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Two-dimensional thermoelasticity solution for functionally graded thick beams

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Science China(Physics,Mechanics & Astronomy) 2006年第4期49卷 451-460页

作者： lü chaofeng1, chen weiqiu1 & zhong zheng2.1. department of civil engineering, {2. University,{3., China 2. Key laboratory of Solid Mechanics of Ministry of Education, School of Aerospace engineering and Ap- plied Mechanics, Tongji University, Shanghai 2.0092. China department of civil {2. Zhejiang University Hangzhou 310027 China Key laboratory of Solid Mechanics of Ministry of Education School of Aerospace Engineering Applied Mechanics Tongji University Shanghai 200092 China

Two-dimensional thermoelasticity analysis of functionally graded thick beams is presented using the state space method coupled with the technique of differential quadrature. Material properties vary continuously and smoothly through the beam thickness, leading to variable coefficients in the state equation derived from the elasticity equations. Approximate laminate model is employed to translate the state equation into the one with constant coefficients in each layer. To avoid numerical instability, joint coupling matrices are introduced according to the continuity conditions at interfaces in the approximate model. The differential quadrature procedure is applied to discretizing the beam in the axial direction to make easy the treatment of arbitrary end conditions. A simply-supported beam with exponentially varying material properties is considered to validate the present method. Numerical examples are performed to investigate the influences of relative parameters.

关键词： state equation differential quadrature approximate laminate model joint coupling matrices thermal stresses.

Potential transformation of organic matter by microbes in cryoconite,Tibetan Plateau

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Science China Earth Sciences 2024年第6期67卷 1978-1989页

作者： Bixi GUO Yongqin lIU Kevin Xu zhong Quan SHI chen HE Qiang {2. Ruanhong CAI State Key laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Center for the Pan-Third Pole Environment Lanzhou UniversityLanzhou 730000China department of Earth Oceanand Atmospheric SciencesUniversity of British ColumbiaVancouverBC V6T 1Z4Canada State Key laboratory of Heavy Oil Processing Petroleum Molecules Engineering Center(PMEC)China University of PetroleumBeijing 102249China State Key laboratory for Marine Environmental Science Collage of Ocean and Earth SciencesXiamen UniversityXiamen 361102China Fujian Key laboratory of Marine Carbon Sequestration Xiamen UniversityXiamen 361005China

Microorganisms play an essential role in the glacier carbon cycle;how they transform organic matter in mountain glacial cryoconite remains to be ***,we applied ultra-high resolution Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR MS)and deep sequencing of 16S rRNA gene,to investigate the temporal microbial transformation of dissolved organic matter(DOM)of the Tibetan Plateau *** the 60-day incubation,we found that DOM in cryoconite underwent a three-stage transformation,with decreasing bioavailability over *** microbial community did not change much in the first week while degrading DOM molecules that were associated with higher H/C_(wa)and lower O/C_(wa).During days 15-3.,DOM composition remained stable while microbial diversity *** day 60,the DOM was microbially converted into a higher state of recalcitrance,with higher values of aromatic index,O/C_(wa),and lower H/C_(wa),which contained molecules containing more *** among various microbial taxa,like Cyanobacteria,Bacteroidota,Gammaproteobacteria,Firmicutes,and Actinobacteriota,drove the DOM transformation in *** study sheds light on the in-situ transformation of DOM composition meditated by microbial populations in cryoconite at a temporal scale,providing new insights into understanding the microbial roles in the glacier organic carbon transformation.

关键词： Cryoconite Dissolved organic matter Biodegradation Microbial community Temporal variation

Basic Survey Scheduling for the Wide Field Survey Telescope(WFST)

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Research in Astronomy and Astrophysics 2024年第1期24卷 59-69页

作者： Yan-Peng chen Ji-An Jiang Wen-Tao luo Xian-zhong {2. Min Fang Chao Yang Yuan-Yu Hong Zong-Fei lü Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China department of Astronomy University of Science and Technology of ChinaHefei 230026China National Astronomical Observatory of Japan National Institutes of Natural Sciences2-21-1 OsawaMitakaTokyo 181-8588Japan Institute of Deep Space Sciences Deep Space Exploration LaboratoryHefei 230026China

