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Ameliorative Effect of Ginsenoside RT-5 on CDDP-Induced Nephrotoxicity

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Wuhan University Journal of Natural Sciences 2015年第4期20卷 343-349页

作者： JIANG Yongtao QIU Xiaolei MA Jinbo lü guangyao WANG Zongliang ZHANG Jingwen FU Fenghua WANG Hongbo Key laboratory of Molecular Pharmacology and Drug Evaluation Yantai University Binzhou Medical University State Key laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaCAMS&PUMC

The aim of this study is to explore whether RT-5, one novel active ginsenosides from Ginseng, has protective effects against cisplatin（CDDP）-induced nephrotoxicity in vivo. One model of acute renal failure induced by CDDP in rats and one model of xenograft tumors of human cervical cancer in nude mice are established. Four groups are assigned： control, CDDP, RT-5, CDDP plus RT-5, in which the RT-5 is administered via oral gavage 24 h before CDDP intraperitoneal injection. The significant increase in blood urea nitrogen and creatinine are induced by CDDP treatment at 6 mg/kg, which are attenuated by pre-treated with RT-5 at 10 mg/kg. RT-5 could ameliorate CDDP-induced morphological damages in kidney by PAS staining, and reduce tubular apoptosis evaluated by TUNEl staining. Pretreatment with RT-5 notably inhibits CDDP-induced oxidative stress in kidney tissues. Interestingly, RT-5 does not interfere with the in vivo anti-cancer effects of CDDP against the growth of xenograft tumors in nude mice. These data suggest that co-treatment RT-5 with CDDP might attenuate the following nephrotoxicity without inhibiting its anti-tumor efficiency, which could provide one novel strategy for cancer treatment in clinics.

关键词： nephrotoxicity ginsenosides RT-5 cisplatin(CDDP)

A semantic segmentation-based underwater acoustic image transmission framework for cooperative SlAM

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Defence Technology（防务技术） 2024年第3期33卷 339-351页

作者： Jiaxu li guangyao Han Shuai Chang Xiaomei Fu School of Marine Science and Technology Tianjin UniversityTianjin 300072China

With the development of underwater sonar detection technology,simultaneous localization and mapping(SlAM)approach has attracted much attention in underwater navigation field in recent *** the weak detection ability of a single vehicle limits the SlAM performance in wide ***,cooperative SlAM using multiple vehicles has become an important research *** key factor of cooperative SlAM is timely and efficient sonar image transmission among underwater ***,the limited bandwidth of underwater acoustic channels contradicts a large amount of sonar image *** is essential to compress the images before ***,deep neural networks have great value in image compression by virtue of the powerful learning ability of neural networks,but the existing sonar image compression methods based on neural network usually focus on the pixel-level information without the semantic-level *** this paper,we propose a novel underwater acoustic transmission scheme called UAT-SSIC that includes semantic segmentation-based sonar image compression(SSIC)framework and the joint source-channel codec,to improve the accuracy of the semantic information of the reconstructed sonar image at the *** SSIC framework consists of Auto-Encoder structure-based sonar image compression network,which is measured by a semantic segmentation network's *** that sonar images have the characteristics of blurred target edges,the semantic segmentation network used a special dilated convolution neural network(DiCNN)to enhance segmentation accuracy by expanding the range of receptive *** joint source-channel codec with unequal error protection is proposed that adjusts the power level of the transmitted data,which deal with sonar image transmission error caused by the serious underwater acoustic *** results demonstrate that our method preserves more semantic information,with advantages over existing methods at the sa

关键词： Semantic segmentation Sonar image transmission learning-based compression

Anomalous negative magnetoresistance in quantum dot Josephson junctions with Kondo correlations

