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Enhancement of liposomal stability and cellular drug uptake by incorporating tributyrin into celecoxib-loaded liposomes

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Asian Journal of Pharmaceutical Sciences 2013年第2期8卷 128-133页

作者： Sung Nam Kang soon-Seok Hong soo-Yeon Kim Heungchan Oh Mi-kyung Lee soo-Jeong Lim Department of Bioscience and Biotechnology Sejong University98 Kunja-dongKwangjin-guSeoul 143-747Republic of Korea hanil High School GongjuChungchungnam-Do 314-714Republic of Korea College of Pharmacy Woosuk UniversityWanju-gunJeollabuk-Do 565-701Republic of Korea

Tributyrin,a triglyceride analog of short chain fatty acid butyrate,can act as a prodrug of an anticancer agent *** view of other reports that demonstrated the improved characteristics of conventional liposomes by incorporating small amount of nonphospholipids such as Tween 80,herein we sought to investigate whether the incorporation of tributyrin into the liposomal layers may provide additional advantages for liposomes as an anticancer drug *** were prepared with dimyristoylphosphatidylcholine as a main phospholipid with or without addition of *** was loaded in liposomes as a model anticancer *** 80-incorporated liposomes were also prepared for ***-incorporated liposomes were ineffective in enhancing the skin permeation of celecoxib compared to Tween 80-incorporated ***,tributyrin-incorporated liposomes enhanced the entrapped celecoxib concentration to an extent comparable to Tween 80-incorporated ***,tributyrin-incorporated liposomes exhibited much higher stability compared to Tween 80-incorporated ***,the cellular uptake of celecoxib loaded in tributyrin-incorporated liposomes into mouse melanoma cells were more than 10-fold higher compared to that loaded in conventional-and Tween 80-incorporated *** together,the incorporation of tributyrin into conventional liposomes loaded with anticancer drugs may provide an advanced anticancer drug carrier delivering both drug and tributyrin.

关键词： Tributyrin Liposomes Celecoxib Cancer Formulation

QKD system with fast active optical path length compensation

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Science China(Physics,Mechanics & Astronomy) 2017年第6期60卷 1-7页

作者： Byung Kwon Park Min soo Lee Min Ki Woo Yong-Su Kim Sang-Wook han Sung Moon Center for Quantum Information Korea Institute of Science and Technology Department of Nano-materials Science and Engineering Korea University of Science and Technology

We develop a quantum key distribution (QKD) system with fast active optical path length compensation. A rapid and reliable active optical path length compensation scheme is proposed and applied to a plug-and-play QKD system. The system monitors changes in key rates and controls it is own operation automatically. The system achieves its optimal performance within three seconds of operation, which includes a sifted key rate of 5.5 kbps and a quantum bit error rate of less than 2% after an abrupt temperature variation along the 25 km quantum channel. The system also operates well over a 24 h period while completing more than 60 active optical path length compensations.

关键词： quantum key distribution optical path length compensation plug and play field programmable gate array

Effects of Bacillus subtilis CSL2 on the composition and functional diversity of the faecal microbiota of broiler chickens challenged with Salmonella Gallinarum

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Journal of Animal Science and Biotechnology 2017年第2期8卷 450-458页

作者： Ju Kyoung Oh Edward Alain B.Pajarillo Jong Pyo Chae In Ho Kim Dong soo Yang Dae-kyung Kang Department of Animal Resources Science Dankook University119 Dandae-roCheonan 31116Republic of Korea Abson BioChem Inc10-1 Yangjimaeul-gilSangrok-guAnsan 15524Republic of Korea

Background： The chicken gastrointestinal tract contains a diverse microbiota whose composition and structure play important roles in gut functionality. In this study, microbial shifts resulting from feed supplementation with Bacillus subtilis CSL2 were evaluated in broilers challenged and unchallenged with Salmonella Gallinarum. To analyse bacterial community composition and functionality, 454 GS-FLX pyrosequencing of 16 S r RNA gene amplicons was ***： The Quantitative Insights into Microbial Ecology（QIIME） pipeline was used to analyse changes in the faecal microbiota over a 24-h period. A total of 718,204 sequences from broiler chickens were recorded and analysed. At the phylum level, Firmicutes, Bacteroidetes, and Proteobacteria were the predominant bacterial taxa. In Salmonellainfected chickens（SC）, Bacteroidetes were more highly abundant compared to control（NC） and Bacillus-treated（BT）chickens. At the genus level, in the NC and BT groups, Lactobacil us was present at high abundance, and the abundance of Turicibacter, unclassified Enterobacteriaceae, and Bacteroides increased in SC broilers. Furthermore, taxon-independent analysis showed that the SC and BT groups were compositional y distinct at the end of the 24-h period. Further analysis of functional properties showed that B. subtilis CSL2 administration increased gut-associated energy supply mechanisms（i.e. carbohydrate transport and metabolism） to maintain a stable microbiota and protect gut ***： This study demonstrated that S. Gallinarum infection and B. subtilis CSL2 supplementation in the diet of broiler chickens influenced the diversity, composition, and functional diversity of the faecal microbiota. Moreover, the findings offer significant insights to understand potential mechanisms of Salmonel a infection and the mode of action of probiotics in broiler chickens.

关键词： Bacillus subtilis Broiler chicken Microbiome Salmonel a Gallinarum 16S rRNA gene

Acoustic radiation force impulse elastography for hepatocellular carcinoma-associated radiofrequency ablation

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World Journal of Gastroenterology 2011年第14期17卷 1874-1878页

作者： Hee-Jin Kwon Myong-Jin Kang Jin-han Cho Jong-Young Oh kyung-Jin Nam Sang-Yeong han Sung Wook Lee Department of Radiology Dong-A University HospitalDongdaesindong 3gaSeo-guPusan 602-715South Korea Department of Internal Medicine Dong-A University HospitalDongdaesindong 3gaSeo-guPusan 602-715South Korea

AIM:To evaluate the potential usefulness of acoustic radiation force impulse (ARFI) images for evaluation of hepatocellular carcinomas (HCC)-associated radiofrequency ablation. METHODS:From January 2010 to June 2010,a total of 38 patients with HCC including recurred HCCs after RFA underwent ARFI elastography. The brightness of tumor was checked and the shear wave velocity was measure-d for the-quantification of stiffne-ss. According to theb-rightne-ss,the-tumors we-re-classifie-d as b-righte-r,samecolor and darker compared with adjacent parenchyma. Using the same methods,8 patients with recurred HCCs after RFA state were evaluated about the brightness compared with adjacent RFA ablation area. RESULTS:In the 38 patients with HCCs,20 (52.6%)were brighter than surrounding cirrhotic parenchyma. Another 13 (34.2%) were darker. The others (5 cases,13.2%) were seen as the same color as the adjacent liver parenchyma. Post-RFA lesions were darker than previous tumor and surrounding parenchyma in all 38 cases. However,recurred HCCs were brighter than the treated site in all 8 cases. CONCLUSION:Using ARFI technique is helpful for differential diagnosis in order to detect recurred HCCs more easily in patients with confusing status.

关键词： Hepatocellular carcinoma Elastography Radiofrequency ablation

MYB46-Mediated Transcriptional Regulation of Secondary Wall Biosynthesis

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Molecular Plant 2012年第5期5卷 961-963页

作者： Jae-Heung Ko Won-Chan Kim Joo-Yeol Kim Sung-Ju Ahn kyung-Hwan han Department of Plant and Environmental New Resources Kyung Hee University Yongin Korea Bioenergy Center Kyung Hee University Yongin Korea Department of Horticulture and Department of Forestry Michigan State University East Lansing MI 48824-1222 USA DOE-Great Lakes Bioenergy Research Center Michigan State University East Lansing MI 48824-1222 USA Department of Bioenergy Science and Technology (WCU) Chonnam National University 333 Yongbongro Buk-gu Gwangju 500-757 Korea

Formation of secondary wall requires coordinated transcrip- tional regulation of the genes involved in the biosynthesis of major secondary wall components （e.g. cellulose, hemicellu- lose, and lignin）. Even though many aspects of plant biology have been extensively elucidated using various model spe- cies, our current understanding of secondary wall formation is limited.

关键词： Biosynthesis Regulation Wall

Fenton oxidation of 2,4- and 2,6-dinitrotoluene and acetone inhibition

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Frontiers of Environmental Science & Engineering 2008年第3期2卷 326-332页

作者： Yiliang HE Bin ZHAO Joseph B.HUGHES Sung soo han School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

The performances and kinetic parameters of Fenton oxidation of 2,4-and 2,6-dinitrotoluene(DNT)in water-acetone mixtures and explosive contaminated soil washing-out solutions were investigated at a laboratory *** experimental results show that acetone can be a significant hydroxyl radical scavenger and result in serious inhibition of Fenton oxidation of 2,4-and 2,*** no serious inhibition was found in contaminated soil washing-out solutions,longer reaction time was needed to remove 2,4-and 2,6-DNT completely,mainly due to the competition of hydroxyl *** oxidation of 2,4-and 2,6-DNT fit well with the first-order kinetics and the presence of acetone also reduced DNT’s degradation *** on the comparison and matching of retention time and ultraviolet(UV)spectra between high performance liquid chromatography(HPLC)and standards,the following reaction pathway for 2,4-DNT primary degradation was proposed:2,4-DNT→2,4-dinitro-benzaldehyde→2,4-dinitrobenzoic acid→1,3-dinitrobenzene→3-nitrophenol.

