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long-term outcomes of hepatocellular carcinoma that underwent chemoembolization for bridging or downstaging

World Journal of Gastroenterology 2019年第37期25卷 5687-5701页

作者： Breno Boueri Affonso Francisco leonardo Galastri Joaquim Mauricio da Motta leal Filho Felipe Nasser Priscila Mina Falsarella Rafael noronha Cavalcante Marcio Dias de Almeida Guilherme Eduardo Goncalves Felga leonardo Guedes Moreira Valle Nelson Wolosker department of Interventional Radiology Hospital Israelita Albert EinsteinSao Paulo 05651-901Sao PauloBrazil department of liver Transplant Hospital Israelita Albert EinsteinSao Paulo 05651-901Sao PauloBrazil department of Vascular Surgery Hospital Israelita Albert EinsteinSao Paulo 05651-901Sao PauloBrazil

BACKGROUND Prospective study of 200 patients with hepatocellular carcinoma(HCC)that underwent liver transplant(lT)after drug-eluting beads transarterial chemoembolization(deB-TACE)for downstaging versus *** survival and tumor recurrence rates were calculated,eligibility for lT,time on the waiting list and radiological response were *** TACE,only patients within Milan Criteria(MC)were *** patients underwent lT in bridging ***-year post-transplant overall survival,recurrence-free survival has no difference between the *** response was observed more frequently in bridging *** in DS group can achieve posttransplant survival and HCC recurrence-free probability,at five years,just like patients within MC in patients undergoing *** To determine long-term outcomes of patients with HCC that underwent lT after deB-TACE for downstaging vs *** Prospective cohort study of 200 patients included from April 2011 through June *** group included patients within *** group(out of MC)was divided in 5 subgroups(G1 to G5).Total tumor diameter was≤8 cm for G1,2,3,4(n=42)and was>8 cm for G5(n=22).Downstaging(n=64)and bridging(n=136)populations were not significantly *** survival and tumor recurrence rates were calculated by the Kaplan-Meier ***,eligibility for lT,time on the waiting list until lT and radiological response were *** After TACE,only patients within MC were *** patients underwent lT in bridging group 65.9%(P=0.001).Downstaging population presented:higher number of nodules 2.81(P=0.001);larger total tumor diameter 8.09(P=0.001);multifocal HCC 78%(P=0.001);more post-transplantation recurrence 25%(P=0.02).Patients with maximal tumor diameter up to 7.05 cm were more likely to receive lT(P=0.005).Median time on the waiting list was significantly longer in downstaging group 10.6 mo(P=0.028).Five-year posttransplant over

关键词： Hepatocellular carcinoma Down-staging liver transplantation localregional therapy Bridging

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Effects on Cell Viability and on Apoptosis in Tumoral(MCF-7)and in Normal(MCF10A)Epithelial Breast Cells after Human Chorionic Gonadotropin and derivated-Angiotensin Peptides Treatments

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Journal of Cancer Therapy 2013年第7期4卷 65-69页

作者： Silvana Aparecida Alves Correa de noronha Werica Bernardo Alexandre Jesus Barros Clovis Ryuichi Nakaie Suma Imura Shimuta Ismael Dale Cotrim Guerreiro da Silva Samuel Marcos Ribeiro de noronha laboratorio de Cirurgia Translacional Departamento de CirurgiaUniversidade Federal De Sao Paulo/Escola Paulista De MedicinaSao PauloBrazil laboratorio de Ginecologia Molecular Universidade Federal de Sao PauloSao PauloBrazil departamento de Biofísica Universidade Federal de Sao PauloSao PauloBrazil

Angiotensin-(1 - 7) [Ang-(1 - 7)] is an endogenous heptapeptide hormone of the renin-angiotensin system that has antiproliferative properties. The aim of this work was to evaluate the anti-proliferative and pro-apoptotic properties of Ang-(1 - 7) and of Ang-(1 - 7)-substituents 9-fluorenylmethyloxycarbonyl (Fmoc) e Ang II-derivatives containing the TOAC (2,2,6,6-tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid) in normal (MCF10A) and in tumoral (MCF7) epithelial mammary cell lines. Both cell lines received an hCG and angiotensin peptides 24-hour treatment, in combination or alone followed by cell viability, apoptosis and cell cycle assays performed by flow cytometer (GUAVA). After hCG, Ang-(1 - 7), hCG + Ang-(1 - 7) and hCG + Ang-(1 - 7)-Fmoc treatments, MCF7 displayed cell viability decrease and mid-apoptosis increase. We also observed cell viability decrease in MCF10A after Ang-(1 - 7), Ang-(1 - 7) Fmoc and hCG + AngII Toac treatments. These cells had an increase in late apoptosis and necrosis after AngII Toac, hCG + Ang-(1 - 7) and hCG + Ang-(1 - 7)-Fmoc treatments. Regarding the cell cycle analysis, we did not observed any changes in cell cycle phases. In summary, cell viability was decreased and apoptosis (initial, mid and late) was increased after hCG and/or Ang-(1 - 7) peptides treatments. These results point out hCG and Ang-(1 - 7) as effective compounds to inhibit cell proliferation, since they decrease cell viability and increase apoptosis in both normal and in tumoral breast cells, being the effect more pronounced in the tumoral cell line. Our results support the idea of investigating more closely the putative use of these compounds as novel therapeutic agents for breast cancer.

