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Characterization of monocarboxylate transporter activity in hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第33期20卷 11780-11787页

作者： Venncio AF Alves Céline pinheiro Filipa Morais-santos Aloisio Felipe-Silva Adhemar longatto-Filho Fátima Baltazar laboratory of Medical Investigation (lIM) 14 Department of Pathology University of S?o Paulo School of Medicine S?oPaulo SP 1246-903 Brazil life and Health Sciences Research Institute (ICVS) School of Health Sciences University of Minho 4704-553 Braga Portugal ICVS/3B’s-PT Government Associate laboratory 4710-057 Braga/ Guimar?es Portugal Barretos School of Health Sciences Dr. Paulo Prata-FACISB Barretos S?o Paulo SP 13083-970 Brazil Molecular Oncology Research Center Barretos Cancer Hospital Barretos Sao Paulo 14780-000 Brazil Molecular Oncology Research Center Barretos Cancer Hospital Pio XII Foundation Barretos 14780-000 Brazil

AIM: To assess the immunoexpression of hypoxia-related markers in samples from cirrhosis and primary and metastatic hepatocellular carcinoma (HCC).

关键词： Hepatocellular carcinoma Monocarboxylate transporters Glycolysis Cirrhosis Glucose transporter-1

Embolization of splenorenal shunt associated to portal vein thrombosis and hepatic encephalopathy

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World Journal of Gastroenterology 2014年第42期20卷 15910-15915页

作者： letícia de Campos Franzoni Fábio Cardoso de Carvalho Rafael Gomes de Almeida Garzon Fábio da Silva Yamashiro laís Augusti lívia Alves Amaral santos Mariana de Souza Dorna Júlio pinheiro Baima Talles Bazeia lima Carlos Antonio Caramori Giovanni Faria Silva Fernando Gomes Romeiro Internal Medicine Department Gastroenterology Division Botucatu Medical School UNESP 18 618 970 Botucatu Sao Paulo Brazil Hospital do Cora??o do Instituto de Moléstias Cardiovasculares S?o José do Rio Preto Sao Paulo 15015-210 Brazil Department of Internal Medicine Division of Cardiology Botucatu School of Medicine UNESP Univ Estadual Paulista

Hepatic encephalopathy(HE)is a cognitive disturbance characterized by neuropsychiatric *** occurs in acute and chronic hepatic disease and also in patients with portosystemic *** presence of these portosystemic shunts allows the passage of nitrogenous substances from the intestines through systemic veins without liver ***,the embolization of these shunts has been performed tocontrol HE manifestations,but the presence of portal vein thrombosis is considered a *** this presentation we show a cirrhotic patient with severe HE and portal vein thrombosis who was submitted to embolization of a large portosystemic *** report:a 57 years-old cirrhotic patient who had been hospitalized many times for persistent HE and hepatic coma,even without precipitant *** had a wide portosystemic shunt and also portal vein *** abdominal angiography confirmed the splenorenal shunt and showed other *** larger shunt was embolized through placement of microcoils,and the patient had no recurrence of overt *** was a little increase of esophageal and gastric varices,but no endoscopic treatment was *** portosystemic shunts are frequent causes of recurrent HE in cirrhotic patients,portal vein thrombosis should be considered a relative contraindication to perform a shunt ***,in particular cases with many shunts and severe HE,we found that one of these shunts can be safely embolized and this procedure can be sufficient to obtain a good HE *** conclusion,we reported a case of persistent HE due to a wide portosystemic shunt associated with portal vein *** the patient had other shunts,she was successfully treated by embolization of the larger shunt.

关键词： Recurrent hepatic encephalopathy liver cirrhosis Port systemic shunt Shunt embolization Portal vein thrombosis

The Semantic Data Dictionary-An Approach for Describing and Annotating Data

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Data Intelligence 2020年第4期2卷 443-486页

作者： Sabbir M.Rashid James P.McCusker Paulo pinheiro Marcello P.Bax Henrique O.santos Jeanette A.Stingone Amar K.Das Deborah l.McGuinness Tetherless World Constellation Rensselaer Polytechnic InstituteTroy NY 12180USA School of Information Science Federal University of Minas GeraisBelo Horizonte 31270-901MGBrazil Mailman School of Public Health Columbia UniversityNew York NY 10032USA IBM Research Cambridge MA 02142USA

It is common practice for data providers to include text descriptions for each column when publishing data sets in the form of data *** these documents are useful in helping an end-user properly interpret the meaning of a column in a data set,existing data dictionaries typically are not machine-readable and do not follow a common specification *** introduce the Semantic Data Dictionary,a specification that formalizes the assignment of a semantic representation of data,enabling standardization and harmonization across diverse data *** this paper,we present our Semantic Data Dictionary work in the context of our work with biomedical data;however,the approach can and has been used in a wide range of *** rendition of data in this form helps promote improved discovery,interoperability,reuse,traceability,and *** present the associated research and describe how the Semantic Data Dictionary can help address existing limitations in the related *** discuss our approach,present an example by annotating portions of the publicly available National Health and Nutrition Examination Survey data set,present modeling challenges,and describe the use of this approach in sponsored research,including our work on a large National Institutes of Health(NIH)-funded exposure and health data portal and in the RPI-IBM collaborative Health Empowerment by Analytics,learning,and Semantics project.

