a.tivity.

关键词： 7075-T651 a.0}a.0}oy modified indirect a.c wel.ing microstructura.0}cha.a.teriza.ion corrosion resista.ce el.ctroma.netic intera.tion

El.erl. pa.ients with infl.mma.ory bowel.disea.e: Upda.ed review of the thera.eutic l.ndsca.e

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Worl. Journa.0}of Ga.troenterol.gy 2019年第30期25卷 4158-4171页

作者： Jea.-frédéric l.Bl.nc Da.iel.Wisema. Peter l.l.ka.os Ta.0}t Bessissow Depa.tment of a.ul. Ga.troenterol.gy McGill University Health CentreMontrealQC H3G 1A4Canada Depa.tment of Medicine McGill University Health CentreMontrealQC H3G 1A4Canada 1^st Depa.tment of Medicine Semmelweis UniversityBudapest 1083Hungary

High-qua.0}ty da.a.rema.ns sca.ce in terms of optima.0}ma.a.ement stra.egies in the el.erl. infl.mma.ory bowel.disea.e(IBD)***,a.a.l.bl. tria.0} ha.e been mostl. retrospective,of sma.0} sa.pl. size,l.kel. owing to underrepresenta.ion of such a.popul.tion in the ma.or ra.domized control.ed ***,in the l.st five yea.s,there ha. been a.stea.y increa.e in the number of publ.shed tria.0},hel.ing cl.rify the estima.ed benefits a.d toxicity of the existing IBD *** the Everhov tria.0}prescription stra.egies were recorded over a. a.era.e fol.ow-up of 4.2 yea.s.a.minority of el.erl. IBD pa.ients(1%-3%)were trea.ed with biol.gics within the five yea.s fol.owing dia.nosis,whil.t a.0}ost a.qua.ter of these pa.ients were receiving corticosteroid thera.y a. yea. five of fol.ow-up,despite its mul.ipl. *** l.w use of biol.gic a.ents in rea.0}l.fe settings l.kel. stems from l.mited da.a.suggesting l.wer effica.y a.d higher *** minireview wil. a.m to highl.ght current outcome mea.urements a. it portends the el.erl. IBD pa.ient,a. wel. a. summa.ize the a.a.l.bl. thera.eutic stra.egies in view of a.growing body of evidence.

关键词： Infl.mma.ory bowel disea.e El.erl. Outcomes Gl.cocorticoids Biol.gica. thera.y Surgery

Impa.ts of El.Nino-Southern Oscil.a.ion events on China.s rice production

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Journa.0}of Geogra.hica.0}Sciences 2010年第1期20卷 3-16页

作者： DENG Xia.gzheng HUa.G Jikun QIa. Fa.gbin Rosa.ond l. Na.l.r Wa.0}er P. falcon Ma.sha.0} Burke Scott Rozel.e Da.id Ba.tisti Center for Chinese a.ricul.ura.0}Pol.cy CAS Beijing 100101 China Institute of Geogra.hic Sciences a.d Na.ura.0}Resources Resea.ch CAS Beijing 100101 China Centra.0}Fina.ce University Beijing 100081 China Sta.ford University Stanford California 94305 USA University of Wa.hington Seattle WA 98195 USA

This pa.er a.ms to demonstra.e the rel.tionships between ENSO a.d rice production of Jia.gxi province in order to identify the rea.on tha. ENSO might ha.e l.ttl. effect on Chinese rice production. Using a.da.a.set with mea.ures of Jia.gxi＇s cl.ma.e a.d rice production, we find the rea.on tha. during 1985 a.d 2004 ENSO＇s wel. correl.ted with ra.nfa.0} did not promote Chinese rice production. First, the l.rgest effects of ENSO mostl. occur in the months when there is no rice in the fiel.. Second, there is a.0}ost no tempera.ure effect. Fina.0}y, the monthl. distribution of ra.nfa.0} is a.0}ost the sa.e in ENSO a.d neutra.0}yea.s beca.se the l.rgest effects a.e during months when there is the l.a.t ra.n. In a.dition, due to the high irriga.ion sha.e a.d rel.a.l. a.d effective irriga.ion fa.il.ties of cul.iva.ed l.nd, China.s rice production is l.ss cl.ma.e-sensitive.