关键词： Angiotensin II Angiotensin 1-7 Angiotensin II Type 1 Receptor(AT1R) Breast Cancer Apoptosis Human Chorionic Gonadotropin

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Plasma levels of Angiotensin-Converting Enzymes 1 and 2 and <i>AGTR</i>2 (T1247G and A5235G) Gene Polymorphisms Are Associated to Breast Cancer Progression

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Journal of Cancer Therapy 2013年第9期4卷 1403-1410页

作者： Maria del Carmen Garcia Molina Wolgien Ismael Dale Cotrim Guerreiro da Silva Afonso Celso Pinto Nazário Clovis Riyuchi Nakaie Silvana Aparecida Alves Corrêa de noronha Samuel Marcos Ribeiro de noronha Gil Facina Biophisics department Escola Paulista de Medicina da Universidade Federal de Sao Paulo (EPM-UNIFESP) Sao Paulo Brazil Gynecology department Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM-UNIFESP) Sao Paulo Brazil Surgery department Escola Paulista de Medicina/Universidade Federal de Sao Paulo (EPM-UNIFESP) Sao Paulo Brazil

Background: Breast cancer is the most common type of cancer among women. Diagnosed and treated timely, patients may have good prognostics. In Brazil, in 2012, the estimate of new cases was 52,680 and the number of registered deaths in 2012 was 12,852. The Renin-Angiotensin System (RAS) is known for its role in arterial hypertension and in other cardiovascular diseases. Angiotensin-Converting Enzyme 2 (ACE2) is the key to Ang-(1-7) formation, and counterbalances the ACE1/AngII/AGTR1 axis actions. RAS components have complex interactions with different tissues and their actions are not restricted to the cardiovascular system. Recently, the RAS has been associated with different types of cancers and in particular with gynecological cancers. Objectives: Our aim is to investigate possible associations between allelic distribution of two genetic polymorphisms in the AGTR2 receptor with ACEs 1 and 2 plasma levels among women with breast cancer. Patients and Methods: Patients with breast cancer were genotyped for two polymorphisms of the AGTR2 (T1247G and A5235G). Genotyping assays (TaqMan) were performed with genomic DNA extracted from blood cells. ACEs plasma level measurements were conducted in women from the breast-cancer group (N = 53). ACEs were measured in the plasma of these patients using ElISA kits. Results: SNPs genotype distribution is correlated with ACEs plasma levels. ACEs plasma levels are also correlated with clinical variables and ACE2 high levels are associated with better prognostics. Conclusions: Changes in circulating levels of ECA1/AngII ECA2/ Ang-(1-7) determine the magnitude of the inflammatory response that an individual can trigger and the variation in ACE 1 and 2 plasma level measurements in the blood of breast cancer patients suggests an association with the process of mammary carcinogenesis. Thus, the RAS may be associated with the process of mammary carcinogenesis by both genotypic variations of RAS components and by circulating levels of ACEs

关键词： Angiotensin-Converting Enzyme 1 Angiotensin-Converting Enzyme 2 Angiotensin II Type 2 Receptor Breast Neoplasm ACEs Plasma level Genetic Polymorphisms

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The Poetics of 'Videopoetry' and Video blogs

The Poetics of 'Videopoetry' and Video blogs

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2012 International Conference on language,Medias and Culture（IClMC 2012）

作者： Emelia noronha HSS department Indian Institute of Technology BombayMumbaiIndia. Prahladrai Dalmia lions College of Commerce and Economics MumbaiIndia.

The present paper aims to identify the elements of 'videopoetry' and classify it into *** further explores the elements that 'videopoetry' shares with video blogs.A brief analysis of a 'videopoem' and a video blog is the methodology used to come to the conclusion that images,sound,motion,special effects of sound and light,materiality and positioning of the text and other cinematographic techniques are the elements that 'videopoetry' shares with video *** short this paper is an attempt to define the poetics of 'videopoetry',the digital avatar of multimedia poetry and video blogs.

关键词： video poem,video blogs,poetics,videopoetry

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Efficacy assessment of peracetic acid in the removal of synthetic 17α-ethinyl estradiol contraceptive hormone in wastewater

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Journal of Environmental Sciences 2020年第3期32卷 1-8页

作者： Rita Maurício Flávia Semedo Rita Dias Joao P.noronha leonor Amaral Michiel A.Daam Antonio P.Mano Mário S.Diniz CENSE Center for Environmental and Sustainability ResearchNOVA School of Science and TechnologyNOVA University LisbonQuinta da Torre2829-516 CaparicaPortugal department of Environmental Sciences and Engineering NOVA School of Science and TechnologyNOVA University LisbonQuinta da Torre2829-516 CaparicaPortugal REQUIMTE/FCT NOVA School of Science and TechnologyNOVA University LisbonQuinta da Torre2829-516 CaparicaPortugal Biotox lab UCIBIODepartment of ChemistryNOVA School of Science and TechnologyNOVA University LisbonQuinta da Torre2829-516 CaparicaPortugal

Increasing concerns have been raised on endocrine disrupting chemicals like the sex hormone 17 a-ethinylestradiol(EE2),the more since traditional wastewater(WW) treatments appear to be ineffective for their *** efficacy of the relatively novel disinfectant peracetic acid(PAA) in EE2 removal was evaluated,as well as its potential effects on WW quality *** treatments tested for EE2 removal were also evaluated in terms of toxicity,through the determination of biochemical responses(antioxidant enzymes,lipid peroxidation and vitellogenin induction) using zebrafish(Danio rerio) as a biological *** contact times less than 20 min appeared insufficient regardless of the PAA dose tested,but a 100% EE2 removal was attained at a PAA concentration of 15 mg/l with a contact time of20 *** suspended solids,chemical oxygen demand and pH in PAA treatments remained well within levels set in European legislation for WW ***2 induced signific ant increased vitellogenin(VTG) levels in both female and male fish,indic ating increased estrogenic activity,especially in males suggesting an endocrine disruption *** the addition of PAA(15 mg/l),however,VTG levels in both sexes returned to control *** this PAA treatment showed increased levels of the antioxidant enzyme catalase,the lipid peroxidation levels were similar or even lower than in *** the results suggest that the use of PAA appears a promising way forward as a less toxic alternative to chlorine disinfection with high efficiency in the removal of EDC like EE2.

关键词： EE2 Wastewater treatment Zebrafish Biomarkers

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leptin Causes the Early Inhibition of Glycolysis-and TCA Cycle-Related Genes in the Brain of Ob/Ob Mice to Restore Fertility

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American Journal of Molecular Biology 2014年第3期4卷 105-113页

作者： Carlos Fernandes Baptista Samuel Marcos Ribeiro de noronha Maria de Nazareth Gamboa Ritto Eduardo Henrique da Silva Freitas Melquíades Pereira Júnior Mauro Abi Haidar Ismael Dale Cotrim Guerreiro da Silva Silvana Aparecida Alves Corrêa de noronha Marisa Teresinha Patriarca Gynecology department Escola Paulista de Medicina/Universidade Federal de Sao Paulo(EPM-UNIFESP)São PauloBrazil departmento de Cirurgia Geral e Especializada Universidade Federal do Rio de Janeiro(UNIRIO)Rio de JaneiroBrazil Surgery department Escola Paulista de Medicina/Universidade Federal de Sao Paulo(EPM-UNIFESP)Sao PauloBrazil departmento de Medicina Geral Universidade Federal do Rio de Janeiro(UNIRIO)Rio de JaneiroBrazil

