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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural regeneration research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel markus Kerbl lászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue regeneration ViennaAustria ludwig Boltzmann institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria Univer.ity Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary medical Univer.ity of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair.is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. in this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. in the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Geochemistry of the uranium-thurium-bearing granitic rocks and pegmatites of Wadi Haleifiya area,Southeastern Sinai,Egypt

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Chinese Journal Of Geochemistry 2012年第3期31卷 242-259页

作者： El Gharbawy r.i El maadawy W.m. Faculty of Science Ain Shams UniveristyCairoEgypt Nuclear materials Authority P.O.Box 030MaadiEgypt

There are two main granitic rocks cropping out in the study area:1) the syn-orogenic granites are moderately weathered,jointed,exfoliated and characterized by low *** rocks are subdivided into tonalite and *** are essentially composed of plagioclase,quartz,biotite,hornblende and potash feldspar;and 2) the post-orogenic granites,characterized by high relief terr.in and represented by monzogranite,syenogranite and alkali *** monzogranites suffered hydrothermal alteration in par.icular along joints,faults,shear zones and fractures,which recorded the highest values of radioactivity,reflecting the role of post-magmatic alteration processes in the enhancement of *** hydrothermal alteration(desilicification and hematitization) resulted in the formation of mineralized(altered) *** altered granites are enriched in TiO 2,Al 2 O 3,FeO T,mnO,mgO,Na 2 O,rb,Sr,Y,Zr,Zn,Ga and Co and depleted in SiO 2,CaO,P 2 O 5,Nb,Pb,Cu,Ni and Cr relative to the fresh *** investigated granites contain basic xenoliths as well as pockets of ***,quartz,plagioclase and sometimes biotite,represent the essential *** accessory minerals like zircon are metamicted reflecting their radiogenic *** alkali granites are characterized by the presence of aegirine,rebeckite and *** syn-and post-orogenic granites show some variations in their bulk chemical *** older granitoids are metaluminous and exhibit characteristics of i-type granites and possess an arc tectonic *** the other hand,the younger granites are peraluminous and exhibit the characteristics of post-collisional *** is interpreted that radioactivity of the studied rocks is mainly controlled by both magmatic and post-magmatic ***,the post-orogenic granites host zoned and unzoned pegmatite *** of these pockets anomalously attain high *** syenogranites and the pegmat

关键词：花岗质岩石伟晶岩西奈半岛地球化学后造山花岗岩东南亚放射性物质碱性花岗岩

Getting physical with medical education:Exer.ise based virtual anatomy review classes for medical students

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World Journal of methodology 2025年第1期15卷 20-25页

作者： Nadeesha r Samarasinghe Taniya S Nagpal michele l Barbeau Charys m mar.in Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into cur.icula within a post-secondary *** investigate the incorporation of PA into medical cur.iculum,we developed a series of optional exer.ise-based review sessions designed to r.inforce musculoskeletal(mSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exer.ises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,par.icipants were asked to evaluate the classes on their self-reported exam preparedness in improving mSK anatomy knowledge,PA levels,and mental *** par.icipants completed surveys;a majority agreed that the classes increased understanding of mSK concepts(90.0%)and activity levels(97.7%).many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement mSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical cur.iculum may improve comprehension of lear.ing material,alleviate stress and foster social connectivity among medical students.

关键词： medical education musculoskeletal Anatomy Exer.ise Online lear.ing

Phase-field lattice Boltzmann model for dendrites growing and moving in melt flow

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npj Computational materials 2019年第1期5卷 140-149页

作者： lászlórátkai Tamás Pusztai lászlóGránásy Wigner research Centre for Physics P.O.Box 49H-1525 BudapestHungary Brunel Centre of Advanced Solidification Technology Brunel UniversityUxbridgeMiddlesex UB83PHUK

The phase-field and lattice Boltzmann methods have been combined to simulate the growth of solid par.icles moving in melt *** handle mobile par.icles,an overlapping multigrid scheme was developed,in which each individual par.icle has its own moving grid,with local fields attached to *** this approach we were able to simulate simultaneous binary solidification,solute diffusion,melt flow,solid motion,the effect of gravity,and collision of the *** method has been applied for describing two possible modes of columnar to equiaxed transition in the Al–Ti system.

关键词： solidification moving lattice

revision of the genus inouenola lászló,ronkay & Witt,2010(lepidoptera,Noctuoidea,Nolidae,Nolini) with description of 6 new species

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Journal of Forestry research 2015年第2期26卷 457-467页

作者： Gyula m.lászló Gábor ronkay lászló ronkay Fadrusz u.25 Budapest 1114Hungary Heterocera Press ltd. Szt.István krt.4Budapest 1137Hungary Department of Zoology Hungarian Natural History Museum

This paper contains the revision of the genus inouenola la′szlo′,ronkay ＆ Witt,2010 and presents the checklist of the known taxa and their distribution and the description of six new species（inouenola brunneolinea... 详细信息

关键词： inouenola Nolini Nolidae Noctuoidea New species New status South East Asia

Prediction of Dynamic and Aerodynamic Characteristics of the Centrifugal Fan with Forward Curved Blades

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Journal of Thermal Science 2013年第6期22卷 517-521页

作者： Jií Polansky lászló Kalmár roman Gápár Univer.itní 8 306 14 PlzeňCzech Republic miskolc-Egyetemváros MiskolcHungary

The main aim of this paper.is deter.ine the centrifugal fan with forward curved blades aerodynamic characteristics based on numerical modeling. Three variants of geometry were investigated. The first, basic "A" variant contains 12 blades. The geometry of second "B" variant contains 12 blades and 12 semi-blades with optimal length[1]. The third, control variant "C" contains 24 blades without semi-blades. Numerical calculations were performed by CFD Ansys. Another aim of this paper.is to compare results of the numerical simulation with results of approximate numerical procedure. Applied approximate numerical procedure [2] is designated to deter.ine characteristics of the turbulent flow in the bladed space of a centrifugal-flow fan impeller. This numerical method is an extension of the hydro-dynamical cascade theory for.incompressible and inviscid fluid flow. Paper also par.ially compares results from the numerical simulation and results from the experimental investigation. Acoustic phenomena observed during experiment, during numerical simulation manifested as deterioration of the calculation stability, residuals oscillation and thus also as a flow field oscillation. Pressure pulsations are evaluated by using frequency analysis for each variant and wor.ing condition.

关键词： Centrifugal Fan CFD Pressure Coefficient Flow Coefficient

Comparison of layer-stacking and Dempster-Shafer Theory-based methods Using Sentinel-1 and Sentinel-2 Data Fusion in Urban land Cover mapping

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Geo-Spatial information Science 2022年第3期25卷 425-438页

作者： Dang Hung Bui lászlómucsi Department of Geoinformatics Physical and Environmental GeographyUniversity of SzegedSzegedHungary institute for Environmental Science Engineering and ManagementIndustrial University of Ho Chi Minh CityHo Chi Minh CityVietnam

Data fusion has shown potential to improve the accuracy of land cover mapping,and selection of the optimal fusion technique remains a *** study investigated the performance of fusing Sentinel-1(S-1)and Sentinel-2(S-2)data,using layer-stacking method at the pixel level and Dempster-Shafer(D-S)theory-based approach at the decision level,for mapping six land cover classes in Thu Dau mot City,*** the pixel level,S-1 and S-2 bands and their extracted textures and indices were stacked into the different single-sensor and multi-sensor datasets(*** datasets).The datasets were categorized into two *** group included the datasets containing only spectral and backscattering bands,and the other group included the datasets consisting of these bands and their extracted *** random forest(rF)classifier was then applied to the datasets within each *** the decision level,the rF classification outputs of the single-sensor datasets within each group were fused together based on D-S ***,the accuracy of the mapping results at both levels within each group was *** results showed that fusion at the decision level provided the best mapping accuracy compared to the results from other products within each *** highest overall accuracy(OA)and Kappa coefficient of the map using D-S theory were 92.67%and 0.91,*** decision-level fusion helped increase the OA of the map by 0.75%to 2.07%compared to that of corresponding S-2 products in the ***,the data fusion at the pixel level delivered the mapping results,which yielded an OA of 4.88%to 6.58%lower than that of corresponding S-2 products in the groups.

