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Microperimetry and spectral domain optical coherence tomography in myelinated retinal nerve fibers

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International Journal of Ophthalmology(English edition) 2016年第1期9卷 170-172页

作者： kyung ho lee Seong-Woo Kim Soon-Sun Kwon Jaeryung Oh Kuhl Huh Department of Ophthalmology Korea University College of Medicine Biomedical Research Institute Seoul National University Bundang Hospital

Dear Sir,I write to present the correlation between microperimetric （MP） values and the density of myelinated retinal nerve fibers （MNFs） in optical coherence tomography （OCT） imaging.

关键词： Microperimetry and spectral domain optical coherence tomography in myelinated retinal nerve fibers OS Figure line

Tests on Alkali-Activated Slag Foamed Concrete with Various Water-Binder Ratios and Substitution Levels of Fly Ash

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Journal of Building Construction and Planning Research 2013年第1期1卷 8-14页

作者： Keun-Hyeok Yang kyung-ho lee Department of Architectural Engineering Kyonggi University Graduate School Seoul Korea Department of Plant & Architectural Engineering Kyonggi University Suwon Korea

To provide basic data for the reasonable mixing design of the alkali-activated (AA) foamed concrete as a thermal insulation material for a floor heating system, 9 concrete mixes with a targeted dry density less than 400 kg/m3 were tested. Ground granulated blast-furnace slag (GGBS) as a source material was activated by the following two types of alkali activators: 10% Ca(OH)2 and 4% Mg(NO3)2, and 2.5% Ca(OH)2 and 6.5% Na2SiO3. The main test parameters were water-to-binder (W/B) ratio and the substitution level (RFA) of fly ash (FA) for GGBS. Test results revealed that the dry density of AA GGBS foamed concrete was independent of the W/B ratio an RFA, whereas the compressive strength increased with the decrease in W/B ratio and with the increase in RFA up to 15%, beyond which it decreased. With the increase in the W/B ratio, the amount of macro capillaries and artificial air pores increased, which resulted in the decrease of compressive strength. The magnitude of the environmental loads of the AA GGBS foamed concrete is independent of the W/B ratio and RFA. The largest reduction percentage was found in the photochemical oxidation potential, being more than 99%. The reduction percentage was 87% - 93% for the global warming potential, 81% - 84% for abiotic depletion, 79% - 84% for acidification potential, 77% - 85% for eutrophication potential, and 73% - 83% for human toxicity potential. Ultimately, this study proved that the developed AA GGBS foamed concrete has a considerable promise as a sustainable construction material for nonstructural element.

关键词： Alkali-Activated Foamed Concrete Granulated Ground Blast-Furnace Slag Fly Ash Water-to-Binder Ratio Environmental Load

Scheduling of Logistics for Polarizer Manufacturing

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Scheduling of Logistics for Polarizer Manufacturing

N-terminal pro-B-type natriuretic peptide as prognostic marker for patients of non ST-segment elevation myocardial infarction

The 12th Asian Pacific Confederation of Chemical Engineering Congress

作者： kyung Tae Park Jun-Hyung Ryu ho-kyung lee In-Beum lee Department of Chemical Engineering PostechPohangKorca LG Chem Ltd./ Research ParkDeajeonSouth Korea Department of Chemical Engineering PostcchPohangKorca

This paper presents a scheduling model for logistics of *** production can be divided into front-end and back-end *** the front-end process is mainly located in technical oriented sites,the back-end is located in sites where cheaper labor is *** front- end process produces intermediate *** completion of the front-end process,intermediate films are then transferred to the back-end *** back-end process produces finished Polar- izer using intermediate films.

关键词： polarizer core scenario-based approach

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Journal of Central South University 2013年第8期20卷 2226-2232页

作者： ShoN ho Sun HWANG kyung Kuk BAE Jang Whan KIM kyung Ah lee Jong Yun RYU Keun ho Database and Bioinformatics Laboratory School of Electrical & Computer Engineering also PSM of School of Medicine Chungbuk National University Department of Medicine School of Medicine Chungbuk National University Department of Biomedical Engineering School of Medicine Chungbuk National University Department of Informatics and Convergence Chungbuk National University Cheongju

In this work, we analyzed only the patients of the NSTEMI (non ST-segment elevation myocardial infarction) who arrived at the hospital within 12 h after symptoms started. Using NSTEMI follow-up data within, the characteristics of the clinical data, the risk factor, and the blood tested in the hospital visit were analyzed for MACE (major adverse cardiac events) patients. MACE includes cardiac death, MI (myocardial infarction), Re-PCI, and CABG (coronary artery bypass graft). As a result, from the NSTEMI patients which can be followed up for over 12 m, NT-ProBNP (p=0.014) and age (p=0.045) are found to be the independent risk factors related to MACE. Accordingly, they can be useful for the diagnosis and prognosis for NSTEMI patients as a biomarker.

