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Percutaneous ablation for perivascular hepatocellular carcinoma: Refining the current status based on emerging evidence and future perspectives

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World Journal of Gastroenterology 2018年第47期24卷 5331-5337页

作者： tae Wook kang Hyo Keun Lim Dong Ik Cha Department of Radiology and Center for Imaging Science Samsung Medical Center Sungkyunkwan University School of Medicine Department of Health Sciences and Technology SAIHST Sungkyunkwan University

Various therapeutic modalities including radiofrequency ablation, cryoablation, microwave ablation, and irreversible electroporation have attracted attention as energy sources for effective locoregional treatment of hepatocellular carcinoma(HCC); these are accepted non-surgical treatments that provide excellent local tumor control and favorable survival. However, in contrast to surgery, tumor location is a crucial factor in the outcomes of locoregional treatment because such treatment is mainly performed using a percutaneous approach for minimal invasiveness; accordingly, it has a limited range of ablation volume. When the index tumor is near large blood vessels, the blood flow drags thermal energy away from the targeted tissue, resulting in reduced ablation volume through a socalled "heat-sink effect". This modifies the size and shape of the ablation zone considerably. In addition, serious complications including infarction or aggressive tumor recurrence can be observed during follow-up after ablation for perivascular tumors by mechanical or thermal damage. Therefore, perivascular locations of HCC adjacent to large intrahepatic vessels can affect post-treatment outcomes. In this review, we primarily focus on physical properties of perivascular tumor location, characteristics of perivascular HCC,potential complications, and clinical outcomes after various locoregional treatments; moreover, we discuss the current status and future perspectives regarding percutaneous ablation for perivascular HCC.

关键词： Hepatocellular carcinoma Perivascular Radiofrequency ablation Liver Cryoablation Microwave ablation Irreversible electroporation

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Dynamic evolution of Co species and morphological reconstruction on Co-N-C during the nitrate reduction reaction in neutral solution

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Nano Research 2025年第1期18卷 164-172页

作者： Yuanlin Fu Xiaoting Yang Ya Yu kang Zhou Xiaoyang Ye Aoxiang Zhang Xiaojiao Hou Bingbing Chen Fuqiang Fan Yuhang Li Yu Fu Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819China Department of Physical Education Shen Yang Institute of Science and TechnologyShenyang 110167China Sungrow Power Supply Co. Ltd.Hefei 230088China

The electrochemical nitrate reduction reaction(eNO_(3)^(-)RR)is considered an effective approach for converting nitrate-containing wastewater to *** adsorption and activation of NO_(3)^(-)is the critical step for many materials and the high energy barrier inhibits the continuation of the reduction *** Co nanoparticles encapsulated in the carbon layer we prepared spontaneously react with NO_(3)^(-)and the resulting Co^(2+)is then reduced by electroreduction to Co^(0),which circulates *** resulted in overcoming the energy input required for NO_(3)^(-)adsorption and conversion,thereby increasing the catalytic *** the same time,the morphology of the catalyst reconstructed from a dodecahedron to an interwoven nanosheet structure and the increased surface area also gives it better *** obtained Co(OH)_(2)@Co-N-C has an excellent eNO_(3)^(-)RR of 2774.7μg·h^(-1)·cm^(-2)with a Faraday efficiency of 81.4%in neutral *** the same time,the material-modified electrode can run stably for more than 100 *** work provides a new idea for the design of Co-based catalysts for eNO_(3)^(-)RR.

关键词： electrochemical nitrate reduction reaction Co-based catalyst dynamic evolution of Co species morphological reconstruction

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Comparison of the efficacy and safety of once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction

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Asian Journal of Andrology 2015年第1期17卷 143-148,I0011,I0012页

作者： Soon Hyun Park Sung Woo Park Bong Yun Cha Ie Byung Park kyung Wan Min Yeon Ah Sung tae Hwa Kim Jae Min Lee kang Seo Park Department of Internal Medicine Eulji University School of Medicine Daejeon 302-799 South Korea Department of Endocrinology and Metabolism Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seou1110-746 South Korea Department of Endocrinology and Metabolism College of Medicine the Catholic University of Korea Seou1137-701 South Korea Department of Internal Medicine Gachon University of Medicine and Science Graduate School of Medicine Incheon 405-760 South Korea Department of Internal Medicine Eulji University School of Medicine Seou1139-872 South Korea Department of Endocrinology Ewha Woman's University School of Medicine Seoul 158-710 South Korea Department of Internal Medicine College of Medicine Hanyang University Seoul 133-792 South Korea.