Introduction: Polycystic ovarian syndrome (PCOS) is undoubtedly the commonest androgen disorder in woman’s fertile period and certainly one of the most prevalent causes of anovulation. The syndrome has an estimated prevalence of 4% - 10% among women of childbearing age. Previously, our group demonstrated the effect of gonadal white adipose tissue transplantation from wild-type lean and fertile female mice to isogenic obese anovulatory ob/ob mice. These complex metabolic interrelationships between obesity and PCOS have yet to be fully understood. The aim of this study was to evaluate the effect of gonadal white adipose tissue (WAT) transplantation from the wild-type lean and fertile female mice to isogenic obese, anovulatory mice (lep ob/lep ob) on the expression of glycolysis- and TCA cycle-related genes and obtain a general view of the glucose metabolism in the brain of these animals. Methods: Fifteen ob/ob mice ranging from 2 to 3 months of age were divided into 3 experimental groups: control normal weight (n = 5), obese control (n = 5) and obese 7 days leptin treated (n = 5). The whole brains of the mice were processed for RNA extraction. The samples from each group were used to perform PCR assays using an array plate containing 84 primers to study the glucose metabolism-related genes. Results: The glycolysis- and TCA cycle-related genes were significantly downregulated. The most significantly affected genes were as follows: for glycolysis (fold regulation with p ldob, andeno3 (119, 45, 18, and 28 times less, respectively);and for the TCA cycle (fold regulation with p less, respectively).Conclusion: The seven-day leptin treated mice show a decrease in the glucose metabolism. These results confirm the ability of the adipose tissue-derived hormone leptin to regulate early crucial genes that are related to glycolysis mechanisms and to the TCA cycle. This hormone seems to revert early the central phys

关键词： PCOS Obesity leptin Glycolysis TCA Cycle Gene Expression

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leptin Signaling Modulates Expression of Polycomb and Trithorax Complexes in the Brain of Fat Tissue Implanted Polycystic Ovarian Sindrome Mice

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American Journal of Molecular Biology 2014年第4期4卷 177-192页

作者： Eduardo Henrique da Silva Freitas Samuel Marcos Ribeiro de noronha Maria Nazareth Gamboa Ritto Carlos Fernandes Baptista Ismael Dale Cotrim Guerreiro da Silva Silvana Aparecida Alves Correa-noronha Ivaldo da Silva Gynecology department Federal University of Sao Paulo Paulista School of Medicine (UNIFESP-EPM) Sao Paulo Brazil General Medicine department Federal University of Rio de Janeiro State (UNIRIO) Rio de Janeiro Brazil Translacional Surgery Division Surgery Department Federal University of Sao Paulo Paulista School of Medicine (UNIFESP-EPM) Sao Paulo Brazil General and Specialized Surgery department Federal University of Rio de Janeiro State (UNIRIO) Rio de Janeiro Brazil

The Polycystic Ovary Syndrome (PCOS) is the most common androgenic disorder in women during reproductive life. PCOS may also be accompanied by metabolic syndrome and recent studies point to leptin as playing a role in disrupting infertility and in changing the energy balance in obese mice through its action on the hypothalamus. The aim is to assess the expression of the Polycomb & Trithorax Complexes genes in brain of mice transplanted with fat tissue from normal mice, in order to better understand the neuronal mechanisms underlying the reversion of PCOS. Three B6 V-lepob/J mouse groups: Normal weight, obese and seven-day-treatment obese had their brain RNA extracted and submitted to an 84 Polycomb & Trithorax Complexes genes PCR Array plate and MetacoreTM pathways localization. Genomic profiles obtained were compared to the ones of the normal-weight-mice group. Differentially expressed genes were 13% and 26% respectively to control and treatment. Major changes were in genes: Snai1/31;Smarca1/?17;Dnmt3b/4.7;Ezh1/ 15. Altered genes were associated to canonical pathways and provided 3 networks related to epigenetics. Underlying neuronal changes caused by leptin in obese mice brain, there is an important role being played by the histone code. Here there is evidence that leptin drives the chromatin packing to a more condensed pattern. Upregulation of methyltransferase genes, like Ezh1, favors this thought. In summary the Polycomb & Trithorax complexes might answer for the silencing of some downregulated genes in the obese mice brain when exposed to leptin.

关键词： Polycistic Ovarian Sindrome Obesity Polycomb and Trithorax Complexes leptin Fat Mouse

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The Optimization of Irrigation Networks Using Genetic Algorithms

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Journal of Water Resource and Protection 2014年第12期6卷 1124-1138页

作者： Francisco Fernando noronha Marcuzzo Edson Cezar Wendland department of Hydrology Applied Geological Survey of Brazil Porto Alegre Brazil department of Hydraulic School of Engineering of Sao Carlos University of Sao Paulo Sao Carlos Brazil

Mathematical-computational optimisation models of irrigation networks with a distributed flow that are capable of providing hydraulic data are important for understanding the behaviour of a system in relation to the distribution of the hydraulic head (energy) and the pressure in the pipes of the network. The objective of this study was to examine the distribution of the parameters of hydraulic irrigation pipes, which were optimised using genetic algorithms. The degree of the optimisation was evaluated with the help of the genetic algorithms based on the diameters of stretch of the network: two for the lateral lines, four for the derivation lines, four for the secondary lines and one for the main line. A Matlab code was developed that considered all of the losses of energy, both distributed losses and those at specific locations between the beginning of the network and the pump system. The sensitivity analysis was based on the variations in the slope of the ground (0%, 2.5% and 5%). The results show that for pipes with a distributed flow, the influence of the behaviour of the kinetic energy in the pipe contributed to the distance between the energy lines and the piezometric lines at the beginning of each stretch after the decrease in the diameter of the pipes. At the end of the pipes, the values of the energy lines and the piezometric lines were very similar, and they were essentially the same for the final emitter.

