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Predicting the Prognosis and Immunotherapeutic Response of Triple-Negative Breast Cancer by Constructing a Prognostic Model Based on CD8+T Cell-Related Immune Genes

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Biomedical and Environmental Sciences 2024年第6期37卷 581-593页

作者： Nani li Xiaoting Qiu Jingsong Xue limu Yi Mulan Chen Zhijian huang Department of Medical Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014FujianChina Department of Breast Surgical Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014FujianChina Departmen of Pathology Shenzhen Longhua Maternity and Child Healthcare HospitalShenzhen 518109GuangdongChina

Objective Triple-negative breast cancer(TNBC)poses a significant challenge for treatment ***8+T cells,which are pivotal immune cells,can be effectively analyzed for differential gene expression across diverse cell populations owing to rapid advancements in sequencing *** leveraging these genes,our objective was to develop a prognostic model that accurately predicts the prognosis of patients with TNBC and their responsiveness to *** Sample information and clinical data of TNBC were sourced from The Cancer Genome Atlas and METABRIC *** the initial stage,we identified 67 differentially expressed genes associated with immune response in CD8+T ***,we narrowed our focus to three key genes,namely CXCl13,GBP2,and GZMB,which were used to construct a prognostic *** accuracy of the model was assessed using the validation set data and receiver operating characteristic(ROC)***,we employed various methods,including Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway,immune infiltration,and correlation analyses with CD274(PD-l1)to explore the model's predictive efficacy in immunotherapeutic ***,we investigated the potential underlying biological pathways that contribute to divergent treatment *** we successfully developed a model capable of predicting the prognosis of patients with *** areas under the curve(AUC)values for the 1-,3-,and 5-year survival predictions were 0.618,0.652,and 0.826,*** this risk model,we stratified the samples into high-and low-risk *** KEGG enrichment analysis,we observed that the high-risk group predominantly exhibited enrichment in metabolism-related pathways such as drug and chlorophyll metabolism,whereas the low-risk group demonstrated significant enrichment in cytokine ***,immune landscape analysis revealed noteworthy variations between(PD-l1)expression and risk scores,indicating that o

关键词： Breast Cancer Immunotherapy Prognosis CD8+T cells PD-l1

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Fusion of Ground-Based and Spaceborne Radar Precipitation Based on Spatial Domain Regularization

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Journal of Meteorological Research 2024年第2期38卷 285-302页

作者： Anfan huang leilei KOU Yanzhi lIANG Ying MAO Haiyang GAO Zhigang CHU School of Atmospheric Physics Nanjing University of Information Science&TechnologyNanjing 210044 Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044

High-quality and accurate precipitation estimations can be obtained by integrating precipitation information measures using ground-based and spaceborne radars in the same target *** the true precipitation state is a typical inverse problem for a given set of noisy radar precipitation *** regularization method can appropriately constrain the inverse problem to obtain a unique and stable *** different types of precipitation with different prior distributions,the l_(1) and l_(2) norms were more effective in constraining stratiform and convective precipitation,*** a combination of l_(1) and l_(2) norms,the Huber norm is more suitable for mixed precipitation *** study uses different regularization norms to combine precipitation data from the C-band dual-polarization ground radar(CDP)and dual-frequency precipitation radar(DPR)on the Global Precipitation Measurement(GPM)mission core *** to single-source radar data,the fused figures contain more information and present a comprehensive precipitation structure encompassing the reflectivity and precipitation *** 27 precipitation cases,the fusion results utilizing the Huber norm achieved a structural similarity index measure(SSIM)and a peak signal-to-noise ratio(PSNR)of 0.8378 and 30.9322,respectively,compared with the CDP *** fusion results showed that the Huber norm effectively amalgamate the features of convective and stratiform precipitation,with a reduction in the mean absolute error(MAE;16.1%and 22.6%,respectively)and root-mean-square error(RMSE;11.7%and 13.6%,respectively)compared to the 1-norm and ***,in contrast to the fusion results of scale recursive estimation(SRE),the Huber norm exhibits superior capability in capturing the localized precipitation intensity and reconstructing the detailed features of precipitation.

