检索结果-南通市图书馆

H pylori infection causes chronic pancreatitis in Mongolian gerbils

World Journal of Gastroenterology 2007年第29期13卷 3939-3947页

作者： Gabriele Rieder Arno Karnholz Mechthild Stoeckelhuber Juanita l Merchant Rainer Haas Max von Pettenkofer-Institute for Hygiene and Medical Microbiology Ludwig-Maximilians-University 80336 Munich Germany Institute of Anatomy Ludwig- Maximilians-University 80336 Munich Germany University of Michigan Departments of Internal Medicine and Molecular and Integrative Physiology Ann Arbor Michigan United States

AIM： To investigate whether chronic H pylori infection has the potential to induce pancreatitis in the Mongolian gerbil model, and whether it is dependent on an intact type Ⅳ secretion system. METHODS： Mongolian gerbils were infected with wild type （WT） H pylori type Ⅰ strain B128 or its isogenic mutant B128 △cag γ （defective type Ⅳ secretion）. After seven months of infection, H pylori was reisolated from antrum and corpus and Hpylori DNA was analyzed by seminested polymerase chain reaction （PCR）. Inflammation and histological changes were documented in the gastric antrum, corpus, and pancreas by immunohistochemistry. Cytokine mRNA, gastric pH, plasma gastrin, amylase, lipase, and glucose levels were determined. RESUlTS： The H pylori infection rate was 95%. Eight infected animals, but none of the uninfected group, developed transmural inflammation and chronic pancreatitis. Extensive interstitial fibrosis and inflammation of the pancreatic lobe adjacent to the antrum was confirmed by trichrome stain, and immuno-histochemically. Pro-inflammatory cytokine mRNA was significantly increased in the antral mucosa of all infected gerbils. In the corpus, only cytokine levels of WT-infected animals andthose developing transmural inflammation and pancreatitis were significantly increased. levels of lipase, but not glucose or amylase levels, were significantly reduced in the pancreatitis group. H pylori DNA was detected in infected antral and corpus tissue,but not in the pancreas CONClUSION： H pylori infection is able to induce chronic pancreatitis in Mongolian gerbils independently of the type Ⅳ secretion system, probably by an indirect mechanism associated with a penetrating ulcer.

关键词： H pylori Mongolian gerbil Pancreatitis Gastritis Penetrating ulcer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

一种固体颗粒酸酸化过程预测新模型及其应用

引用

科学技术与工程 2024年第20期24卷 8504-8511页

作者：何晓波苏军伟罗攀登王乐吕新雄中国石化西北油田分公司石油工程技术研究院乌鲁木齐830011 中国石化缝洞型油藏提高采收率重点实验室乌鲁木齐830011 西安交通大学人居环境与建筑工程学院西安710049 西安石油大学土木工程学院西安710065

固体颗粒酸作为一种缓速酸液体系,在碳酸盐岩储层酸化过程中具有能够沟通储层深部的优势。理清碳酸盐岩储层内固体颗粒酸的酸化机制,对于优选评价酸种类具有重要意义。为此,提出一种新的能够描述碳酸盐岩固体颗粒酸化过程的数学模型,能... 详细信息

固体颗粒酸作为一种缓速酸液体系,在碳酸盐岩储层酸化过程中具有能够沟通储层深部的优势。理清碳酸盐岩储层内固体颗粒酸的酸化机制,对于优选评价酸种类具有重要意义。为此,提出一种新的能够描述碳酸盐岩固体颗粒酸化过程的数学模型,能够刻画表征颗粒酸的缓释性能,进而研究不同注入速度及颗粒酸浓度等对碳酸盐岩储层酸化过程的影响机理。结果表明:入口周围区域颗粒酸浓度较低碳酸盐岩储层溶蚀较少,距离入口远端酸浓度存在高值分布。随着颗粒酸浓度的不断增大,溶蚀类型由均匀溶蚀转为特定方向的锥型蚓孔,且蚓孔长度不断增大而宽度不断降低;随着注入速度的增大,溶蚀类型由蚓孔转为均匀溶蚀,储层突破时间不断增大。

关键词：固体颗粒酸酸化数值模拟模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of ginsenoside on brain-derived neurotrophic factor and tyrosine kinase B mRNA expression in the hippocampal formation of aged rats