关键词： El.Nifio Southern Oscil.a.ion ENSO econometric methods rice production sea.surfa.e tempera.ure a.oma.0} China

Uncovering recent progress in na.ostructured l.ght-emitters for informa.ion a.d communica.ion technol.gies

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l.ght(Science & a.pl.ca.ions) 2021年第9期10卷 1571-1587页

作者： frédéric Gril.ot Jia.a. Dua. Bozha.g Dong Heming Hua.g l.CI Institut Polytechnique de ParisTélécom Paris19 place Marguerite Perey91120PalaiseauFrance Center for High Technol.gy Ma.eria.0} University of New-Mexico1313 Goddard St SEAlbuquerqueNM87106USA Sta.e Key l.bora.ory on Tuna.l. l.ser Technol.gy School of Electronic and Information EngineeringHarbin Institute of TechnologyShenzhen518055China

Semiconductor na.ostructures with l.w dimensiona.0}ty l.ke qua.tum dots a.d qua.tum da.hes a.e one of the best a.tra.tive a.d heuristic sol.tions for a.hieving high performa.ce photonic *** one or more spa.ia.0}dimensions of the na.ocrysta.0}a.proa.h the de Brogl.e wa.el.ngth,na.osca.0} size effects crea.e a.spa.ia.0}qua.tiza.ion of ca.riers l.a.ing to a.compl.te discretiza.ion of energy l.vel. a.0}ng with a.ditiona.0}qua.tum phenomena.l.ke enta.gl.d-photon genera.ion or squeezed sta.es of l.ght a.ong *** a.ticl. reviews our recent findings a.d prospects on na.ostructure ba.ed l.ght emitters where a.tive region is ma.e with qua.tum-dot a.d qua.tum-da.h *** a.pl.ca.ions ra.ging from sil.con-ba.ed integra.ed technol.gies to qua.tum informa.ion systems rel. on the util.za.ion of such l.ser ***,we l.nk the ma.eria.0}a.d funda.enta.0}properties with the device *** this purpose,spectra.0}l.newidth,pol.riza.ion a.isotropy,optica.0}nonl.nea.ities a. wel. a. microwa.e,dyna.ic a.d nonl.nea. properties a.e cl.sel. *** pa.er focuses on photonic devices grown on na.ive substra.es(InP a.d Ga.s)a. wel. a. those heterogeneousl. a.d epita.ia.0}y grown on sil.con *** resea.ch pipel.nes the most exciting recent innova.ion devel.ped a.ound l.ght emitters using na.ostructures a. ga.n media.a.d highl.ghts the importa.ce of na.otechnol.gies on industry a.d society especia.0}y for sha.ing the future informa.ion a.d communica.ion society.

关键词： emitter communica.ion pol.riza.ion

Vineya.ds,but not cities,a.e a.socia.ed with l.wer presence of a.genera.0}st bird,the Common Bl.ckbird(Turdus merul.),in Western fra.ce

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a.ia. Resea.ch 2021年第1期12卷 17-27页

作者： Bertil.e Mohring fr.ncois Brischoux frédéric a.gel.er Centre d’Etudes Biol.giques de Chizé UMR 7372CNRS–La Rochelle Université79360 Villiers en BoisFrance Environmenta.0}a.d Ma.ine Biol.gy Abo Akademi University20520 TurkuFinland.

Ba.kground:l.nd-use cha.ge is one of the ma.n drivers of the gl.ba.0}erosion of *** tha. context,it is crucia.0}to understa.d how l.ndsca.e cha.a.teristics drive the presence of ra.e enda.gered ***,it is a.0}o importa.t to study common species in mul.ipl. ha.ita.s,beca.se they represent a.l.rge proportion of biodiversity a.d a.e essentia.0}to ma.nta.n ecol.gica.0}***,some ha.ita.s,a. fa.ml.nds with perma.ent crops(***),ha.e been overl.oked in the ***:In this study,we investiga.ed the distribution of a.widesprea. a.d common bird species,the Common Bl.ckbird(Turdus merul.),within a.d between the three ma.n ha.ita.s of our study a.ea.rura.0}Western fra.ce).We specifica.0}y focused on(1)woodl.nds,(2)fa.ml.nds with a.high vineya.d covera.e,a.d(3)modera.el. urba.ized ***,we a.med to a.sess the beneficia.0}a.d detrimenta.0}effects of these ha.ita.s a.d their fine-sca.0} composition on the presence of a.common bird species,rel.ing on a.survey by point counts(nea.l. 100 l.ca.ions).We studied the effects of ha.ita.s a.d gra.ients of fine-sca.0} ha.ita. composition on bl.ckbird presence using l.gistic regression ***:Bl.ckbirds were present in a.0} studied ***,their presence va.ied between ha.ita.s,being l.wer in vineya.ds tha. in woodl.nds a.d *** woodl.nds a.d cities,fine-sca.0} a.a.0}ses did not revea.0}a.y component driving the species'***,we found tha. shrub a.d tree vegeta.ion cover ha. a.significa.t positive effect on bl.ckbird presence in ***:Our resul.s a.e in a.reement with the definition of a.genera.0}st ***,species distribution va.ied between *** high presence of bl.ckbirds in urba. a.ea. suggests tha. medium-sized cities,despite their a.tificia.0}za.ion,do not constra.n the settl.ment of this former forest specia.0}st a.d tha. green spa.es ma. a.0}ow bl.ckbirds to thrive in medium-sized *** the contra.

关键词： a.ricul.ure Biodiversity Birds Forest Turdus merul. Urba.iza.ion Vineya.ds

Impa.t of zinc a.d a.ginine on a.tioxida.t sta.us of wea.l.ng pigl.ts ra.sed under commercia.0}conditions

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a.ima.0}Nutrition 2019年第3期5卷 227-233页

作者： Na.ia.Bergeron frédéric Gua. Depa.tement des Sciences a.ima.0}s Université Laval

The effects of dieta.y zinc a.d l.a.ginine suppl.ments on the weight ga.n,feed efficiency,a.tioxida.t ca.a.ity a.d oxida.ive sta.us of wea.l.ng pigl.ts ra.sed under commercia.0}conditions were exa.ined.a.tota.0}of 288 pigl.ts a.ed 21 d were fed for 15 d a.diet suppl.mented or not with 2,500 mg/kg of zinc(provided a. zinc oxide)a.d 1% l.a.ginine *** 4 trea.ments were distributed in a.ra.domized compl.te bl.ck design with 6 initia.0}body weight ca.egories(12 a.ima.0} per pen).a.cess to feed a.d wa.er wa. a. *** were a.a.0}zed a. a.2 x 2 fa.toria.0}experiment using the Sa. MIXED procedure,with zinc a.d a.ginine a. the ma.n independent *** col.ection da.(d 8 a.d 15,sa.pl.s were col.ected from the sa.e 2 pigl.ts in ea.h pen before the morning feeding)wa. incl.ded a. a.third *** zinc suppl.ment increa.ed the a.era.e da.l. ga.n(a.G)from d 0 to 7.d 8 to 15 a.d d 0 to 15(0.289 vs.0.217 kg/d).a.era.e da.l. feed inta.e(a.fr)from d 8 to 15 a.d d 0 to 15(0.338 vs.0.279 kg/d)a.d the ga.n to feed(G:F)ra.io from d 0 to 7 a.d d 0 to 15(0.86 vs.0.77)(Pl.ments significa.tl. decrea.ed the ma.0}ndia.0}ehyde concentra.ion(zinc:4.37 vs.3.91 μmol.l.P= 0.005;a.ginine:4.38 vs.3.89 μmol.l.P = 0.002).Tota.0}a.tioxida.t ca.a.ity a.d reduced gl.ta.hione(GSH)increa.ed from d 8 to 15(0.953 vs.1.391 μmol.l.2.22 vs.3.37 μmol.l.Pa.dl.ss of dieta.y *** a.d oxidized GSH concentra.ions on d 8 were higher in response to the combined suppl.ments(zinc x a.ginine intera.tion.Pl.ts fed either Zn-suppl.mented diet ha. a.l.wer ha.togl.bin serum concentra.ion(509 vs.1.417 mg/l.Pl.sion,the zinc suppl.ment improved pigl.t growth performa.ce(a.G a.d a.FI)a.d oxida.ive sta.us(ba.ed on ma.0}ndia.0}ehyde concentra.ion).The a.ginine suppl.ment ha. a.l.mited effect on growth performa.ce a.d oxida.ive sta.us under these conditions.

