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低水平情感认知预示银屑病患者对皮肤病学治疗的反应性较好

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世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 46-47页

作者： Consoli S.M. Rolhion S. Martin C. l. misery 罗素菊徐波 Department of Dermatology CHU Morvan FR- 29609 Brest Cedex FranceProf.

Background: Personality and emotional factors are thought to influence the onset of psoriasis, the occurrence of relapses, and the sensitivity of this condition to dermatological treatments. Objective: To explore the relationships between emotional disorders and emotional information processing in the one hand, and psoriasis severity and response to treatment on the other. Methods: We recruited 93 patients through an article in the local press. These patients attended three consultations. We evaluated psoriasis severity by Psoriasis Area and Severity Index (PASI) score and response to treatment by change in PASI score from baseline to the 3- month visit. We screened for comorbid mental disorders, using the Mini International Neuropsychiatric Interview. We used the Hospital Anxiety and Depression Scale to assess anxiety and depressive symptoms. Alexithymia (difficulty in identifying and expressing emotions) was evaluated with the 26- item version of the Toronto Alexithymia Scale (TAS- 26) and the ability to integrate and differentiate emotions (emotional awareness)was assessed with the lane and Schwartz levels of Emotional Awareness Scale (lEAS). Results: Forty patients presented at least one psychiatric diagnosis and 33 were considered alexithymic (TAS ≥ 73). No psychological score was associated with baseline PASI score, which was higher in men and positively correlated with disease duration. Patients who considered their disease to be stress- reactive tended to have lower lEAS scores (p=0.052). At the 3- month visit, PASI scores had significantly improved in the subset of patients (n=67) presenting severe psoriasis at inclusion (PASI>2); emotional awareness and anxiety scores had also improved in these patients (plogical and psychological changes were not statistically related. Dermatological improvement at 3 months with respect to baseline PASI was predicted by longer disease duration (>20 years) and lower baseline lEAS score (p=0.044 and p =

关键词：银屑病皮肤病学 PASI 情感认知情感性精神病严重度精神疾病情感障碍精神检查应激反应

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对法国大学医院皮肤科急诊的评估

世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 22-22页

作者： legoupil D. Davaine A.-C. Karam A. l.misery 周少娜 Service de Dermatologie CHU Morvan 29609 Brest

Introduction. The aim of our study was to understand the motivations of outpatients who come to dermatological emergencies in a university hospital. Patients and method. This 6-week prospective study included outpatients who came to the dermatology emergency unit. This consultation is proposed each morning (from 8 to 9), from Mondays to Fridays. A questionnaire was distributed to outpatients. They answered questions on the functioning of this consultation and their own symptoms. The consulting dermatologist answered questions on the referring physician, the really urgent characteristics of the disease and the diagnosis. Results. Patients were satisfied by the functioning of the consultation. Indeed, 59 p. 100 of outpatients thought that the timetable was convenient and 70 p. 100 that the delay before getting a consultation was rapid. 75 p. 100 felt they needed treatment rapidly. Nonetheless, 45 p. 100 did not think they had a serious disease. More than half of the outpatients were referred by their general practitioner; the others came spontaneously, or were referred by other departments or general emergencies. The most frequent diagnoses were cutaneous infections (27.6 p. 100), eczema (21 p. 100), then benign tumors, psoriasis, physical dermatoses, viral eruptions... Discussion. A consultation for dermatological emergencies appears to reply to patients demands. Nonetheless, most of these outpatients do not present with real dermatological emergencies. Criteria for real emergencies needs to be further defined and understood by citizens.

关键词：大学医院皮肤科急诊室门诊患者法国时间安排前瞻性研究调查问卷咨询回答

舒缓特护面霜辅助治疗862例面部敏感性皮肤患者疗效观察

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实用皮肤病学杂志 2015年第2期8卷 85-88页

作者：李芸孙秋宁杨蓉娅刘玮刘玲玲杨秀敏夏文华郑捷徐金华陈向东许爱娥陈柳青赖维杨慧兰高兴华张丽李铁男郝飞刁庆春李利何黎刘晓明沈新朱晓丹王曼姬 V.SIBAUD C.JEAN-DECOSTER l.misery 中国医学科学院北京协和医学院北京协和医院皮肤科北京100730 北京军区总医院空军总医院北京大学第一医院北京同仁医院海军总医院上海交通大学医学院附属瑞金医院上海华山医院上海交通大学医学院附属第九人民医院杭州市第三人民医院武汉市第一医院中山大学附属第三医院广州军区总医院中国医科大学附属第一医院沈阳第七人民医院第三军医大学西南医院重庆市第一人民医院四川大学华西医院昆明医科大学附属第一医院大连医科大学附属第一医院 laboratoires dermatologiques Avène Department of Dermatology University Hospital Brest

目的探讨舒缓特护面霜辅助治疗面部敏感性皮肤的疗效及安全性。方法对862例门诊就诊且符合条件的受试者进行观察,每日外用面霜2次,连续外用3周。采用包含9项主观症状（皮肤刺激感、刺痛、烧灼感、热感、紧绷感、瘙痒、疼痛、整体不适、... 详细信息

