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Catheter-directed thrombolysis in inflammatory bowel diseases:Report of a case

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World Journal of Gastroenterology 2012年第34期18卷 4791-4793页

作者： Péter Ilonczai Judit tóth lászló tóth István Altorjay Zoltán Boda Károly Palatka Division of Haemostasis 2nd Department of MedicineMedical and Health Science CentreUniversity of Debrecen4032 DebrecenHungary Euromedic Diagnostics Hungary ltd. Medical and Health Science CentreUniversity of Debrecen4032 DebrecenHungary Department of Pathology Medical and Health Science CentreUniversity of Debrecen4032 DebrecenHungary Division of Gastroenterology 2nd Department of MedicineMedical and Health Science CentreUniversity of Debrecen4032 DebrecenHungary

In patients with inflammatory bowel diseases (IBD) the prevalence of thrombosis is 6.2%, the average incidence of thromboembolism (tE) is 3.6 times higher compared to normal population. the tE is a common extraintestinal complication of IBD, squarely associated with the IBD activity. the application of antico-agulant and thrombolytic therapy in severe IBD is an unresolved issue. Herein we report the first case in literature of an active IBD patient with an upper limb acute arterial occlusion and successful catheter-directed thrombolysis (CDt). A 46-year-old male patient is reported who had Crohn's disease for 10 years. His right hand suddenly became cold and painful. Angiography proved acute occlusion of the brachial and radial artery. Vascular surgery intervention was not applicable. Endoscopy showed extended, severe inflammation of the colon. Despite the severe endoscopic findings, frequent bloody stools and moderate anaemia, CDt with recombinant tissue plasminogen activator was performed. the control angiography proved improvement, the radial artery pulse appeared. No bleeding complication was observed. this case supports that CDt-after careful estimation of the bleeding risk-can be effective and safe in patients with severe or life-threatening tE and active IBD.

关键词： Inflammatory bowel disease Crohn's dis-ease thromboembolism Catheter-directed thromboly-sis Gastrointestinal haemorrhage

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Intelligent Control and Automation 2012年第3期3卷 278-283页

作者： lászló Richárd tóth lajos Nagy Ferenc Szeifert Department of Process Engineering University of Pannonia Veszprém Hungary

to reach an acceptable controller strategy and tuning it is important to state what is considered “good”. to do so one can set up a closed-loop specification or formulate an optimal control problem. It is an interesting question, if the two can be equivalent or not. In this article two controller strategies, model predictive control (MPC) and constrained direct inversion (CDI) are compared in controlling the model of a pilot-scale water heater. Simulation experiments show that the two methods are similar, if the manipulator movements are not punished much in MPC, and they act practically the same when a filtered reference signal is applied. Even if the same model is used, it is still important to choose tuning parameters appropriately to achieve similar results in both strategies. CDI uses an analytic approach, while MPC uses numeric optimization, thus CDI is more computationally efficient, and can be used either as a standalone controller or to supplement numeric optimization.

关键词： Model Predictive Control Inverse Control Objective Function Closed-loop Specification Heat transfer

Pedigree and genetic analysis of a novel mutation carrier patient suffering from hereditary nonpolyposis colorectal cancer

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World Journal of Gastroenterology 2006年第8期12卷 1192-1197页

作者： Miklós tanyi Judith Olasz Géza lukács Orsolya Csuka lászló tóth Zoltán Szentirmay Zsuzsa Ress Zsolt Barta János l tanyi lászló Damjanovich 1~(st)Department of Surgery University of DebrecenMedical and Health Sciences CenterDebrecenHungary Department of Pathogenetics National Institute of OncologyBudapestHungary Department of Pathology University of DebrecenMedical and Health Sciences CenterDebrecenHungary Department of Human and Experimental tumor Pathology National Institute of OncologyBudapestHungary 3~(rd)Department of Medicine University of DebrecenMedical and Health Sciences CenterDebrecenHungary Department of Obstetrics and Gynecology Baylor College of MedicineHoustonTXUnited States

AIM： to screen a suspected Hungarian HNPCC family to find specific mutations and to evaluate their effect on the presentation of the disease. MEthODS： the family was identified by applying the Amsterdam and Bethesda Criteria. Immunohistochemistry was performed, and DNA samples isolated from tumor tissue were evaluated for microsatellite instability. the identification of possible mutations was carried out by sequencing the hMlH1 and hMSH2 genes. RESUltS： two different mutations were observed in the index patient and in his family members. the first mutation was located in exon 7, codon 422 of hMSH2, and caused a change from Glu to StOP codon. No other report of such a mutation has been published, as far as we could find in the international databases. the second mutation was found in exon 3 codon 127 of the hMSH2 gene, resulting in Asp→Ser substitution. the second mutation was already published, as a non-pathogenic allelic variation. CONClUSION： the pedigree analysis suggested that the newly detected nonsense mutation in exon 7 of the hMSH2 gene might be responsible for the development of colon cancers. In family members where the exon 7 mutation is not coupled with this missense mutation, colon cancer appears after the age of 40. the association of these two mutations seems to decrease the age of manifestation of the disease into the early thirties.