We compared the efficacy and safety between once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction （ED）. A multi-center, randomized, open-label, parallel-group, 12-week study was conducted. 161 patients who improved with on-demand 200 mg of udenafil according to Sexual Encounter Profile （SEP） diary Question 2 and 3 （Q2 and Q3） were randomized into 200 mg on-demand （n = 80） or 50 mg once-daily （n = 81） dosing groups for 8 weeks. The dosing period was followed by a 4-week treatment-free period. The primary efficacy endpoint was the change of the International Index of Erectile Function （IIEF） erectile function domain （EFD） score. The secondary efficacy endpoints included changes to the SEP diary Q2, Q3, IIEF Q3, Q4, other domains of IIEF, Global Assessment Question, and shift to the normal rate （EFD 〉 26）. Vascular endothelial markers were also assessed. The IIEF-EFD score of both groups improved after 8 weeks of treatment （P 〈 0.0001）. There was no statistically significant difference between two groups. Improvement was not maintained after the treatment-free follow-up period. Similar results were observed in the secondary efficacy endpoints. There was also no significant difference in vascular endothelial markers. Daily udenafil was well-tolerated, and there was no significant difference in the adverse drug reactions and adverse events between the two groups. Flushing and headache were the most frequent adverse events. Both regimens improved ED in diabetic patients and were well-tolerated. Further studies are needed to assess the effect of daily udenafil treatment in diabetic patients.

关键词： erectile dysfunction International Index of Erectile Function once-daily dosing ptiosphodiesterase type 5 inhibitor type 2 diabetes mellitus udenafil

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One-year clinical outcomes in invasive treatment strategies for acute ST-elevation myocardial infarction complicated by cardiogenic shock in eld-erly patients

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Journal of Geriatric Cardiology 2013年第3期10卷 235-241页

作者： Yeon Pyo Yoo Ki-Woon kang Hyeon Soo Yoon Jin Cheol Myung Yu Jeong Choi Won Ho Kim Sang Hyun Park kyung tae Jung Myung Ho Jeong Division of Cardiology Hyosung General Hospital 162-90 Sandang dong Chungju 360-802 South Korea Division of Cardiology Eulji University Hospital Eulji University School of Medicine 1306 Dunsan dong Seogu Daejeon 302-120 South Korea Division of Cardiology Worker`s Compensation&Welfare Service Hospital 833 Gaejok-ro Daejeon 306-060 South Korea Division of Cardiology Chunman National University Hospital 42 Jaebong-ro Kwangju 501-757 South Korea

Objective To investigate the clinical outcomes of an invasive strategy for elderly (aged≥75 years) patients with acute ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS). Methods Data on 366 of 409 elderly CS patients from a total of 6,132 acute STEMI cases enrolled in the Korea Acute Myocardial Infarction Registry between January 2008 and June 2011, were collected and analyzed. In-hospital deaths and the 1-month and 1-year survival rates free from major adverse cardiac events (MACE;defined as all cause death, myocardial infarction, and target vessel revascularization) were reported for the patients who had undergone invasive (n=310) and conservative (n=56) treatment strategies. Results The baseline clinical characteristics were not significantly different between the two groups. There were fewer in-hospital deaths in the invasive treatment strategy group (23.5%vs. 46.4%, P<0.001). In addition, the 1-year MACE-free survival rate after invasive treatment was significantly lower compared with the conservative treatment (51%vs. 66%, P=0.001). Conclusions In elderly patients with acute STEMI complicated by CS, the outcomes of invasive strategy are similar to those in younger patients at the 1-year follow-up.

关键词： Acute myocardial infarction Cardiogenic shock Elderly patients

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Microstructure analyses and phase-field simulation of partially divorced eutectic solidification in hypoeutectic Mg-Al Alloys

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Journal of Magnesium and Alloys 2022年第6期10卷 1672-1679页

作者： Joo-Hee kang Jiwon Park kyung Song Chang-Seok Oh Oleg Shchyglo Ingo Steinbach Korea Institute of Materials Science Changwon 51508Republic of Korea Interdisciplinary Centre for Advanced Materials Simulation Ruhr-University Bochum44801 BochumGermany

In this study the partially divorced eutectic microstructure ofα-Mg andβ-Mg17Al12was investigated by electron backscatter diffraction,transmission electron microscopy,and phase-field modeling in hypoeutectic Mg-Al *** orientation relationships between the individual eutecticαgrains,eutecticβphase,and primaryαgrains were *** the amount of eutectic morphology is primarily determined by the Al content,the in-depth microstructure analyses and the phase-field simulation suggest non-interactive nucleation and growth of eutecticαphase in theβphase grown on the interdendritic primaryα***,phase-field simulations showed a preferred nucleation sequence where theβphase nucleates first and subsequently triggers the nucleation of eutecticαphase at the movingβphase solidification front,which supports the microstructural analysis results.

关键词： Mg-Al alloy Partially divorced eutectic Solidification Electron backscatter diffraction Phase-Field modeling

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Leptin and peroxisome proliferator-activated receptor γ expression in colorectal adenoma

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World Journal of Gastroenterology 2012年第6期18卷 557-562页

作者： Hyung Hun Kim You Sun Kim Yun kyung kang Jeong Seop Moon Department of Internal Medicine Seoul Paik HospitalInje University College of MedicineSeoul 100-032South Korea Department of Pathology Seoul Paik HospitalInje University College of MedicineSeoul 100-032South Korea Hyung Hun Kim Department of Internal Medicine Kosin University College of MedicineBusan 602-702South Korea

AIM： To investigate the expressions of leptin and per- oxisome proliferator-activated receptor y （PPARG） in relation to body mass index （BMI）. METHODS： We evaluated leptin and PPARG expres- sion in 30 adenomas over 1 cm in size by immunohisto- chemical staining. In addition, clinicopathologic features including BMI were assessed. RESULTS： PPARG and leptin expression showed a strong positive correlation （P = 0.035）. The average BMI of the leptin-positive group was higher than that of the leptin-negative group （25.4 ＋ 3.4 kg/m2 vs 22.6 ＋ 2.4 kg/m2, P = 0.018）, and leptin expression was sig- nificantly correlated with high BMI （P = 0.024）. Leptinexpression was more frequently observed in intermedi- ate/high grade dysplasia than in low grade dysplasia （P = 0.030）. However, PPARG expression was not cor- related with BMI and grade of dysplasia. CONCLUSION： BMI has influenced on the leptin ex- pression of colorectal adenoma. The exact mechanism underlies the strong correlation between leptin and PPARG expression needs further study.

关键词： Leptin Peroxisome proliferator-activated re-ceptor y Obesity Body mass index Colorectal adenoma

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Strategy of photo-protection in phytoplankton assemblages in the Kongsfjorden, Svalbard, Arctic

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Chinese Journal of Oceanology and Limnology 2016年第1期34卷 1-12页

作者： Sun-Yong HA Doo Byoul LEE Sung-Ho kang kyung-Hoon SHIN Korea Polar Research Institute 26 Songdomirae-ro Yeonsu-gu Incheon 406-840 Republic of Korea Hanyang University Marine Environmental Science Department 1271 Sa-3 dong Sangnok-gu Ansan Kyeonggi-do 425-791 Republic of Korea

Photo-protective functions were investigated in phytoplankton assemblages at Kongsfjorden, Svalbard in spring, using their UV-absorbing compounds （mycosporine-like amino acids （MAAs））, xanthophyllpigments （diadinoxanthin （DD） and diatoxanthin （DT）） and〈beta〉-dimethylsulphoniopropionate （〈beta〉-DMSP）. The dominant phytoplankton species in the inner bay were dominated by Phaeocystis spp. and nanoflagellates, while the offshore waters were dominated by Thalassiosira spp. In the inner bay, UV- absorbing compounds and xanthophyll pigments exhibited higher ratios of MAA to chlorophyll a （MAA：chl a ratio）, and both DD and DT to chlorophyll a （DD：chl a ratio and DT：chl a ratio）, respectively. Thus, the photoprotective-pigrnents such as DD and DT appear to complement MAAs in the natural phytoplankton assemblage. However, the ratio of 〈beta〉-DMSP to chlorophyll a （〈beta〉-DMSP：chl a ratio） did not show a distinct spatial distribution according to environmental factors or interspecies differences. In this study, we found that photoprotective compounds occurred in a manner dependent on the phytoplankton species composition in Kongsfjorden Bay, where Phaeocystis is the dominant species.