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 3-13页

作者： Mingtang Deng Chunlin Yu guangyao Huang Rosa lópez Philippe Caroff Sepideh Ghalamestani Gloria Platero Hongqi Xu Institute for Quantum Information&State Key laboratory of High Performance Computing College of Computer Science and TechnologyNational University of Defense TechnologyChangsha 410073China Nanolund and Division of Solid State Physics Lund UniversityLund S-22100Sweden China Greatwall Quantum laboratory Changsha 410006China Institut de Física Interdisciplinària i de Sistemes Complexos IFISC Palma de Mallorca E-07122Spain Instituto de Ciencia de Materiales de Madrid Madrid 28049Spain Beijing Key laboratory of Quantum Devices Key Laboratory for the Physics and Chemistry of Nanodevicesand Department of ElectronicsPeking UniversityBeijing 100871China Beijing Academy of Quantum Information Sciences Beijing 100193China Hefei National laboratory Hefei 230088China

The interplay between superconductivity and the Kondo effect has stimulated significant interest in condensed matter *** compete when their critical temperatures are close and can give rise to a quantum phase transition that can mimic Majorana zero ***,we have fabricated and measured Al-InSb nanowire quantum dot-Al *** the Kondo regime,a supercurrent-induced zero-bias conductance peak *** zero-bias peak shows an anomalous negative magnetoresistance(NMR)at weak magnetic *** attribute this anomalous NMR to quasiparticle trapping at vortices in the superconductor leads as a weak magnetic field is *** trapping effect lowers the quasiparticle-caused dissipation and thus enhances the Josephson *** work connects the vortex physics and the supercurrent tunneling in Kondo regimes and can help further understand the physics of Josephson quantum dot system.

关键词： quantum dot Kondo correlation InSb nanowire quasiparticle trapping

Numerical Simulation Study on Influence of Equation of State on Internal Flow Field and Performance of S-CO_(2)Compressor

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Journal of Thermal Science 2024年第3期33卷 888-898页

作者： ZHANG lei YANG Zhenyu SUN Enhui ZHANG Qian AN guangyao YUAN Wei Hebei Key laboratory of low Carbon and High Efficiency Power Generation Technology North China Electric Power UniversityBaoding071003China School of Energy Power&Mechanical EngineeringNorth China Electric Power UniversityBaoding071028China

The low power consumption of the near-critical compressor is the key factor for the high efficiency of supercritical CO_(2)Brayton *** the numerical simulation of the compressor,the rapid changes in the thermophysical properties of the CO_(2)near the critical point make it difficult to capture the condensation *** paper investigates the influence of fluid physical properties on the condensation ***,the differences in the physical properties of CO_(2)in the SRK EOS(equation of state),PR EOS,and SW EOS are ***,the simulation of nozzles and compressors were carried out and *** show that the condensation positions predicted by the three EOSs are basically the *** with SW EOS,the disparities between the maximum condensation mass fraction predicted by the PR and SRK EOSs is5.7%and 11.5%,and that of total pressure ratio is 0.3%and 3.8%,*** results show that PR EOS can be considered for numerical simulation in engineering *** its physical property calculation results are closer to the actual physical properties while the physical properties change more gently,it has considerable accuracy and numerical stability.

关键词： supercritical carbon dioxide equation of state centrifugal compressor numerical simulation condensation

Analytical investigations of in situ stress inversion from borehole breakout geometries

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2375-2387页

作者： Zizhuo Xiang Taehyun Moon Joung Oh guangyao Si Ismet Canbulat School of Minerals and Energy Resources Engineering University of New South WalesSydneyNSW2052Australia HNTB Corporation 3505th Ave.58th FloorNew YorkNY10118USA