关键词： Hereditary nonpolyposis colon cancer Bethesda criteria Mutation hMlH1 hMSH2

Microscopic colitis: A retrospective study of clinical presentation in 53 patients

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World Journal of Gastroenterology 2005年第9期11卷 1351-1355页

作者： Zsolt Barta Gabriella Mekkel István Csíp(o|") lászló tóth Szabolcs Szakáll Gábor G.Szabó Gyula Bakó Gyula Szegedi Margit Zeher third Department of Medicine Department of Pathology

AIM: to evaluate the relationship between symptoms and microscopic colitis (MC) subtypes: to test whether collagenous colitis (CC) and/or lymphocytic colitis (lC)might be related to both constipation and ***: A cohort of patients with independently confirmed typical histopathological changes was investigated. Fifty-three patients with histologically proved MC (46 with CC, 7 with lC) were included. the existence of diarrhea or constipation and the co-existence of autoimmune diseases were also investigated and all data were retrospectively ***: twenty-three (43.39%) of MC patients had chronic constipation (20 in CC, 3 in lC patients). twentyfour(45.28%) of MC patients had autoimmune disease and the diagnosis of autoimmune disease was always prior to MC. Sjogren's syndrome was associated only with the constipation ***: the Janus face of MC resembles the subgroups of irritable bowel syndrome. the co-existence of autoimmune diseases and MC is confirmed in both the constipation and diarrhea subgroups.

关键词： Microscopic colitis Constipation Autoimmune

A single micro-lED manipulation system based on micro-gripper

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Nanotechnology and Precision Engineering 2024年第2期7卷 45-52页

作者： Jie Bai Pingjuan Niu Erdan Gu Jianming li Clarence Augustine th tee School of Mechanical Engineering Tiangong University School of Electronic and Information Engineering Tiangong University Institute of Photonics University of Strathclyde tianjin Key laboratory of Micro low Gravity Environment Simulation technology Tianjin Aerospace Electromechanical Equipment Research Institute Department of Electrical and Information Engineering School of Physics and Electrical Information EngineeringZhejiang Normal University

Micro-lEDs(μlEDs) have advantages in terms of brightness, power consumption, and response speed. In addition, they can also be used as micro-sensors implanted in the body via flexible electronic skin. One of the key techniques involved in the fabrication of μlED-based devices is transfer printing. Although numerous methods have been proposed for transfer printing, improving the yield of μlED arrays is still a formidable task. In this paper, we propose a novel method for improving the yield of μlED arrays transferred by the stamping method, using an innovative design of piezoelectrically driven asymmetric micro-gripper. traditional grippers are too large to manipulate μlEDs, and therefore two micro-sized cantilevers are added at the gripper tips. A μlED manipulation system is constructed based on the micro-gripper together with a three-dimensional positioning system. Experimental results using this system show that it can be used successfully to manipulate μlED arrays.

关键词： Micro-gripper Micro-lED transfer printing Manipulation

Some Mean Convergence theorems for the Maximum of Normed Double Sums of Banach Space Valued Random Elements

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1727-1740页

作者： Andrew ROSAlSKY le Van thANH Nguyen thi thUY Department of Statistics University of FloridaGainesvilleFL 32611-8545USA Department of Mathematics Vinh UniversityVinhNghe AnViet Nam High School for Gifted Students Vinh UniversityVinhNghe AnViet Nam

In this correspondence,we establish mean convergence theorems for the maximum of normed double sums of Banach space valued random *** of the results pertain to random elements which are *** expand and improve a number of particular cases in the literature on mean convergence of random elements in Banach *** of the main contributions of the paper is to simplify and improve a recent result of li,Presnell,and Rosalsky[Journal of Mathematical Inequalities,16,117–126(2022)].A new maximal inequality for double sums of M-dependent random elements is proved which may be of independent *** sharpness of the results is illustrated by four examples.