关键词： photo-protective compounds dimethylsulphoniumpropionate (DMSP) xanthophyll pigment Kongsf]orden Bay UV radiation

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Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients

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World Journal of Gastroenterology 2015年第5期21卷 1457-1467页

作者： Jeong Mo Bae tae Hun Lee Nam-Yun Cho tae-You Kim Gyeong Hoon kang Laboratory of Epigenetics Cancer Research InstituteSeoul National University College of MedicineSeoul 110-799South Korea Department of Pathology Seoul National University College of MedicineSeoul 110-799South Korea Department of Internal Medicine Seoul National University College of MedicineSeoul 110-799South Korea

AIM:To investigate the clinicopathologic characteristics and prognostic implications associated with loss of CDX2 expression in colorectal cancers(CRCs).METHODS:We immunohistochemically evaluated CDX2 expression in 713 CRCs and paired our findings to clinicopathologic and molecular characteristics of each *** included cytokeratin 7 and CK20 expression,microsatellite instability,Cp G island methylator phenotype,and KRAS and BRAF mutation *** and multivariate survival analysis was performed to reveal the prognostic value of CDX2 ***:CDX2 expression was lost in 42(5.9%) ***,loss of CDX2 expression was associated with proximal location,infiltrative growth,advanced T,N,M and overall *** microscopic examination,loss of CDX2 expression was associated with poor differentiation,increased number of tumor-infiltrating lymphocytes,luminal serration and mucin *** of CDX2 expression was also associated with increased CK7 expression,decreased CK20 expression,Cp G island methylator phenotype,microsatellite instability and BRAF *** a univariate survival analysis,patients with loss of CDX2 expression showed worse overall survival(P < 0.001) and progression-free survival(P < 0.001).In a multivariate survival analysis,loss of CDX2 expression was an independent poor prognostic factor of overall survival [hazard ratio(HR) = 1.72,95%CI:1.04-2.85,P = 0.034] and progression-free survival(HR = 1.94,95%CI:1.22-3.07,P = 0.005).CONCLUSION:Loss of CDX2 expression is associated with aggressive clinical behavior and can be used as a prognostic marker in CRCs.

关键词： CDX2 CpG island methylator phenotype Microsatellit

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Ultra-thin vertical tft photosensor and photosynapse based on au-doped-graphene under transition metal selenide reaction

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Journal of Materials Science & Technology 2024年第16期183卷 215-222页

作者： Ting kang Adila Rani Wanqi Ren M Junaid Sultan Nae-Eung Lee tae Geun Kim School of Electrical Engineering Korea UniversitySeoul 02841South Korea School of Advanced Materials Science&Engineering Sungkyunkwan UniversityGyeonggi-do 16419South Korea

The development of artificial photosensitive synapses with high sensitivity and biomimetic properties that combine innovative concepts and neuromorphic architectures is crucial to achieving highly integrated and flexible intelligent visual ***,graphene heterostructure-based photosensitive synaptic transistors have been extensively studied for this ***,compared to traditional transistors,vertical structure thin film transistors(VTFTs)with ultra-short channels and advantages,such as high integration,have yet to be investigated in photosensitive ***,we report an ultra-thin VTFT featuring a graphene/W_(x)Se_(x-1)van der Waals heterostructure that combines photonic and neuromorphic *** demonstrate a VTFT in which the channel layer is formed by covalently bonded W_(x)Se_(x-1)nanomaterials produced by introducing Se atoms on the surface of a tungsten metal thin film deposited via radio-frequency *** structure successfully simulated the main synaptic function,exhib-ited photosensitive synaptic responses to ultraviolet(λ=365 nm)light,and demonstrated highly reliable electrical ***,the incorporation of gold nanoparticles changed the photosensitive synaptic response properties of the graphene/W_(x)Se_(x-1)heterostructure from excitatory to inhibitory,show-ing a responsivity of about∼14 A W-1,which was attributed to the heterojunction interface resonant effects and efficient charge transfer induced by localized surface *** further enabled optical artificial synaptic applications while operating with low voltage spikes and low light *** work provides a novel strategy for integrating and developing biological and nano-electronic systems.

关键词： Ultra-thin Vertical TFT Au nanoparticles Photo sensor Photo responsivity Photo synapse

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li Wen‑Xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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