目的探讨舒缓特护面霜辅助治疗面部敏感性皮肤的疗效及安全性。方法对862例门诊就诊且符合条件的受试者进行观察,每日外用面霜2次,连续外用3周。采用包含9项主观症状（皮肤刺激感、刺痛、烧灼感、热感、紧绷感、瘙痒、疼痛、整体不适、潮红）和5项客观症状（红肿、脱屑、水肿/肿胀、渗液、结痂）的敏感指数评估标尺评估敏感肌肤严重程度及临床疗效,用皮肤病生活质量问卷评估敏感性皮肤对生活的影响。治疗结束后评估患者对其的耐受性,评分为0~3;受试者及观察者对舒缓特护面霜有效性进行评价,分非常满意、满意、不满意、非常不满意4个等级。结果使用3周后与使用前对比14项评价敏感皮肤严重程度的指标及生活质量评估均有明显改善（P〈0.001）,改善最明显的指标是疼痛（ΔT值-83%）和水肿/肿胀（ΔT值-81.2%）,耐受性好（64%为非常好,32%为好）,受试者及观察者对其有效性的评价为好（97.1%观察者对面霜满意,96.4%受试者对面霜满意）。结论舒缓特护面霜对敏感性皮肤、皮肤疾病或美容术后形成的敏感性皮肤具有较好的辅助治疗作用,且耐受性良好。

关键词：皮肤,敏感性舒缓特护面霜

TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation： pro-inflammatory response induced by their activation and their sensitization

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Protein & Cell 2017年第9期8卷 644-661页

作者： Olivier Gouin Killian l'Herondelle Nicolas lebonvallet Christelle le Gall-lanotto Mehdi Sakka Virginie Buhe Emmanuelle PIee-Gautier Jean-luc Carre luc lefeuvre laurent misery~,Raphaele le Garrec laboratory on Interaction Neurons-Keratinocytes (lINK) University of Western Brittany 29200 Brest France Uriage Dermatological laboratories 92400 Courbevoie France

Cutaneous neurogenic inflammation （CNI） is inflammation that is induced （or enhanced） in the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations are mainly sensory and vascular disorders such as pruritus and erythema. Transient receptor potential vanilloid 1 and ankyrin 1 （TRPV1 and TRPA1, respectively） are non-selective cation channels known to specifically participate in pain and CNI. Both TRPV1 and TRPA1 are co-expressed in a large subset of sensory nerves, where they integrate numerous noxious stimuli. It is now clear that the expression of both channels also extends far beyond the sensory nerves in the skin, occuring also in keratinocytes, mast cells, dendritic cells, and endothelial cells. In these non-neu- ronal cells, TRPV1 and TRPA1 also act as nociceptive sensors and potentiate the inflammatory process. This review discusses the role of TRPV1 and TRPA1 in the modulation of inflammatory genes that leads to or maintains CNI in sensory neurons and non-neuronal skin cells. In addition, this review provides a summary of current research on the intracellular sensitization pathways of both TRP channels by other endogenous inflammatory mediators that promote the self-maintenance of CNI.

关键词： sensory nervenflammation inflammatory geneneurogenic skinregulation pruritus

MUlTI-lEVEl misery DESPITE IllEGAlITY AND VIOlENCE, PYRAMID SCHEMES ARE STIll FRUSTRATING BOTH VICTIMS AND POlICE

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The World of Chinese 2018年第4期 8-9页

作者： H.l.

On June 11, eleven months after college graduate li Wenxing was found dead in a river in Tianjin, the Jinghai District Procuratorate finally began prosecutions against the multi-level marketing （MlM） organization be... 详细信息

关键词：李文星传销组织中国司法工作

灾荒冲击下的乡村社会冲突——以近代淮河流域为中心的考察

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中国农史 2017年第2期36卷 102-108,69页

作者：房利铜陵学院马克思主义学院安徽铜陵244061

近代淮河流域,几乎连年灾荒,自然灾害在不同程度上对乡民的生产和生活造成极大破坏,民众生活困苦不堪。为了生存的需要,群体之间常引发争夺紧缺资源的社会冲突。在淮河流域,灾害引起水资源、粮食资源以及税租征收等方面的社会冲突。这... 详细信息

近代淮河流域,几乎连年灾荒,自然灾害在不同程度上对乡民的生产和生活造成极大破坏,民众生活困苦不堪。为了生存的需要,群体之间常引发争夺紧缺资源的社会冲突。在淮河流域,灾害引起水资源、粮食资源以及税租征收等方面的社会冲突。这几种社会冲突类型都与乡民的生计和经济收入直接相关,其社会冲突仍以经济斗争为主,是灾民求生存谋生计的无奈之举。鉴于此,灾害发生后,灾民的救灾安置工作显得尤为重要,否则灾民无以为生,社会势必冲突不断。因此,灾害的有效防治和救助就成为各级政府和民间社会的重中之重。

关键词：近代淮河流域自然灾害社会冲突