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The wheat receptor-like cytoplasmic kinase TaRlCK1B is required for host immune response to the necrotrophic pathogen Rhizoctonia cerealis

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Journal of Integrative Agriculture 2020年第11期19卷 2616-2627页

作者： WU Tian-ci ZHU Xiu-liang lüliang-jie CHEN Xi-yong XU Gang-biao ZHANG Zeng-yan laboratory of Forestry Genetics Central South University of Forestry and TechnologyChangsha 410004P.R.China National Key Facility for Crop Gene Resources and Genetic Improvement/Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081P.R.China Institute for Cereal and Oil Crops Hebei Academy of Agriculture and Forestry SciencesShijiazhuang 050035P.R.China

Receptor-like cytoplasmic kinases(RlCKs)represent a large family of proteins in *** Arabidopsis and rice,several RlCKs in subfamily VII(RlCKs-VII)have been implicated in pathogen-associated molecular pattern-triggered immunity and basal resistance against bacterial and fungal ***,little is known about roles of RlCKs-VII of the important crop common wheat(Triticum aestivum)in immune ***,we isolated a RlCK-VII-encoding gene from wheat,designated as TaRlCK1B,and investigated its role in host immune response to infection of a necrotrophic fungus Rhizoctonia cerealis that is a major pathogen of sharp eyespot,a destructive disease of ***-sequencing and RT-qPCR analyses showed that transcriptional level of TaRlCK1B was significantly higher in sharp eyespot-resistant wheat cultivars than in susceptible wheat *** gene transcription was rapidly and markedly elevated in the resistant wheat cultivars by *** *** TaRlCK1B protein was closely related to OsRlCK176,a rice resistance-related RlCKs-VII,with 84.03%***-induced gene silencing plus wheat response to *** assay results indicated that silencing of TaRlCK1 impaired resistance to ***,silencing of TaRlCK1 significantly elevated both the content of H2 O2(a major kind of reactive oxygen species,ROS)and the transcriptional level of the ROS-generating enzyme-encoding gene RBOH,but repressed the expression of the ROS-scavenging enzyme-encoding gene CAT1 at 18 hours after inoculation(hai)with *** together,these data suggested that TaRlCK1B was required for the early immune response of wheat to *** through modulating ROS signaling in wheat.

关键词： common wheat(Triticum aestivum) H2 O2 immune response reactive oxygen species receptor-like cytoplasmic kinase Rhizoctonia cerealis

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A visual modeling method for spatiotemporal and multidimensional features in epidemiological analysis:Applied COVID-19 aggregated datasets

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Computational Visual Media 2024年第1期10卷 161-186页

作者： Yu Dong Christy jie liang Yi Chen jie Hua School of Computer Science University of Technology SydneySydneyNSW2007Australia Beijing Key laboratory of Big Data Technology for Food Safety Beijing Technology and Business UniversityBeijing100048China

The visual modeling method enables flexible interactions with rich graphical depictions of data and supports the exploration of the complexities of epidemiological ***,most epidemiology visualizations do not support the combined analysis of objective factors that might influence the transmission situation,resulting in a lack of quantitative and qualitative *** address this issue,we developed a portrait-based visual modeling method called+*** method considers the spatiotemporal features of virus transmission patterns and multidimensional features of objective risk factors in communities,enabling portrait-based exploration and comparison in epidemiological *** applied+msRNAer to aggregate COVID-19-related datasets in New South Wales,Australia,combining COVID-19 case number trends,geo-information,intervention events,and expert-supervised risk factors extracted from local government area-based *** perfected the+msRNAer workflow with collaborative views and evaluated its feasibility,effectiveness,and usefulness through one user study and three subject-driven case *** feedback from experts indicates that+msRNAer provides a general understanding for analyzing comprehension that not only compares relationships between cases in time-varying and risk factors through portraits but also supports navigation in fundamental geographical,timeline,and other factor *** adopting interactions,experts discovered functional and practical implications for potential patterns of long-standing community factors regarding the vulnerability faced by the *** confirmed that+msRNAer is expected to deliver visual modeling benefits with spatiotemporal and multidimensional features in other epidemiological analysis scenarios.

关键词： visual modeling epidemiological analysis spatiotemporal multidimensional COVID-19

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Supramolecular Biomaterials for Cancer Immunotherapy

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Research 2024年第2期2023卷 491-509页

作者： Huan liang Qingqing lu jie Yang Guocan Yu College of Science Nanjing Forestry UniversityNanjing 210037P.R.China Key laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084P.R.China

Cancer immunotherapy has achieved tremendous successful clinical results and obtained historic victories in tumor ***,great limitations associated with feeble immune responses and serious adverse effects still cannot be neglected due to the complicated multifactorial etiology and pathologic microenvironment in *** rapid development of nanomedical science and material science has facilitated the advanced progress of engineering biomaterials to tackle critical *** supramolecular biomaterials with flexible and modular structures have exhibited unparalleled advantages of high cargo-loading efficiency,excellent biocompatibility,and diversiform immunomodulatory activity,thereby providing a powerful weapon for cancer *** past decades,supramolecular biomaterials were extensively explored as versatile delivery platforms for immunotherapeutic agents or designed to interact with the key moleculars in immune system in a precise and controllable *** this review,we focused on the crucial role of supramolecular biomaterials in the modulation of pivotal steps during tumor immunotherapy,including antigen delivery and presentation,T lymphocyte activation,tumor-associated macrophage elimination and repolarization,and myeloid-derived suppressor cell *** on extensive research,we explored the current limitations and development prospects of supramolecular biomaterials in cancer immunotherapy.

关键词： biomaterials limitations thereby

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NiO-Doped Fe_(2)O_(3)/MgO Properties for the Chemical looping Oxidative Dehydrogenation of Ethane

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 27-33页

作者： liang Hao Chen Junjie Sun jie Sun Hui Shenyang ligong University Shenyang 110159China Fushun Ecology Environment Bureau Qingyuan County Branch Fushun 113399China

Ethane chemical looping oxidative dehydrogenation(Cl-ODH)to ethylene is a new technology for ethylene ***_(2)O_(3)/MgO oxygen carrier was prepared using the co-precipitation *** influence of added NiO and its different loadings on Fe_(2)O_(3)/MgO were ***,a series of oxygen carriers were applied in the Cl-ODH of the ethane cycle ***-Emmett-Teller(BET),X-ray diffractometry(XRD),X-ray photoelection spectroscopy(XPS),and H2-temperature programmed reduction(TPR)were used to characterize the physicochemical properties of these oxygen *** was confirmed that an interaction between NiO and Fe_(2)O_(3) occurred based on the XPS and H2-TPR *** on the Cl-ODH activity performance tests conducted in a fixed-bed reactor,it was revealed that ethylene selectivity was significantly improved after NiO ***_(2)O_(3)-10%NiO/MgO showed the best activity performance with 93%ethane conversion and 50%ethylene selectivity at a reaction temperature of 650℃,atmospheric pressure,and space velocity of 7500 ml/(g·h).

关键词： chemical looping oxidative dehydrogenation oxygen carrier Fe_(2)O_(3)/MgO NiO

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Comprehensive evaluation of multi-energy complementary ecosystem based on improved multicriteria decision-making method

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Clean Energy 2024年第1期8卷 226-236页

作者： Huang Shuyi Zou Xuetong liang Huaguang Chen jie Shenzhen Power Supply Bureau China Southern Power GridShenzhen 518048China

The multi-energy complementary ecosystem is an important form of the modern energy ***,standardized evaluation criteria and the corresponding method framework have not yet been formed,resulting in unclear standards and irregular processes of its *** cope with this issue,a novel comprehensive evaluation framework for multi-energy complementary ecosystems is proposed in this ***,a 5D comprehensive evaluation criteria system,including environment,economy,technology,safety and systematicness,is ***,a novel multicriteria decision-making model integrating an analytic network process,entropy and preference-ranking organization method for enrichment evaluation under an intuitional fuzzy environment is ***,four practical cases are used for model testing and empirical *** results of the research show that the unit cost of the energy supply and the internal rate of return indexes have the highest weights of 0.142 and 0.010,*** means that they are the focus in the construction of a multi-energy complementary *** net flows of four cases are 0.015,0.123,-0.132 and-0.005,indicating that cases with a variety of energy supply forms and using intelligent management and control platforms to achieve cold,heat and electrical coupling have more advantages.

关键词： multi-energy complementary ecosystem comprehensive evaluation intuitionistic fuzzy multicriteria decision-making

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Controllable Ring-opening Polymerization ofδ-Valerolactone Catalyzed by Quinolinyl-Urea/MTBD Systems

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Chinese Journal of Polymer Science 2024年第8期42卷 1103-1110页

作者： Xin-Yu liu liang Zhu Su-Yun jie Bo-Geng li State Key laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China

Due to their excellent biocompatibility and biodegradability,aliphatic polyesters are widely used in the biomedical,packaging and agricultural fields,which are usually accessed by the ring-opening polymerization(ROP)of lactones and the catalysts particularly play an important *** a series of quinolinyl-urea catalysts have been synthesized via the reaction between isocyanate and aminoquinoline with an amino group at different substitution positions and *** combination with 7-methyl-1,5,7-triazabicyclo[4,4,0]dec-5-ene(MTBD)as a cocatalyst and benzyl alcohol(BnOH)as an initiator,1-(3,5-bis(trifluoromethyl)phenyl)-3-(quinolin-3-yl)urea(3-QU)was observed to be most active for the ROP ofδ-valerolactone(δ-Vl).The polymerization conditions were optimized by varying the type of organic base,catalyst concentration and reaction *** changing the ratio of[M]_0/[I],linear polyvalerolactones(PVls)with different molecular weights and narrow molecular weight distribution were *** kinetic and chain extension experiments were carried out to prove the"living"/controllable *** the NMR experiments were used to support the proposal of possible mechanism.

关键词： Quinolinyl-urea Ring-opening polymerization PVl

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Gut microbiota-bile acid crosstalk and metabolic fatty liver in spotted seabass(lateolabrax maculatus): The role of a cholesterol, taurine and glycine supplement

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Animal Nutrition 2024年第2期17卷 87-99页

作者： Tingting Song Xiaofang liang Hao Wang Min Xue jie Wang National Aquafeed Safety Assessment Center Institute of Feed Research Chinese Academy of Agricultural Sciences

The prevalent practice of substituting fishmeal with plant protein frequently leads to disturbances in bile acid metabolism, subsequently increasing the incidence of metabolic liver diseases. Bile acid nutrients such as cholesterol, taurine and glycine have been shown to enhance bile acid synthesis and confer beneficial effects on growth. Therefore, this study aimed to investigate the effects of cholesterol-taurineglycine(Ch-Tau-Gly) supplement on bile acid metabolism and liver health in spotted seabass(lateolabrax maculatus) fed a plant-based diet. Two isonitrogenous and isolipidic diets were formulated:(1) plant protein-based diet(PP);(2) PP supplemented 0.5% cholesterol, 0.5% taurine and 1.3% glycine(CTG). Each experimental diet was randomly fed to quadruplicate groups of 30 feed-trained spotted seabass in each tank. The results revealed that supplementing plant-based diet with Ch-Tau-Gly supplement led to an increase in carcass ratio(meat yield) in spotted seabass(P ly contributing positively to their growth. The dietary supplement effectively suppressed endogenous cholesterol synthesis in the liver, promoted the expression of bile acid synthesis enzyme synthesis, and simultaneously the expression of intestinal fxr and its downstream genes, including hnf4a and shp(P lactobacillus＿salivarius and bile salt hydrolase(BSH) were observed in CTG group with concurrently increased conjugated chenodeoxycholic acid(CDCA) bile acids(P licity of the bile acid pool. In CTG group, fatty liver was alleviated with a corresponding increase in lipid metabolism, characterized by a downregulation of genes associated with lipogenesis and lipid droplet deposition, along with an upregulation of genes related to lipolysis. Our study underscored the ability of Ch-Tau-Gly supplement to influence the gut microbiota, leading to an increase in the levels of conjugated CDCA(P le aci

关键词： Cholesterol-taurine-glycine supplement Plant-based diets Fatty liver Gut microbiota–bile acid crosstalk lipid metabolism

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Small-diameter acellular porcine corneal stroma for peripheral corneal ulceration treatment

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 831-837页

作者： Tian liang Xia Wang jie Wu Yan Cheng Department of Ophthalmology Xi’an No.1 HospitalXi’an 710002Shaanxi ProvinceChina

AIM:To evaluate the clinical efficacy of small-diameter acellular porcine corneal stroma(SAPS)for the treatment of peripheral corneal ulceration(PCU).METHODS:This retrospective clinical study included 18 patients(18 eyes)with PCU between April 2018 and December *** patients had PCU and underwent lamellar keratoplasty with *** indicators included preoperative and postoperative best-corrected visual acuity(BCVA)and transparency of *** infection control rate in the surgical eye-lesion area was also ***:Eighteen patients underwent lamellar keratoplasty with SAPS to treat *** of the patients experienced rejection after 6mo(18/18)and 12mo(16/16)of *** BCVA(0.47±0.30)at the 6mo followup after operation was significantly improved compared with the baseline(0.99±0.80),and the difference was statistically significant(Z=-3.415,Pllow-up after operation was not statistically significant compared to the 6mo(Z=0,P=1).With time,the SAPS graft gradually became *** the 6mo(18/18)and 12mo(16/16)follow-up,none of the patients had recurrent corneal ***:SAPS is clinically effective in the treatment of PCU,improving the patient’s BCVA and reducing the incidence of rejection after keratoplasty.

关键词： acellular porcine corneal stroma lamellar keratoplasty infectious corneal ulcer

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Nd^(3)+:YAG-Al_(2)O_(3) nanocrystalline transparent ceramics with high inflexion concentration quenching of Nd^(3+) prepared by amorphous crystallization

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Journal of Advanced Ceramics 2024年第8期13卷 1242-1253页

作者： Xiujuan Wan Guangfan Tan liang Cai jie Fu Jianqiang li Yingchun Zhang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China State Key laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100080China State Key lab for Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Rare earth ion-doped Y_(3)Al_(5)O_(12)(YAG)-based transparent ceramics have been used as important laser gain media for a long time,yet the doping concentration of active ions is limited due to concentration quenching,wherein the inflexion concentration quenching of Nd^(3+)is recognized as 1.0 at%.In this work,YAG-Al_(2)O_(3) nanocrystalline transparent ceramics with a concentration of Nd^(3+)(O-5.0 at%)were fabricated via amorphous crystallization,and the crystal structure evolution,morphology,and optical properties were systematically investigated by differential scanning calorimetry(DSC),X-ray powder diffraction(XRD),transmission electron microscopy(TEM),magnetic resonation(MAS),nuclear magnetic resonation(NMR),and fluorescence *** doping of Nd^(3+)can promote the transition of Al[5]and Al[6]to Al[14],indicating improvements in the ability of the amorphous material to form Nd^(3+):Y_(2)O_(3)-Al_(2)O_(3) vitrified beads,and 1.5 at%Nd^(3+):YAG-Al_(2)O_(3) nanocrystalline transparent ceramics can be obtained by crystallization at 1050℃ with a matrix composed of YAG and concomitant δ-Al_(2)O_(3) and θ-Al_(2)O_(3).The nanocrystalline transparent ceramics show an internal transmitance of 89.56%at 1064 nm,and the strongest emission peak corresponds to the energy transfer from 4F_(3/2) to 4l_(11/2) of Nd^(3+)with a fluorescence lifetime of 231μs when pumped by an 808 nm ***,spectral broadening begins to occur,indicating the onset of concentration quenching,when the concentration of Nd^(3+)exceeds 1.5 at%,substantially higher than the 1.0 at% observed in YAG ***-Al_(2)O_(3) nanocrystalline transparent ceramics obtained by amorphous crystalization can be utilized as the matrix to increase the inflexion point of doping concentration quenching of Nd^(3+),and this material may have great potential as a laser gain medium.

关键词： Y_(3)Al_(5)O_(12)(YAG)-Al_(2)O_(3) nanocrystalline transparent ceramics laser gain medium Nd^(3+)

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The E3 ubiquitin ligase TRAF6 controls CTlA-4 turnover and promotes T-cell-mediated antitumor immunity

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Cellular & Molecular Immunology 2024年第1期21卷 97-99页

作者： Xiao-liang jie Hua Guo Guang-Biao Zhou State Key laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College100021 BejingChina

Yu et al.[1]reported that the tumor necrosis factor(TNF)receptor OX40(CD134)-TNF receptor-associated factor 6(TRAF6)axis mediates lys63-linked ubiquitination and subsequent lysosomal degradation of cytotoxic T-lymphocyte antigen 4(CTlA-4),leading to the enhancement of CD8^(+)T-cell-mediated antitumor *** findings unveil a previously unknown mechanism in controlling the stability of the immune checkpoint CTlA-4 and provide a potential therapeutic target for the improvement of Tcell-based immunotherapy.

关键词： immunity OX40 ubiquitin

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