Aiming at improving the survey efficiency of the Wide Field Survey Telescope, we have developed a basic scheduling strategy that takes into account the telescope characteristics, observing conditions, and weather conditions at the lenghu site. The sky area is divided into rectangular regions, referred to as “tiles,” with a size of2.. 577 × 2.. 63. slightly smaller than the focal area of the mosaic CCDs. These tiles are continuously filled in annulars parallel to the equator. The brightness of the sky background, which varies with the moon phase and distance from the moon, plays a significant role in determining the accessible survey fields. Approximately 50connected tiles are grouped into one block for observation. To optimize the survey schedule, we perform simulations by taking into account the length of exposures, data readout, telescope slewing, and all relevant observing conditions. We utilize the Greedy Algorithm for scheduling optimization. Additionally, we propose a dedicated dithering pattern to cover the gaps between CCDs and the four corners of the mosaic CCD array, which are located outside of the 3. field of view. This dithering pattern helps to achieve relatively uniform exposure maps for the final survey outputs.

关键词： telescopes surveys Moon

HSP110 aggravates ischemia-reperfusion injury after liver transplantation by promoting NF-κB pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 344-352页

作者： Qing-Zhi Hu Zhen-Rui Cao Wei-Xiong zheng Min-Jie Zhao Jun-Hua Gong Cong chen {2.-Jun Wu Rui Tao department of Hepatobiliary Surgery Bishan Hospital of Chongqing Medical UniversityChongqing 402760China department of Cardiothoracic Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China c department of Hepatobiliary Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China department of Hepatobiliary Surgery the Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

Background:Ischemia-reperfusion injury(IRI)poses a significant challenge to liver transplantation(lT).The underlying mechanism primarily involves overactivation of the immune *** shock protein 110(HSP110)functions as a molecular chaperone that helps stabilize protein ***:An IRI model was established by performing lT on Sprague-Dawley rats,and HSP110 was silenced using ***-eosin staining,TUNEl,immunohistochemistry,ElISA and liver enzyme analysis were performed to assess IRI following *** blotting and quantitative reverse transcription-polymerase chain reaction were conducted to investigate the pertinent molecular ***:Our findings revealed a significant increase in the expression of HSP110 at both the mRNA and protein levels in the rat liver following lT(P110,IRI subsequent to lT was notably reduced(Plly,the levels of liver enzymes and inflammatory chemokines in rat serum were significantly reduced(Plencing HSP110 with siRNA resulted in a marked decrease in M1-type polarization of Kupffer cells in the liver and downregulated the NF-κB pathway in the liver(Plusions:HSP110 in the liver promotes IRI after lT in rats by activating the NF-κB pathway and inducing M1-type polarization of Kupffer *** HSP110 to prevent IRI after lT may represent a promising new approach for the treatment of lT-associated IRI.

关键词： Ischemia-reperfusion injury liver transplantation Inflammation HSP110 Heat shock proteins NF-κB

Shared diagnostic genes and potential mechanisms between COVID-19 and sepsis revealed by bioinformatics analysis

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World Journal of Emergency Medicine 2024年第5期15卷 410-412页

作者： Weifei Wang zhong chen Wenyuan Zhang Yuan lin Yaqi Sun Qi Yao Jian lu Jungang {2. department of Gerontology the First Affi liated Hospital of Ningbo UniversityNingbo 315010China department of Anesthesiology Beilun District People’s HospitalNingbo 315800China Meigu County People’s Hospital Meigu 616450China National Clinical Research Center for Child Health Children’s HospitalZhejiang University School of MedicineHangzhou 310052China department of Anesthesiology the First Affi liated Hospital of Ningbo UniversityNingbo 315010China department of Ultrasound in Medicine the First Affi liated Hospital of Ningbo UniversityNingbo 315010China The First People’s Hospital of Yuexi County Yuexi 616650China zhejiang University School of Medicine Hangzhou 310058China

The coronavirus disease 2.19(COVID-19)pandemic,triggered by the novel coronavirus severe acute respiratory syndrome coronavirus 2.SARS-CoV-2.,has ravaged the globe,resulting in a staggering loss of life and wreaking havoc on the worldwide economy.[1,2.Sepsis is a cascade of abnormal responses provoked by infection,leading to a critical deterioration in organ function that poses a life-threatening risk.[3.However,it is unclear from published reports whether COVID-19 and sepsis are commonly aff ected by molecular ***,we performed a bioinformatics analysis to uncover shared diagnostic genes and potential mechanisms between COVID-19 and sepsis.