关键词： land cover mapping data fusion random forest Dempster-Shafer theory optical data radar data pixel level decision level

Discrepancies between clinical and autopsy findings in patients who had an acute stroke

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Stroke & Vascular Neurology 2022年第3期7卷 215-221页

作者： lilla Hudák Attila Csaba Nagy Sarolta molnár Gábor méhes Katalin Erzsébet Nagy lászlóOláh lászlóCsiba Department of Neurology University of Debrecen Faculty of MedicineDebrecenHungary Department of Preventive medicine University of Debrecen Faculty of Public HealthDebrecenHungary Department of Pathology University of Debrecen Clinical CenterDebrecenHungary Doctoral School of Neuroscience University of Debrecen Faculty of MedicineDebrecenHungary

Objectives Accor.ing to international observations,the incidence of clinical autopsies is declining worldwide,plummeting below 5%in the USA and many European *** is an unfavourable trend as,in 7%-12%of cases,recent clinicopathological studies found discrepancies that might have changed the therapy or the outcome if known *** previous large-scale observations have examined varied patient populations,we aimed to focus on the differences between the clinical and pathological diagnostic findings in only patients who had a *** and methods We assessed the postmortem non-neuropathological and neuropathological findings of 534 consecutive patients who had a stroke who passed *** neoplasms,pneumonias,thromboembolisms and haemorrhagic transformations revealed only by autopsy were considered severe abnormalities;in addition,benign abnormalities important from an educational or scientific point of view were also *** in 26 of the 534 cases(4.9%),the presence of systemic neoplasms had already been confirmed in the clinical stage;however,8(1.5%)malignant tumours were only detected during ***,80(15%)thromboembolic events,73(13.6%)pneumonias and 66(18%)haemorrhagic transformations were only diagnosed at *** hospital stay(from admission to death)resulted in fewer discrepancies between clinical and autopsy diagnosis of thromboembolic events and pneumonias(pin 169 cases,benign findings were *** While the type of acute stroke is reliably diagnosed with imaging techniques,postmortem autopsies are also important in patients who had a stroke as autopsies may reveal clinically silent diseases(eg,tumour),and contribute to knowing the actual incidence of stroke-related thromboembolic and pneumonia complications.

关键词： neoplasms clinical finding

Early Analogue modeling Experiments and related Studies to Today's Problems of Geo-electromagnetic Exploration

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Journal of China Univer.ity of Geosciences 2009年第3期20卷 618-625页

作者： lászló Szarka Geodetic and Geophysical research institute of the Hungarian Academy of Sciences University of West-HungaryH-9401 Sopron POB 5 Hungary

As i learned it from extensive geo-electromagnetic analogue modeling experiments, some specific nonconventional interpretation parameters, in certain conditions, give more detailed information about the geometry of subsurface resistivity inhomogeneities than the routinely used parameters. in this ar.icle, i show several examples, and i present how these early results influenced our later research. An enhanced geometric sensitivity may be due to special array geometry （as we call it ＂null array＂）, or.it may be due to a narrow and very special frequency range （i.e., the so-called ＂keyhole＂ range）. Nonconventional but physically based interpretation parameters （like the Poynting vector） or higher order.invariants of resistivity or.impedance tensors may also give useful additional information about the shape of subsurface bodies. One should be very careful in their application because a large part of these nontraditional approaches are strongly constr.ined by measuring errors and geological noise.

关键词： electromagnetic method analogue modeling null component rotational invariant.