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The management of water heritage in Portuguese cities:Recent regeneration projects in Évora,lisbon,Braga and Guimarães

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Frontiers of Architectural Research 2022年第1期11卷 73-88页

作者： Celia lópez-Bravo JoséPeral lópez Eduardo Mosquera Adell Department of Architectural History Theory and CompositionUniversity of SevilleSevilleSpain

Given the cultural and environmental potential presented by historical water infrastructures in urban contexts,this article states the evidence of a not much documented urban phenomenon in Portugal,the refurbishment of water heritage protected areas motivated by European-based regeneration *** employing a case-study design,four good practices-placed inÉvora,lisbon,Braga and Guimarães-are chosen to enlighten this growing and aware *** assets located there-theÁgua de Prata Aqueduct,theÁguas livres Aqueduct,the Sete Fontes water-supply system and the Zona de Couros industrial area,respectively-are geographical,historical and culturally characterised,while the projects that concern them are documented by visiting the areas and analysing the available ***,open-data platforms and heritage protection decrees are processed to graphically code the topography,hydrology,urban land use,infrastructures,landmarks and protected areas,employing QGIS free software for Geographic Information *** a result,the four practices are documented,discussed and compared.A table assesses and summarises their pre-existing and currently added values and a series of diagrams illustrates the landscape changes *** graphics validate the practices and update the status of the assets,enhancing the rediscovery of the existing landscapes and showing the main challenges and future opportunities faced by these areas.

关键词： Heritage characterization Infrastructures landscape Obsolescence Urban planning Waterworks

Identification of SUMO Targets by a novel Proteomic Approach in Plants

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Journal of Integrative Plant Biology 2013年第1期55卷 96-107页

作者： Gema lópez-Torrejón Davide Guerra Rafael Catal Julio Salinas Juan C. del Pozo Centro de Biotecnología y Genómica de Plantas (InIA-UPM) Campus de Montegancedo CRA-Genomics Research Centre (GPG) Centro de Investigaciones Biológicas (CSIC) Campus de la Ciudad Universitaria de Madrid

Post-translational modifications （PTMs） chemically and physically alter the properties of proteins, including their folding, subcellular localization, stability, activity, and consequently their function. In spite of their relevance, studies on PTMs in plants are still limited. Small Ubiquitin-like Modifier （SUMO） modification regulates several biological processes by affecting protein-protein interactions, or changing the subcellular Iocalizations of the target proteins. Here, we describe a novel proteomic approach to identify SUMO targets that combines 2-D liquid chromatography, immunodetection, and mass spectrometry （MS） analyses. We have applied this approach to identify nuclear SUMO targets in response to heat shock. Using a bacterial SUMOylation system, we validated that some of the targets identified here are, in fact, labeled with SUMO1. Interestingly, we found that GIGAnTEA （GI）, a photoperiodic-pathway protein, is modified with SUMO in response to heat shock both in vitro and in vivo.

关键词： Mass spectrometry plants post-translational modification proteomics SUMO.

Amyotrophic lateral sclerosis: a complex syndrome that needs an integrated research approach

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neural Regeneration Research 2019年第2期14卷 193-196页

作者： Javier Riancho Francisco J.Gil-Bea Ana Santurtun Adolfo lópez de Munaín Service of neurology Hospital Sierrallana-Idival CIBERnED (Center for networked Biomedical Research on neurodegenerative Diseases Ministry of Economy and Competitiveness Institute Carlos Ⅲ) neurosciences Area Institute Biodonostia Department of Physiology and Pharmacology University of Cantabria-Idival Department of neurology University Hospital Donostia Department of neurosciences University of the Basque Country Universidad País Vasco-Euskal Herria Unibertsitatea

Amyotrophic lateral sclerosis, the most common neurodegenerative disease affecting motor neurons, lacks an effective treatment. A small fraction of amyotrophic lateral sclerosis cases have a familial origin, related to mutations in causative genes, while the vast majority of amyotrophic lateral sclerosis cases are considered to be sporadic, resulting from the interaction between genes and environmental factors in predisposed individuals. During the past few years, dozens of drugs have been postulated as promising strategies for the disease after showing some beneficial effects in preclinical cellular and murine models. However, the translation into clinical practice has been largely unsuccessful and the compounds failed when were tested in clinical trials. This might be explained, at least partially, by the enormous complexity of the disease both from clinico-epidemiological and a pathogenic points of view. In this review, we will briefly comment on the complexity of the disease focusing on some recent findings, and we will suggest how amyotrophic lateral sclerosis research might be reoriented to foster the advance in the diagnostic and therapeutic questions.

