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Structural Ultrafine Grained Steels Obtained by Advanced Controlled Rolling

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Journal of Iron and Steel Research International 2013年第1期20卷 62-70页

作者： R González J O García M A Barbés M J Quintana l f verdeja J I verdeja School of Engineering Panamerican UniversityMexico City 03920Mexico E T S I M O Oviedo UniversityOviedo 33004Spain

Steels with ultrafine grains （lower than 5 μm）, which usually known as ultrafine ferrite or ultrafine grained materials, are presently the object of intense research, because of the improvement in resistance and fracture toughness they may reach compared to conventional steels （with grain sizes above this value）. It is shown that the forenamed steels designated in the Euronorm EN 10149-2, which are manufactured by advanced techniques of controlled rolling and mainly used in automotive industry, have an ultrafine grain size in the range of 2.5 to 3.5 μm, and with elastic yield stresses higher than 400 MPa. Based on the Morrison-Miller criterion, it is shown that values of the strain-hardening coefficient lower than 0.08 would make the industrial application of these steels unfeasible.

关键词： ultrafine grained steel mechanical property manufacturability strain-hardening

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

frontotemporal dementia and amyotrophic lateral sclerosis:frontotemporal dementia(f T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with fTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel l.Barrow Matthew f.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Kinetics of the reaction of OH radical with ethylfluoroacetate,ethyl 4,4,4-trifluorobutyrate,and butylfluoroacetate

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Journal of Environmental Sciences 2025年第5期151卷 273-283页

作者： Pedro l.lugo Vianni Straccia Mariano A.Teruel María B.Blanco laboratorio Universitario de Química y Contaminación del Aire(l.U.Q.C.A) Institute for Research in Physical Chemistry of Córdoba(I.N.F.I.Q.C.)Department of Physical ChemistryFaculty of Chemical SciencesNational University of CórdobaUniversity CityCórdoba 5000Argentina Institute for Atmospheric and Environmental Research University of WuppertalWuppertal DE-42097Germany

Kinetics of the gas-phase reactions of•OH radicals with a series of fluoroesters were studied for the first time at 298±3 K and atmospheric *** rate coefficients were determined by in situ fTIR spectroscopy in nitrogen and GC-fID in air to monitor the decay of reactants and *** following coefficient values(in 10^(−12)cm^(3)/(molecule•sec))were obtained for ethyl fluoroacetate(EfA),ethyl 4,4,4-trifluorobutyrate(ETB),and butyl fluoroacetate(BfA),respectively:k_(1)(EfA+OH)=1.15±0.25 by fTIR and 1.34±0.23 by GC-fID;k_(2)(ETB+OH)=1.61±0.36 by fTIR and 2.02±0.30 by GC-fID;k_(3)(BfA+OH)=2.24±0.37 by *** trends were developed and correlated with the number of CH_(3)and f substituents in the fluoroester,and structure-activity relationships(SARs)calculations were *** addition,the tropospheric lifetimes of EfA,ETB,and BfA upon degradation by OH radicals were calculated to be 9,6,and 5 days,respectively,indicating that these fluorinated compounds could have a possible regional effect from the emission *** small photochemical ozone creation potentials of 9,7,and 19 were estimated for EfA,ETB,and BfA,*** GlobalWarming Potentials(GWPs)for EfA,ETB,and BfA were calculated for different time *** a 20-year time horizon,the GWPs were 1.393,0.063,and 0.062,*** the case of a 100-year time horizon,the GWPs were 0.379,0.017,and 0.017,and for a 500-year time horizon,the GWPs were 0.108,0.005,and 0.005 for EfA,ETB,and BfA.

关键词： CfC replacements sinks in situ fTIR SAR Acidification potentials Greenhouse gases

C3 glomerulopathy post kidney transplantation:A single center experience

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World Journal of Transplantation 2025年第2期15卷 245-256页

作者： Jonathan Zuckerman Phuong-Thu Pham Meena Parakkal Alexis f Velazquez Mrinalini Sarkar Michael A Pablos Suphamai Bunnapradist Erik l lum Department of Pathology and laboratory Medicine David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095United States Department of Medicine Division of NephrologyDavid Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095United States Department of Medicine David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095United States

BACKGROUND C3 glomerulopathies(C3G)are a rare cause of kidney failure resulting from complement *** studies demonstrate a high rate of recurrence and poor outcomes in kidney *** efficacy in this setting with eculizumab,a terminal complement inhibitor,is largely *** To determine the outcomes of kidney transplantation in patients with C3G and the potential impact of *** We retrospectively studied kidney transplant recipients who underwent a post-transplant biopsy confirming C3G between January 1,1993 and December 31,2023 at a single *** the first episode of kidney transplant was *** electronic medical records were reviewed for post-transplant allograft function,indication for biopsy,time to biopsy from transplant,time to allograft failure from transplantation,post-C3G treatment,complement laboratory testing,and concurrent malignancy/***,and when available slides and immunofluorescence/electron microscopic images,were re-reviewed by a renal *** A total of fifteen patients were included in this *** patients had suspected recurrent disease,with a pre-transplant native kidney report of *** patient developed de novo *** post kidney transplant clinical follow up time was 91 *** time to recurrence was 7 months with median graft survival of 48 months post kidney *** most common index biopsy pattern of injury was endocapillary prolif-erative glomerulonephritis(often with exudative features)with or without mesangial hypercellularity(56%)followed by membranoproliferative glomerulonephritis(25%).Most patients developed membranoproliferative glomerulonephritis pattern of injury on follow up biopsies(63%).Seven patients with recurrent disease received treatment with eculizumab with a median graft survival of 73 months,with five functioning grafts by the end of the study *** patients with recurrent disease did not receiv