关键词： Semantic Data Dictionary Dictionary mapping Codebook Knowledge modeling Data integration Data dictionary Mapping language Metadata standard Semantic Web Semantic ETl FAIR Data

Vegetation structure and edaphic factors in veredas reflect different conservation status in these threatened areas

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Forest Ecosystems 2022年第3期9卷 387-395页

作者： Yule Roberta Ferreira Nunes Camila Silveira Souza Islaine Francielly pinheiro de Azevedo Odirlei Simôes de Oliveira leidivan Almeida Frazão Rúbia santos Fonseca Rubens Manoel dos santos Walter Viana Neves Programa de Pós-Graduaçao Em Botânica Aplicada Departamento de Biologia GeralUniversidade Estadual de Montes ClarosAvenida Dr.Ruy BragaS/N-Bairro Vila MauricéiaMontes ClarosMinas Gerais39401-089Brazil laboratório de Ecologia Vegetal Universidade Estadual de Montes ClarosAvenida Dr.Ruy BragaS/N-Bairro Vila MauricéiaMontes ClarosMinas Gerais39401-089Brazil Instituto de Ciências Agrarias-Universidade Federal de Minas Gerais Avenida Universitária1.000-Bairro Universit�arioMontes ClarosMinas Gerais39404-547Brazil Departamento de Ciências Florestais Universidade Federal de LavrasCP 3037LavrasMinas Gerais37200-000Brazil Instituto Mineiro de Gestao dasÁguas Secretaria de Estado de Meio Ambiente e Desenvolvimento SustentávelAvenida JoséCorreia Machado900-Bairro IbiturunaMontes ClarosMinas Gerais39401-832Brazil

Background:In Cerrado humid areas,veredas are considered as hygrophilous communities,marked by the presence of the Mauritia flexuosa palm tree emerging in the wetter *** in veredas ecosystems due to drought and changes in the water table,which represent important areas for biodiversity maintenance in the Brazilian cerrado,can lead to the emergence of new landscapes and *** that the veredas are changed in species composition due to anthropogenic factors,in this study,we evaluated the flora composition and described the current vegetation profile of two veredas under different disturbances levels that are located in the north of Minas Gerais State,***:Altogether,2,268 individuals of 91 species belonging to 36 families were *** results demonstrated that the studied veredas were floristically different in terms of the arboreous-shrubby species composition,richness,and *** the hygrophilous forest formations and open areas in the two veredas present typical species from these environments(same species with high importance values),the drought in the water table caused an expansion of Cerrado species in the open areas and in the hygrophilous ***,in the hygrophilous forest there was an increase in the abundance of species that occur in less saturated ***:Our results demonstrate that the studied veredas are changing in species composition due to anthropogenic factors which leads to the drought of these formations(water balance effect).These anthropogenic effects cause a modification with the expansion and increase in the abundance of typical species of other areas of Cerrado and resistant to less saturated soils,leading to the veredas ***,future studies should investigate other veredas on a broader scale to detect changes in the water table that lead to a consequent change in vegetation *** this way,we will have support for the conscientious management and conservatio

关键词： Cerrado Conservation Palm swamp Plant distribution Climate change Water balance effect Vereda drought Phytosociological analysis

Al_2O_3负载Cu,Fe或Ni掺杂氧化钼催化乙苯氧化脱氢(英文)

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催化学报 2015年第5期36卷 712-720页

作者： Tiago pinheiro Braga Ant?nio Narcísio pinheiro Edson R.leite Regina Cláudia R.dos santos Antoninho Valentini lABPEMOl-laboratório de Peneiras Moleculares Institute of Chemistry Federal University of Rio Grande do Norte Department of Chemistry Federal University of S?o Carlos langmuir-laboratório de Adsor??o e Catálise Department of Analytical Chemistry and Physical Chemistry Federal University of Ceará

