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Enhancing the vertical resolution of lunar penetrating radar data using predictive deconvolution

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Earth and Planetary Physics 2024年第4期8卷 570-578页

作者： Chao li jinhai Zhang CAS Engineering laboratory for Deep Resources Equipment and Technology Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China

The Yutu-2 rover onboard the Chang’E-4 mission performed the first lunar penetrating radar detection on the farside of the *** high-frequency channel presented us with many unprecedented details of the subsurface structures within a depth of approximately 50 ***,it was still difficult to identify finer layers from the cluttered reflections and scattering *** applied deconvolution to improve the vertical resolution of the radar profile by extending the limited bandwidth associated with the emissive radar *** overcome the challenges arising from the mixed-phase wavelets and the problematic amplification of noise,we performed predictive deconvolution to remove the minimum-phase components from the Chang’E-4 dataset,followed by a comprehensive phase rotation to rectify phase anomalies in the radar ***,we implemented irreversible migration filtering to mitigate the noise and diminutive clutter echoes amplified by *** processed data showed evident enhancement of the vertical resolution with a widened bandwidth in the frequency domain and better signal clarity in the time domain,providing us with more undisputed details of subsurface structures near the Chang’E-4 landing site.

关键词： Chang’E-4 lunar penetrating radar data processing predictive deconvolution irreversible migration filtering

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PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity

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Virologica Sinica 2024年第2期39卷 264-276页

作者： Ruiqi Sun Yanyu Guo lilin Zhang Huixia Zhang Boxuan Yin Xiaoyang li Changyan li liu Yang lei Zhang Zexing li jinhai Huang School of life Sciences Tianjin UniversityTianjin300072China

Porcine reproductive and respiratory syndrome virus(PRRSV)is a major economically devastating pathogen that has evolved various strategies to evade innate *** of antiviral interferon largely promotes PRRSV immunoevasion by utilizing cytoplasmic melanoma differentiation-associated gene 5(MDA5),a receptor that senses viral *** this study,the downregulated transcription and expression levels of porcine MDA5 in PRRSV infection were observed,and the detailed mechanisms were *** found that the interaction between P62 and MDA5 is enhanced due to two factors:the phosphorylation modification of the autophagic receptor P62 by the upregulated kinase CK2αand the K63 ubiquitination of porcine MDA5 catalyzed by the E3 ubiquitinase TRIM21 in PRRSV-infected *** a result of these modifications,the classic P62-mediated autophagy is ***,porcine MDA5 interacts with the chaperonin containing TCP1 subunit 2(CCT2),which is enhanced by PRRSV *** interaction promotes the aggregate formation and autophagic clearance of MDA5-CCT2-nsp3 independently of *** summary,enhanced MDA5 degradation occurs in PRRSV infection via two autophagic pathways:the binding of MDA5 with the autophagy receptor P62 and the aggrephagy receptor CCT2,leading to intense innate immune *** research reveals a novel mechanism of immune evasion in PRRSV infection and provides fundamental insights for the development of new vaccines or therapeutic strategies.

关键词： Porcine reproductive and respiratory syndrome virus(PRRSV) nsp3 Autophagy MDA5

latest Scientific Results of China's lunar and Deep Space Exploration(2022–2024)

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空间科学学报 2024年第4期44卷 622-632页

作者： XU lin li lei liU Jianzhong liN Honglei li Yang liU Yang XIE lianghai ZHANG jinhai QIAO Fuhao HAN Juanjuan ZOU Yongliao General Office of the lunar and Deep Space Exploration Chinese Academy of SciencesBeijng 100190 State Key laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190 Institute of Geochemistry Chinese Academy of SciencesGuiyang 550081 Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029

China has successfully launched six lunar probes so *** Chang'E-1 to Chang'E-4,they completed the circling,landing and roving exploration,of which Chang'E-4 was the first landing on the far side of the Moon in human ***'E-5 was launched in December 2020,bringing back 1731 g of lunar soil *** the detailed analysis of the samples,the scientists understand the history of late lunar volcanism,specifically extending lunar volcanism by about 800 million to 1 billion years,and proposed possible *** addition,there are many new understandings of space weathering such as meteorite impacts and solar wind radiation on the ***'s first Mars exploration mission Tianwen-1 was successfully launched in July *** the study of scientific data,a number of important scientific achievements have been made in the topography,water environment and shallow surface structure of *** paper introduces the main scientific achievements of Chang'E-4,Chang'E-5 and Tianwen-1 in the past two years,excluding technical and engineering *** to the large number of articles involved,this paper only introduces part of the results.

关键词： lunar and deep space exploration of China Chang’E-4 mission Chang’E-5 mission Tianwen-1 mission

BMP9 induces osteogenic differentiation through up-regulating lGR4 via the mTORC1/ Stat3 pathway in mesenchymal stem cells

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Genes & Diseases 2024年第3期11卷 468-483页

作者： Jie Zhang jinhai Jiang Hang liu Shiyu Wang Kaixin Ke Siyuan liu Yue Jiang lu liu Xiang Gao Baicheng He Yuxi Su Department of Pharmacology School of PharmacyChongqing Medical UniversityChongqing 400016China Key laboratory of Biochemistry and Molecular Pharmacology of Chongqing Chongqing Medical UniversityChongqing 400016China Department of Orthopedics Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China orthopedics Department Children's Hospital of Chongqing Medical UniversityChongqing 400014China China International Science and Technology Cooperation Base of Child Development and Critical Disorders Jiangxi Hospital Affiliated Children's Hospital of Chongqing Medical UniversityJiangxi 330000China National Clinical Research Center for Child Health and Disorders China

Bone defects and non-union are prevalent in clinical orthopedy,and the outcomes of current treatments are often *** tissue engineering offers a promising approach to treating these conditions *** morphogenetic protein 9(BMP9)can commit mesenchymal stem cells to osteogenic lineage,and a knowledge of the underlying mechanisms may help advance the field of bone tissue ***-rich repeats con-taining G protein-coupled receptor 4(lGR4),a member of G protein-coupled receptors,is essential for modulating bone *** study is aimed at investigating the impact of lGR4 on BMP9-induced osteogenesis in mesenchymal stem cells as well as the underlying *** marrow stromal cells from BMp9-knockout mice exhibited diminished lGR4 expression,and exogenous lGR4 clearly restored the impaired osteogenic potency of the bone marrow stromal ***,lGR4 expression was increased by BMP9 in C3H10T1/2 ***4 augmented the benefits of BMP9-induced osteogenic markers and bone formation,whereas lGR4 inhibition restricted these ***,the BMP9-induced li-pogenic markers were increased by lGR4 *** protein levels of Raptor and p-Stat3 were elevated by *** knockdown or p-Stat3 suppression attenuated the osteoblastic markers and lGR4 expression brought on by ***4 significantly reversed the blocking ef-fect of Raptor knockdown or p-Stat3 suppression on the BMP9-induced osteoblastic *** interacts with p-Stat3,and p-Stat3 activates the lGR4 promoter *** conclusion,lGR4 boosts BMP9 osteoblastic potency in mesenchymal stem cells,and BMP9 may up-regulate lGR4 via the mTORC1/Stat3 signal activation.

关键词： BMP9 lGR4 mTORC1 Osteogenic differentiation Stat3

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一种内离子源惯性静电约束聚变技术

南方能源建设 2024年第3期11卷 47-55页

作者：李金海东华理工大学核应用技术研究所江西南昌344000

[目的]惯性静电约束聚变是一种小型聚变装置。文章目的是要解决惯性静电约束聚变装置目前存在阴极熔化和Q值低等问题。[方法]首先分析了产生这些问题的原因,然后提出一种内离子源惯性静电约束聚变技术,以便降低离子在约束过程中的损失,... 详细信息

[目的]惯性静电约束聚变是一种小型聚变装置。文章目的是要解决惯性静电约束聚变装置目前存在阴极熔化和Q值低等问题。[方法]首先分析了产生这些问题的原因,然后提出一种内离子源惯性静电约束聚变技术,以便降低离子在约束过程中的损失,解决阴极熔化问题,同时提高装置内的真空度,以及提高装置的Q值。[结果]最后通过估算的方法定性分析了中子产额的提高,并通过数值仿真模拟计算,模拟了内离子源惯性静电约束聚变装置内的非常复杂的离子运动情况,得到了各向异性的离子运动轨迹。[结论]根据估算和数值模拟计算结果,确证了内离子源惯性静电约束聚变技术的可行性,可以解决阴极熔化和Q值低的问题。

关键词： Q值惯性静电约束聚变中子源内离子源仿真

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Erratum to:Detecting gravitational wave with an interferometric seismometer array on lunar nearside[***.66,109513(2023)]

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 182-183页

作者： Junlang li Fangfei liu Yuan Pan Zijian Wang Mengdi Cao Mengyao Wang Fan Zhang jinhai Zhang Zong-Hong Zhu Department of Astronomy Beijing Normal UniversityBeijing 100875China Advanced Institute of Natural Sciences Beijing Normal University at ZhuhaiZhuhai 519087China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Engineering laboratory for Deep Resources Equipment and Technology Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China

This paper"Detecting gravitational wave with an interferometric seismometer array on lunar nearside"[1]was published in SCIENCE CHINA Physics,Mechanics&Astronomy(66,109513(2023),doi:10.1007/s11433-023-2179-9).Due to an oversight on our part,some errors were made in the originally published *** apologize for these errors and offer the corresponding explanations and corrections for the readers.

关键词： gravitational seism wave

Return to the Moon:New perspectives on lunar exploration

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Science Bulletin 2024年第13期69卷 2136-2148页

作者： Yangting lin Wei Yang Hui Zhang Hejiu Hui Sen Hu long Xiao Jianzhong liu Zhiyong Xiao Zongyu Yue jinhai Zhang Yang liu Jing Yang Honglei lin Aicheng Zhang Dijun Guo Sheng Gou lin Xu Yuyang He Xianguo Zhang liping Qin Zongcheng ling Xiongyao li Aimin Du Huaiyu He Peng Zhang Jinbin Cao Xianhua li Key laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China State Key laboratory for Mineral Deposits Research and School of Earth Sciences and Engineering Nanjing UniversityNanjing 210023China State Key laboratory of Geological Processes and Mineral Resources School of Earth SciencesChina University of GeosciencesWuhan 430074China Institute of Geochemistry Chinese Academy of SciencesGuiyang 550002China Planetary Environmental and Astrobiological Research laboratory School of Atmospheric SciencesSun Yat-sen UniversityZhuhai 519082China National Space Science Center Chinese Academy of SciencesBeijing 100190China Deep Space Exploration laboratory/CAS Key laboratory of Crust-Mantle Materials and Environments University of Science and Technology of ChinaHefei 230026China Shandong Key laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space SciencesShandong UniversityWeihai 264209China Technology and Engineering Center for Space Utilization Chinese Academy of SciencesBeijing 100094China School of Space and Environment Beihang UniversityBeijing 100191China

lunar exploration is deemed crucial for uncovering the origins of the Earth-Moon system and is the first step for advancing humanity’s exploration of deep *** the past decade,the Chinese lunar Exploration Program(ClEP),also known as the Chang’e(CE)Project,has achieved remarkable *** has successfully developed and demonstrated the engineering capability required to reach and return from the lunar ***,the CE Project has made historic firsts with the landing and on-site exploration of the far side of the Moon,along with the collection of the youngest volcanic samples from the Procellarum KREEP *** achievements have significantly enhanced our understanding of lunar *** on this success,China has proposed an ambitious crewed lunar exploration strategy,aiming to return to the Moon for scientific exploration and *** plan encompasses two primary phases:the first crewed lunar landing and exploration,followed by a thousand-kilometer scale scientific expedition to construct a geological cross-section across the lunar *** the limitations of current lunar exploration efforts and China’s engineering and technical capabilities,this paper explores the benefits of crewed lunar exploration while leveraging synergies with robotic *** study refines fundamental lunar scientific questions that could lead to significant breakthroughs,considering the respective engineering and technological *** research lays a crucial foundation for defining the objectives of future lunar exploration,emphasizing the importance of crewed missions and offering insights into potential advancements in lunar science.

