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Erectile potentials of a new phosphodiesterase type 5 inhibitor,DA-8159,in diet-induced obese rats

Asian Journal of Andrology 2006年第3期8卷 325-329,388页

作者： Jae-YoungYu kyung-kookang MoohiYoo Research Institutes of Dong A Pharmaceutical Company KiheungYounginKyunggi 449-905Korea

Aim:To examine the changes in the erectile function in diet-induced obese rats and investigate the oral efficacy of DA-8159,a new phosphodiesterase type 5(PDE5)inhibitor,on penile erection in obese ***:The rats were fed a high-energy diet for 12 weeks and divided into three groups:an obesity-resistant(OR)control group,an obesity- prone(OP)control group,and an OP-DA-8159 treatment(DA-8159)*** electrostimulation-induced erectile responses were measured in all *** body weight,plasma cholesterol,triglyceride and glucose levels were also ***:In the OP control group,the maximum intracavernous pressure(ICP)and ICP/blood pressure(ICP/BP)ratio after electric stimulation were significantly lower than those in OR control *** corresponding area under the curve(AUC)of the ICP/BP ratio,the detumescence time and the baseline cavernous pressure were also lower than those in the OR control group,but this difference was not *** body weight gain,plasma cholesterol and triglyceride level in the OP group were significantly higher than those in the OR group. After administering the DA-8159,a significant increase in the maximum ICP and the ICP/BP ratio were *** coerrsponding AUCs in the DA-8159 group were also higher than those in the two control ***,the detumescence time was significantly prolonged after treatment with ***:These results demon- strate that diet-induced obesity affects the erectile function in rats and these erectile dysfunction(ED)can be im- proved by the treatment with DA-8159,indicating DA-8159 might be a treatment option for ED associated with obesity.

关键词： phosphodiesterase type 5 inhibitor penile erection obesity DA-8159 intracavernous pressure

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