关键词： non ST-segment elevation myocardial infarction NT-ProBNP cardiovascular disease

Effect of Ionic Liquid on Retention of Solutes on C_(18) Column Based on Linear Solvation Energy Relationships

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Chemical Research in Chinese Universities 2009年第3期25卷 306-311页

作者： ROW kyung ho Center for Advanced Bio Technology Department of Chemical Engineering Inha University

Several chromatography systems with ionic liquids and a mixture of water with the modifier as mobile phase were characterized via the linear solvation energy relationships（LSER） model. The effects of the ionic liquids and modifier（methanol） concentrations on the retention of 10 solutes（caffeine, pyridine, aniline, phenol, methylparaben, acetopenone, m-cresol, p-cresol, o-cresol, and benzene） were discussed. The LSER model demonstrated high potential to predict retention factors with high squared correlation coefficients（r^2〉 0.97）. A comparison of predictable and experimental retention factors revealed that LSER can adequately reproduce the experimental retention factors of the solutes under different investigated experimental conditions. This model is a helpful tool to evaluate the retention characteristics of ionic liquid systems and to understand the interactions of solutes and ionic liquids.

关键词： Ionic liquid Linear solvation energy relationships Retention Modifier

Adsorption Isotherms of Quercetin and Catechin Compounds on Quercetin-MIP

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Chemical Research in Chinese Universities 2007年第4期23卷 412-416页

作者： ROW kyung ho Center for Advanced Bioseparation Technology and Department of Chemical Engineering Inha University253 Yonghyun-DongNam-KuIncheon 402-751Korea

A molecular imprinted polymer（MIP） was prepared with quereetin as the template and methaerylie acid（MAA） as the functional monomer. Aeetonitrile and methanol were used as the porogen with ethylene glycol dimethaerylate （EGDMA） as the erosslinker and 2,2＇-azobis （ isobutyronitrile ）（ AIBN ） as the initiator. The experimental parameters of the equilibrium isotherms were estimated via linear and nonlinear regression analyses. The linear equadon as the functions of the adsorption concentration of the single compound in its solution and the competitive adsorption of the single compound in its mixed compounds solution was then expressed, and the adsorption equilibrium data were correlated to Langmuir and Freundlich isotherm models. The mixture compounds show competitive adsorption on the specific binding sites of quereetin-MIP. Furthermore, the competitive Langmnir isotherms were applied to the mixture compounds. The adsorption concentrations of quercetin, （＋）eatechin（＋C）, and （-）epieateehin（EC） on the quercetin molecular imprinted polymer were compared. The quercetin-imprinted polymer shows extraordinarily higher adsorption ability for quercetin than for the two eateehin compounds that were also assessed.

关键词： Adsorption isotherm Molecular imprinted polymer Quercetin (+) Catechin (-) Epicatechin

Evaluation of the safety of hair essence containing 0.05% purified bee venom on the skin and eyes of rabbits

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Journal of Traditional Chinese Medicine 2020年第1期40卷 67-72页

作者： Mi kyung Lim Eun Hye Han Sang ho lee Jee Hee Kim R&D Center KoreaeundanGyeonggi-do 13207Republic of Korea

OBJECTIVE:To investigate the safety of hair essence containing 0.05%purified bee venom(HE-PBV)on the skin and eyes of New Zealand White ***:HE-PBV which contained 0.05%PBV,purified water,and glycerin,was used as the test *** skin-irritation test(SIT)and eye-irritation test(EIT)were conducted according to the Draize *** the SIT,HE-PBV(0.5 m L)dropped gauze was attached both intact and abraded skin for 24 *** other side of the skin was used as *** 24 and 72 h,the treatment site was observed and scored according to evaluation criteria for skin *** the EIT,the rabbits were divided into two groups:eye-washed(three rabbits)and non-eye-washed(six rabbits).HE-PBV(0.1 m L)was squirted into the right eye of *** left eye was untreated and used as a ***,20-30-s later,the eyes of rabbits in the eye-washed group were washed with^50 m L of physiologic(0.9%)salt ***,1,2,3,4 and 7 d after the start of the EIT,the eyes and behavior of the rabbits were *** degree of eye irritation elicited by HE-PBV was determined in three steps and then the criteria of the classification of eye-irritation ***:The SIT revealed erythema and edema at the site of HE-PBV *** 72 h,the body weight of rabbits was reduced slightly,but other symptoms(except erythema and edema)were not *** Primary Irritation Index score was0.6,and HE-PBV was deemed to be a slight *** EIT did not show mortality or body-weight fluctuation,but hyperemic conjunctiva and eyelid closure were noted after HE-PBV *** for these results,the score for the ophthalmic response on days 1,2,3,4 and 7 was 0,and HE-PBV was deemed to be a ***:These data suggest that HE-PBV did not elicit eye irritation,but was a slight irritant to the skin of rabbits;the latter slight would have been due to the excipients used in manufacture of the hair essence because PBV has been shown to be safe.