This study aims to investigate the feasibility of deriving in situ horizontal stresses from the breakout width and depth using the analytical ***-three breakout data with different borehole sizes were collected and three failure criteria were *** on the Kirsch equations,relatively accurate major horizontal stress(sH)estimations from known minor horizontal stress(sh)were achieved with percentage errors ranging from 0.33%to 44.08%using the breakout *** Mogi-Coulomb failure criterion(average error:13.1%)outperformed modified Wiebols-Cook(average error:19.09%)and modified lade(average error:18.09%)failure ***,none of the tested constitutive models could yield reasonable sh predictions from known sH using the same approach due to the analytical expression of the redistributed stress and the nature of the constitutive *** consideration of this issue,the horizontal stress ratio(sH/sh)is suggested as an alternative input,which could estimate both sH and sh with the same level of ***,the estimation accuracies for both large-scale and laboratory-scale breakouts are comparable,suggesting the applicability of this approach across different breakout *** breakout depth,conformal mapping and complex variable method were used to calculate the stress concentration around the breakout tip,allowing the expression of redistributed stresses using binomials composed of sH and ***,analysis of the breakout depth stabilisation mechanism indicates that additional parameters are required to utilise normalised breakout depth for stress estimation compared to breakout *** parameters are challenging to obtain,especially under field conditions,meaning utilising normalised breakout depth analytically in practical applications faces significant challenges and remains infeasible at this ***,the normalised breakout depth should still be considered a critical input for any empirical and statistical stres

关键词： Borehole failure In situ stress estimation In situ horizontal stress ratio Conformal mapping Complex variable method Breakout stabilisation

Stall Evolution Mechanism of a Centrifugal Compressor with a Wide-long Vaneless Diffuser

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Journal of Thermal Science 2024年第3期33卷 899-913页

作者： ZHANG lei KANG Jiacheng lANG Jinhua AN guangyao ZHANG Qian WANG longyao WANG Qifang Department of Power Engineering North China Electric Power UniversityBaoding071003China Hebei Key laboratory of low Carbon and High Efficiency Power Generation Technology North China Electric Power UniversityBaoding071003China

The rotating stall mechanism is of high importance for the stability of centrifugal compressors and thermal power *** majority of research concerning this topic has concentrated on the initial stall ***,the evolution of stall cells in wide-long diffusers has not been comprehensively *** this paper,the causes of rotating stall in the wide-long diffuser and the three-dimensional evolution mechanism of stall cells during the stall process were thoroughly *** the stall induction phase,an annulus vortex structure was found in the reverse-flow zone near the hub side of the diffuser outlet,which was the initial form of stall *** whole evolution process of stall cells was divided into three phases as the flow rate *** the initial stall phase,the dynamic equilibrium was built under effects of the impeller wake and the adverse pressure *** a result,the number of stall cells was kept at seven and the size of stall cells remained *** the transition phase,the flow in the diffuser became *** cells extended to the impeller outlet,and the effect of the wake flow was strengthened *** cells started integrating and separating *** a result,the number and propagation speed of stall cells varied periodically at a constant mass flow *** the deep stall phase,the size of stall cells remained unchanged,and the number of stall cells kept at *** study has important practical guidance and engineering value for the high-efficiency design and safe operation of centrifugal compressors.

关键词： centrifugal compressor wide-long vaneless diffuser stall evolution mechanism wake flow

Analysis and Optimization of the Electrohydraulic Forming Process of Sinusoidal Corrugation Tubes

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Fluid Dynamics & Materials Processing 2024年第4期20卷 873-887页

作者： Da Cai Yinlong Song Hao Jiang guangyao li Junjia Cui State Key laboratory of Advanced Design and Manufacturing Technology for Vehicle Hunan UniversityChangsha410082China

Aluminum alloy thin-walled structures are widely used in the automotive industry due to their advantages related to light weight and *** can be produced at room temperature by the electrohydraulic forming *** the present study,the influence of the related parameters on the forming quality of a 6063 aluminum alloy sinusoidal corrugation tube has been *** particular,the orthogonal experimental design(OED)and central composite design(CCD)methods have been *** the range analysis and variance analysis of the experimental data,the influence degree of wire diameter(WD)and discharge energy(DE)on the forming quality was *** regression analysis was performed using the response surface methodology.A prediction model for the attaching-die state coefficient was established *** following optimal arrangement of parameters was obtained(WD=0.759 mm,DE=2.926 kJ).The attaching-die state coefficient reached the peak value of *** optimized wire diameter and discharge energy for a better attaching-die state could be screened by CCD compared with *** response surface method in CCD was more suitable for the design and optimization of the considered process parameters.

