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Effects of octreotide on acute necrotizing pancreatitis in rabbits

World Journal of Gastroenterology 2004年第14期10卷 2082-2086页

作者： lászl6Czakó péterHegyi TamásTakács CsabaGóg AndrásFarkas YvetteMándy Ilona Sz.Varga lászlóTiszlavicz Jánoslonovics First Department of Internal Medicine University of SzegedSzegedHungary Second Department of Internal Medicine and Cardiological Center University of SzegedSzegedHungary Department of Microbiology University of SzegedSzegedHungary Biological Department of pathology University of SzegedSzegedHungary

AIM:To assess the role of oxygen-derived free radicals and cytokines in the pathogenesis of taurocholic acid-induced acute pancreatitis,and to evaluate the preventive effects of octreotide towards the development of acute pancreatitis. METHODS:Acute pancreatitis was induced in male New Zealand white rabbits by retrograde injection of 0.8 ml/kg·b.m,of 50 g/l sodium taurocholate (NaTC) in the pancreatic ***- operated animals served as *** i mg/kg·b.m. was administered subcutaneously before the induction of *** was taken from the jugular vein before and at 1,3,6,12 and 24 h after pancreatitis induction. Serum activities of amylase,Il-6 and TNF-α and levels of malonyl dialdehyde (MDA),glutathione (GSH),glutathione peroxidase (Gpx),catalase and superoxide dismutase (Mn-, Cu-,and Zn-SOD) in pancreatic tissue were measured. RESUlTS:Serum TNF-α and Il-6 levels increased significantly 3 h after the onset of pancreatitis,and then returned to control *** tissue concentration of MDA was significantly elevated at 24 h,while the GSH level and Gp-x,catalase,Mn-SOD,Cu-,Zn-SOD activities were all significantly decreased in animals with pancreatitis as compared to the *** pretreatmnent significantly reversed the changes in cytokines and reactive oxygen *** treatment did not alter the serum amylase activity and did not have any beneficial effects on the development of histopathological changes. CONClUSION:Oxygen-derived free radicals and proinflammatory cytokines are generated at an early stage of NaTc-induced acute pancreatitis in *** octreotide treatment can prevent release of cytokines and generation of reactive oxygen metabolites,but does not have any beneficial effects on the development of necrotizing pancreatitis.

关键词： Animals Cytokines inhibitors Male Octreotide pancreas pancreatitis, Acute Necrotizing control Rabbits Reactive Oxygen Species Research Support, Non-U.S. Gov't Taurocholic Acid

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A comprehensive review on the processing-property relationships of laser strengthened magnesium

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Journal of Magnesium and Alloys 2024年第1期12卷 1-34页

作者： Alessandro M.Ralls Aaksheta Agnel pradeep l.Menezes Department of Mechanical Engineering University of Nevada RenoRenoNV 89557United States

Among the existing series of softer metals,magnesium(Mg)has attracted much attention due to its impressive strength-to-weight ***,due to its ease of deformability,Mg tends to suffer from rapid degradation in a wide variety of abrasive and electrochemical *** method of improving its surface properties is through surface modification *** the existing techniques,laser shock peening(lSp)has been one of the most widely utilized processes due to its surface-hardening-like *** this understanding,a comprehensive review has yet to exist that encapsulates the strengthening mechanism of lSp for Mg and its influence in degradation *** review aims to encapsulate the existing research around the lSp field for ***,an understanding of the surface-strengthening effects in relation to its mechanical,tribological,corrosion,and tribo-corrosion characteristics is ***,the feasibility of lSp for Mg materials in critical industries is also *** this work,a novel understanding of lSp for Mg can be understood,which can provide a future direction for research in this field.

关键词： laser shock peening Magnesium Surface deformation Tribology Microstructure

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Novel medium entropy perovskite oxide Sr(FeCoNiMo)_(1/4)O_(3−δ)for zinc-air battery cathode

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Journal of Energy Chemistry 2024年第9期96卷 669-678页

作者： Kaixin li Juntao Gao Xu Han Qi Shao Zhe lü School of physics Harbin Institute of TechnologyHarbin 150001HeilongjiangChina Heilongjiang provincial Key laboratory of Advanced Quantum Functional Materials and Sensor Components Harbin 150001HeilongjiangChina

It is widely recognized that the development of ZABs is impeded by the kinetic bottleneck of oxygen evolution reaction(OER)and oxygen reduction reaction(ORR).The application of conformational entropy strategy to oxides often involves introducing multiple elements with different properties,thereby providing outstanding bifunctional catalytic activity for OER/***,the possible underlying catalytic pathways and potential interactions between various components are still poorly *** paper presents an excellent medium-entropy perovskite oxide,Sr(FeCoNiMo)_(1/4)O_(3−δ)(lower overpotential of 301 mV at 10 mA cm^(−2)).Zinc-air batteries employing it as a cathode catalyst demonstrate excellent round-trip efficiency(62%).By combining theoretical calculation with experiments,we aim to establish the link between the electronic structure of perovskite oxides with different elemental compositions and their OER *** reveals that the conformational entropy strategy can simultaneously shift the O 2p-band center and metal d-band center of perovskite oxide towards the vicinity of the Fermi energy level,thereby triggering a more favorable lattice oxygen-participated mechanism(lOM)during the OER *** outcomes of this work provide crucial insights into the role of conformational entropy strategies in oxygen catalysis and offer potential avenues for constructing efficient and stable electrocatalysts.