关键词： Conduits under Pressure Hydraulic Head Micro-Sprinkler Irrigation Mathematical Optimisation

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Angiotensin-(1-7)and Human Chorionic Gonadotropin(hCG)Modulate the Nuclear Transcription Factors or Nuclear Receptors Genes in the Tumorigenic Undifferentiated Breast Cancer Cell line SKBR3

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Journal of Cancer Therapy 2013年第7期4卷 70-74页

作者： Isidoro Binda Neto Samuel Marcos Ribeiro de noronha Silvana Aparecida Alves Correa de noronha Maria del Carmen Garcia Molina Wolgien Alexandre Jesus Barros Clovis Ryiuchi Nakaie Suma Imura Shimuta Gil Facina Ismael Dale Cotrim Guerreiro da Silva laboratorio de Ginecologia Molecular Universidade Federal de Sao PauloSao PauloBrazil Universidade Federal do Estado do Rio de Janeiro Rio de JaneiroBrazil laboratorio de Cirurgia Translacional Departamento de CirurgiaUNIFESP/EPMSao PauloBrazil departamento de Biofísica Universidade Federal de Sao PauloSao PauloBrazil

Breast cancer is the most common cancer among women. Angiotensin-(1 - 7) [Ang-(1 - 7)] has been correlated with cancer antiproliferative and apoptotic effects, similar properties of the human Chorionic Gonadotrofin (hCG). The aims of this work are to evaluate the role of Ang-(1 - 7) and of hCG in modulating the expression of Nuclear Receptors and Coregulators related genes in the tumorigenic breast cell line SK-BR3. Three experimental groups were created: control, hCG and hCG + Ang-(1 - 7). Cells were treated for 11 days and then had their RNA extracted. Samples were loaded into PCR Array plates containing 84 genes relate to Nuclear Receptors and Coregulators pathways. Gene expression data were used to construct canonical pathways (MetacoreTM). hCG and hCG + Ang-(1 - 7) treatments markedly modulate the expression of Nuclear Receptors and Coregulators related genes. hCG differentially expressed 17% of the genes, being 29% upregulated and 71% downregulated. Meanwhile, hCG + Ang-(1 - 7) changed the expression of 30% of the genes on the plate, among these genes 56% were upregulated and 44% downregulated. Among these differentially expressed genes, we highlight Esr1, Nr2f2, and Nr2f1, Esr1, Hdac5, and Nr4A1 (>4 fold). Finally MetaCore analysis based on Gene Ontology (GO) generated six networks for hCG and ten networks for the combined treatment. All generated networks are related to regulation of apoptosis or to Programmed Cell death processes. In summary, our results herein demonstrate that the modulation of sexual hormones and of other nuclear factor genes expression might underlie the tumorigenic protection effect and the induction of cell differentiation caused by the hormones hCG and Ang-(1 - 7), especially in Cancer Stem Cells.

关键词： Breast Stem Cancer Cells SK-BR3 hCG Angiotensin-(1-7)

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Systematic study of acuABC operon in Bacillus subtilis 168

Systematic study of acuABC operon in Bacillus subtilis 168

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2012 International Conference on Bioscience, Biochemistry and Bioinformatics（ICBBB 2012）

作者： Pratibha Sharma Santosh noronha department of Bioscience and Bioengineering Indian Institute of Technology BombayIndia department of Chemical Engineering Indian Institute of Technology BombayIndia

Bacillus subtilis grown in media containing glycolytic carbon sources secretes pyruvate,organic acids and *** can be reused by Bacillus when other carbon sources are exhausted from growth *** and acoABCl operons are two proposed pathways for acetoin *** the mode of involvement of acuABC is not well understood *** work presented here focuses on the comparative study of acuABC and acoABCl *** have observed an accumulation of acetoin in a 168acuA-strain upto the late stationary phase of *** expression studies in acetoin and other carbon source suggest that acuABC operon had a direct role in acetoin catabolism.

关键词： Bacillus,Acetoin,Acetoin catabolism

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