关键词： sepsis acute respiratory

Click-hydrogel delivered aggregation-induced emissive nanovesicles for simultaneous remodeling and antibiosis of deep burn wounds

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Aggregate

Aggregate 2024年第1期5卷 244-256页

作者： Xu chen Meijiao Zhao Qihu Xie Sitong Zhou Xiaoping zhong Judun {2. Ronghua Yang Xianjin Du Jinyu Xia Yuhui liao department of Infectious Diseases The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhaiChina Molecular Diagnosis and Treatment Center for Infectious Diseases Dermatology HospitalSouthern Medical UniversityGuangzhouChina department of Burns and Plastic Surgery The Second Affiliated Hospital of Shantou University Medical CollegeShantouChina department of Dermatology TheFirst People’s Hospital of FoshanFoshanChina department of Burn and Plastic Surgery Guangzhou First People’s HospitalSouth China University of TechnologyGuangzhouChina department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhanChina

As a high-risk trauma,deep burns are always hindered in their repair process by decreased tissue regeneration capacity and persistent *** this study,we developed a simultaneous strategy for deep burn wounds treatment using functional nanovesicles with antibacterial and tissue remodeling properties,delivered via a click-chemistry *** aggregation-induced emission photosensitizer of 4-(2.(5-(4-(diphenylamino)phenyl)thiophen-2.yl)vinyl)-1-(2.hydroxyethyl)pyridin-1-ium bromide(THB)with excellent photodynamic properties was first prepared,and then combined with readily accessible adipose stem cells-derived nanovesicles to generate the THB functionalized nanovesicles(THB@ANVs).The THB@ANVs showed strong antibacterial activity against Gram-positive bacteria(up to 100%killing rate),and also beneficial effects on tissue remodeling,including promoting cell migration,cell proliferation,and regulating *** addition,we prepared a click-hydrogel of carboxymethyl chitosan for effective delivery of THB@ANVs on *** hydrogel could be injected to conform to the wound morphology while responding to the acidic *** vivo evaluations of wound healing revealed that the THB@ANVs hydrogel dressing efficiently accelerated the healing of second-degree burn wounds by reducing bacterial growth,regulating inflammation,promoting early angiogenesis,and collagen *** study provides a promising candidate of wound dressing with diverse functions for deep burn wound repair.

关键词： aggregation-induced emission burn wounds nanovesicles

Gas exchange optimization in aircraft engines using sustainable aviation fuel:A design of experiment and genetic algorithm approach

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Energy and AI

Energy and AI 2024年第3期17卷 261-280页

作者： zheng Xu Jinze Pei Shuiting Ding longfei chen Shuai Zhao Xiaowei Shen Kun Zhu longtao Shao Zhiming {2. Huansong Yan Farong Du Xueyu li Pengfei Yang Shenghui {2. Yu Zhou hangzhou International Innovation Institute Beihang UniversityHangzhou311115China Research Institute of Aero-Engine Beihang UniversityBeijing102206China civil Aviation University of China Tianjin300300China Aircraft/Engine Integrated System Safety Beijing Key laboratory Beijing100083China Aero Engine Academy of China Beijing101304China School of Energy and Power engineering Beihang UniversityBeijing100083China AVIC chengdu Aircraft Design and Research Institute Chengdu610091China AVIC Nanjing engineering Institute of Aircraft Systems Nanjing211106China School of Transportation Science and engineering Beihang UniversityBeijing100083China Faculty of Science and engineering University of Nottingham Ningbo ChinaNingbo315100China

The poppet valves two-stroke(PV2.)aircraft engine fueled with sustainable aviation fuel is a promising option for general aviation and unmanned aerial vehicle propulsion due to its high power-to-weight ratio,uniform torque output,and flexible valve ***,its high-altitude gas exchange performance remains unexplored,presenting new opportunities for optimization through artificial intelligence(AI)*** study uses validated 1D+3. models to evaluate the high-altitude gas exchange performance of PV2. aircraft *** valve timings of the PV2. engine exhibit considerable flexibility,thus the latin hypercube design of experiments(DoE)methodology is employed to fit a response surface model.A genetic algorithm(GA)is applied to iteratively optimize valve timings for varying *** optimization process reveals that increasing the intake duration while decreasing the exhaust duration and valve overlap angles can significantly enhance high-altitude gas exchange *** optimal valve overlap angle emerged as 93.CA at sea level and 82.CA at 4000 m *** effects of operating parameters,including engine speed,load,and exhaust back pressure,on the gas exchange process at varying altitudes are further *** higher engine speed increases trapping efficiency but decreases the delivery ratio and charging efficiency at various *** effect is especially pronounced at elevated *** increase in exhaust back pressure will significantly reduce the delivery ratio and increase the trapping *** study demonstrates that integrating DoE with AI algorithms can enhance the high-altitude performance of aircraft engines,serving as a valuable reference for further optimization efforts.