关键词： Double sum mean convergence Rademacher type p Banach space Banach space valued random element M-dependent random elements

Enabling technologies for Autonomous Robotic Systems in Manufacturing

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transactions of Nanjing University of Aeronautics and Astronautics 2024年第4期41卷 403-431页

作者： ERDŐS Gábor ABAI Kristóf BEREGI Richárd CSEMPESZ János CSERtEG tamás GODÓGábor HAJÓS Mátyás HÁY Borbála HORVÁth Dániel HORVÁth Gergely JUNIKIÁdám KEMÉNY Zsolt KOVÁCS András NACSA János PANItI Imre PEDONE Gianfranco tAKÁCS Emma tIPARY Bence ZAHORÁN lászló VÁNCZA József Institute for Computer Science and Control Hungarian Research Network(HUN-REN SZTAKI)BudapestHungary Department of Manufacturing Science and technology Budapest University of Technology and Economics(BME)BudapestHungary EPIC Innolabs Nonprofit ltd. BudapestHungary Eötvös loránd University(EltE) BudapestHungary

Research of autonomous manufacturing systems is motivated both by the new technical possibilities of cyber-physical systems and by the practical needs of the *** operation in semi-structured industrial environments can now be supported by advanced sensor technologies,digital twins,artificial intelligence and novel communication *** enable real-time monitoring of production processes,situation recognition and prediction,automated and adaptive(re)planning,teamwork and performance improvement by *** paper summarizes the main requirements towards autonomous industrial robotics and suggests a generic workflow for realizing such *** case studies will be presented from recent practice at HUN-REN SZtAKI in a broad range of domains such as assembly,welding,grinding,picking and placing,and *** various solutions have in common that they use a generic digital twin concept as their *** making general recommendations for realizing autonomous robotic solutions in the industry,open issues for future research will be discussed.

关键词： industrial robotics autonomy digital twin enabling technology

Very weak solutions to the two-dimensional Monge-Ampére equation Dedicated to Professor Jean-Yves Chemin on the Occasion of His 60th Birthday

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Science China Mathematics 2019年第6期62卷 1041-1056页

作者： Wentao Cao lászló Székelyhidi Jr. Institut für Mathematik Universit?t Leipzig

In this short note we revisit the convex integration approach to constructing very weak solutions to the 2D Monge-Ampére equation with H?lder-continuous ?rst derivatives of exponent β the approach of lewicka and Pakzad(2017) with a new diagonalization procedure which avoids the use of conformal coordinates, which was introduced by De lellis et al.(2018) for the isometric immersion problem.

关键词： Monge-Ampére equation convex integration weak solutions

Intraoperative complication rates in cataract surgery performed by resident trainees and staff surgeons in a tertiary eyecare center in Hungary

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International Journal of Ophthalmology(English edition) 2022年第4期15卷 586-590页

作者： Márton Magyar Gábor lászló Sándor lászló Ujváry Zoltán Zsolt Nagy Gábor tóth Department of Ophthalmology Semmelweis UniversityBudapest 1085Hungary

AIM: to compare the incidence of intraoperative complications during primary phacoemulsification(phaco) surgery between resident surgeons(residents) and staff surgeons(specialists) and to objectively determine the difficulty of stages in phaco surgery. MEthODS: this retrospective study included cases of phaco cataract surgery performed between January and December 2019. there were no exclusion criteria. For each patient, demographics, clinical history, case complexity, type of surgeon, and operative details were reviewed. Primary outcomes included intraoperative complication rates and the objective measure of difficulty in the steps of the surgery performed by residents and ***: A total of 3272 cases were included;7.4%(n=241) of cases were performed by residents. the overall complication rate was 5.4%(n=177). the intraoperative complication rate was significantly higher(Pts(n=33, 13.7%) than in specialists(n=144, 4.8%). the most frequent complications were posterior capsule tear(n=85, 2.6%), anterior capsule tear(n=50, 1.53%), zonular fiber loss(n=45, 1.38%), and dropped nucleus(n=15, 0.46%). Objectively, the most difficult steps during surgery were phaco in 66(60.0%), capsulorhexis in 21(19.1%), irrigation/aspiration in 13(11.8%), hydrodissection in 9(8.2%), and intraocular lens(IOl) implantation in 1(0.9%) case. CONClUSION: Intraoperative complication rates are higher in residents than in specialists. the order of objective difficulty in phaco surgery steps is in line with the subjective findings of other surveys, revealing that the most challenging parts of phaco surgery are phaco and capsulorhexis.

关键词： cataract intraoperative complications resident phacoemulsification staff surgeon