关键词： Electrohydraulic forming aluminum alloy tube process parameters attaching-die state 1 Introduction

Electrospun nanofibrous membranes with antimicrobial activity for air filtration

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Chinese Chemical letters 2024年第10期35卷 147-157页

作者： guangyao Wang Zhitong Xu Ye Qi Yueguang Fang Guiling Ning Junwei Ye State Key laboratory of Fine Chemicals and School of Chemical Engineering Dalian University of TechnologyDalian 116012China Engineering laboratory of Boric and Magnesic Functional Material Preparative and Applied Technology Dalian 116024China

Air pollution,including airborne pathogens and particulate matter(PM),has become a prominent issue affecting human health and *** air filtration materials do not meet the requirements for efficient PM capture or do not instantly kill pathogens,leading to increased risk of direct/indirect contact transmission and infection due to the accumulation of pathogens during *** nanofibrous membranes have emerged as a promising platform due to their rich porous structure,finer fiber diameters,good internal connectivity,and the ability to easily incorporate active chemicals for antimicrobial *** this review,antimicrobial mechanisms of nanofibrous membranes for air filtration and PM capture mechanisms of nanofibers were firstly investigated,and various types of electrospun nanofibrous membranes with different antimicrobial agents for efficient air filtration were described in detail,including organic antimicrobial agents,inorganic antimicrobial agents and metal-organic *** hope this work could provide a better practical insight for designing novel electrospun nanofibrous membranes with antimicrobial efficacy for efficient air filtration.

关键词： Electrospinning Nanofibrous membrane Antimicrobial Particulate matter Airfiltration

Identification of prognostic molecular subtypes and model based on CD8+ T cells for lung adenocarcinoma

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BIOCEll 2024年第3期48卷 473-490页

作者： HONGMIN CAO YING XUE FEI WANG guangyao lI YUlAN ZHEN JINGWEN GUO Internal Medicine-Oncology Dongguan Songshan Lake Central HospitalDongguan523326China Tumor Center First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguan523888China

Background:Cytotoxic T lymphocytes(CD8+T)cells function critically in mediating anti-tumor immune response in cancer *** the speciﬁc functions of CD8+T cells in lung adenocarcinoma(lUAD)could help better understand local anti-tumor immune responses and estimate the effect of ***:Gens related to CD8+T cells were identiﬁed by cluster analysis based on the single-cell sequencing data of three lUAD tissues and their paired normal *** gene co-expression network analysis(WGCNA),consensus clustering,differential expression analysis,least absolute shrinkage and selection operator(lASSO)and Cox regression analysis were conducted to classify molecular subtypes for lUAD and to develop a risk model using prognostic genes related to CD8+T *** of the genes in the prognostic model,their effects on tumor cell invasion,and interactions with CD8+T cells were veriﬁed by cell ***:This study deﬁned two lUAD clusters(CD8+0 and CD8+1)based on CD8+T cells,with cluster CD8+0 being signiﬁcantly associated with the prognosis of *** heterogeneous subtypes(clusters 1,2,and 3)differing in prognosis,genome mutation events,and immune status were categorized using 42 prognostic genes.A prognostic model created based on 11 signiﬁcant genes(including CD200R1,ClEC17A,ZC3H12D,GNG7,SNX30,CDCP1,NEIl3,IGF2BP1,RHOV,ABCC2,and KRT81)was able to independently estimate the death risk for patients in different lUAD ***,the model also showed general applicability in external validation ***-risk patients could beneﬁt more from taking immunotherapy and were signiﬁcantly related to the resistance to anticancer *** results from cell experiments demonstrated that the expression of CD200R1,ClEC17A,ZC3H12D,GNG7,and SNX30 was signiﬁcantly downregulated,while that of CDCP1,NEIl3,IGF2BP1,RHOV,ABCC2 and KRT81 was upregulated in lUAD *** of CD200R1 greatly increased the invasiveness of the lUAD cell

关键词： CD8+T cell lung adenocarcinoma Molecular subtype Prognostic model Immunotherapy