关键词： Sr(FeCoNiMo)_(1/4)O_(3−δ) Bifunctional catalyst Medium entropy lOM Rechargeable zinc-air batteries

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Biomaterials and emerging technologies for tissue engineering and in vitro models

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Bio-Design and Manufacturing 2024年第3期7卷 237-239页

作者： J.Miguel Oliveira Rui l.Reis 3B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-pT Government Associate laboratory 4806-909 Braga/GuimarãesPortugal

The latest advances in the field of biomaterials have opened new avenues for scientific breakthroughs in tissue engineer-ing which greatly contributed for the successful translation of tissue engineering products into the market/***-materials are easily processed to become similar to natural extracellular matrix,making them ideal temporary supports for mimicking the three-dimensional(3D)microenvironment required for maintaining the adequate cell/tissue functions both in vitro and in vivo^([1]).

关键词： breakthrough biomaterials engineer

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Spark plasma Sintering of Mg-based Alloys:Microstructure,Mechanical properties,Corrosion Behavior,and Tribological performance

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Journal of Magnesium and Alloys 2024年第2期12卷 405-442页

作者： Alessandro M.Ralls Mohammadreza Daroonparvar pradeep l.Menezes Department of Mechanical Engineering University of Nevada RenoRenoNV89557United States

Within the past ten years,spark plasma sintering(SpS)has become an increasingly popular process for Mg *** the SpS process,interparticle diffusion of compressed particles is rapidly achieved due to the concept of Joule *** to traditional and additive manufacturing(AM)techniques,SpS gives unique control of the structural and microstructural features of Mg *** doing so,their mechanical,tribological,and corrosion properties can be *** great advancements in this field have been made,these pieces of knowledge are scattered and have not been contextualized into a single *** motivation of this work is to address this scientific gap and to provide a groundwork for understanding the basics of SpS manufacturing for *** do so,the existing body of SpS Mg literature was first surveyed,with a focus on their structural formation and degradation *** was found that successful Mg SpS fabrication highly depended on the processing temperature,particle size,and particle *** addition of metal and ceramic composites also affected their microstructural features due to the Zener pinning *** degradative environments,their performance depends on their structural features and whether they have secondary phased *** industrial applications,SpS'd Mg was found to have great potential in biomedical,hydrogen storage,battery,automotive,and recycling *** prospects to advance the field include using Mg as a doping agent for crystallite size refinement and using bulk metallic Mg-based glass powders for amorphous SpS *** these findings,the interactions of multi-composites on the processing-structure-property relationships of SpS Mg is not well *** total,this work will provide a useful direction in the SpS field and serve as a milestone for future Mg-based SpS manufacturing.

关键词： Spark plasma sintering Magnesium alloys Nanocrystalline Tribology Mechanical properties Corrosion

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A seed and soil model of loneliness in Alzheimer's disease

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Neural Regeneration Research 2024年第12期19卷 2575-2576页

作者： Hannah l.Apostolou Ian M.McDonough Department of psychology The University of AlabamaTuscaloosaALUSA Department of psychology Binghamton UniversityBinghamtonNYUSA

loneliness is classically defined as a result of perceiving a discrepancy between the desired quantity and quality of one's social life and actual social relationships(perlman and peplau,1984).lifespan research has indicated older adults are among the highest risk for experiencing loneliness because their social network size decreases more frequently than that of younger adults.

关键词： Alzheimer younger soil

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Calibration of the DEM sliding friction and rolling friction parameters of a cohesionless bulk material

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particuology 2024年第9期92卷 126-139页

作者： Jonatan Marín pérez Tugrul Comlekci Yevgen Gorash Donald MacKenzie University of Strathclyde 75 Montrose StreetG11XJGlasgowUnited Kingdom

The discrete element method(DEM)has become a valuable tool for understanding the mechanical behaviour of granular assemblies,however,the accuracy of the DEM simulations depends on several interaction parameters such as the sliding friction and rolling friction ***,these parameters are estimated using bulk calibration approach(BCA)where the draw down test has been suggested as an effective way to approach these *** test provides up to four bulk criteria,the angle of repose,shear angle,mass flow rate and the mass loss which are used to narrow down the possible ***,there is still more research needed around it to fully understand how this methodology *** experimental and numerical study was carried out using the draw down test to assess the influence of different mass flow rates and particle shapes on DEM parameters for a cohesionless bulk *** is concluded that use of multi-sphere particles and three aperture sizes in the draw down test to calibrate the sliding and rolling friction parameters of a cohesionless bulk material can converge to a small feasible region in which a single combination of the friction coefficients can be *** calibrated sliding and rolling friction coefficients were validated using multi-sphere particles,where the maximum deviation was 5.9%from the experimental values.