关键词： amyotrophic lateral sclerosis AlS environment epidemiology genes phenotype therapy

Ventilation during cardiopulmonary resuscitation in children: a survey on clinical practice

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World Journal of Pediatrics 2017年第6期13卷 544-550页

作者： Rafael González lázaro Pascual Alexandra Sava Sara Tolón Javier Urbano Jesus lópez-Herce Pediatric Intensive Care Department Gregorio Mara(n)ón General University HospitalSchool of MedicineComplutense University of MadridMadridSpain

Background:This study aimed to investigate the ventilation practice during cardiopulmonary resuscitation (CPR) and after return of spontaneous circulation (ROSC) in ***:An online survey of CPR practices was designed and sent to healthcare professionals treating ***:A total of 477 healthcare professionals from 46 countries responded to this survey;92.7% were physicians and 64.2% worked in pediatric intensive care *** CPR guidelines were used by 97.7% of *** respiratory rate most frequently used for children over 12 months was 13 to 20 respirations per minute (rpm) (46% in intubated and 41.8% in non-intubated).For infants under 12 months,the most frequently used respiratory rate was 21 to 30 rpm in intubated patients (37.3%):in non-intubated infants,13 to 20 rpm (26.5%) and 21 to 30 rpm (26.5%) were used with the same *** north America,the respiratory rate most widely used was 7 to 12 rpm;higher rates (13 to 20 rpm and 21 to 30 rpm) were used in Europe and latin America (Pno significant differences in the respiratory rates used were found between the *** than 40% of healthcare professionals had a target oxygen saturation below 94%;more than 10% used a target arterial PCO2 below 35 mmHg and more than 13% above 45 ***:There is considerable variation in the management of ventilation of children in cardiac arrest,and international recommendations are not being followed in a high percentage of cases.

关键词： cardiopulmonary resuscitation resuscitation ventilation

Depth of closure:new calculation method based on sediment data

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International Journal of Sediment Research 2018年第2期33卷 198-207页

作者： luis Aragonés Jose Ignacio Pagán Isabel lópez José C.Serra Department of civil engineering University of Alicante Department of transportation ETSI Caminos Polytechnic University of Valencia

Obtaining depth of closure(DoC) in an accurate manner is a fundamental issue for coastal engineering,since good results for coastal structures and beach nourishment depend mainly on DoC. Currently, there are two methods for obtaining the DoC, mathematical formulations and profile surveys. However, these methods can incur important errors if one does not take into account the characteristics and morphology of the area, or if one does not have a sufficiently long time series. In this work the DoC is obtained from the break in the trend of the sediment with the depth, that is, in general with the increase of the depth a decrease in the size of the sediment takes place. However, at one point this tendency changes and the size increases, and then decreases again. When comparing the point where the minimum sediment size occurs before the increase, it is observed that the error incurred is small compared to other methods. If the Standard Deviation of Depth Change(SDDC) method is considered as the most accurate method, the error incurred by the proposed method is less than 7%. In addition, it can be seen that the dispersion of the sediment method always occurs outside the zone of bar movement. Whereas in the methods of profiles survey(using 2 cm precision profiles), sometimes the DoC is obtained within the active zone of bar movement. In addition, where the relative minimum of the median sediment size is found, and the sizes of 0.063 and 0.125 mm predominate in the composition of the sample. Therefore, this new method allows the precise location of the DoC to be obtained in a fast and simple way. Furthermore, this method has the advantage that it is not affected by the modifications that may be experienced by both the study area and the cross-shore beach profile.

