检索结果-南通市图书馆

Asian Pacific Journal of Tropical Medicine 2023年第7期16卷 305-312页

作者： nicolás Rozo Montoya Juliana Quintero Pulgarín liliana lópez Carvajal Grupo de Investigación Clínica PECET(GIC-PECET) Universidad de AntioquiaMedellínColombia

Objective:To analyze the therapeutic response and safety of different treatments for cutaneous leishmaniasis,received by patients in the Program for the Study and Control of Tropical Diseases-PECET-Medellí***:This is a retrospective cross-sectional study of patients attended at PECET Research Center during *** information regarding sociodemographic characteristics,history of leishmaniasis,characterization of current infection,treatment received,follow-up of therapeutic response and safety was collected from the medical *** were analyzed with Pearson's Chi-square association tests and Mann-Whitney U test using statistical ***:A total of 486 clinical records of patients were analyzed,and 356 received *** different therapeutic alternatives(systemic,local and in combination)were *** therapeutic response of the different alternatives used(except thermotherapy)was higher than 50%.Most frequent adverse events were myalgias,arthralgias and headache,and vesicles for systemic and local treatment,***:Safety profile and performance of local therapeutic alternatives and combined schemes for the treatment of uncomplicated cutaneous leishmaniasis are an interesting option for the management of the disease.

关键词： Cutaneous leishmaniasis Systemic treatment local treatment Combined treatment Tropical neglected disease Safety Therapeutic response

The bottlenose dolphin Tursiops truncatus foraging around a fish farm:Effects of prey abundance on dolphins' behavior

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2009年第4期55卷 243-248页

作者： Bruno A■DZ lópez The Bottlenose Dolphin Research Institute BDRI

The extent to which prey abundance influences both bottlenose dolphin foraging behavior and group size in the presence of human activities has not previously been *** primary aim of this study was to identify and quantify how wild bottlenose dolphins respond,individually and as groups,to the relative abundance of prey around a fish *** views of dolphins' behavior were obtained by focal following individual animals whilst simultaneously collecting surface and underwater behavioral data.A total of 2150 dive intervals were analyzed,corresponding to 342 focal samples,lasting over 34 *** dolphins remained submerged for a mean duration of 46.4 seconds and a maximum of 249 *** study provides the first quantified data on bottlenose dolphin diving behavior in a marine fin-fish farm *** study's results indicate that within a fish farm area used intensively by bottlenose dolphins for feeding,dolphins did not modify dive ***,underwater observations confirmed that dolphins find it easier to exploit a concentrated food source and it appears that hunting tactic and not group size plays an important role during feeding ***,bottlenose dolphins appear capable of modifying their hunting tactics according to the abundance of *** top predators display behavioral responses to activities not directed at them,the task of studying all possible effects of human activities can become even more challenging.

关键词： Bottlenose dolphin Tursiops truncatus Diving behavior Foraging behavior Prey abundance Human activities,Hunting tactics Aquaculture

A cellular automata model for simulating grain structures with straight and hyperbolic interfaces

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2012年第8期19卷 699-710页

作者： A.Ramírez-lópez M.Palomar-Pardavé D.Muñoz-negrón C.Duran-Valencia S.lópez-Ramirez G.Soto-Cortés Materials and Energy Department Metropolitan Autonomous UniversityMexico Department of Industrial Engineering Technological Autonomous Institute of MexicoMexico Department of Molecular Engineering Mexican Institute of PetroleumMexico

A description of a mathematical algorithm for simulating grain structures with straight and hyperbolic interfaces is shown. The presence of straight and hyperbolic interfaces in many grain structures of metallic materials is due to different solidification conditions, in- eluding different solidification speeds, growth directions, and delaying on the nucleation times of each nucleated node. Grain growth is a complex problem to be simulated; therefore, computational methods based on the chaos theory have been developed for this purpose. Straight and hyperbolic interfaces are between columnar and equiaxed grain structures or in transition zones. The algorithm developed in this work involves random distributions of temperature to assign preferential probabilities to each node of the simulated sample for nucleation according to previously defined boundary conditions. Moreover, more than one single nucleation process can be established in order to gen- erate hyperbolic interfaces between the grains. The appearance of new nucleated nodes is declared in sequences with a particular number of nucleated nodes and a number of steps for execution. This input information influences directly on the final grain structure （grain size and dislribution）. Preferential growth directions are also established to obtain equiaxed and columnar grains. The simulation is done using rou- tines for nucleation and growth nested inside the main function. Here, random numbers are generated to place the coordinates of each new nucleated node at each nucleation sequence according to a solidification probability. nucleation and growth routines are executed as a func- tion of nodal availability in order to know if a node will be part of a grain. Finally, this information is saved in a two-dimensional computa- tional array and displayed on the computer screen placing color pixels on the corresponding position forming an image as is done in cellular automaton.