Molybdenum-based catalysts supported on Al_2O_3 doped with Ni, Cu, or Fe oxide were synthesized and used in ethylbenzene dehydrogenation to produce styrene. The molybdenum oxide was supported using an unconventional route that combined the polymeric precursor method(Pechini) and wet impregnation on commercial alumina. The samples were characterized by X-ray diffraction(XRD), N_2 adsorption-desorption isotherms, temperature-programmed reduction of H_2(H_2-TPR),and thermogravimetric(TG) analysis. XRD results showed that the added metals were well dispersed on the alumina support. The addition of the metal oxide(Ni, Cu, or Fe) of 2 wt% by wet impregnation did not affect the texture of the support. TPR results indicated a synergistic effect between the dopant and molybdenum oxide. The catalytic tests showed ethylbenzene conversion of 28%–53% and styrene selectivity of 94%–97%, indicating that the addition of the dopant improved the catalytic performance, which was related to the redox mechanism. Molybdenum oxides play a fundamental role in the oxidative dehydrogenation of ethylbenzene to styrene by its redox and acid–base properties. The sample containing Cu showed an atypical result with increasing conversion during the reaction, which was due to metal reduction. The Ni-containing solid exhibited the highest amount of carbon deposited, shown by TG analysis after the catalytic test, which explained its lower catalytic stability and selectivity.

关键词：氧化铝载体乙苯脱氢铁氧化物氧化脱氢钼氧化物镍掺杂氧化还原机理金属氧化物

Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress

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Hepatobiliary & Pancreatic Diseases International 2015年第2期14卷 194-200页

作者： Vinicius Rocha-santos Estela RR Figueira Joel A Rocha-Filho Ana MM Coelho Rafael Soraes pinheiro Telesforo Bacchella Marcel CC Machado luiz AC D'Albuquerque Department of Gastroenterology Laboratory of Medical Investigations LIM37 Discipline of Liver and Gastrointestinal Transplantation Hospital das Clinicas University of Sao Paulo School of Medicine Discipline of Anesthesiology Hospital das Clinicas University of Sao Paulo School of Medicine Department of Gastroenterology Laboratory of Medical Investigations LIM37 Discipline of Liver and Gastrointestina Hospital das Clinicas University of Sao Paulo School of Medicinel Transplantation

BACKGROUND：liver ischemia reperfusion（IR）injury triggers a systemic inflammatory response and is the main cause of organ dysfunction and adverse postoperative outcomes after liver ***（PTX）and hypertonic saline solution（HTS）have been identified to have beneficial effects against IR *** study aimed to investigate if the addition of PTX to HTS is superior to HTS alone for the prevention of liver IR ***： Male Wistar rats were allocated into three groups. Control rats underwent 60 minutes of partial liver ischemia, HTS rats were treated with 0.4 ml/kg of intravenous 7.5% NaCl 15 minutes before reperfusion, and HPTX group were treated with 7.5% NaC1 plus 25 mg/kg of PTX 15 minutes before reperfusion. Samples were collected after reperfusion for determination of AlT, AST, TNF-α, Il-6, Il-10, mitochondrial respiration, lipid peroxidation, pulmonary permeability and myeloperoxidase. RESUlTS： HPTX significantly decreased TNF-α 30 minutes after reperfusion. HPTX and HTS significantly decreased AlT,AST, Il-6, mitochondrial dysfunction and pulmonary myelo- peroxidase 4 hours after reperfusion. Compared with HTS only, HPTX significantly decreased hepatic oxidative stress 4 hours after reperfusion and pulmonary permeability 4 and 12 hours after reperfusion. CONClUSION： This study showed that PTX added the beneficial effects of HTS on liver IR injury through decreases of hepatic oxidative stress and pulmonary permeability.

关键词： pentoxifylline hypertonic saline solution hepatic oxidative stress ischemia reperfusion injury pulmonary permeability

Evaluation of the Antibacterial and Antifungal Capacity of Nanoemulsions loaded with Synthetic Chalcone Derivatives Di-Benzyl Cinnamaldehyde and Benzyl 4-Aminochalcone

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Journal of Renewable Materials 2024年第2期12卷 285-304页