关键词： dual-frequency precipitation radar(DPR) dual-polarization radar data fusion regularization Huber norm

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Anti-abrasion collagen fiber-based membrane functionalized by UiO-66-NH_(2)with ultra-high efficiency and stability for oil-in-water emulsions separation

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Chinese Journal of Chemical Engineering 2024年第2期66卷 285-297页

作者： Xiaoxia Ye Rixin huang Zhihong Zheng Juan liu Jie Chen Yuancai lv College of Environmental and Safety Engineering Fuzhou UniversityFuzhou 350108China College of Chemical Engineering Fuzhou UniversityFuzhou 350108China

Membrane separation strategies offer promising platform for the emulsion ***,the low mechanical strength of membrane separation layers and the trade-off between separation flux and efficiency present significant *** this study,we report a CFM@UiO-66-NH_(2)membrane with high separation flux,efficiency and stability,through utilizing a robust anti-abrasion collagen fiber membrane(CFM)as the multifunctional support and UiO-66-NH_(2)by an in-situ growth as the separation *** high mechanical strength of the CFM compensated for the weakness of the separation layer,while the charge-breaking effect of UiO-66-NH_(2),along with the size sieving of its constituent separating layers and the capillary effect of the collagen fibers,contributed to the potential for efficient ***,the CFM@UiO-66-NH_(2)membrane exhibited superhydrophilic properties,making it suitable for separating oil-in-water microemulsions and nanoemulsions stabilized by anionic *** membrane demonstrated remarkable separation efficiencies of up to 99.960%and a separation flux of370.05 l·m^(-2)·h^(-1).Moreover,it exhibits stability,durability,and abrasion resistance,maintaining excellent separation performance even when exposed to strong acids and alkalis without any damage to its structure and *** six cycles of reuse,it achieved a separation flux of 417.97 l·m^(-2)·h^(-1)and a separation efficiency of 99.747%.Furthermore,after undergoing 500 cycles of strong abrasion,the separation flux remained at 124.39 l·m^(-2)·h^(-1),with a separation efficiency of 99.992%.These properties make it suitable for the long-term use in harsh operating *** attribute these properties to the electrostatic effect resulting from the amino group on UiO-66-NH_(2)and its in-situ growth on the CFM,which forms a size-screening separation *** work highlights the potential of the CFM@UiO-66-NH_(2)membrane as an environmentally friendly size-screening

关键词： Collagen fibers Metal-organic frameworks Oil-in-water emulsion separation Size sieving

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The role of the auxin-response genes MdGH3.1 and MdSAUR36 in bitter pit formation in apple

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Horticultural Plant Journal 2024年第5期10卷 1085-1098页

作者： Daqing huang wen Peng Na Gong lina Qiu Yongzhang wang Haiyong Qu College of Horticulture Qingdao Agricultural UniversityQingdaoShandong 266109China

Apples often exhibit bitter pits in response to metabolic disorders during ripening and storage;however,the mechanisms underlying the bitter pit(BP)development remain ***,metabolome and transcriptome analyses were performed to investigate BP pulp of‘Fuji’.Two auxin-response genes,MdGH3.1 and MdSAUR36,were *** expression as well as the auxin content in BP pulp were found to be higher than those in healthy pulp(Pld,excess CO(NH2)2 increased the incidence of ***,the auxin content and MdGH3.1 expression increased in apples after nitrogen *** Day 30 before harvest,the two genes were transiently transferred to the fruit,and 20.69%and 23.21%of BP fruits were *** 10 mmol$l1 auxin was infiltrated at low pressure into postharvest fruit,the increase in MdGH3.1 expression occurred earlier than that in ***3.1 increased the expression of MdSAUR36,but MdSAUR36 did not increase expression of ***,we suggest that MdGH3.1 acts upstream of MdSAUR36 during BP formation and that these genes induce BP formation by regulating auxin and phenylpropanoid biosynthesis.

关键词： Apple Malusdomestica Auxin Bitter pit Flavonoids Nitrogen fertilizer widely targeted metabolomics

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Carbon Dots as“On–Off–On”Fluorescence Sensors for Selective and Consecutive Detection of 4-Nitrophenol and Cerium(IV)in water Samples

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Journal of Analysis and Testing 2024年第2期8卷 201-209页

作者： Jing Yang Hao liu Yan huang li li Huajie liu Yaping Ding Department of Chemistry College of SciencesShanghai UniversityShanghai200444China School of Chemical Science and Engineering Tongji UniversityShanghai200092China

An“on–off–on”fluorescence sensor was designed for rapidly and consecutively detecting 4-nitrophenol and cerium(IV)without the use of any labeling *** yellow carbon dots were synthesized by a simple one-step hydrothermal approach,and various techniques were applied to investigate the morphology,structure,and optical properties of the carbon *** the optimal experimental conditions,4-nitrophenol rapidly quenched the fluorescence of carbon dots as a result of the inner filter eff ect(IFE).The fluorescence intensity of carbon dots was linear with the concentration of 4-nitrophenol(1–150μmol/l)and the limit of detection was 0.32μmol/*** fluorescence was gradually recovered as the cerium(IV)concentration(0.5–100μmol/l)increased in CDs/4-NP,and the limit of detection was 0.16μmol/*** sensor showed good selectivity and demonstrated high accuracy for the analysis of 4-nitrophenol and cerium(IV)in actual water samples.

关键词： Carbon dots Fluorescence sensor 4-Nitrophenol Cerium(IV) water samples

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Optical two-dimensional coherent spectroscopy of excitons in transition-metal dichalcogenides

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Frontiers of physics 2024年第2期19卷 141-148页

作者： YanZuo Chen ShaoGang Yu Tao Jiang XiaoJun liu XinBin Cheng Di huang State Key laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China MOE Key laboratory of Advanced Micro-Structured Materials Shanghai Frontiers Science Center of Digital OpticsInstitute of Precision Optical Engineeringand School of Physics Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Intelligent Science and Technology Tongji UniversityShanghai 200092China

Exciton physics in atomically thin transition-metal dichalcogenides(TMDCs)holds paramount importance for fundamental physics research and prospective ***,the experimental exploration of exciton physics,including excitonic coherence dynamics,exciton many-body interactions,and their optical properties,faces challenges stemming from factors such as spatial heterogeneity and intricate many-body *** this perspective,we elaborate upon how optical two-dimensional coherent spectroscopy(2DCS)emerges as an effective tool to tackle the challenges,and outline potential directions for gaining deeper insights into exciton physics in forthcoming experiments with the advancements in 2DCS techniques and new materials.

关键词： monolayer transition-metal dichalcogenides two-dimensional coherent spectroscopy

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基于共享储能的台区多元负荷协同控制策略

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电力自动化设备 2024年第1期44卷 32-39页

作者：吕斌黄丹丁宏吕朋朋国网安徽省电力有限公司安徽合肥230022 国网安徽省电力有限公司营销服务中心安徽合肥230088 国网电力科学研究院江苏南京211106

大规模不确定可再生能源的接入,对台区电网负荷的灵活性调整提出了更高的要求。基于共享储能的商业模式,考虑各类电器设备的用电及功能特性,提出了台区多元负荷协同控制策略。提出了基于共享储能的台区多元负荷协同优化框架,并详细阐述... 详细信息

大规模不确定可再生能源的接入,对台区电网负荷的灵活性调整提出了更高的要求。基于共享储能的商业模式,考虑各类电器设备的用电及功能特性,提出了台区多元负荷协同控制策略。提出了基于共享储能的台区多元负荷协同优化框架,并详细阐述了多元负荷的协同控制过程;根据负荷的可调特性,对用户负荷进行分类,建立负荷功率模型和舒适度成本模型;建立了以用电综合成本最低为目标的用户层优化模型和以调峰为目标的台区层优化模型。基于实际数据进行仿真验证,结果表明所提控制策略可以有效保证新能源的消纳,降低峰值负荷,并协助用户参与电力辅助服务市场。

关键词：共享储能可再生能源消纳多元负荷需求响应调峰辅助服务协同控制

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Carleson Measure Associated with the Fractional Heat Semigroup of Schrodinger Operator

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Communications in Mathematical Research 2024年第2期40卷 191-213页

作者： Jizheng huang Shuangshuang Ying Key laboratory of Mathematics and Information Networks and School of Science Beijing University of Posts and TelecommunicationsBeijing 100876P.R.China.

let l=-△+V be a Schrodinger operator,where△is the laplacian on Rd and the nonnegative potential V belongs to the reverse Holder class Ba/*** this paper,we define a new version of Carleson measure associated with the fractional heat semigroup of Schrodinger operator *** will characterize the Campanato spaces and the predual spaces of the Hardy spaces by the new Carleson measure.