关键词： grain growth interfaces grain size and shape computational methods algorithms cellular automata computer simulation

Modeling and measuring glucose diffusion and consumption by colorectal cancer spheroids in hanging drops using integrated biosensors

在线全文

学校读者我要写书评

暂无评论

Microsystems & nanoengineering 2022年第1期8卷 193-210页

作者： nassim Rousset Rubén lópez Sandoval Mario Matteo Modena Andreas Hierlemann Patrick M.Misun ETH Zürich Department of Biosystems Science and EngineeringBio Engineering LaboratoryMattenstrasse 26CH-4058 BaselSwitzerland

As 3D in vitro tissue models become more pervasive,their built-in nutrient,metabolite,compound,and waste gradients increase biological relevance at the cost of analysis *** these gradients and the resulting metabolic heterogeneity requires invasive and time-consuming *** alternative is using electrochemical biosensors and measuring concentrations around the tissue model to obtain size-dependent metabolism *** our hanging-dropintegrated enzymatic glucose biosensors,we conducted current measurements within hanging-drop compartments hosting spheroids formed from the human colorectal carcinoma cell line *** developed a physics-based mathematical model of analyte consumption and transport,considering(1)diffusion and enzymatic conversion of glucose to form hydrogen peroxide(H_(2)O_(2))by the glucose-oxidase-based hydrogel functionalization of our biosensors at the microscale;(2)H_(2)O_(2)oxidation at the electrode surface,leading to amperometric H_(2)O_(2)readout;(3)glucose diffusion and glucose consumption by cancer cells in a spherical tissue model at the microscale;(4)glucose and H_(2)O_(2)transport in our hangingdrop compartments at the macroscale;and(5)solvent evaporation,leading to glucose and H_(2)O_(2)*** model relates the measured currents to the glucose concentrations generating the *** low limit of detection of our biosensors(0.4±0.1μM),combined with our current-fitting method,enabled us to reveal glucose dynamics within our *** measuring glucose dynamics in hanging-drop compartments populated by cancer spheroids of various sizes,we could infer glucose distributions within the spheroid,which will help translate in vitro 3D tissue model results to in vivo.

关键词： diffusion hanging simplicity

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang Dong liang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang Jie Dang Jia Guo Hanghang Zhou Xuewei lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key laboratory of Vanadium-Titanium Metallurgy and new Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

Hepatitis B and immunosuppressive therapies for chronic inflammatory diseases: When and how to apply prophylaxis, with a special focus on corticosteroid therapy

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2015年第3期7卷 539-547页

作者： Pilar lópez-Serrano Elsa de la Fuente Briongos Elisa carrera Alonso Jose lázaro Pérez-Calle Conrado Fernández Department of Gastroenterology University Hospital Fundación Alcorcón Department of Gastroenterology University Hospital of Guadalajara

Currently immunosuppressive and biological agentsare used in a more extensive and earlier way in patients with inflammatory bowel disease, rheumatic or dermatologic diseases. Although these drugs have shown a significant clinical benefit, the safety of these treatments is a challenge. Hepatitis B virus(HBV) reactivations have been reported widely, even including liver failure and death, and it represents a deep concern in these patients. Current guidelines recommend to preemptive therapy in patients with immunosuppressants in general, but preventive measures focused in patients with corticosteroids and inflammatory diseases are scarce. Screening for HBV infection should be done at diagnosis. The patients who test positive for hepatitis B surface antigen, but do not meet criteria for antiviral treatment must receive prophylaxis before undergoing immunosuppression, including corticosteroids at higher doses than prednisone 20 mg/d during more than two weeks. Tenofovir and entecavir are preferred than lamivudine because of their better resistance profile in long-term immunosuppressant treatments. There is not a strong evidence, to make a general recommendation on the necessity of prophylaxis therapy in patients with inflammatory diseases that are taking low doses of corticosteroids in short term basis or low systemic bioavailability corticosteroids such as budesonide or beclomethasone dipropionate. In these cases regularly HBV DnA monitoring is recommended, starting early antiviral therapy if DnA levels begin to rise. In patients with occult or resolved hepatitis the risk of reactivation is much lower, and excepting for Rituximab treatment, the prophylaxis is not necessary.