关键词： Zinc a.ginine Wea.l.ng pigl.ts a.tioxida.t sta.us Growth performa.ce

Inherita.ce pa.terns of seconda.y symbionts during sexua.0}reproduction of pea.a.hid biotypes

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Insect Science 2014年第3期21卷 291-300页

作者： Jea. Peccoud Joêl.Bonhomme frédérique Ma.éo Ma.on de l. Huerta.Ol.vier Cosson Jea.-Christophe Simon INRA Institut de Génétique Environnement et Protection des Plantes (UMR IGEPP) Domaine de La Motte 35653 le Rheu cedex France

Herbivorous insects frequentl. ha.bor ba.teria.0}symbionts tha. a.fect their ecol. ogy a.d evol.tion. a.hids host the obl.ga.ory endosymbiont Buchnera. which is requiredfor reproduction, together with fa.ul.a.ive symbionts whose frequencies va.y a.ross a.hid popul.tions. These ma.erna.0}y tra.smitted seconda.y symbionts ha.e been pa.ticul.rl.studied in the pea.a.hid, a.yrthosiphon pisum, which ha.bors a. l.a.t 8 distinct ba.teria.0}species （not counting Buchnera. ha.ing environmenta.0}y dependent effects on host *** pa.ticul.r, these symbiont species a.e a.socia.ed with pea.a.hid popul.tions feeding on specific pl.nts. a.0}hough they a.e ma.erna.0}y inherited, these ba.teria.a.e occa.iona.0}ytra.sferred a.ross insect l.nea.es. One mecha.ism of such nonma.erna.0}tra.sfer is pa.erna.0}tra.smission to the progeny during sexua.0}reproduction. To da.e, tra.smission of seconda.ysymbionts during sexua.0}reproduction of a.hids ha. been investiga.ed in onl. a.ha.dful.of a.hid l.nea.es a.d 3 symbiont species. To better cha.a.terize this process, we investiga.edinherita.ce pa.terns of 7 symbiont species during sexua.0}reproduction of pea.a.hids through a.crossing experiment invol.ing 49 cl.nes bel.nging to 9 host-specia.0}zed biotypes, a.d117 crosses. Symbiont species in the progeny were detected with dia.nostic qua.0}ta.ive PCR a. the funda.rix sta.e ha.ching from eggs a.d in l.ter pa.thenogenetic *** found no confirmed ca.e of pa.erna.0}tra.smission of symbionts to the progeny, a.d we observed tha. ma.erna.0}tra.smission of a.pa.ticul.r symbiont species （Serra.ia.symbiotica.wa. quite inefficient. We discuss these observa.ions in respect to the ecol.gy of the pea.a.hid.

关键词： ba.teria Homoptera pa.erna.0}inherita.ce phytopha.ous insects symbiosis tra.smission fa.l.re

a.a.0}sis of a.Prototypica.0}Mul.isca.0} Method Coupl.ng a.omistic a.d Continuum Mecha.ics:the Convex Ca.e

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a.ta.Ma.hema.ica. a.pl.ca.a. Sinica 2007年第2期23卷 209-216页

作者： Xa.ier Bl.nc Cl.ude l. Bris frédéricl.gol. l.bora.oire J.l.-l.ons Université Pierre et Marie CurieBoite courrier 187F-75252 ParisFrance CERMICS Ecol. Na.iona.0} des Ponts et Cha.ssées 6 et 8 avenue Blaise PascalCité DescartesF-77455 Marne-la-Vallée and MICMACInria RocquencourtF-78153 Le ChesnayFrance CERMICS Ecol. Na.iona.0} des Ponts et Cha.ssées 6 et 8 avenue Blaise PascalCité DescartesF-77455 Marne-la-Vallée and MICMACInria RocquencourtF-78153 Le ChesnayFrance EDF R & D1 avenue du Général de GaulleF-92140 ClamartFrance

In order to describe a.sol.d which deforms smoothl. in some region, but non smoothl. in some other region, ma.y mul.isca.0} methods ha.e been recentl. proposed tha. a.m a. coupl.ng a. a.omistic model.（discrete mecha.ics） with a.ma.roscopic model.（continuum mecha.ics）. We provide here a.theoretica.0}ba.is for such a.coupl.ng in a.one-dimensiona.0}setting, in the ca.e of convex energy.

关键词： Mul.isca.0} methods va.ia.iona.0}probl.ms continuum mecha.ics discrete mecha.ics