关键词： Schrodinger operator reverse Holder class Carleson measure fractional heat semigroup Campanato spaces

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Toxicity of the disinfectant benzalkonium chloride(C_(14))towards cyanobacterium Microcystis results from its impact on the photosynthetic apparatus and cell metabolism

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Journal of Environmental Sciences 2024年第1期135卷 198-209页

作者： Yunlu Jia Yi huang Jin Ma Shangwei Zhang Jin liu Tianli li lirong Song Institute of Hydrobiology Chinese Academy of SciencesWuhan 430072China School of Environmental Studies China University of GeosciencesWuhan 430074China Advanced Interdisciplinary Institute of Environment and Ecology Beijing Normal UniversityZhuhai 519087China

Quaternary ammonium compounds(QACs)are commonly used in a variety of consumer and commercial products,typically as a component of *** the COVID-19 pandemic,QACs became one of the primary agents utilized to inactivate the SARS CoV-2 virus on ***,the ecotoxicological effects of QACs upon aquatic organisms have not been fully *** this study,we examined the effects of a widely used QAC(benzalkonium chloride-C_(14),BAC-14)on two toxigenic Microcystis strains and one non-toxigenic freshwater Microcystis strain and carried out an analysis focused on primary,adaptive and compensatory stress responses at apical(growth and photosynthesis)and metabolic *** analysis revealed that the two toxic Microcystis strains were more tolerant than the non-toxic strain,with 96 hr-EC_(50)values of 0.70,0.76,and 0.38 mg/l BAC-14 for toxigenic *** FACHB-905,toxigenic *** FACHB-469,and non-toxigenic *** FACHB-908,*** photosynthetic activities of the Microcystis,assessed via F_(v)/F_(m) values,were significantly suppressed under 0.4 mg/l ***,this analysis revealed that BAC-14 altered 14,12,and 8 metabolic pathways in *** FACHB-905,*** FACHB-469,and *** FACHB-908,*** is noteworthy that BAC-14 enhanced the level of extracellular microcystin production in the toxigenic Microcystis strains,although cell growth was not significantly ***,these data show that BAC-14 disrupted the physiological and metabolic status of Microcystis cells and stimulated the production and release of microcystin,which could result in damage to aquatic systems.

关键词： Disinfectants Quaternary ammonium compounds Microcystis Cyanotoxin Metabolomics Chlorophyll fluorescence

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Damaged apple detection with a hybrid YOlOv3 algorithm

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Information Processing in Agriculture 2024年第2期11卷 163-171页

作者： Meng Zhang Huazhao liang Zhongju wang long wang Chao huang Xiong luo Schoolof Computer and Communication Engineering University of Science and Technoogy BejingBejing 1083China lShunde Innovation SchoolUniversity of Science and Technology BeijingFoshan 528399China

This paper proposes an improved You Only look Once(YOlOv3)algorithm for automatically detecting damaged apples to promote the automation of the fruit processing *** the proposed method,a clustering method based on Rao-1 algorithm is introduced to optimize anchor box *** clustering method uses the intersection over the union to form the objective function and the most representative anchor boxes are generated for normal and damaged apple *** verify the feasibility and effectiveness of the proposed method,real apple images collected from the Internet are *** with the generic YOlOv3 and Fast Region-based Convolutional Neural Network(Fast R-CNN)algorithms,the proposed method yields the highest mean average precision value for the test ***,it is practical to apply the proposed method for intelligent apple detection and classification tasks.

关键词： Rao algorithm Apple detection Clustering Smart agriculture

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