关键词： Poppet valves two-stroke Design of experiment Genetic algorithm optimization Heavy fuel aircraft engine High altitude gas exchange performance

Determination of ocean tide loading displacements in Hong Kong using GPS technique

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Science China Earth Sciences 2010年第7期53卷 993-1007页

作者： YUAN linGuo1,3. DING Xiaoli1, SUN HePing2. zhong Ping1,3.& chen Wu1 1 {2. of land Surveying and Geo-Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China 2.Key laboratory of Dynamic Geodesy, Institute of Geodesy and Geophysics, Chinese Academy of Sciences, Wuhan 43.077, China 3.{2. of Surveying engineering, School of civil engineering, Southwest Jiaotong University, chengdu 61003., China 1. department of land Surveying and Geo-Informatics The Hong Kong Polytechnic University Kowloon Hong Kong China3. Department of Surveying Engineering School of Civil Engineering Southwest Jiaotong University Chengdu 610031 China2. Key Laboratory of Dynamic Geodesy Institute of Geodesy and Geophysics Chinese Academy of Sciences Wuhan 430077 China

Ocean tide loading (OTl) displacements of eight principal constituents at 12.sites in Hong Kong were determined using more than eight years of continuous GPS observations. Parameters of the OTl displacements were estimated using daily GPS solutions obtained with precise point positioning (PPP) technique. The results were compared with predictions from seven latest global ocean tide models. Gravity measurements of OTl in Hong Kong were also used to validate the GPS results. The study shows that the results from both the GPS and gravity measurements agree best with the GOT4.7 and NAO99b models, when the K1 and K2.constituents are excluded. The agreements between the GPS and the model estimates are generally at sub-millimeter level in both the horizontal and vertical directions, except for S2. K2.and K1 constituents that have relatively larger errors. After removing the systematic biases between the GPS and the model estimates, the misfits of M2. S2. N2. O1, P1 and Q1 at all sites are within 0.5 and 1.0 mm in the horizontal and the vertical directions, respectively, whereas K1 and K2.show relatively larger misfits of up to 2.3.mm. Both the GPS and the gravity S2.estimates have large biases with unknown reasons when compared with the modeled values, which needs to be further investigated. The study demonstrates that GPS is capable of estimating the OTl displacements with the same accuracy as the model predictions, especially for coastal areas.

关键词： GPS ocean tide loading ocean tide model site displacement

High Hydrostatic Pressure Exacerbates Bladder Fibrosis through Activating Piezo1

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Current Medical Science 2024年第4期44卷 718-725页

作者： Bo-lang DENG Dong-xu lIN Zhi-peng lI Kang lI Peng-yu WEI Chang-cheng lUO Meng-yang ZHANG Quan ZHOU zheng-long YANG {2. chen department and Institute of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China department of Rehabilitation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Mechanical Science and engineering Huazhong University of Science and TechnologyWuhan 430074China

Objective Bladder outlet obstruction(BOO)results in significant fibrosis in the chronic stage and elevated bladder ***1 is a type of mechanosensitive(MS)channel that directly responds to mechanical *** identify new targets for intervention in the treatment of BOO-induced fibrosis,this study investigated the impact of high hydrostatic pressure(HHP)on Piezo1 activity and the progression of bladder *** Immunofluorescence staining was conducted to assess the protein abundance of Piezo1 in fibroblasts from obstructed rat *** fibroblasts were cultured under normal atmospheric conditions(0 cmH_(2.O)or exposed to HHP(50 cmH_(2.O or 100 cmH_(2.O).Agonists or inhibitors of Piezo1,YAP1,and ROCK1 were used to determine the underlying *** The Piezo1 protein levels in fibroblasts from the obstructed bladder exhibited an elevation compared to the control *** significantly promoted the expression of various pro-fibrotic factors and induced proliferation of ***,the protein expression levels of Piezo1,YAP1,ROCK1 were elevated,and calcium influx was increased as the pressure *** effects were attenuated by the Piezo1 inhibitor *** Piezo1 activator Yoda1 induced the expression of pro-fibrotic factors and the proliferation of fibroblasts,and elevated the protein levels of YAP1 and ROCK1 under normal atmospheric conditions in ***,these effects could be partially inhibited by YAP1 or ROCK inhibitors.

关键词： high hydrostatic pressure bladder outlet obstruction fibrosis Piezo1