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Suppression of Oxidative Stress of Modified Gongjin-Dan (WSY^1075) in Detrusor Underactivity Rat Model Bladder Outlet Induced by Obstruction

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Chinese Journal of Integrative Medicine 2018年第9期24卷 670-675页

作者： Jin-Woo Jung Seung Hwan Jeon woong Jin Bae Su Jin kim Mun Su Chung Byung II Yoon Sae woong Choi U Syn Ha Sung Yeoun Hwang Sae woong kim Department of Urology International St. Mary's Hospital Catholic Kwandong University College of Medicine Incheon Republic of Korea Institute for Bio-Medical Convergence College of Medicine Catholic Kwandong University Gangneungsi Gangwon-do Republic of Korea Department of Urology College of Medicine The Catholic University of Korea Seoul Republic of Korea Catholic Integrative Medicine Research Institute College of Medicine The Catholic University of Korea Seoul Republic of Korea Korea Bio Medical Science Institute Seoul Republic of Korea

Objective： To investigate the anti-oxidative stress and preventive effect of modified Gongjin-dan （WSY-1075） in a detrusor underactivity rat model. Methods： Rats were randomly allocated to three groups： sham- operated （control）, bladder outlet obstruction-induced detrusor underactivity （BOO-DU）, and BOO-DU with WSY-1075 （WSY） groups. WSY-1075 was orally administrated to rats 200 mg daily for 2 weeks pdor to the operation and 4 weeks after the operation. Bladder outlet obstruction was surgically induced in rats by ligation around the urethra avoiding total obstruction. Cystometrography was conducted on rats in each group for examination of bladders. Results： Compared with the control group, bladder outlet obstruction led to a significant increase in oxidative stress with consequent changes to molecular composition, and decrease in maximal detrusor pressure （P〈0.05）. WSY-1075 treatment significantly suppressed oxidative stress and prevented degenerative and dysfunctional changes in bladder, as compared with BOO-DU group （P〈0.05）. Conclusion： WSY-1075 had beneficial effect on prevention of BOO-DU.

关键词： detrusor underactivity anti-oxidant herbal

Extraction and Purification of Depigmenting Agents from Chinese Plants

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Chemical Research in Chinese Universities 2006年第2期22卷 162-167页

作者： AHN So-young ROW kyung-ho kim Eun-ki School of Chemical and Biological Engineering Center for Advanced Bioseparation Technology Inha University Nam-Ku Incheon 402-751 Korea

Depigmenting agents were solvent-extracted and purified by preparative and analytical HPLC from three Chinese plants; Chrysanthemum morifolium Ramat（ Xizang Caijuhua）, Rhodiola sachalinensis, and Terminalia chebula Retzius. Four fractions obtained from the ethyl ether layer of C. m. Rama and two fractions from the ethyl acetate layer of Rhodiola salientness show depigmenting effects. At 8 200, the ethyl acetate layers of Chrysanthemum morifolium Ramat, Rhodiola sachalinensis and the methanol extract of Terminalia chebula Retzius, can inhibit the melanin production of mouse B16 melanoma cells by 92%, 60% and 90%, respectively, whereas 46% inhibition was observed by commercially available depigmenting agents（arbutin）. These results show the potential of these three Chinese plants as a novel resource for depigmenting agents in the cosmetic industry.

关键词： Chrysanthemum Morifolium Ramat Rhodiola Sachalinensis Terminalia Chebula Retzius Melanin Inhibitory Effect HPLC

A GIS-Based Framework for Real-Time Debris-Flow Hazard Assessment for Expressways in Korea

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International Journal of Disaster Risk Science 2016年第3期7卷 293-311页

作者： Han-Saem kim Choong-Ki Chung Sang-Rae kim kyung-Suk kim Earthquake Research Center Korea Institute of Geoscience and Mineral Resources Department of Civil and Environmental Engineering Seoul National University Department of Civil and Environmental Engineering Northwestern University Expressway and Transportation Research Institute Korea Expressway Corporation

