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Associations of sense of coherence with psychological distress and quality of life in inflammatory bowel disease

World Journal of Gastroenterology 2015年第21期21卷 6713-6727页

作者： Thiago H Freitas Elias Andreoulakis Gilberto S Alves Hesley ll Miranda lúcia lbc braga Thomas Hyphantis André F Carvalho Translational Psychiatry Research Group Department of Clinical MedicineFaculty of MedicineFederal University of Ceará 3~(rd) Department of Psychiatry Aristotle University of ThessalonikiUniversity Campus Institute of Biomedicine of Brazilian SemiArid(INCT-IBISAD) Department of Clinical MedicineFaculty of MedicineFederal University of Ceará Department of Psychiatry Faculty of MedicineSchool of Health SciencesUniversity of Ioannina

AIM:To investigate the relationship between sense of coherence,psychological distress and health related quality of life in inflammatory bowel disease(IBD).METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD(aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroenterology ***-four participants met diagnostic criteria for Crohn's disease,while eightythree patients had ulcerative ***-demographic data(education,age,race,gender,gross monthly income and marital status),disease-related variables(illness activity,relapse rate in past 2 years,history of surgery and time since diagnosis),sense of coherence(Antonovsky's SOC scale),psychological distress symptoms(Hospital Anxiety and Depression Scale) and health-related quality of life(HRQo l; WHOQOlBref) were *** multiple regression analyses were performed to identify factors that are independently associated with psychological distress and HRQo l in patients with IBD and to provide indications for possible moderating or mediating *** addition,formal moderation and mediation analyses(Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC,psychological distress symptoms and ***:lower SOC scores(std beta=-0.504; P le gender(std beta = 0.176; P = 0.021) and White race(std beta = 0.164; P = 0.033) were independently associated with higher levels of depressive symptoms,while lower levels of SOC(std beta =-0.438; P lapse rate(std beta = 0.161; P = 0.033) were independently associated with more severe anxiety symptoms.A significant interaction between time since diagnosis and SOC was found with regard to the severity of depressive or anxiety symptoms,as the interaction term(time since diagnosis X SOC) had beta coefficients of-0.191(P = 0.009) and-0.172(P = 0.026),*** levels of anxiety symptoms(std beta =-0.369; P levels

关键词： Sense of coherence Coping Anxiety Depression Quality of life Crohn's disease Ulcerativecolitis

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Evaluation of HPV Molecular Tests in Primary Screening for Cervical Cancer in Brazil

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Open Journal of Obstetrics and Gynecology 2014年第8期4卷 470-478页

作者： José E.levi Adhemar longatto-Filho José Eluf-Neto Célia l.Rodrigues Cristina M.Oliveira Adriana C.Carloni Adriana T.lorenzi Maricy Tacla José H.Fregnani Alexandre M.Ab’Saber Cristovam Scapulatempo luisa lVilla National Institute of Science and Technology for the Diseases Associated to Papillomaviruses(INCT-HPV) Sao PauloBrazil Virology lab Tropical Medicine InstituteUniversidade de Sao PauloSao PauloBrazil laboratory of Medical Investigation(lIM)14 Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil ICVS/3B’s-PT Government Associate laboratory Life and Health Sciences Research Institute(ICVS)School of Health SciencesUniversity of MinhoBragaPortugal Molecular Oncology Research Center Pio XII FoundationBarretosBrazil Department of Preventive Medicine Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Department of Infectious Diseases Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Department of Ginecology and Obstetrics Faculdade de MedicinaUniversidade de São PauloSao PauloBrazil Center for the Researcher Support Pio XII FoundationBarretos Cancer HospitalBarretosBrazil Department of Pathology Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Department of Radiology Center on Translational Oncology InvestigationSao Paulo State Cancer InstituteFaculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Santa Casa de Sao Paulo Medical School Sao PauloBrazil

Background: Incorporation of HPV tests into cervical cancer screening programs may be advantageous over conventional cytology, especially in developing nations, where the largest burden of cervical cancer is observed. Objectives: To conduct an evaluation of commercially available molecular HPV tests in Brazilian women. Study design: Two groups were recruited: group A was composed of 511 women referred to the clinics because of a previous abnormal Pap test while group B consisted of 2464 subjects under routine screening. Cervical samples were collected using SurePath liquid cytology (lbc) device, and split into aliquots which were submitted to molecular testing by Hybrid Capture and cobas HPV. Colposcopy and biopsies were made according to the standard guidelines, directed by cytological diagnosis. Results: Prevalence of HSIl was 5.97% and 0.7% in Group A and B respectively. High-Risk HPV DNA was found in about 9% of group B women, while in group A this frequency was 24%. Having CIN3+ as the study end-point, the negative predictive values for molecular methods were above 99.8%. All “in-situ” and invasive cervical carcinomas were detected by both HPV nucleic acid assays. Conclusion: Use of HPV DNA testing was feasible and highly sensitive in cancer screening settings of Brazil.

关键词： High-Risk HPV Test HPV-DNA Cervical Cancer Screening

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