引用

Neural Regeneration Research 2008年第7期3卷 723-727页

作者： Hong lai Wensu liu Zhaosheng li Haihua Zhao Yongli lü Department of Anatomy College of Basic Medical Science China Medical University Shenyang 110001 Liaoning Province China School of Geophysics and Information Technology China University of Geosciences Beijing

BACKGROUND： There are a limited number of studies involving the effects of ginsenosides, the active component of ginseng, on expression of hippocampal TrkB mRNA in aged rats. OBJECTIVE： To observe expression of brain-derived neurotrophic factor （BDNF） and tyrosine kinase B （TrkB） mRNA in the hippocampal formation of aged rats, as well as changes after ginsenoside administrated. DESIGN, TIME AND SETTING： A randomized, controlled experiment was performed at the Department of Anatomy, College of Basic Medical Sciences, China Medical University in March 2005. MATERIAlS： A total of 39 female, Wistar rats were randomly divided into 3 groups （n = 13 each）： young （3-5 months old）, aged （27 months old）, and ginsenoside group （received 25mg/kg/d ginsenoside in the drinking water between 17 and 27 months of age）. METHODS： Following anesthesia, the rats were exsanguinated and perfused transcardially with chilled, heparinized, 0.9% saline. The brains were removed and post-fixed in 40 g/l paraformaldehyde/phosphate buffer for 20 minutes, and further incubated in 30% sucrose/phosphate buffer overnight. MAIN OUTCOME MEASURES： In situ hybridization, immunohistochemistry, and image analysis were used to investigate expression of BDNF and TrkB mRNA in the hippocampal formation. RESUlTS： The expression levels of BDNF in the hippocampal CA3 and CA1 of aged rats was significantly less than the young group （t = 2.879, 1.814, 1.984, P 〈 0.05）. BDNF expression was significantly greater in the dentate gyrus of the ginsenoside group, compared with the aging group （t = 1.943, P 〈 0.01）. The expression of TrkB mRNA in the hippocampal CA3, CA1, and dentate gyrus of aged rats was less than the young group （t = 3.540, 3.629, 17.905, P 〈 0.01）. TrkB mRNA expression in the CA3 region and dentate gyrus of the ginsenoside group was significantly greater compared with the aging group （t = 1.293, 3.386, P 〈 0.05, 0.01 ）. CONClUSION： BDNF and TrkB mRNA expression in the hippocampal formation

关键词： ginsenosides brain-derived neurotrophic factor tyrosine kinase B hippocampus

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

不同浓度卡拉胶对汉麻分离蛋白凝胶性质及结构的影响

引用

食品工业科技 2024年第12期45卷 28-37页

作者：吕铭守王子涵刘琳琳孙冰玉朱颖黄雨洋曲敏朱秀清哈尔滨商业大学食品工程学院黑龙江省普通高校食品科学与工程重点实验室黑龙江省谷物食品与谷物资源综合加工重点实验室黑龙江哈尔滨150028

为阐明不同浓度的卡拉胶(0.4%、0.8%、1.2%、1.6%、2.0%,w/w)对汉麻分离蛋白凝胶特性和结构的影响,以未添加卡拉胶的汉麻分离蛋白凝胶为对照,测定复合凝胶的持水能力、质构、流变特性,同时检测了卡拉胶的加入对复合凝胶水分分布、蛋白... 详细信息

为阐明不同浓度的卡拉胶(0.4%、0.8%、1.2%、1.6%、2.0%,w/w)对汉麻分离蛋白凝胶特性和结构的影响,以未添加卡拉胶的汉麻分离蛋白凝胶为对照,测定复合凝胶的持水能力、质构、流变特性,同时检测了卡拉胶的加入对复合凝胶水分分布、蛋白结构及分子间作用力的影响。结果表明:添加卡拉胶显著(P<0.05)提高了汉麻分离蛋白凝胶持水能力和凝胶强度,改变了蛋白结构。与对照组相比,0.8%卡拉胶的添加显著(P<0.05)提高凝胶的硬度、弹性模量并降低了凝胶的频率依赖性,并与水分子结合最为紧密,α-螺旋向β-折叠和无规卷曲转变,增加凝胶刚性结构;此时维持凝胶结构的主要作用力由疏水相互作用力向二硫键转变,凝胶网络更加致密,电镜结果证明了这一结论。因此,添加0.8%的卡拉胶可显著(P<0.05)提高汉麻分离蛋白的凝胶性质并改善其结构,为提高汉麻分离蛋白在食品领域的应用提供了理论和实验基础。