Debris flows caused by heavy rainfall in mountain areas near expressways lead to severe social and economic losses and sometimes result in ***, the development of a real-time system for debris-flow hazard assessment is necessary to provide preliminary information for rapid decision making about evacuations or restoration measures, as well as to prevent secondary disasters caused by debris flows. Recently,various map-based approaches have been proposed using multi-attribute criteria and assessment methods for debrisflow susceptibilities. For the macrozonation of debris-flow hazard at a national scale, a simplified method such as the Korea Expressway Corporation(KEC) debris-flow hazard assessment method can be applied for systematic analysis based on geographic information systems(GIS) and monitoring networks. In this study, a GIS-based framework of real-time debris-flow hazard assessment for expressway sections is proposed based on the KEC debris-flow hazard assessment method. First, the KEC-based method was standardized in a systematic fashion using Arc GIS,enabling the objective and quantitative acquisition of various attribute datasets. The quantification of rainfall criteria also was considered. A safety management system for debris-flow hazard was developed based on the GIS platform. Finally, the method was applied and verified on three expressway sections in Korea. The grading standard for each individual influencing attribute was subsequently modified to more accurately assess the debris-flow hazards.

关键词： Debris-flow hazard Expressway management GIS Korea Real-time hazard assessment

Robust vision-based displacement measurement and acceleration estimation using RANSAC and Kalman filter

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Earthquake Engineering and Engineering Vibration 2023年第2期22卷 347-358页

作者： Jongbin Won Jong-woong Park Min-Hyuk Song Youn-Sik kim Dosoo Moon Department of Civil and Environmental Engineering Chung-Ang UniversityDongjakSeoul 06974Korea Department of Smart Cities Chung-Ang UniversityDongjakSeoul 06974Korea R&D Division Tantan Safety co.LtdSeongdongSeoul 04798Korea Department of Civil and Environmental Engineering University of Hawaii at ManoaHonolulu 96822USA

Computer vision(CV)-based techniques have been widely used in the field of structural health monitoring(SHM)owing to ease of installation and cost-effectiveness for displacement *** paper introduces computer vision based method for robust displacement measurement under occlusion by incorporating random sample consensus(RANSAC).The proposed method uses the Kanade-Lucas-Tomasi(KLT)tracker to extract feature points for tracking,and these feature points are filtered through RANSAC to remove points that are noisy or *** the filtered feature points,the proposed method incorporates Kalman filter to estimate acceleration from velocity and displacement extracted by the *** validation,numerical simulation and experimental validation are *** the simulation,performance of the proposed RANSAC filtering was validated to extract correct displacement out of group of displacements that includes dummy displacement with noise or *** the experiment,both RANSAC filtering and acceleration measurement were validated by partially occluding the target for tracking attached on the *** results demonstrated that the proposed method successfully measures displacement and estimates acceleration as compared to a reference displacement sensor and accelerometer,even under occluded conditions.

关键词： computer vision structural displacement structural acceleration RANSAC Kalman filter

Miniaturized Twin-legged Robot with an Electromagnetic Oscillatory Actuator

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Journal of Bionic Engineering 2018年第1期15卷 106-113页

作者： Buhyun Shin Youngshik kim Jamie Paik kyung-min Lee Department of Mechanical Engineering Hanbat National University 125 Dongseodaero Yuseong-gu Daejeon 34158 Republic of Korea The Institute of Mechanical Engineering EPFL BM 4118 Station 17 1015-Lausanne Switzerland School of Mechanical Engineering Yeungnam University 280 Daehak-Ro Gyeongsan Gyeongbuk 38541 Republic of Korea

There have been many studies on the moving mechanism of micro robots, such as stick-slip, inchworm like motion, and impact drive. Novel actuators like lead zirconate titanate （PZT）, Shape Memory Alloy （SMA）, magnetostrictive materials, electromagnetic actuators, electoractive polymers, ultrasonic linear motors, and dielectric elastomers are utilized to realize the moving mechanism. The use of a conventional electromagnetic actuator is unfavorable, because of a few drawbacks, such as generation of stray magnetic fields, hard to miniaturize to the millimeter scale because of 3D integration and a scaling law, and power consumption to maintain a certain position. This research presents a micro robot that uses an electromagnetic actuator customized and developed for micro robot. The electromagnetic actuator is designed from a Brushless Direct Current （BLDC） motor to overcome the drawbacks mentioned above. The developed robot is composed of two electromagnetic actuators. The overall size of the robot is 20 mm × 11 mm× 9 mm （length × height × width） and the weight is 3 g. The developed robot is able to move bidirectionally with a maximum moving speed of 15.76 mm·s︿-1 （0.79 body-length per second）. The optimal conditions of an input signal are calculated theoretically and verified with experiments.

关键词： electromagnetic actuator oscillatory actuator bionic micro robot stick-slip brushless DC motor

Promoting dynamic recrystallization and improving strength and ductility of Mg-7Bi alloy through Al addition

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Journal of Magnesium and Alloys 2024年第8期12卷 3339-3356页

作者： Gun woong An Sang-Cheol Jin Hyun Ji kim Sumi Jo Sung Hyuk Park Department of Materials Science and Metallurgical Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Graduate School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

This study investigated the influence of the addition of Al to a Mg-7Bi(B7,wt%)alloy,particularly its recrystallization behavior during extrusion and its resulting mechanical *** addition of 2 wt%Al to the B7 alloy resulted in a lower grain size,a reduction in the number density of fine Mg3Bi2 particles,and a higher area fraction of relatively coarse Mg3Bi2 particles in the extrusion *** microstructural changes increased the nucleation sites for recrystallization,reduced the Zener pinning effect,and enhanced particle-stimulated nucleation,all of which promoted dynamic recrystallization behavior during *** a result,the area fraction of recrystallized grains in the extruded alloy increased from 77%to 94%.The extruded B7 alloy exhibited a strongfiber texture,whereas the extruded Mg-7Bi-2Al(BA72)alloy had a weak-texture,which was attributed to the minimal presence of unrecrystallized grains and the dispersed orientation of the recrystallized *** tensile yield strength(TYS)of the extruded BA72 alloy was higher than that of the extruded B7 alloy(170 and 124 MPa,respectively),which resulted from the enhanced grain-boundary and solid-solution strengthening *** tensile elongation(EL)of the BA72 alloy also exceeded that of the B7 alloy(20.3%and 6.1%,respectively),the result of the uniform formation of fine twins under tension in the former and the formation of a few coarse twins among the unrecrystallized grains in the ***,the addition of a small amount of Al to the B7 alloy significantly improved both the strength and ductility of the extruded alloy,resulting in a remarkable increase in the product of the TYS and EL from 756 to 3451 MPa%and expanding its potential range of applications as a lightweight extruded structural component.

关键词： Mg-7Bi alloy Al addition Extrusion Recrystallization Microstructure

Preclinical Long-term Magnetic Resonance Imaging Study of Silymarin Liver-protective Effects

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1167-1175页

作者： Yeon Ji Chae Hwon Heo Chul-woong Woo Sang-Tae kim Jae-Im Kwon Monica Young Choi Yu Sub Sung kyung Won kim Jeong Kon kim Yoonseok Choi Dong-Cheol Woo Department of Convergence Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Convergence Medicine Research Center Asan Institute for Life SciencesAsan Medical CenterSeoulRepublic of Korea Clinical Research Center Asan Medical CenterSeoulRepublic of Korea Department of Radiology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Medical Research Institute Gangneung Asan HospitalGangneung-siGangwon-doRepublic of Korea

Background and Aims:Efficacy evaluations with preclini-cal magnetic resonance imaging(MRI)are uncommon,but MRI in the preclinical phase of drug development provides information that is useful for longitudinal *** study aim was to monitor the protective effectiveness of silymarin with multiparameter MRI and biomarkers in a thioacetamide(TAA)-induced model of liver injury in *** analysis was conducted to assess compare the monitoring of liver function by MRI and ***-ods:TAA was injected three times a week for 8 weeks to generate a disease model(TAA group).In the TAA and sily-marin-treated(TAA-SY)groups,silymarin was administered three times weekly from week *** images were acquired at 0,2,4,6,and 8 weeks in the control,TAA,and TAA-SY ***:The area under the curve to maximum time(AUCtmax)and T_(2)*values of the TAA group decreased over the study period,but the serological markers of liver abnormality increased significantly more than those in the control *** the TAA-SY group,MRI and serological biomarkers indicated attenuation of liver function as in the TAA ***,pattern changes were observed from week 6 to comparable levels in the control group with si-lymarin *** correlations between either AUCtmax or T_(2)*values and the serological biomarkers were ***:Silymarin had hepatoprotective effects on TAA-induced liver injury and demonstrated the usefulness of multiparametric MRI to evaluate efficacy in preclinical studies of liver drug development.

关键词： Liver fibrosis Magnetic resonance imaging Silymarin T1-weight-ed dynamic contrast-enhanced T_(2)*

Single-atom Pd catalyst anchored on Zr-based metal-organic polyhedra for Suzuki-Miyaura cross coupling reactions in aqueous media

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Nano Research 2021年第2期14卷 486-492页

作者： Seongsoo kim Seohyeon Jee kyung Min Choi Dong-Sik Shin Division of Chemical and Bioengineering Kangwon National UniversityGangwon-do 24341Republic of Korea Department of Chemical and Biological Engineering Sookmyung Womens University100 Cheongpa-ro 47-gilYongsan-guSeoul 04310Republic of Korea

The challenge for single-atom catalysts in various C-C cross coupling reaction exists in the development of solid supporting *** has been desired tofind a supporting material designed in molecular level to anchor a single-atom catalyst and provide high degree of dispersion and substrate access in aqueous ***,we prepared discrete cages of metal-organic polyhedra anchoring single Pd atom(MOP-BPY(Pd))and successfully performed a Suzuki-Miyaura cross coupling reaction with various substrates in aqueous *** was revealed that each tetrahedral cage of MOP-BPY(Pd)has 4.5 Pd atoms on average and retained its high degree of dispersion up to 3 months in *** coupling efficiencies of the Suzuki-Miyaura cross coupling reaction exhibited more than 90.0%for various substrates we have tested in the aqueous media,which is superior to those of the molecular Pd complex and metal-organic framework(MOF)anchoring Pd ***,MOP-BPY(Pd)was successfully recovered and recycled without performance degradation.

关键词： metal-organic polyhedra Suzuki-Miyaura cross coupling reaction structure characterization aqueous phase reaction high-degree of dispersion

K2Ti6O13 Nanoparticle-Loaded Porous rGO Crumples for Supercapacitors

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Nano-Micro Letters 2020年第1期12卷 115-123页

作者： Chongmin Lee Sun kyung kim Hankwon Chang Hee Dong Jang Department of Nanomaterials Science and Engineering University of Science and TechnologyYuseong‑guDaejeon 34113Republic of Korea Resources Utilization Research Center Korea Institute of Geoscience and Mineral ResourcesYuseong‑guDaejeon 34132Republic of Korea

One-dimensional alkali metal titanates containing potassium,sodium,and lithium are of great concern owing to their high ion mobility and high specific surface *** those titanates are combined with conductive materials such as graphene,carbon nanotube,and carbon nanofiber,they are able to be employed as efficient electrode materials for *** hexa-titanate(K2Ti6O13,KTO),in particular,has shown superior electrochemical properties compared to other alkali metal titanates because of their large lattice parameters induced by the large radius of potassium ***,we present porous rGO crumples(PGC)decorated with KTO nanoparticles(NPs)for application to *** KTO NP/PGC composites were synthesized by aerosol spray pyrolysis and post-heat *** NPs less than 10 nm in diameter were loaded onto PGCs ranging from 3 to 5μ*** porous structure of the composites was obtained by the activation of rGO by adding an excessive amount of KOH to the *** KTO NP/PGC composite electrodes fabricated at the GO/KOH/TiO2 ratio of 1:3:0.25 showed the highest performance(275 F g−1)in capacitance with different KOH concentrations and cycling stability(83%)after 2000 cycles at a current density of 1 A g−1.

关键词： Potassium hexa-titanate Porous graphene crumples Supercapacitors