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Physiopathology of ischemic stroke and its modulation using memantine:evidence from preclinical stroke

Neural Regeneration Research 2021年第3期16卷 433-439页

作者： Hilda Martínez-Coria Isabel Arrieta-Cruz María-Esther Cruz Héctor E.lópez-Valdés División de Investigación Facultad de MedicinaUniversidad Nacional Autónoma de México(UNAM)Ciudad de MéxicoMéxico laboratorio Experimental de Enfermedades Neurodegenerativas Facultad de MedicinaUNAM/Instituto Nacional de Neurología y NeurocirugíaCiudad de MéxicoMéxico Departamento de Investigación Básica Instituto Nacional de GeriatríaCiudad de MéxicoMéxico Unidad de Investigación en Biología de la Reproducción Laboratorio de NeuroendocrinologíaFacultad de Estudios Superiores ZaragozaUNAMCiudad de MéxicoMéxico Unidad Periférica de Neurociencia Facultad de MedicinaUNAM/Instituto Nacional de Neurología y NeurocirugíaCiudad de MéxicoMéxico

Ischemic stroke is the most common type of cerebrovascular disease and is caused by an interruption of blood flow in the *** this disease,two different damage areas are identifying:the lesion core,in which cells quickly die;and the penumbra(surrounding the lesion core),in which cells are functionally weakened but may recover and restore their *** currently approved treatments for ischemic stroke are the recombinant tissue plasminogen activator and endovascular thrombectomy,but they have a short therapeutic window(4.5 and 6 hours after stroke onset,respectively)and a low percentage of stroke patients actually receive these *** is an approved drug for the treatment of Alzheimer's *** is a noncompetitive,low affinity and use-dependent antagonist of N-methyl-D-aspartate glutamate *** has several advantages over developing a new drug to treat focal ischemic stroke,but the most important is that it has sufficient safe probes in preclinical models and humans,and if the preclinical studies provide more evidence about pharmacological actions in tissue protection and repair,this could help to increase the number of clinical *** present review summarizes the physiopathology of isquemic stroke and the pharmacological actions in neuroprotection and neuroplasticity of memantine in the post stroke stage of preclinical stroke models,to illustrate their potential to improve functional recovery in human patients.

关键词： focal ischemic stroke memantine neuroplasticity neuroprotection stroke therapy

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Preparation and Dye Adsorption of low-cost Polyaniline-tea Saponin Nanocomposites

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Journal of Wuhan University of Technology(Materials Science) 2021年第4期36卷 546-556页

作者： ZOU Zhijin lI Yunlong MA Zhengwei JIN Yanqiao lüQiufeng Key laboratory of Advanced Materials Technology(Fuzhou University) Fujian Province UniversityCollege of Materials Science and EngineeringFuzhou UniversityFuzhou 350116China

Four polyaniline-tea saponin (PTS) nanocomposites were prepared by an in-situ polymerization with tea saponin (TS) as a biosurfactant,and they were used to remove organic dyes from aqueous *** PTS nanocomposites were characterized by using field emission scanning electron microscopy,the Fourier transform infrared spectroscopy,the Ultraviolet-visible spectroscopy,and the thermogravimetric *** adsorption performances of the PTS nanocomposites for organic dyes were studied by a static adsorption *** experimental results reveal that adsorption capacities of the PTS nanocomposites are higher than that of pure ***,the PTS nanocomposites exhibit excellent adsorption performances for anionic dyes because of the electrostatic interaction between the positively charged nitrogen atoms on the PTS chains and the negatively charged sulfonate ions in the anionic *** to the adsorption kinetics and thermodynamics results,the adsorption processes of PTS20 for CR and AB74 follow well with the pseudo second-order and langmuir isotherm *** is indicated that TS should be very useful in the preparation of PTS nanocomposite and in removal of toxic dyes from waste water.

关键词： polyaniline tea saponin nanocomposite adsorption

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Oxidation behavior of FeV_(2)O_(4)and FeCr_(2)O_(4)particles in the air:Nonisothermal kinetic and reaction mechanism

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1839-1848页

作者： Junyi Xiang Xi lu luwei Bai Hongru Rao Sheng liu Qingyun Huang Shengqin Zhang Guishang Pei Xuewei lü School of Metallurgy and Materials Engineering Chongqing University of Science and TechnologyChongqing 401331China Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Rep.of Korea College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

High-temperature oxidation behavior of ferrovanadium(FeV_(2)O_(4))and ferrochrome(FeCr_(2)O_(4))spinels is crucial for the application of spinel as an energy material,as well as for the clean usage of high-chromium vanadium ***,the nonisothermal oxidation behavior of FeV_(2)O_(4)and FeCr_(2)O_(4)prepared by high-temperature solid-state reaction was examined by thermogravimetry and X-ray diffraction(XRD)at heating rates of 5,10,and 15 K/*** apparent activation energy was determined by the Kissinger-Akahira-Sunose(KAS)method,whereas the mechanism function was elucidated by the Malek ***,in-situ XRD was conducted to deduce the phase transformation of the oxidation mechanism for FeV_(2)O_(4)and FeCr_(2)O_(4).The results reveal a gradual increase in the overall apparent activation energies for FeV_(2)O_(4)and FeCr_(2)O_(4)during *** stages of the oxidation process are observed based on the oxidation conversion rate of each *** oxidation mechanisms of FeV_(2)O_(4)and FeCr_(2)O_(4)are complex and have distinct *** particular,the chemical reaction controls the entire oxidation process for FeV_(2)O_(4),whereas that for FeCr_(2)O_(4)transitions from a three-dimensional diffusion model to a chemical reaction *** to the in-situ XRD results,numerous intermediate products are observed during the oxidation process of both compounds,eventually resulting in the final products FeVO_(4)and V2O_(5)for FeV_(2)O_(4)and Fe_(2)O_(3)and Cr_(2)O_(3)for FeCr_(2)O_(4),respectively.

关键词： FeV_(2)O_(4) FeCr_(2)O_(4) oxidation nonisothermal kinetics mechanism

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Antibiotic Resistance and Heavy Metals Tolerance in Gram-Negative Bacteria from Diseased American Bullfrog (Rana catesbeiana) Cultured in Malaysia

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Agricultural Sciences in China 2009年第10期8卷 1270-1275页

作者： M Najiah S W lee W Wendy l W Tee M Nadirah S H Faizah Department of Fisheries Science and Aquaculture Faculty of Agrotechnology and Food Science Universiti Malaysia Terengganu Institute of Tropical Aquaculture Universiti Malaysia Terengganu Faculty of Agro Industry and Natural Resources Universiti Malaysia Kelantan

A total of 140 bacterial isolates have been successfully isolated from various organs of diseased American bullfrog （Rana catesbeiana） cultured in Malaysia. The most frequently isolated bacteria was Edwardsiella spp. （46 isolates） followed by Aeromonas spp. （33 isolates）, Flavobacterium spp. （31 isolates）, and Vibrio spp. （30 isolates）. Majority of the bacterial isolates were found sensitive to furazolidone （85.0%）, chloramphenicol （85.0%）, oxolinic acid （90.0%）, florfenicol （95.0%）, and flumequine （97.5%）. On the other hand, most of the bacterial isolates were resistant to oleandomycin （77.5%） and lincomycin （87.5%）. Nitrofurantoin and flumequine can be inhibited the growth of all of Vibrio spp. whereas all isolates of Edwardsiella spp. were found sensitive to florfenicol and flumequine. Multiple antibiotic resistance （MAR） index were in range of 0.30-0.40, indicating that bacterial isolates from cultured bullfrogs may have received high risk exposure to the tested antibiotics. In addition, 90-100% of the isolates were resistant to copper, cadmium, and chromium. These results provided insight information on tolerance level of bacterial isolates from cultured bullfrogs to 21 antibiotics as well as heavy metals.

关键词： Rana catesbeiana MAR index Edwardsiella Aeromonas Flavobaeterium Vibrio antibiotic resistance,heavy metal tolerance

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A new species of the genus Theloderma Tschudi, 1838 (Amphibia： Anura： Rhacophoridae) from Tay Nguyen Plateau, central Vietnam

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Zoological Research 2018年第3期39卷 158-184页

作者： Nikolay A. Poyarkov Ivan I. Kropachev Svetlana S. Gogoleva Nikolai l. Orlov Department of Vertebrate Zoology Biological Faculty Lomonosov Moscow State University Moscow 119234 Russia Joint Russian-Vietnamese Tropical Research and Technological Center Nghia Do Cau Giay Hanoi Vietnam Tula Exotarium Tula 300004 Russia A.N. Severtsov Institute of Ecology and Evolution Russian Academy of Sciences Moscow 119071 Russia Joint Russian-Vietnamese Tropical Research and Technological Center South Branch Ho Chi Minh City Vietnam Zoological Museum of the lomonosov Moscow State University Moscow 125009 Russia Zoological Institute Russian Academy of Sciences St. Petersburg 199034 Russia

A new species of small tree frog from a primary montane tropical forest of central Vietnam, Tay Nguyen Plateau, is described based on morphological, molecular, and acoustic evidence. The Golden Bug-Eyed Frog, Theloderma auratum sp. nov., is distinguishable from its congeners and other small rhacophorid species based on a combination of the following morphological attributes：（1） bony ridges on head absent; （2） smooth skin completely lacking calcified warts or asperities; （3） pointed elongated tapering snout; （4） vocal opening in males absent; （5） vomerine teeth absent; （6） males of small body size （SVl 21.8-26.4 mm）; （7） head longer than wide; ED/SVl ratio 13%-15%; ESl/SVl ratio 16%-20%; （8） small tympanum （TD/El ratio 50%-60%） with few tiny tubercles; （9） supratympanic fold absent; （10） ventral surfaces completely smooth; （11 ） webbing between fingers absent; （12） outer and inner metacarpal tubercles present, supernumerary metacarpal tubercle single, medial, oval in shape; （13） toes half-webbed： I 2-21/4 II 11/^-23/~ III 2-31/4 IV 3-11/2 V; （14） inner metatarsal tubercle present, oval; outer metatarsal tubercle absent; （15） iris bicolored; （16） dorsal surfaces golden-yellow with sparse golden-orange speckling or reticulations and few small dark-brown spots; （17） lateral sides of head and body with wide dark reddish-brown to black lateral stripes, clearlyseparated from lighter dorsal coloration by straight contrasting edge; （18） ventral surfaces of body, throat, and chest greyish-blue with indistinct brown confluent blotches; （19） upper eyelids with few （3-5） very small flat reddish superciliary tubercles; （20） limbs dorsally reddish-brown, ventrally brown with small bluish-white speckles. The new species is also distinct from all congeners in 12S rRNA to 16S rRNA mitochondrial DNA fragment sequences （uncorrected genetic distance P〉8.9%）. Advertisement call and tadpole morphology of the new species are described. Our molecular data showed Theloderma auratum sp. nov.

关键词： Theloderma auratum sp. nov. mtDNAphylogeny 12S rRNA 16S rRNA Kon Tum Gia lai Endemism Taxonomy

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EFFECTS OF IMPURITIES AND RARE EARTH ADDITION ON THE TOUGHENING lEVElS OF Al-li BASED AllOYS 2090 AND 1420

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Acta Metallurgica Sinica(English letters) 1998年第3期11卷 163-168页

作者： l.Meng T.P.Tu Y.Z.Yang M.S.liu Zhejiang Univ Hangzhou China

The effects of the impurities Fe, Si, Na, K and a rare earth addition, Ce, on the intrinsic and extrinsic toughening levels have been investigated for the Al-li based alloys 2090 and 1420. 29K reduction in the toughening level for the alloy 2090 with impurities 0.42% Fe+Si or 0.0132% Na+K i4 identified to be caused by the *** improvement on the fracture toughness can be made by adding 0.05%-0.25% Ce to the alloy 2090. The reason behind this is that Ce microalloying can not only enhance both the intrinsic toughening level and the extrinsic toughening level but also suppress the embrittling behavior of the impurities. However, 0.06%-0.15% Ce microalloying fails to bring about any beneficial effect to the toughening level for the alloy 1420.

关键词： Al-li based alloy impurity Ce addition toughening

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The Development of a Geographic Information System(GIS) Database for Jiuzhaigou National Nature Reserve and Its Application

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Journal of Mountain Science 2013年第3期10卷 398-409页

作者： DI Bao-feng ZHANG Kai-shan TANG Ya ZHANG Ming-hua Susan l.USTIN Department of Environmental Science and Engineering Sichuan University Department of land Airand Water ResourcesUniversity of California Davis

The objective of this paper is to develop a GIS(Geographic Information System) database for Jiuzhaigou National Nature Reserve(Jiuzhaigou,hereafter) in China and demonstrate its application as a research tool.A cost-effective procedure was developed to compile a variety of geographical and biological data of the study area in terms of popular GIS format such as shape *** files were further calibrated and validated using field surveys *** developed GIS database was used to quantify the distributions of the wildlife(amphibians,mammals,and birds) using the distances of the wildlife to the centerline of the bus-tour *** Pearson correlation coefficient was used to quantify the correlation in space between pairs of different wildlife using the number of habitats for given space *** ArcObject-based macro was developed to perform the *** results showed the majority of the habitats of wildlife are located in the proximity of the tour-bus routes with an average distance ranging from 564 to 894 m depending on types of *** indicates a possibility of the disturbance to the wildlife by human *** correlation coefficient of the wildlife ranged from 0.36 to 0.64 depending on pairs of wildlife,indicating some correlations in ***,due to the limited sample size,the statistical significances need to be further *** paper has successfully demonstrated the use of the GIS-based database as a research tool for environmental study.

关键词： Geographic Information System (GIS) Database Remote sensing Wildlife CorrelationCoefficient Jiuzhaigou

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Microstructure and mechanical properties of Fe/NbC composite layer prepared by in-situ reaction

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China Foundry 2023年第4期20卷 356-364页

作者： le Chen Ji-lin li Meng-jun Wang Jie Zheng Yao Zhu Zhuo-lin liu Bing-gui lü School of Materials Science and Engineering Central South UniversityChangsha 410083China School of Materials Science and Engineering Xi'an University of TechnologyXi'an 710048China Institute of New Materials Guangdong Academy of SciencesGuangzhou 510650China Guangdong Provincial Key laboratory of Metal Toughening Technology and Application Guangzhou 510650China Guangdong Guangyun New Material Co. Ltd.Yunfu 527527GuangdongChina Yunfu Guangyun Technology R&D Co. Ltd.Yunfu 527527GuangdongChina

NbC ceramic surface-reinforced steel matrix composites were prepared by an in-situ reaction method at different temperatures(1,050℃,1,100℃and 1,150℃)for different times(1 h,2 h and 3 h).The phase constitution,microstructure and fracture morphology of NbC ceramic surface-reinforced steel matrix composites were analyzed by XRD,SEM and EDS,and the effects of the in-situ reaction temperature and time on the mechanical properties were systematically *** results indicate that the NbC reinforcement layer is formed through the reaction between Nb atoms and carbon atoms diffused from the steel matrix to the Nb *** thickness of this reinforcement layer increases as the reaction time ***,an increase in reaction temperature results in a thicker reinforcement layer,although the rate of increase gradually *** relationship among the thickness of the Nb C reinforcement layer,the reaction time and temperature was established by data *** optimal tensile performance is achieved at 1,100℃for 1 h,with a tensile strength of 228 *** is also found that the defects between the reinforcement layer and the steel matrix are related to reaction *** 1,100℃,these defects are *** mostly occurs in the NbC reinforced layer of the composites,and the fracture mode is characterized by typical intergranular brittle fracture.

关键词： in-situ reaction NbC reinforcement layer microstructure mechanical property

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Wildland fires and moist deciduous forests of Chhattisgarh, India: divergent component assessment

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Journal of Forestry Research 2014年第4期25卷 857-866页

作者： B.H.Kittur S.l.Swamy S.S.Bargali Manoj Kumar Jhariya Department of Silviculture & Agroforestry College of Forestry Kerala Agriculture University Vellanikara Thrissure Kerala India Department of Forestry College of Agriculture Indira Gandhi Krishi Vishwavidyalaya Raipur (C.G.) 492006 India Department of Botany DSB Campus Kumaun University Nainital–263001 (Uttarakhand) India

We studied moist deciduous forests of Chhattisgarh, India （1） to assess the effect of four levels of historic wildland fire frequency （high, medium, low, and no-fire） on regeneration of seedlings in fire affected areas during pre and post-fire seasons, （2） to evaluate vegetation struc- ture and diversity by layer in the four fire frequency zones, （3） to evalu- ate the impact of fire frequency on the structure of economically impor- tant tree species of the region, and （4） to quantify fuel loads by fire fre- quency level. We classified fire-affected areas into high, medium, low, and no-fire frequency classes based on government records. Tree species were unevenly distributed across fire frequency categories. Shrub density was maximum in zones of high fire frequency and minimum in low- frequency and no-fire zones. lower tree density after fires indicated that regeneration of seedlings was reduced by fire. The population structure in the high-frequency zone was comprised of seedlings of size class （A） and saplings of size class （B）, represented by Diospyros melanoxylon, Dalbergia sissoo, Shorea robusta and Tectona grandis. Younger and older trees were more abundant for Tectona grandis and Dalbargia sis- soo after fire, whereas intermediate-aged trees were more abundant pre- fire, indicating that the latter age-class was thinned by the catastrophic effect of fire. The major contributing components of fuel load included duff litter and small woody branches and twigs on the forest floor. Total fuel load on the forest floor ranged from 2.2 to 3.38 Mg/ha. The netchange in fuel load was positive in high- and medium-frequency fire zones and negative under low- and no-fire zones. Repeated fires, how- ever, slowly reduced stand stability. An ecological approach is needed for fire management to restore the no-fire spatial and temporal structure of moist deciduous forests, their species composition and fuel loads. The management approach should incorporate participatory forest ma

关键词： forest fire diversity fuel load vegetation structure

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Simplified seismic scenario analysis of existing masonry buildings accounting for local site effects

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Frontiers of Structural and Civil Engineering 2024年第2期18卷 309-318页

作者： Ayşe E.ÖZSOYÖZBAY Işıl SANRI KARAPINAR Zehra N.KUTlU İsmail E.KIlIÇ Department of Civil Engineering Maltepe UniversityIstanbul 34857Turkey School of Engineering and Construction Oryx Universal CollegeDoha 12253Qatar

This study discusses the effects of local sites and hazard amplification on the seismic vulnerability assessment of existing masonry *** this context,a rapid seismic evaluation procedure was implemented on an old masonry building stock in the historical center Galata,located inİstanbul,to determine the seismic risk priority of the built *** scenarios were generated for all soil classes,different moment magnitudes,and source-to-site distances to obtain more accurate results for the seismic vulnerability assessment of the studied building ***,damage distributions estimated under nine different scenarios with/without site effects were compared and illustrated in maps to discuss changes in vulnerability owing to amplification *** this study,by re-examining the rapid seismic evaluation procedure by including geo-hazard-based assessment,the importance of site effects on the vulnerability and risk assessment of built heritage was *** proposed framework integrating field data and local site effects is believed to advance the current applications for vulnerability assessment of masonry buildings and provide an improvement in the application of rapid seismic assessment procedures with more reliable results.

关键词： masonry buildings seismic vulnerability assessment cultural heritage local site effect

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