关键词： dinitrotoluenes Fenton oxidation acetone inhibition degradation kinetic reaction pathway

Reconfigurable generation of optical vortices based on forward stimulated intermodal Brillouin scattering in subwavelength-hole photonic waveguides

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Photonics Research 2019年第7期7卷 69-76页

作者： DAE SEOK han MYEONG soo KANG Department of Physics Korea Advanced Institute of Science and Technology(KAIST)

An all-optically reconfigurable generation of optical vortices would be highly beneficial to the implementation of next-generation optical communication and advanced information processing. The previously demonstrated approaches based on the parametric nonlinear optical processes, however, have exhibited limited conversion efficiency due to the group velocity mismatch and nonlinear phase shifts, and require the cumbersome preparation of either the optical element or initial seed beam having a non-zero topological charge. Here, we propose and analyze a novel scheme for highly efficient all-optical generation and control of optical vortices based on the dynamic acoustic vortex grating created by forward stimulated intermodal Brillouin scattering in a subwavelength-hole photonic waveguide. The dual-frequency pump beams in two different hybrid optical modes drive an acoustic vortex mode, which transforms a signal in the fundamental optical mode into an optical vortex mode. This scheme not only eliminates the need for the initial preparation of an angular-momentum-carrying medium or an optical vortex seed but also guarantees high modal purity and nearly 100% conversion efficiency assisted by the energymomentum conservation. We also investigate the feasibility and practicability of the subwavelength-hole waveguides by examining the intermodal conversion efficiency and robustness of guidance of the optical vortices,taking into account the impact of the Kerr-type nonlinear effects on the intermodal Brillouin interactions based on our rigorous full-vectorial analytical theory.

关键词： Reconfigurable generation waveguides effects

Investigation of Domain Wall Velocity to External Fields for High-Quality Waveguide-Type Periodically Poled LiNbO_(3) Fabrication

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Journal of Rare Earths 2006年第Z1期24卷 131-135页

作者： soo Woo Kwon Woo Seok Yang H M Lee Woo kyung Kim hang Yong Lee Dae Ho Yoon Yo Seung Song Department of Materials Engineering Hankuk Aviation UniversityGoyang 412-791Korea Nano Bio-Photonics Team Korea Electronics Technology InstituteBundang 463-816Korea Department of Advanced Material Engineering Sungkyunkwan UniversitySuwon 440-746Korea

The Ti-doped waveguide-type periodically poled LiNbO_(3)(PPLN)were fabricated and the dependence of domain wall velocity on an external field applied for domain inversion was *** whole polarization reversal process was computer-controlled to regulate domain wall expansion at a feedback time shorter than 5μ*** coercive voltage and several values of excess voltage were applied on 500μm-thick wafers serially connected to a 1-MOhm external resistor which had an effect of the poling current reduction,*** deceleration of domain wall *** domain wall velocity is sensitive to the poling voltage,precisely speaking,to the excess *** domain wall velocities were 28.70,16.02 and 5.75μm·s^(-1)under poling field of 23.5,22.0 and 21.0 kV·mm^(-1),***,average duty cycle of PPLN is about 49.93%.

关键词： periodically poled lithium niobate coerciv field duty cycle domain wall velocity quasi phase matching

Carbon stock measurements of a degraded tropical logged-over secondary forest in Manokwari Regency,West Papua,Indonesia

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Forestry Studies in China 2012年第1期14卷 8-19页

作者： Hendri Takao YAMASHITA Arno Adi KUNTORO han soo LEE Department of Development Technology Graduate School for International Development and CooperationHiroshima University1-5-1 KagamiyamaHigashi-Hiroshima 739-8529Japan Faculty of Forestry State University of PapuaManokwari 98314Indonesia Faculty of Civil and Environmental Engineering Institute of Technology BandungBandung 40132Indonesia

Several studies have been conducted in the past on carbon stock measurements in the tropical forests of Indonesia. This study is the first related research conducted in the New Guinea Island. In a degraded logged-over secondary forest in Manokwari Regency （West Papua, Indonesia）, carbon stocks were measured for seven parts, i.e., above-ground biomass （AGB）, below-ground biomass （BGB）, under-storey biomass （B）, necromass of dead leaves （N~）, necromass of dead trees （Art）, litter （L） and soil （S） using appropriate equations and laboratory analysis. Total carbon stocks were measured at 642.8 tC.h~~ in the low disturbance area, 536.9 tC＇ha-~ in the moderate disturbance area and 490.4 tC＇ha ~ in the high disturbance area. Bu, N1 and N were not significant in the carbon stock and were collectively categorized as a total biomass complex. The carbon stock of litter was nearly equal to that of the total biomass complex, while the total carbon stock in the soil was eight times larger than the total biomass complex or the carbon stock of the litter. We confirmed that the average ratio of AGB and BGB to the total biomass （TB） was about 84.7% and 15.3%, respectively. Improvements were made to the equations in the low disturbance logged-over secondary forest area, applying corrections to the amounts ofbiomass of sample trees, based on representative commercial trees of category one. TB stocks before and after correction were estimated to be 84.4 and 106.7 ***-~, indicating that these corrections added significant amounts of tree biomass （26.4%） dur- ing the sampling procedure. In conclusion, the equations for tree biomass developed in this study, will be useful for evaluating total carbon stocks, especially TB stocks in logged-over secondary forests throughout the Papua region.

关键词： West Papua equation carbon stock biomass necromass litter soil