关键词： Depth of Closure Median sediment size Profile surveys Profile change GIS

Population structure and range expansion:the case of the invasive gastropod Cyclope neritea in northwest Iberian Peninsula

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Integrative Zoology 2012年第3期7卷 286-298页

作者： lucía COUCEIRO lúa lÓpez JoséMiguel RUIZ Rodolfo BARREIRO Department of Ecology College of ScienceUniversity of A CoruñaA CoruñaSpain

Biotic invasions have a reputation for unpredictable ***,we report how slight changes in human activity responsible for the introduction and range expansion of a non-native mollusk have led to detectable differences in the genetics of the *** neritea is a non-predatory gastropod introduced to 2 areas of the European Atlantic:the northwest Iberian Peninsula(nWIP)and the French Atlantic coast(FAC).Shellfish seabed farming is intense in both areas but focuses on different commercial *** mitochondrial gene sequences,the lower genetic diversity recorded along the nWIP suggests a more homogeneous range of source populations than in the *** FAC,genetic diversity and haplotype composition in the nWIP correlate with the date of first occurrence of *** at each site rather than with geographical *** this pattern evokes the genetic signature expected under a serial-founder colonization model from a single initial enclave,a comparison with samples from potential source populations suggests that the nWIP probably experienced several independent *** jump dispersal pattern of *** in the nWIP,together with the observation that populations established in the same year are genetically undifferentiated,point to human transport as the most plausible explanation for the current range *** evidence for human-mediated dispersal,*** managed to develop a seemingly non-random genetic pattern in the *** is suggested that caution must be exerted when interpreting genetic patterns in invaders.

关键词： alien species Cyclope neritea cytochrome oxidase I genetic geographic pattern population structure

Programmed cell death in seeds of angiosperms

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Journal of Integrative Plant Biology 2015年第12期57卷 996-1002页

作者： María Paula lópez-Fernández Sara Maldonado laboratory of Plant Development Department of Biodiversity and Experimental Biology Faculty of Exact and Natural Sciences University of Buenos Aires national Research Council of Argentine (COnICET)

During the diversification of angiosperms, seeds have evolved structuralp chemical, molecular and physiolog- ically developing changes that specially affect the nucellus and endosperm. All through seed evolution, programmed celldeath （PCD） has played a fundamental role. However, examples of PCD during seed development are limited. The present review examines PCD in integuments, nucellus, suspensor and endosperm in those representative examples of seeds studied to date.

关键词： Caspases endosperm KDEl-CysEP metacaspases nucellus nucleases programmed cell death perisperm ricinosomes

Determination of Soil Aggregate Porosity Using the Modified Water Saturation Method

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Pedosphere 2019年第6期29卷 794-800页

作者： David MORET-FERnánDEZ María Victoria lópez Departamento de Suelo y Agua Estación Experimental de Aula Dei Consejo Superior de Investigaciones Científicas (EEAD-CSIC)

The need to find a simple method for measuring soil aggregate porosity (φ) is justified by the growing interest of researchers in this important parameter of soil physical status. The aim of this study was to present a simple method (AM) for estimating the total 0 of a single soil aggregate. In this case, soil aggregate 0 was calculated as the quotient between the pore volume, estimated from the weight of the aggregate saturated with ethanol, and the total volume (V T ) of aggregate, calculated from the particle density and dry aggregate weight. The V T estimated with AM was compared with the corresponding volume measured with the photogrammetry (PHM) technique using soil aggregates of 8–16 mm in diameter and collected from three different tillage systems: conventional tillage (CT), reduced tillage (RT), and no tillage (nT). next, the AM was used to study the effects of the tillage system on soil aggregate φ. Although a strong relationship ( R 2 = 0.99, P n aggregate V T measured with PHM and that estimated with AM was obtained, AM tended to underestimate aggregate V T with an average deviation of 2.85%. This difference may be due to ethanol evaporation during the first 10 s before the ethanol-saturated aggregate was weighed. The use of AM to determine the effects of different tillage systems on aggregate φ showed that this method was sensitive to detect significant differences among the tillage treatments. The results showed that AM could be an accurate, simple, and inexpensive alternative to estimate φ of a single soil aggregate.

关键词： Aggregate stability Bulk density Particle density Photogrammetry technique Tillage system

Olfactory receptors in neural regeneration in the central nervous system

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neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael Franco Claudia Garrigós Toni Capó Joan Serrano-Marín Rafael Rivas-Santisteban Jaume lillo Molecular neurobiology laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain Ciberned network Center for Biomedical Research in neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain School of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons