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Phase classification of multi-principal element alloys via interpretable machine learning

npj Computational Materials 2022年第1期8卷 206-217页

作者： Kyungtae Lee Mukil V.Ayyasamy Paige Delsa Timothy Q.Hartnett Prasanna V.Balachandran Department of Materials Science and Engineering University of VirginiaCharlottesvilleVA22904USA Department of Physics University of RichmondRichmondVA23173USA Department of Mechanical and Aerospace Engineering University of VirginiaCharlottesvilleVA22904USA

There is intense interest in uncovering design rules that govern the formation of various structural phases as a function of chemical composition in multi-principal element alloys (MPEAs).In this paper,we develop a machine learning (ML) approach built on the foundations of ensemble learning,post hoc model interpretability of black-box models,and clustering analysis to establish a quantitative relationship between the chemical composition and experimentally observed phases of MPEAs.The originality of our work stems from performing instance-level (or local) variable attribution analysis of ML predictions based on the breakdown method,and then identifying similar instances based on k-means clustering analysis of the breakdown results.We also complement the breakdown analysis with Ceteris Paribus profiles that showcase how the model response changes as a function of a single variable,when the values of all other variables are fixed.Results from local model interpretability analysis uncover key insights into variables that govern the formation of each phase.Our developed approach is generic,model-agnostic,and valuable to explain the insights learned by the black-box models.An interactive web application is developed to facilitate model sharing and accelerate the design of MPEAs with targeted properties.

关键词： alloys element instance

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Efficacy and safety of newly developed cross-linked dextran gel injection for glans penis augmentation with a novel technique

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Asian Journal of Andrology 2018年第1期20卷 80-84页

作者： Dae Yul Yang kyungtae Ko Seong Ho lee Du Geon Moon Jong Wook Kim Won Ki lee Department of Urology College of Medicine Hallym University Chuncheon Korea Department of Urology College of Medicine Korea University Seoul Korea.

There is no safe and effective standard method for glans penis augmentation. Furthermore, there has been scant research on glans penis augmentation due to a poor understanding of glans anatomy, technical difficulty, and a lack of suitable substances for augmentation. Cross-linked dextran gel is a newly developed filler for soft-tissue augmentation. We evaluated the efficacy and safety of using a novel technique to inject cross-linked dextran gel for glans penis augmentation during a 24-week follow-up study. This prospective, single-arm, multicenter study enrolled twenty healthy adult men who underwent glans penis augmentation between June and August 2013. Cross-linked dextran gel was injected into the glans penis using a simple and easy technique. The sizes of the glans penis and individual satisfaction were assessed. Any adverse event was also reported. A total of 18 individuals were analyzed; two of them were lost to follow-up. The mean procedure time and injected volume were about 30 rain and 6.6 ＋- 0.9 ml, respectively. The mean surface areas of the glans at baseline and 24 weeks were 20.0 _＋ 3.5 cm2 and 33.6 -＋ 5.4 cm2, respectively, representing a mean increase of 68.7% _＋ 14.0% （P 〈 0.001）. Sixteen individuals （88.9%） were satisfied with the outcomes, and none were dissatisfied. There were no serious adverse events during the study. Cross-linked dextran gel injection for glans penis augmentation was easy and showed a significant augmentative effect on the glans penis, good durability, and was well tolerated without serious adverse events. Therefore, cross-linked dextran gel injection may be an effective, new technique for glans penis augmentation.

关键词： cosmetic technique dermal fillers dextran glans penis

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Razzer：通过模糊测试查找内核数据竞争漏洞

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中国教育网络 2019年第8期 42-43页

作者：谈心 DR Jeong kyungtae Kim Basavesh Shivakumar Byoungyoung lee 复旦大学韩国科学技术院(KAIST) 普渡大学首尔大学

内核中的数据竞争可能导致许多有害行为。最严重的后果是数据竞争导致内存污染最终可能造成非法权限提升,例如CVE-2016-8655,CVE-2017-2636,and CVE-2017-17712。目前的技术在内核数据竞争漏洞的检测与防护方面都存在一定的局限性,其原... 详细信息

内核中的数据竞争可能导致许多有害行为。最严重的后果是数据竞争导致内存污染最终可能造成非法权限提升,例如CVE-2016-8655,CVE-2017-2636,and CVE-2017-17712。目前的技术在内核数据竞争漏洞的检测与防护方面都存在一定的局限性,其原因是内核中的数据竞争漏洞受到一些系统不确定性行为的影响,比如线程的调度与同步机制。因此与普通的漏洞相比,要检测这类漏洞除了需要控制流和数据流信息以外,还需要精准地执行信息。

关键词：数据竞争模糊测试同步机制控制流 CVE 线程漏洞权限提升

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Strong contact coupling of neuronal growth cones with height-controlled vertical silicon nanocolumns

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Nano Research 2018年第5期11卷 2532-2543页

作者： Seong-Min Kim Seyeong lee Dongyoon Kim Dong-Hee Kang Kisuk Yang Seung-Woo Cho Jin Seok lee Insung S. Choi kyungtae Kang Myung-Han Yoon School of Materials Science and Engineering Gwangju Institute of Science and Technology Gwongju 61005 Republic of Korea Department of Biotechnology Yonsei University 50 Yonsei-ro Seodaemun-gu Seoul 03722 Republic of Korea Department of Chemistry Sookmyung Women's University Seoul 04310 Republic of Korea Center for Cell-Encapsulation Research Department of Chemistry KAIST Daejeon 34141 Republic of Korea Department of Applied Chemistry Kyung Hee University Yongin Gyeonggi 17104 Republic of Korea

In this study, we report that height-controlled vertically etched silicon nano- column arrays （vSNAs） induce strong growth cone-to-substrate coupling and accelerate in vitro neurite development while preserving the essential features of initial neurite formation. Large-scale preparation of vSNAs with flat head morphology enabled the generation of well-controlled topographical stimulation without cellular impalement. A systematic analysis on topography- induced variations on cellular morphology and cytoskeletal dynamics was conducted. In addition, neurite development on the grid-patterned vSNAs exhibited preferential adhesion to the nanostructured region and outgrowth directionality. The arrangement of cytoskeletal proteins and the expression of a focal adhesion complex indicated that a strong coupling existed between the underlying nanocolumns and growth cones. Furthermore, the height-controlled nanocolumn substrates differentially modulated neurite polarization and elongation. Our findings provide an important insight into neuron-nanotopography interactions and their role in cell adhesion and neurite development.

关键词： vertical silicon nanostructures,metal-assisted chemical etching,primary hippocampal neurons,neurite outgrowth,cytoskeletal dynamics

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