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Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey

World Journal of Gastroenterology 2009年第1期15卷 86-94页

作者： Ho Gak Kim Jimin Han Myung-Hwan Kim Kyu Hyun Cho Im hee Shin Gwang Ha Kim Jae Seon Kim Jin Bong Kim Tae Nyeun Kim Tae Hyeon Kim Tae Hyo Kim Jae Woo Kim Ji Kon Ryu Young-Soo Moon Jong Ho Moon Sung Jae Park Chan Guk Park Sung-Jo Bang Chang Heon Yang Kyo-Sang yoo Byung Moo yoo Kyu Taek Lee Dong Ki Lee Byung Seok Lee Sang Soo Lee Seung Ok Lee Woo Jin Lee Chang Min Cho Young-Eun Joo Gab Jin Cheon Young Woo Choi Jae Bok Chung Yong Bum yoon Department of Internal Medicine Catholic University of Daegu School of Medicine Daegu 705-718 South Korea Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul 138-736 South Korea Department of Medical Statistics Catholic University of Daegu School of Medicine Daegu 705-718 South Korea Department of Internal Medicine Pusan National University School of Medicine Busan 602-739 South Korea Department of Internal Medicine Korea University College of Medicine Seoul 136-705 South Korea Department of Internal Medicine Hallym University College of Medicine Chuncheon 200-704 South Korea Department of Internal Medicine Yeungnam University College of Medicine Daegu 705-717 South Korea Department of Internal Medicine Wonkwang University College of Medicine Iksan Jeonbuk 570-711 South Korea Department of Internal Medicine Gyeongsang National University School of Medicine Jinju Gyeongnam 660-702 South Korea Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Gangwon 220-701 South Korea Department of Internal Medicine Seoul National University College of Medicine Seoul 110-799 South Korea Department of Internal Medicine lnje University College of Medicine Seoul 139-713 South Korea Department of Internal Medicine Soonchunhyang University College of Medicine Bucheon Gyunggi 420-767 South Korea Department of Internal Medicine Inje University College of Medicine Busan 614-735 South Korea Department of Internal Medicine Chosun University College of Medicine Gwangju Jeonbuk 501-717 South Korea Department of Internal Medicine Ulsan University Hospital University of Ulsan College of Medicine Ulsan 681-714 South Korea Department of Internal Medicine Dongguk University College of Medicine Gyeongju Gyeongbuk 791-707 South Korea Department of Internal Medicine Hallym University College of Medicine Anyang Gyeonggi 431-070 South Korea Department of Internal Medicine Ajou University School of Medicine Suwon

AIM： To investigate prevalence of C/onorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea. METHODS： Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire. RESULTS： Of 3080 patients with gastrointestinal diseases, 396 （12.9%） had clonorchiasis and 1140 patients （37.2%） had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 （20.9%） patients had clonorchiasis. Cholangiocarcinoma was more prevalent in C. sinensis-infected patients than nonnfected patients [34/396 （8.6%） vs 145/2684 （5.4%）, P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation （P = 0.008）. Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis. CONCLUSION： Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite.

关键词： Clonorchis sinensis Epidemiology Cholangiocarcinoma Korea Multicenter study Clonorchiasis

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基于HITS的微种植体-舌侧矫治系统Typodont模型的制作及测量

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全科口腔医学电子杂志 2016年第20期3卷 88-90页

作者：荆璇 hee-Moon kyung 李冰李世锋武秀萍山西医科大学口腔医院正畸科山西太原030001 韩国庆北国立大学齿科医院正畸科

目的探索一种微种植体—舌侧矫治系统Typodont模型的制作及测量方法。方法通过模拟排牙、粘结舌侧托槽、制备硅橡胶阴模、灌制Typodont模型、电磁感应模拟矫治装置(HITS)的运用、Micro CT扫描模型、软件模拟重建等实验步骤,进行Typodon... 详细信息