关键词： Hepatitis B virus Inflammatory boweldisease Rheumatic disease. Dermatologic diseases Corticosteroids Anti-tumor necrosis factor Prophylaxis Immunosuppressants

Association between Helicobacter *** and hepatobiliary malignancies:A review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第5期21卷 1414-1423页

作者： Fany Karina Segura-lópez Alfredo Güitrón-Cantú Javier Torres Hospital de Especialidades UMAE no 71 Instituto Mexicano del Seguro SocialTorreónCoahuila 27000México Departamento de Endoscopia Gastrointestinal Hospital de Especialidades UMAE No 71Instituto Mexicano del Seguro SocialTorreónCoahuila 2700México Unidad de Investigación en Enfermedades Infecciosas y Parasitarias Hospital de Pediatría UMAECentro Médico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMéxico CP 06720DFMéxico

Hepatobiliary cancers are highly lethal cancers that comprise a spectrum of invasive carcinomas originating in the liver hepatocellular carcinoma,the bile ducts intrahepatic cholangiocarcinoma and extrahepaticcholangiocarcinoma,the gallbladder and the ampulla of Vater(collectively known as biliary tract cancers).These tumors account for approximately 13% of all annual cancer-related deaths worldwide and for 10%-20% of deaths from hepatobiliary ***(CCA) is a devastating disease that displays a poor survival rate for which few therapeutic options are *** genetics,geographical and environmental factors,cholelithiasis,obesity,parity,and endemic infection with liver flukes have been identified as risk factors that influence the development of biliary tract *** important factors affecting the carcinogenesis of these tumors include chronic inflammation,obstruction of the bile ducts,and impaired bile *** has been suggested that CCA is caused by infection with Helicobacter species,such as Helicobacter bilis and Helicobacter hepaticus,in a manner that is similar to the reported role of Helicobacter pylori in distal gastric *** to the difficulty in culturing these Helicobacter species,molecular methods,such as polymerase chain reaction and sequencing,or immunologic assays have become the methods of choice for ***,clinical studies of benign or malignant biliary tract diseases revealed remarkable variability in the methods and the findings,and the use of uniform and validated techniques is needed.

关键词： Helicobacter bilis Helicobacter hepaticus Helicoba

Effect of aging on behaviour of mesenchymal stem cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2019年第6期11卷 337-346页

作者： Juan Antonio Fafián-labora Miriam Morente-lópez María C Arufe Grupo de Terapia Celular y Medicina Regenerativa Departamento de Fisioterapia Ciencias Biomédicas y MedicinaUniversidade da Coru?a

Organs whose source is the mesoderm lineage contain a subpopulation of stem cells that are able to differentiate among mesodermal derivatives (chondrocytes, osteocytes, adipocytes). This subpopulation of adult stem cells, called “mesenchymal stem cells” or “mesenchymal stromal cells (MSCs)”, contributes directly to the homeostatic maintenance of their organs;hence, their senescence could be very deleterious for human bodily functions. MSCs are easily isolated and amenable their expansion in vitro because of the research demanding to test them in many diverse clinical indications. All of these works are shown by the rapidly expanding literature that includes many in vivo animal models. We do not have an in-depth understanding of mechanisms that induce cellular senescence, and to further clarify the consequences of the senescence process in MSCs, some hints may be derived from the study of cellular behaviour in vivo and in vitro, autophagy, mitochondrial stress and exosomal activity. In this particular work, we decided to review these biological features in the literature on MSC senescence over the last three years.

关键词： Mesenchymal stem cells Aging Autophagy Mitochondrial stress Extracellular vesicles

Advanced modeling of embedded piezo-electric transducers for the health-monitoring of layered structures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Smart and nano Materials 2020年第4期11卷 325-342页

作者： Enrico Zappino Erasmo carrera Department of Mechanical and Aerospace Engineering Politecnico di TorinoMul2 Research GroupTorinoItaly

The present paper presents an innovative approach for the numerical modeling of piezo-electric transducers for the health-monitoring of layered *** numerical approach has been developed in the frameworks of the carrera Unified *** computa-tional tool allows refined numerical models to be derived in a unified and efficient *** use of higher-order models and the cap-ability to connect different kinematic models using the node-depen-dent kinematic approach has led to an efficient modeling technique for global-local *** approach can refine the model only in those regions where it is required,e.g.,the areas where piezo-electric transducers are *** model has been used to study embedded and surface-mounted *** accuracy of the pre-sent model has been verified by comparing the current results with numerical and experimental data from the *** mod-eling solutions have been developed,mixing one-,two-and threedimensional finite *** results show that the use of the present modeling technique allows the computational cost to be reduced with respect to the classical approaches preserving the ccuracy of the results in the critical areas.

关键词： carrera Unified Formulation Embedded Sensor Health Monitoring layered Structures Refined models