关键词： Crewed lunar exploration Water and volatiles Composition and structure of lunar interior Volcanic activity and evolution of lunar mantle Space weathering and radiation environments Exploration technology

Generation of Eco-Friendly and Disease-Resistant Channel Catfish(Ictalurus punctatus)Harboring the Alligator Cathelicidin Gene via CRISPR/Cas9 Engineering

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Engineering 2024年第8期39卷 273-286页

作者： jinhai Wang Baofeng Su De Xing Timothy J.Bruce Shangjia li logan Bern Mei Shang Andrew Johnson Rhoda Mae C.Simora Michael Coogan Darshika U.Hettiarachchi Wenwen Wang Tasnuba Hasin Jacob Al-Armanazi Cuiyu lu Rex A.Dunham School of Fisheries Aquacultureand Aquatic SciencesAuburn UniversityAuburnAL 36849USA

As a precise and versatile tool for genome manipulation,the clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)platform holds promise for modifying fish traits of *** the aim of reducing transgene introgression and controlling reproduction,upscaled disease resistance and reproductive intervention in catfish species have been studied to lower the potential environmental risks of the introgression of escapees as transgenic *** advantage of the CRISPR/Cas9-mediated system,we succeeded in integrating the cathelicidin gene(As-Cath)from an alligator(Alligator sinensis)into the target luteinizing hormone(lh)locus of channel catfish(Ictalurus punctatus)using two delivery systems assisted by double-stranded DNA(dsDNA)and single-stranded oligodeoxynucleotides(ssODNs),*** this study,high knock in(KI)efficiency(22.38%,64/286)but low ontarget events was achieved using the ssODN strategy,whereas adopting a dsDNA as the donor template led to an efficient on-target KI(10.80%,23/213).The on-target KI of As-Cath was instrumental in establishing the lh knockout(lH^(–)_As-Cath^(+))catfish line,which displayed heightened disease resistance and reduced fecundity compared with the wild-type(WT)sibling ***,administration of human chorionic gonadotropin(HCG)and luteinizing hormone-releasing hormone analogue(lHRHa)can restore the reproduction of the transgenic fish ***,we replaced the lh gene with an alligator cathelicidin transgene and then administered hormone therapy to move towards complete reproductive control of diseaseresistant transgenic catfish in an environmentally responsible *** strategy not only effectively improves consumer-valued traits but also guards against unwanted introgression,providing a breakthrough in aquaculture genetics to confine fish reproduction and prevent the establishment of transgenic or domestic genotypes in the natural environment.

关键词： Genome editing ssODN dsDNA Antimicrobial peptide Reproductive confinement Aquaculture

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知识空间理论综述

模式识别与人工智能 2024年第2期37卷 106-127页

作者：李金海张瑞智慧来孙文昆明理工大学数据科学研究中心昆明650500 昆明理工大学理学院昆明650500 泉州师范学院数学与计算机科学学院泉州362000 闽南师范大学数学与统计学院漳州363000

知识空间理论是一种研究教育规律的科学方法,已取得一系列研究成果.文中旨在全面综述知识空间理论的研究工作.首先,阐述构建知识结构的方法和原则,介绍良级性的研究内容,并强调其在知识空间理论研究中的重要性,归纳总结推测关系的相关工... 详细信息

知识空间理论是一种研究教育规律的科学方法,已取得一系列研究成果.文中旨在全面综述知识空间理论的研究工作.首先,阐述构建知识结构的方法和原则,介绍良级性的研究内容,并强调其在知识空间理论研究中的重要性,归纳总结推测关系的相关工作,并介绍问题之间、项目之间推测关系的研究方法.然后,分别从技能映射、技能函数、能力-绩效方法三方面梳理基于能力的知识空间理论的研究进展.进一步地,概述知识空间理论与概率模型、粒计算等结合的研究现状,并介绍知识空间理论在辅助学习与自适应测试方面的应用.最后,探讨上述研究中存在的关键科学问题,并提出初步的研究思路,为该领域的后续研究提供有益的参考.

关键词：知识空间理论知识结构技能映射良级性推测关系形式概念分析

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