目的探索一种微种植体—舌侧矫治系统Typodont模型的制作及测量方法。方法通过模拟排牙、粘结舌侧托槽、制备硅橡胶阴模、灌制Typodont模型、电磁感应模拟矫治装置(HITS)的运用、Micro CT扫描模型、软件模拟重建等实验步骤,进行Typodont的制作及测量。结果获得了适用于舌侧矫治力学分析研究的Typodont模型及阴模,并可精确计算加载力前后牙齿的移动情况。结论使用该方法可快速精确地获得多个相同的舌侧矫治Typodont模型,并且测量结果更加准确,为微种植体-舌侧矫治系统的后续力学研究奠定基础。

关键词： Typodont模型舌侧矫治电磁感应模拟矫治装置(HITS)

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舌侧矫治系统中控制前牙转矩牵引力方向的HITS实验研究

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临床口腔医学杂志 2017年第8期33卷 471-473页

作者：荆璇李冰 hee-Moon kyung 李世锋武秀萍山西医科大学口腔医院正畸科山西太原030001 韩国庆北国立大学齿科医院正畸科

目的:通过HITS系统中关闭间隙阶段的Typodont实验,对在舌侧矫治中良好控制前牙转矩方向进行优化组合。方法:选取16副标准上颌安氏Ⅱ~1拔除第一前磨牙的Typodont模型,分别在后牙区舌侧区和前牙区唇侧根尖区植入微种植体,通过改变舌侧微... 详细信息

目的:通过HITS系统中关闭间隙阶段的Typodont实验,对在舌侧矫治中良好控制前牙转矩方向进行优化组合。方法:选取16副标准上颌安氏Ⅱ~1拔除第一前磨牙的Typodont模型,分别在后牙区舌侧区和前牙区唇侧根尖区植入微种植体,通过改变舌侧微种植体位置和牵引钩长度来调节回收力的方向,及HITS模拟牙齿移动效果,并借助Micro CT扫描加力前后模型并进行Mimics 17.0软件三维重建,用SPSS22.0软件进行析因方差分析。结果:舌侧矫治关闭拔牙间隙过程中,在加载回收力的同时配合唇侧压低力可较好的控制前牙转矩。当牵引钩高度为4mm,舌侧微种植体距牙槽嵴顶6 mm时,前牙切缘与根尖的位移差值较小;当牵引钩高度为8 mm,舌侧微种植体距牙槽嵴顶10 mm时,位移差值较小。结论:"微种植体支抗—双槽沟舌侧托槽"矫治系统下,拔牙间隙关闭阶段牵引钩4 mm/微种植体6 mm及牵引钩8 mm/微种植体10 mm时可较好的控制前牙转矩。

关键词： Typodont模型双槽沟舌侧托槽电磁感应模拟矫治装置(HITS) 力学实验

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组织学比较即刻负载对不锈钢及钛合金微种植体周围组织的影响

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中华口腔正畸学杂志 2014年第2期21卷 87-90页

作者：陈岩 Shin Hong-in 邓耀强赵文婷 kyung hee-moon 呼和浩特内蒙古医科大学附属医院 010050 韩国庆北大学齿科学院

目的临床与组织学比较即刻负载对正畸用不锈钢及钛合金微种植体及周围组织的影响.方法不锈钢及钛合金微种植体各24枚,植入于3头18个月龄的微型猪上颌骨内.相邻两枚种植体之间用镍钛闭合弹簧即刻加载约150克左右的水平力.十周后检查微... 详细信息