关键词： Discrete element method Calibration Draw down Sliding friction Rolling friction particle shape

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Efficacy evaluation of standardized Rheum rhaponticum root extract(ERr 731®)on symptoms of menopause:A systematic review and meta-analysis study

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Journal of Biomedical Research 2024年第3期38卷 278-286页

作者： Vishal p.Dubey Varun p.Sureja Dharmeshkumar B.Kheni Department of Scientific and Medical Affairs Sundyota Numandis Probioceuticals Pvt.Ltd.AhmedabadGujarat 380015India

Menopause is characterized by various physical,mental and emotional *** 731®is a standardized extract from Rheum rhaponticum root and has been clinically studied for its role in reducing menopausal *** current systematic review and meta-analysis aimed to evaluate the efficacy of ERr 731®supplementation in alleviating the severity of menopausal *** this review,we searched across three online databases up to March 2023,evaluated the quality of the included studies by the physiotherapy Evidence Database scale,and assessed the risk of bias by the Cochrane Risk of Bias *** then performed a metaanalysis using RevMan software to estimate the pooled mean difference(MD).The study protocol was registered in the prospective Register of Systematic Reviews(CRD42023416808).After screening and evaluation,we included four high-quality studies(a total of 390 participants;the ERr 731®group:193 participants;the control group:197 participants)in the *** results showed that ERr 731®supplementation significantly reduced the Menopause Rating Scale score(MD:–15.12;ppared with control *** analysis revealed no effect of individual studies on the overall pooled estimate or overall observed *** current review provides evidence that ERr 731®supplementation is effective in reducing menopause *** bias and high heterogeneity in the results warrant further clinical studies.

关键词： menopause Rheum rhaponticum hot flashes systematic review

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Error-based adaptive optimal tracking control of nonlinear discrete-time systems

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Science China(Information Sciences) 2024年第1期67卷 154-167页

作者： Chun lI Jinliang DING Frank l.lEWIS Tianyou CHAI State Key laboratory of Synthetical Automation for process Industries Northeastern University UTA Research Institute The University of Texas at Arlington

In this paper,for the output tracking problem of nonlinear discrete-time systems,a performance index is newly defined using the adaptive dynamic programming(ADp) technique to completely eliminate tracking errors in *** contrast to traditional definitions of performance indices in other ADp-based methods,the proposed performance index is not only designed from the perspective of output tracking errors but also introduced errors of system states and control inputs at adjacent stages,which is suitable for practical situations in many industrial applications,such as the alumina production,the flotation process,and the mineral grinding *** proved that the obtained controller can make the system output fully track the given reference trajectory by applying the iterative criteria of the ADp *** addition,the proposed algorithm was implemented using a data-driven technique and neural networks to avoid analyzing and deducing the complicated dynamics of actual industrial ***,using historical data for a forced-circulation evaporation system in the alumina production process,the effect of the proposed approach was verified through a numerical simulation and compared with that of the proportional-integral controller.

关键词： adaptive dynamic programming iterative criteria performance index tracking errors tracking problem

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Enhancing force sensing in a squeezed optomechanical system with quantum nondemolition measurement

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Communications in Theoretical physics 2024年第1期76卷 49-60页

作者： Shi-lei Chao Zi-Hao li Xin-You lü School of physics Huazhong University of Science and Technology430074 WuhanChina

A theoretical scheme is proposed to enhance the sensitivity of force sensors with quantum nondemolition measurement(QND)in an optomechanical setup assisted by four-tone optical driving and an optical parametric amplifier(OpA).With the help of special drive,the system can be simplified as the typical type of QND for force sensing,so that the backaction noise can be evaded to surpass the standard quantum ***,the added noise can be suppressed owing to the modified optical susceptibility resulting from the *** introducing two oscillators coupling with two charged bodies respectively,the signal can be enhanced with the nonlinearity caused by Coulomb interaction,while the noise presents an exponential ***,considering the homodyne detection effect,the range of system parameters and frequency bands will be *** present investigation may provide a route toward simultaneously evading backaction noise,reducing the mechanical thermal noise,and enhancing the external signal,which can be an alternative design for sensitive devices.

关键词： force sensing optical parametric amplifier quantum non-demolition measurement optomechanical system

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