关键词：卡拉胶汉麻分离蛋白凝胶特性二级结构

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Modified malleable prosthesis with a fixed mesh:case series for the Ghattas technique

引用

Asian Journal of Andrology 2022年第2期24卷 167-170页

作者： Osama Ghattas Mohamed Fahmy Doheim Hossam Kotb Arthur l Burnett Dar-elzokora Center of Andrology Alexandria 21500Egypt Alexandria Faculty of Medicine Alexandria UniversityAlexandria 21131Egypt Department of Urology Johns Hopkins University School of MedicineBaltimoreMD 21287USA

Penile prosthetic implantation represents a cornerstone for patients with organic erectile dysfunction(ED)that is refractory,unsatisfactory,or contra-indicated for other approved medical or mechanical *** this study,we introduce the“Ghattas technique,”wherein we constructed a polypropylene mesh sheath that surrounds and is fixed to a 13-mm malleable prosthesis cylinder,which can increase the cylinder diameter for cases that need a larger *** patients underwent preoperative evaluation and completed the five-item International Index of Erectile Function questionnaire(IIEF-5).Postoperative outcomes were evaluated by IIEF-5 and Erectile Dysfunction Inventory of Treatment Satisfaction(EDITS)questionnaires at final *** mean age of the 23 included patients was 57.9(standard deviation[s.d.]:11.4)years and the mean duration of ED was 8.5(s.d.:7.9)*** improvement was determined by comparing mean preoperative and postoperative IIEF-5 scores(8.3[s.d.:3.9]vs 24.6[s.d.:0.6],Plarger than 13 *** studies are needed to confirm these results.

关键词： erectile dysfunction mesh penile prosthesis surgical technique

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Simple Efficient Smart Finite Elements for the Analysis of Smart Composite Beams

引用

Computer Modeling in Engineering & Sciences 2016年第5期111卷 437-471页

作者： M.C.Ray l.Dong S.N.Atluri Department of Mechanical Engineering Indian Institute of TechnologyKharagpurIndia School of Aeronautic Science and Engineering Beihang UniversityChina Department of Mechanical Engineering Texas Tech UniversityUSA

This paper is concerned with the development of new simple 4-noded locking-alleviated smart finite elements for modeling the smart composite *** exact solutions for the static responses of the overall smart composite beams are also derived for authenticating the new smart finite *** overall smart composite beam is composed of a laminated substrate conventional composite beam,and a piezoelectric layer attached at the top surface of the substrate *** piezoelectric layer acts as the actuator layer of the smart *** finite element models of the beams,based on an“equivalent single layer high order shear deformation theory”,and a“layer-wise high order shear deformation theory”,are also derived for the purpose of investigating the required number of elements across the thickness of the overall smart composite *** cross-ply substrate beams are considered for presenting the *** responses computed by the present new“smart finite element model”excellently match with those obtained by the exact *** new smart finite elements developed here reveal that the development of finite element models of smart composite beams does not require the use of conventional first order or high order or layer-wise shear deformation theories of ***,the use of the presently developed locking-free 4-node elements based on conventional linear piezo-elasticity is sufficient.

关键词： Piezoelectricity exact solutions smart finite element smart structures

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anal intraepithelial neoplasia: A review of diagnosis and management

引用

World Journal of Gastrointestinal Oncology 2017年第2期9卷 50-61页

作者： Joseph R Roberts lacey l Siekas Andrew M Kaz Department of Medicine Division of Gastroenterology University of Washington School of Medicine Gastroenterology Section VA Puget Sound Health Care System