关键词： Alopecia Bee Venoms Hair essence Skin irritancy tests Eye irritancy tests Complementary therapies

Evaluation of Retention Factors for Nine Solutes with Ionic Liquid Additives via Linear Solvation Energy Relationships

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Chemical Research in Chinese Universities 2010年第4期26卷 532-536页

作者： ROW kyung-ho Department of Chemical Engineering Inha University

A linear solvation energy relationships（LSERs） model was used to examine the fundamental chemical interactions governing the retention of 9 organic compounds on a C18 column by means of reversed-phase high performance liquid cbromatography（RP-HPLC）. Three ionic liquids, 1-hexyl-3-methylimidazolium tetrafluoroborate （[Hmin][BF4]）, 1-butyl-3-methylimidazolium tetrafluoroborate（[Bmin][BF4]） and 1-octyl-3-methylimidazolium tetrafluoroborate（[OMIm][BF4]） as additives, were added to a methanol-water mobile phase. The effects of these three ionic liquids additives on the retention of nine organic compounds were investigated, and a comparison between the predicted and experimental retention factors was made via the LSERs model, which indicated that the LSERs model could be used to reproduce the experimental retention factors of the solutes under different mobile phase conditions. It is also a useful tool for modeling the interactions of the solutes between the stationary and mobile phases and evaluating the retention characteristics of HPLC.

关键词： Retention factor Ionic liquid Additive Mobile phase Model

Beneficial Effect of Berberis amurensis Rupr. on Penile Erection

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Chinese Journal of Integrative Medicine 2018年第6期24卷 448-454页

作者： Rui Tan Yun Jung lee kyung Woo Cho Dae Gill Kang ho Sub lee College of Oriental Medicine and Professional Graduate School of Oriental Medicine Wonkwang University Hanbang CardioRenal Syndrome Research Center Wonkwang University Brain Korea 21 Plus Team Professional Graduate School of Oriental MedicineWonkwang University

Objective： To investigate whether the methanol extract of Berberis amurensis Rupr. （BAR） augments penile erection using in vitro and in vivo experiments. Methods： The ex vivo study used corpus cavemosum strips prepared from adult male New Zealand White rabbits. In in vivo studies for intracavernous pressure （ICP）, blood pressure, mean arterial pressure （MAP）, and increase of peak ICP were continuously monitored during electrical stimulation of Sprague-Dawley rats. Results： Preconstricted with phenylephrine （PE） in isolated endothelium- intact rabbit corus cavernosum, BAR relaxed penile smooth muscle in a dose-dependent manner, which was inhibited by pretreatment with NG-nitro-L-arginine methyl ester （L-NAME）, a nitric oxide synthase inhibitor, and 1H-[1,2,4]-oxadiazole-[4,3-α]-quinoxalin-l-one, a soluble guanylyl cclase inhibitor. BAR significantly relaxed penile smooth muscles dose-dependently in ex vivo, and this was inhibited by pretreatment with L-NAME 1H-[1,2,4]- oxadiazole-[4,3-α ]-quinoxalin-l-one. BAR-induced relaxation was significantly attenuated by pretreatment with tetraethylammonium （TEA, P〈0.01）, a nonselective K＋ channel blocker, 4-aminopyridine （4-AP, P〈0.01）, a voltage-dependent K＋ channel blocker, and charybdotoxin （P〈0.01）, a large and intermediate conductance Ca2. sensitive-K＋ channel blocker, respectively. BAR induced an increase in peak ICP, ICP/MAP ratio and area under the curve dose dependently. Conclusion： BAR augments penile erection via the nitric oxide/cyclic guanosine monophosphate system and Ca2. sensitive-K＋（BK＋ and IK＋） channels in the corpus cavemosum.

关键词： penile erection Berberis amurensis Rupr. nitric oxide cyclic guanosine monophosphate K+ channel