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The role of histone modifications:from neurodevelopment to neurodiseases

Signal Transduction and Targeted Therapy 2022年第8期7卷 2710-2732页

作者： Jisu Park Kyubin Lee kyunghwan kim Sun-Ju Yi Department of Biological Sciences and Biotechnology Chungbuk National UniversityCheongjuChungbukRepublic of Korea

Epigenetic regulatory mechanisms,including DNA methylation,histone modification,chromatin remodeling,and microRNA expression,play critical roles in cell differentiation and organ development through spatial and temporal gene *** is a sophisticated and complex process by which neural stem cells differentiate into specialized brain cell types at specific times and regions of the brain.A growing body of evidence suggests that epigenetic mechanisms,such as histone modifications,allow the fine-tuning and coordination of spatiotemporal gene expressions during *** histone modifications contribute to the development of neurodegenerative and neuropsychiatric ***,recent progress in understanding histone modifications in regulating embryonic and adult neurogenesis is comprehensively *** histone modifications implicated in neurodegenerative and neuropsychiatric diseases are also covered,and future directions in this area are provided.

关键词： diseases specialized modification

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The KDM4B–CCAR1–MED1 axis is a critical regulator of osteoclast differentiation and bone homeostasis

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Bone Research 2021年第3期9卷 323-335页

作者： Sun-Ju Yi You-Jee Jang Hye-Jung kim Kyubin Lee Hyerim Lee Yeojin kim Junil kim Seon Young Hwang Jin Sook Song Hitoshi Okada Jae-Il Park Kyuho Kang kyunghwan kim Department of Biological Sciences and Biotechnology Chungbuk National UniversityCheongjuChungbukRepublic of Korea Korea Basic Science Institute Gwangju Center at Chonnam National UniversityGwangjuRepublic of Korea New Drug Development Center KBIO Osong Medical Innovation FoundationCheongjuChungbukRepublic of Korea Data Convergence Drug Research Center Therapeutics&Biotechnology DivisionKorea Research Institute of Chemical TechnologyDaejeonRepublic of Korea Department of Biochemistry Kindai University Faculty of MedicineOsakasayamaOsakaJapan

Bone undergoes a constant and continuous remodeling process that is tightly regulated by the coordinated and sequential actions of bone-resorbing osteoclasts and bone-forming *** studies have shown that histone demethylases are implicated in osteoblastogenesis;however,little is known about the role of histone demethylases in osteoclast ***,we identified KDM4B as an epigenetic regulator of osteoclast *** of KDM4B significantly blocked the formation of tartrate-resistant acid phosphatase-positive multinucleated *** with myeloid-specific conditional knockout of KDM4B showed an osteopetrotic phenotype due to osteoclast *** analysis revealed that KDM4B physically and functionally associates with CCAR1 and MED1 in a *** genome-wide chromatin immunoprecipitation(ChIP)-sequencing,we revealed that the KDM4B–CCAR1–MED1 complex is localized to the promoters of several osteoclast-related genes upon receptor activator of NF-κB ligand *** demonstrated that the KDM4B–CCAR1–MED1 signaling axis induces changes in chromatin structure(euchromatinization)near the promoters of osteoclast-related genes through H3K9 demethylation,leading to NF-κB p65 recruitment via a direct interaction between KDM4B and ***,small molecule inhibition of KDM4B activity impeded bone loss in an ovariectomized mouse *** together,our findings establish KDM4B as a critical regulator of osteoclastogenesis,providing a potential therapeutic target for osteoporosis.

关键词： formation. critical MED1

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Acousto-Optics Tunable Filter Based on a Hollow Optical Fiber for Broadband Polarization Switch Application

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光学学报 2003年第S1期23卷 193-194页

作者： Jaewon Lee Jaewang Yu Sangsoo Choi kyunghwan Oh Dong Il Yum Byoung Yoon kim Department of Information and Communications Kwang- Ju Institute of Science and Technology Kwangju Buk-gu 500-712 Rep. of Korea Department of Physics Korea Advanced Institute Science and Technology Taejon 305701 Rep. of Korea

A novel acousto-optic tunable filter (AOTF) using a hollow optical fiber (HOF) is proposed. Its broadband rejection over 100nm was observed and high polarization dependence as a polarization switch is discussed.

关键词： Hollow Optical Fiber hollow optical fiber tunable filter

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Laser-driven self-exfoliation of graphene oxide layers on a fiber facet for Q switching of an Er-doped fiber laser at the longest wavelength

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Photonics Research 2020年第8期8卷 1324-1332页

作者： BYUNGJOO kim SEONGJIN HONG JAEDEOK PARK YONGSOO LEE DONG-IL YEOM kyunghwan OH Photonic Device Physics Laboratory Institute of Physics and Applied PhysicsYonsei UniversitySeoul 03722South Korea Department of Physics and Energy Systems Research Ajou UniversitySuwon 16499South Korea

A new method to make an all-fiber nonlinear optic device for laser pulse generation is developed by depositing multi-layer graphene oxide(GO)selectively onto the core of the cleaved fiber facet by combining the electrical arc discharge and the laser-driven *** the GO colloid droplet with sub-nanoliter volume,we obtained a GO bulk layer deposited on a fiber facet of the order of milliseconds by using an electric *** prepared fiber facet was then included in an Er-doped fiber laser(EDFL)cavity and we obtained a few layers of GO having nonlinear optic two-dimensional(2D)characteristics selectively on the fiber core by the laser-driven *** 2D GO layers on the fiber core served as a stable and efficient saturable absorber enabling robust pulse train generation atλ1600.5 nm,the longest Q-switched laser wavelength in *** characteristics were analyzed as we varied the pump power atλ980 nm from 105.2 mW to 193.6 mW,to obtain the maximum repetition rate of 17.8 kHz and the maximum output power of 2.3 mW with the minimum pulse duration of 7.8μ*** proposed method could be further applied to other novel inorganic 2D materials opening a window to explore their novel nonlinear optic laser applications.

关键词： fiber laser switched

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