关键词： C3 glomerulopathy Dense deposit disease C3 glomerulonephritis Kidney transplant Renal pathology,Kidney biopsy Recurrent disease Complement disorder

Survival of patients with hepatopulmonary syndrome related to cirrhotic and non-cirrhotic(schistosomiasis)portal hypertension

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World Journal of Hepatology 2025年第2期17卷 65-71页

作者： Melissa M Rolim liana G farsoun Carlos f luna Brivaldo Markman-filho Paulo Querette Edmundo P lopes Ana l Domingues Postgraduate Program in Tropical Medicine Center of Medical SciencesUniversidade Federal de PernambucoRecife 50670901PernambucoBrazil faculdade de Medicina UniNassau Grupo Ser EducacionalRecife 50100220PernambucoBrazil Statistics and Geoprocessing Center Institute Aggeu MagalhãesOswaldo Cruz FoundationRecife 50740465PernambucoBrazil Department of Cardiology Division Hospital das Clínicas/EBSERHUniversidade Federal de PernambucoRecife 50670901PernambucoBrazil Department of Internal Medicine Center of Medical SciencesUniversidade Federal de PernambucoRecife 50670901PernambucoBrazil Postgraduate Program in Translational Health Center of Medical SciencesUniversidade Federal de PernambucoRecife 50670901PernambucoBrazil Department of Gastroenterology Division Hospital das Clínicas/EBSERH-Universidade Federal de PernambucoRecife 50670901PernambucoBrazil

BACKGROUND The hepatosplenic schistosomiasis(HSS)with portal hypertension can cause vascular complications such as hepatopulmonary syndrome(HPS).HPS increases the risk of mortality in patients with cirrhosis;however,there is no data on the mortality of patients with HSS and *** To perform a survival analysis of patients with HPS related to cirrhotic and non-cirrhotic(schistosomiasis)portal *** from August 2023 to January 2024,medical records and the official mortality information service of 121 patients who participated in a cross-sectional study on HPS between 2010 and 2012 were *** curves were created using the Kaplan-Meier method,and comparisons were performed using the log-rank *** regression models estimated the hazard ratios(HR).RESUlTS Overall,data of 113 patients were analyzed;most(55.8%)had HSS and concomitant cirrhosis(HSS/cirrhosis).Meanwhile,HPS was present in 39(34.5%)*** occurred in 65 patients[57.5%];95%confidence interval(CI):48%-67%.The average time to death was lower in those with HPS when compared to those without HPS(3.37 years vs 5.65 years;P=0.017).According to the cause of liver disease,patients with HSS/cirrhosis died earlier,and their risk of death was twice as high compared with patients with HSS without cirrhosis(HR:2.17;95%CI:1.3-3.60;P=0.003).Meanwhile,there were no differences when comparing the two groups with and without HPS(HR:1.01;95%CI:0.59-1.73;P=0.967).CONClUSION Patients with HSS and concomitant cirrhosis had a lower survival rate,but there was no difference in survival regardless of the presence of HPS.

关键词： Schistosomiasis Portal hypertension Hepatopulmonary syndrome Survival Mortality Non-cirrhotic portal hypertension

Non-existence of Shimura curves of Mumford type generically in the non-hyperelliptic locus

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Science China Mathematics 2025年

作者： Xin lü Shengli Tan Kang Zuo School of Mathematical Sciences Key Laboratory of Mathematics and Engineering Applications(Ministry of Education) Shanghai Key Laboratory of Pure Mathematics and Mathematical PracticeEast China Normal University School of Mathematics and Statistics Wuhan University Institut für Mathematik Universit?t Mainz

We show that there does not exist any Shimura curve with a strictly maximal Higgs field generically in the Torelli locus of non-hyperelliptic curves of genus g≥4. In particular, Shimura curves of Mumford type are not...

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Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 120-127页

作者： lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang Chen Shen Almas f.Sadreev Yong li Andrey E.Miroshnichenko School of Physics and Electronic Sciences East China Normal UniversityShanghai 200241China Institute of Acoustics Tongji UniversityShanghai 200092China l.V.Kirensky Institute of Physics Krasnoyarsk 660036Russia Department of Mechanical Engineering Rowan UniversityGlassboro 08028USA School of Engineering and Technology University of New South Wales at CanberraACT 2610Australia

Bound states in the continuum(BICs)are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional toΔl^(−4),whereΔl embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective non-Hermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

Two-plasmon-decay instability stimulated by dual laser beams in inertial confinement fusion

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Matter and Radiation at Extremes 2025年第1期10卷 48-56页

作者： C.-W.lian Y.Ji R.Yan J.li l.-f.Wang Y.-K.Ding J.Zheng Department of Modern Mechanics University of Science and Technology of ChinaHefeiAnhui 230026China Collaborative Innovation Center of IfSA Shanghai Jiao Tong UniversityShanghai 200240China Department of Plasma Physics and fusion Engineering University of Science and Technology of ChinaHefei 230026China Institute of Applied Physics and Computational Mathematics Beijing 100088China

Two-plasmon-decay instability(TPD)poses a critical target preheating risk in direct-drive inertial confinement *** this paper,TPD collectively driven by dual laser beams consisting of a normal-incidence laser beam(Beam-N)and a large-angle-incidence laser beam(Beam-l)is investigated via particle-in-cell *** is found that significant TPD growth can develop in this regime at previously unexpected low laser intensities if the intensity of Beam-l exceeds the large-angle-incidence *** beams contribute to the growth of TPD in a“seed-amplification”manner in which the absolute instability driven by Beam-l provides the seeds that are convectively amplified by Beam-N,making TPD energetically important and causing significant pump depletion and hot-electron generation.

关键词： laser pump decay