作者： Flavia Oliveira Monteiro da Silva Abreu Taysse Holanda Joice Farias do Nascimento Henety Nascimento pinheiro Rachel Menezes Castelo Hélcio Silva dos santos Thais Benincá Patrícia da Silva Malheiros Júlio César Sousa Prado Raquel de Oliveira Fontenelle Maria Madalena de Camargo Forte Natural Polymers laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Polymeric Materials laboratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Product Chemistry laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Food Hygiene and Microbiology laboratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Microbiology laboratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With the increase in antimicrobial resistance,it has become necessary to explore alternative approaches for combating and preventing ***-cinnamaldehyde(CNM)and Benzyl4-amino(B4AM)are bioactive compounds derived from chalcones but with restricted solubility in aqueous *** can enhance the solubility of compounds and can be a promising alternative in the development of novel antimicrobials,with reduced side effects and prolonged *** objective of this study was to evaluate the stability of oil-in-water nanoemulsions loaded with two distinct types of chalcones at two different dosages,to propose a stable formulation with antimicrobial *** showed that nanoemulsions presented high encapsulation efficiency,low polydispersity index(PDI)and particle size below 200 nm,indicating that emulsification was a suitable method for nanoemulsion *** with higher dosages exhibited significant antimicrobial effects when compared to free chalcones and positive ***,B4AM nanoemulsions at higher dosages showed expressive activity against Salmonella minnesota,with a 420%greater inhibitory response compared to the free form and showing equivalence to the positive *** nanoemulsions showed excellent inhibitory activity at the highest dosage,equivalent to the positive control against *** and Staphylococcus *** greater number of conjugated bonds in CNM increased the antimicrobial activity in comparison with B4AM,and the formation of nanometric domains enhanced the bioavailability,being a promising alternative for antimicrobial applications.

关键词： Polysaccharide nanoemulsions S.aureus S.minnesota chalcones alginate

New avenues for the treatment of immunotherapy-resistant pancreatic cancer

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1134-1153页

作者： luis Guilherme de Oliveira Silva Fabian Fellipe Bueno lemos Marcel Silva luz Samuel luca Rocha pinheiro Mariana dos santos Calmon Gabriel lima Correa santos Gabriel Reis Rocha Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Pancreatic cancer(PC)is characterized by its extremely aggressive nature and ranks 14th in the number of new cancer cases ***,due to its complexity,it ranks 7th in the list of the most lethal cancers *** pathogenesis of PC involves several complex processes,including familial genetic factors associated with risk factors such as obesity,diabetes mellitus,chronic pancreatitis,and *** in genes such as KRAS,TP53,and SMAD4 are linked to the appearance of malignant cells that generate pancreatic lesions and,consequently,*** this context,some therapies are used for PC,one of which is immunotherapy,which is extremely promising in various other types of cancer but has shown little response in the treatment of PC due to various resistance mechanisms that contribute to a drop in immunotherapy *** is therefore clear that the tumor microenvironment(TME)has a huge impact on the resistance process,since cellular and non-cellular elements create an immunosuppressive environment,characterized by a dense desmoplastic stroma with cancerassociated fibroblasts,pancreatic stellate cells,extracellular matrix,and immunosuppressive *** to this are genetic mutations in TP53 and immunosuppressive factors that act on T cells,resulting in a shortage of CD8+T cells and limited expression of activation markers such as *** this way,finding new strategies that make it possible to manipulate resistance mechanisms is ***,techniques such as the use of TME modulators that block receptors and stromal molecules that generate resistance,the use of genetic manipulation in specific regions,such as microRNAs,the modulation of extrinsic and intrinsic factors associated with T cells,and,above all,therapeutic models that combine these modulation techniques constitute the promising future of PC ***,this study aims to elucidate the main mechanisms of resistance to immunotherapy in PC and new ways of manipulating thi

关键词： Pancreatic cancer Immunotherapy Resistance Tumor microenvironment manipulation Combined immunotherapy

Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis

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World Journal of Gastroenterology 2023年第14期29卷 2202-2221页

作者： Fabian Fellipe Bueno lemos Caroline Tianeze de Castro Mariana santos Calmon Marcel Silva luz Samuel luca Rocha pinheiro Clara Faria Souza Mendes dos santos Gabriel lima Correa santos Hanna santos Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029094BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919899ParanáBrazil

BACKGROUND Gastric mucosa-associated lymphoid tissue(MAlT)lymphoma(GMl)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(***)-induced chronic *** practice guidelines currently recommend *** eradication as the preferred initial treatment for early-stage *** determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GMl,an updated analysis and review of available evidence is *** To perform a meta-analysis to assess the rate of complete remission(CR)of ***-positive early-stage GMl following bacterial *** We performed independent,computer-assisted literature searches using the PubMed/MEDlINE,Embase,and Cochrane Central databases through September *** and retrospective observational studies evaluating the CR of early-stage GMl following bacterial eradication in ***-positive *** risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal *** pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects *** and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P50%,*** and meta-regression analyses were conducted to explore potential sources of *** The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text ***,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational *** overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 ***-positive early-stage GMl patients,in whom *** was successfully eradicated,were incl

关键词： lymphoma B-cell Marginal zone Gastric mucosa-associated lymphoid tissue lymphoma Stomach lymphoma Helicobacter pylori Therapeutics Eradication therapy