Anal intraepithelial neoplasia(AIN) is a premalignant lesion of the anal mucosa that is a precursor to anal cancer. Although anal cancer is relatively uncommon, rates of this malignancy are steadily rising in the United States, and among certain high risk populations the incidence of anal cancer may exceed that of colon cancer. Risk factors for AIN and anal cancer consist of clinical factors and behaviors that are associated with the acquisition and persistence of human papilloma virus(HPV) infection. The strongest HPV-associated risk factors are HIV infection, receptive anal intercourse, and high risk sexual behavior. A history of HPVmediated genital cancer, which suggests infection with an oncogenic HPV strain, is another risk factor for AIN/anal cancer. Because progression of AIN to anal cancer is known to occur in some individuals over several years, screening for AIN and early anal cancer, as well as treatment of advanced AIN lesions, is reasonable in certain high-risk populations. Although randomized controlled trials evaluating screening and treatment outcomes are lacking, experts support routine screening for AIN in high risk populations. Screening is performed using anal cytological exams, similar to those performed in cervical cancer screening programs, along with direct tissue evaluation and biopsy via high resolution anoscopy. AIN can be treated using topical therapies such as imiquimod, 5-flurouracil, and trichloroacetic acid, as well as ablative therapies such as electrocautery and laser therapy. Reductions in AIN and anal cancer rates have been shown in studies where high-risk populations were vaccinated against the oncogenic strains of HPV. Currently, the CDC recommends both high-risk and average-risk populations be vaccinated against HPV infection using the quadrivalent or nonavalent vaccines. It is important for clinicians to be familiar with AIN and the role of HPV vaccination, particularly in high risk populations.

关键词： Anal cancer Anal intraepithelial neoplasia Anal squamous cell carcinoma Human papillomavirus vaccine Human papillomavirus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Coherence of a Chain of Chaotic Oscillators in a Nonlinear Gyrotropic Medium

引用

Communications in Theoretical Physics 2008年第12期50卷 1381-1386页

作者： A.Ugulava l.Chotorlishvili V.Skrinnikolv G.Mchedlishvili Physics Department of Tbilisi State University Chavchavadze Av.30128TbilisiGeorgia Physics Department of Tbilisi State University Chavchavadze Av.30128TbilisiGeorgia Institute for PhysikUniversitat Augsburg86135 AugsburgGermany

We investigate the generalized Kuhn＇s model, namely, a chain of nonlinear chaotic oscillators describing a nonlinear gyrotropic medium. It is shown that despite the chaotic behavior of separate oscillators the chain preserves some coherency as a whole. The relation between the chain synchronization and the physical properties of a random mean field is established.

关键词： dynamical stochasticity gyrotropic medium

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ElECTROCHEMICAl INVESTIGATION ON CARBON NANOTUBE FIlM WITH DIFFERENT PRETREATMENTS

引用

Acta Metallurgica Sinica(English letters) 2003年第4期16卷 295-301页

作者： C.G.Hu W.l.Wang W.Zhu DepartmentofAppliedPhysics ChongqingUniversityChongaing400044China KeylaboftheEducationMinistryforPhotoelectricTechnologyandSystem ChongqingUniversityChongqing400044China DepartmentofChemistry ChongqingUniversityChongqing400044ChinaManuscriptreceived25November2002

Wide potential windows were found at carbon nanotube film electrodes in neutral solutions after being treated with nitric acid and mixed acid. Electrochemical reversibility was investigated at carbon nanotube films with different pretreatments for ferri/ferrocyanide and quinone /hydroquinone. Carbon nanotube film electrodes presented quasi-reversible electrochemical behavior for both electrolytes. In the range of scan rate, carbon nanotube film electrodes treated with acids showed heterogeneous electron-transfer properties, which was mainly controlled by its electron state density on the surface of the film. On the whole, the carbon nanotube electrode with nitric acid treatment presented the best electrochemical behaviors, so we chose it as an analytical electrode to determine the trace compound in dilute solution. The results demonstrated that this new electrode material exhibits superior performance characteristics for the detection of azide anion.

关键词： carbon nanotubes cyclic voltammetry treatment azide anion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

GRAFT　COPOlYMERIZATION　OF　BUTYl　ACRYlATE　ONTO　CASEIN　INITIA　BY　POTASSIUM　DIPERIODATOARGENTATE

引用

Chinese Chemical letters 1996年第5期7卷 463-466页

作者： liu, WH liu, YH Shang, YJ Han, MJ Shi, l HEBEI UNIV DEPT CHEMBAODING 071002PEOPLES R CHINA

Abstract: A new initiator. potassium diperiodatoargentate (Ⅲ). was used to initiate graft copolymerization of butryl acrylate(BuA) onto casein which showed a very high grafiting efficiency. grafting efficiency andpercent conversion of monomer were evaluated in all cases. Infrared spectra and thermal analysis for casein and the grafting copolymer were taken to establish evidence for grafting. A possible initiation mechanism was proposed.

关键词： COMPlEXES

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：