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Atomic Force Microscopy-based Cell Nanostructure for ligand-conjugated Quantum Dot Endocytosis

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Acta Biochimica et Biophysica Sinica 2006年第9期38卷 646-652页

作者： Yun-long PAN~1* Ji-Ye CAI~2 li QIN~3 Hao WANG~4 1 The First Affiliated Hospital of jinan university,guangzhou 510632.china 2 College of life Science and Technology,jinan university,guangzhou 510632.china 3 department of Histology and Embryology,Medical College of jinan university,guangzhou 510632.china 4 Information and Optoelectronic Science and Engineering.South china Normal university,guangzhou 510631,china The First Affiliated Hospital of jinan universityguangzhou 510632 China College of life Science and Technology Jinan UniversityGuangzhou 510632 China department of Histology and Embryology Medical College of Jinan UniversityGuangzhou 510632 China School for Information and Optoelectronic Science and Engineering South China Normal UniversityGuangzhou 510631 China

While it has been well demonstrated that quantum dots (QDs) play an important role inbiological labeling both in vitro and in vivo,there is no report describing the cellular nanostructure basis ofreceptor-mediated ***,nanostructure evolution responses to the endocytosis of transferrin(Tf)-conjugated QDs were characterized by atomic force microscopy (AFM).AFM-based nanostructureanalysis demonstrated that the Tf-conjugated QDs were specifically and tightly bound to the cell receptorsand the nanostructure evolution is highly correlated with the cell membrane receptor-mediated ***,confocal microscopic and flow cytometry results have demonstrated the specificity anddynamic property of Tf-QD binding and *** found that the internalization of Tf-QD is linearlyrelated to ***,while the nanoparticles on the cell membrane increased,the endocytosis was stillvery active,suggesting that QD nanoparticles did not interfere sterically with the binding and function ***,ligand-conjugated QDs are potentially useful in biological labeling of cells at a nanometerscale.

关键词： quantum dot endocytosis nanostructure atomic force microscopy

Catalytically generated noncovalent ammonium dienolate:a versatile platform for the development of organocatalytic asymmetric cascade reactions

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Science china Chemistry 2024年第8期67卷 2524-2546页

作者： Jun-Bing lin Dong-Sheng Ji Peng-fei xu State Key laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China Shaanxi Key laboratory of Chemical Reaction Engineering College of Chemistry and Chemical EngineeringYan’an UniversityYan’an 716000China

Organocatalytic cascade reactions represent a powerful strategy for the rapid construction of complex chiral molecules with multiple stereocenters from simple substrates under mild conditions. The intriguing structural feature and diverse reactivity of catalytically generated dienolate species render them competent and versatile intermediates for the development of practical and valuable cascade reactions. Over the past years, a plethora of innovative and pioneering noncovalent ammonium dienolatemediated cascade reactions have been designed and implemented under the catalysis of chiral organocatalysts, making dienolate activation a general, robust, and complementary method for the functionalization of unsaturated carbonyl compounds and related substances. This review illustrates the recent advances in organocatalytic noncovalent ammonium dienolate-mediated cascade reactions(mainly from 2.10 to 2023), including the cascade transformations of ammonium dienolates directly generated from unsaturated ketone/aldehyde, ester/lactone/azlactone, amide/lactam/pyrazolone/oxindole, and alkylidene nitrile compounds. The contents are arranged based on the reaction types of the ammonium dienolates, with an emphasis on cascade 2,5-, 3,5-, and 4,5-difunctionalizations of these intermediates. Furthermore, other cascade reactions involving the 1,3-, 2,3-, and even more complex 3,4,5-reactivities of ammonium dienolates were also discussed. The reaction pathway, reaction stereoinduction, and synthetic applications of the ammonium dienolate-mediated cascade reactions were highlighted throughout the article. As a stimulating and ever-growing research area, the organocatalytic noncovalent ammonium dienolate-mediated cascade reactions are expected to continue demonstrating their magic power for constructing chiral targets in the future and further expanding the boundaries of asymmetric catalysis.

关键词： organocatalysis asymmetric catalysis ammonium dienolate cascade reaction difunctionalization

Photoinduced Bending and Curling Motions in Molecular Microcrystals of Naphthyl Meldrum’s Acid Derivative Based on E-to-Z Photoisomerization

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Chemical Research in Chinese Universities 2024年第5期40卷 907-913页

作者： ZHANG Xiaowen xu Tianyi ZHANG Chenchen TONG fei Key laboratory for Advanced Materials and Joint International Research laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai200237P.R.China

Dynamic photoresponsive molecular crystals are promising candidates for making intelligent devices and materials in the ***,we synthesized a new photoactive molecule(E)-2,2-dimethyl-5-[3-(naphthalen-1-yl)allylide]-1,3-dioxane-4,6-dione[(E)-DNADD]that undergoes an E-to-Z photoisomerization in both liquid solution and solids when exposed to visible light(405 nm).Compared to the bulk crystals,the photoresponsive behavior in microcrystals was profoundly *** crystalline(E)-DNADD microplate crystals exhibit robust motions,including bending,curling,and coiling under light *** photoproduct conversion of the photochemical reaction in the microplate is no more than 20%,while the large bending curvature of the coiled illuminated samples was estimated at approximately 150–300 mm−1,comparable to some photoactive *** results indicate that shrinking crystal dimensions can boost the photoresponses in molecular crystals and provide a facile strategy for developing dynamic molecular crystals at the microscopic scale.

关键词： Photochemistry Molecular crystal E-to-Z photoisomerization Photoinduced motion

BOUND　ON　SOlUTIONS　TO　THE　GENERAl　SYSTEM　OF　VOlTERRA－TYPE　lINEAR　INTEGRAl　INEQUAlITIES　IN　SEVERAl　VARIABlES　AND　ITS　APPlICATIONS　TO　INTEGRO－PARTIAl　DIFFERENTIAl　EQUATIONS

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Systems Science and Mathematical Sciences 1995年第4期8卷 338-345页

作者： YANG Enhao(department of mathematics,jinan university,guangzhou 510632.china) 暨南大学数学系广东广州 510632

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ＢＯＵＮＤＯＮＳＯＬＵＴＩＯＮＳＴＯＴＨＥＧＥＮＥＲＡＬＳＹＳＴＥＭＯＦＶＯＬＴＥＲＲＡ－ＴＹＰＥＬＩＮＥＡＲＩＮＴＥＧＲＡＬＩＮＥＱＵＡＬＩＴＩＥＳＩＮＳＥＶＥＲＡＬＶＡＲＩＡＢＬＥＳＡＮＤＩＴＳＡＰＰＬＩＣＡＴＩＯＮＳＴＯＩＮＴＥＧＲＯ－ＰＡＲＴ...

关键词： linear Volterra type integral inequality in n variables integropartial differential equation.boundary value problem.

On Some Nonlinear Integral and Discrete Inequalitites Related to Ou-Iang's Inequality

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Acta Mathematica Sinica,English Series 1998年第3期14卷 353-360页

作者： Yang Enhao department of mathematics, jinan university, guangzhou 510632, china 暨南大学数学系广东广州

Nonlinear integral and discrete inequalities are obtained. which are related to some recent results of B. C. Pachpatte in [1] given therein as generalizations of Ou-Iang’s integral inequality[2]. As special cases, some new inequalities with the power nonlinearity are derived from the main results. To show the contribution of our results, boundedness of solutions to certain nonlinear difference equation is also considered.

关键词： Nonlinear integral inequality Discrete analogue Power nonlinearity A priori bound

langmuir-Blodgett Films and Calcium Ion Coordination of Biliverdin and Its Amphiphilic Derivatives

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Chinese Chemical letters 2001年第5期12卷 457-460页

作者： Jian Ming OUYANG department of Chemistry, jinan university, guangzhou 510632 department of Chemistry Jinan University Guangzhou 510632 China

Monolayer formation and lB film fabrication of amphiphilic derivative of biliverdin 1, diododecyl biliverdinamide [B(CONHC12H25)(2), 2] at an air-water interface on pure water subphase and subphase containing calcium ion were investigated and compared with 1. The coordination in ordered molecular films is much different from that in bulk solution. The formation of ligand-calcium complex was confirmed by X-ray photoelectron spectroscopy.

关键词： monolayer langmuir-Blodgett films biliverdin calcium ion

A Pre-Selection-Based Ant Colony System for Integrated Resources Scheduling Problem at Marine Container Terminal

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Computers, Materials & Continua 2024年第8期80卷 2363-2385页

作者： Rong Wang Xinxin xu Zijia Wang fei Ji Nankun Mu School of Electronic and Information Engineering South China University of TechnologyGuangzhou510641China School of Computer Science and Technology Ocean University of ChinaQingdao266100China School of Computer Science and Cyber Engineering Guangzhou UniversityGuangzhou510006China School of Computer Science Chongqing UniversityChongqing400044China

Marine container terminal(MCT)plays a key role in the marine intelligent transportation system and international logistics ***,the efficiency of resource scheduling significantly influences the operation performance of *** solve the practical resource scheduling problem(RSP)in MCT efficiently,this paper has contributions to both the problem model and the algorithm ***,in the problem model,different from most of the existing studies that only consider scheduling part of the resources in MCT,we propose a unified mathematical model for formulating an integrated *** new integrated RSP model allocates and schedules multiple MCT resources simultaneously by taking the total cost minimization as the ***,in the algorithm design,a pre-selection-based ant colony system(PACS)approach is proposed based on graphic structure solution representation and a pre-selection *** the one hand,as the RSP can be formulated as the shortest path problem on the directed complete graph,the graphic structure is proposed to represent the solution encoding to consider multiple constraints and multiple factors of the RSP,which effectively avoids the generation of infeasible *** the other hand,the pre-selection strategy aims to reduce the computational burden of PACS and to fast obtain a higher-quality *** evaluate the performance of the proposed novel PACS in solving the new integrated RSP model,a set of test cases with different sizes is *** results and comparisons show the effectiveness and efficiency of the PACS algorithm,which can significantly outperform other state-of-the-art algorithms.

关键词： Resource scheduling problem(RSP) ant colony system(ACS) marine container terminal(MCT) pre-selection strategy

New strategies for asymmetric photocatalysis: asymmetric organocatalytic/photoredox relay catalysis for efficient synthesis of polycyclic compounds containing vicinal amino alcohols

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Science china Chemistry 2024年第3期67卷 945-952页

作者： Jia-lu Zhang Wen-Bo He Xiu-Qin Hu Peng-fei xu State Key laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China State Key laboratory of Veterinary Etiological Biology College of Veterinary MedicineLanzhou UniversityLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou 730000China MOE Frontiers Science Center for Rare Isotopes Lanzhou UniversityLanzhou 730000China

An asymmetric catalytic strategy in photocatalysis utilizing a chirality-induced approach through an organocatalytic/photoredox relay catalysis strategy is successfully achieved for the rapid construction of polycyclic compounds containing vicinal amino alcohols in a one-pot protocol. This methodology facilitates the efficient synthesis of diverse substituted polycyclic tetrahydroquinoline and benzofuran-derived vicinal amino alcohols, each containing five consecutive chiral centers, with high yields,excellent diastereoselectivities and enantioselectivities(up to 95% yield, >20:1 dr and 98% ee), under mild reaction conditions driven by sequential bifunctional squaramide organocatalyst-catalyzed [4+2] annulation and photocatalyst-catalyzed ketyl radical addition cyclization reaction process. Furthermore, investigations into the stereoselectivity mechanism and high-resolution mass spectrometry(HRMS) experiments on free radical trapping have provided evidence for elucidating the detailed mechanism of chirality-induced processes and chiral intermediate conversions in this procedure.

关键词： enantioselective photocatalysis asymmetric organocatalytic/photocatalysis relay catalysis five consecutive chiral centers chirality-induced strategy chirality vicinal amino alcohols

Highly selective and eco-friendly dihydroisoquinoline synthesis via Cu/Co synergistic catalysis in Cu NPs@MOFs catalyst under mild conditions

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Science china Chemistry 2024年第5期67卷 1561-1568页

作者： Peng-fei Guo Ze-long liang Yue-E Jiao Hang xu Bin Zhao Key laboratory of Advanced Energy Material Chemistry Renewable Energy Conversion and Storage CenterDepartment of ChemistryNankai UniversityTianjin 300071China

3,4-Dihydroisoquinoline(DHIQ)is an important precursor used in the production of drugs for treating cancer,HIV,Alzheimer's disease,*** studies on DHIQ synthesis show low catalytic selectivity due to the susceptible over-oxidation feedstock of1,2,3,4-tetrahydroisoquinoline(THIQ),which often requires alkali ***,it is desirable yet challenging to explore a highly selective and efficient oxydehydrogenation capacity for DHIQ synthesis under eco-friendly reaction ***,a novel framework 1 was synthesized,exhibiting 1D channels with the size of 4.6 A×9.6 A and high solvent/p H/thermal stability.A stable framework allows it to encapsulate Cu nanoparticles(NPs)to form Cu NPs@1-x(x=1,2,3,and 4)with varying loading amounts of Cu NPs at 2.0 wt%,3.0 wt%,4.0 wt%,and 6.0 wt%,*** NPs@1-3 could selectively catalyze the reaction from THIQ to DHIQ with a high selectivity of 98%and a recorded turnover frequency(TOF)of 22.1 h-1under eco-friendly mild *** corresponding catalytic activity can maintain at least five recyclings and can be further applied to gram-scale ***,the efficient preparation of DHIQ catalyzed by Cu NPs@1-3 could be realized even under air ***,the anticancer molecule precursor synthesis of 6,7-dimethoxy-3,4-dihydroisoquinoline was also selectively catalyzed by Cu NPs@*** investigations revealed that high catalytic performance can be attributed to the stable framework and the synergistic catalytic effect of the loaded Cu NPs and Co metal *** importantly,this work represents the first example of MOF catalysts for selectively thermo-catalytic DHIQ synthesis and demonstrates a simple approach to obtain efficient catalysts for selective oxydehydrogenation in the production of unsaturated compounds.

关键词： metal-organic frameworks Cu NPs@MOFs 3 4-dihydroisoquinoline selective oxydehydrogenation synergistic catalysis