目的临床与组织学比较即刻负载对正畸用不锈钢及钛合金微种植体及周围组织的影响.方法不锈钢及钛合金微种植体各24枚,植入于3头18个月龄的微型猪上颌骨内.相邻两枚种植体之间用镍钛闭合弹簧即刻加载约150克左右的水平力.十周后检查微种植体的稳定性.每组选择8枚稳定性好的微种植体进行不脱钙处理,制作组织学磨片,在光学及荧光光学显微镜下观察.用组织测量学图像分析软件测量两组微种植体的骨结合率.P＜0.05有统计学意义.结果 1.植入时折断微种植体：不锈钢组2枚,折断率为7.7％;钛合金组9枚,折断率为27.3％;P＞0.05.2.临床成功率：不锈钢组75.0％,钛合金组83.3％;P＞0.05.3.骨结合率：不锈钢组平均值16.94％,钛合金组37.33％,P＜0.05.结论不锈钢微种植体在即刻负载水平力的条件下有较高的临床成功率和骨结合率,但是,明显的低于钛合金微种植体.

关键词：不锈钢钛合金正畸微种植体即刻负载骨结合

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Atypical onset of bicalutamide-induced liver injury

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World Journal of Gastroenterology 2016年第15期22卷 4062-4065页

作者： Gee Young Yun Seok Hyun Kim Seok Won Kim Jong Seok Joo Ju Seok Kim Eaum Seok Lee Byung Seok Lee Sun Hyoung Kang hee Seok Moon Jae Kyu Sung Heon Young Lee kyung hee Kim Department of Internal Medicine Chungnam National University School of Medicine Chungnam National University Hospital Departments of Pathology Chungnam National University School of Medicine Chungnam National University Hospital

Anti-androgen therapy is the leading treatment for advanced prostate cancer and is commonly used for neoadjuvant or adjuvant treatment. Bicalutamide is a non-steroidal anti-androgen, used during the initiation of androgen deprivation therapy along with a luteinizing hormone-releasing hormone agonist to reduce the symptoms of tumor-related flares in patients with advanced prostate cancer. As side effects, bicalutamide can cause fatigue, gynecomastia, and decreased libido through competitive androgen receptor blockade. Additionally, although not as common, drug-induced liver injury has also been reported. Herein, we report a case of hepatotoxicity secondary to bicalutamide use. Typically, bicalutamideinduced hepatotoxicity develops after a few days; however, in this case, hepatic injury occurred 5 mo after treatment initiation. Based on this rare case of delayed liver injury, we recommend careful monitoring of liver function throughout bicalutamide treatment for prostate cancer.

关键词： Bicalutamide Drug-induced liver injury Prostate neoplasm

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The Fungal Flora Survey of Gyeyang Mountain in Incheon City

The Fungal Flora Survey of Gyeyang Mountain in Incheon City

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The 7th Korea-China Joint Symposium for Mycology

作者： Yun hee OH Sang Beom KIM Seong Hwan KIM kyung Rim LEE Min Woong LEE U Yun LEE Tae soo LEE Deparment of Biology University of Incheon Deparment of Biology University of Incheon Deparment of Biology University of Incheon Deparment of Biology University of Incheon Deparment of Biology Dongguk University Deparment of Biology University of Incheon Deparment of Biology University of Incheon

＜正＞Higher fungi were collected at Gyeyang Mountain of Incheon City from June, 2001 to October, 2003.A total of 115 species of fungi were collected. These fungi belong to 3 division, 10 orders, 26 families, 50 gener...

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Analysis of Worm Cutting Characteristics in Whirling Process

Analysis of Worm Cutting Characteristics in Whirling Process

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第五届国际材料与热加工物理模拟及数值模拟学术会议

作者： Young-Moon Lee Won-Sik Choi Jae-Hwan Son kyung-Jun Oh Sun-Il Kim Geon-Woo Park hee-Chul Jung School of Mechanical Engineering Kyungpook National University Daegu S. Korea School of Biosystems Engineering Pusan National University Miryang S. Korea Daegu Machinery Institute of Component & Materials Foundation Daegu S. Korea Daehan Machinery Corporation (DMC) Daegu S. Korea Graduate School of Mechanical Engineering Kyungpook National University Daegu S. Korea

Improved geometrical accuracy and better surface finish of worms are required, especially in automobile industry. To meet this requirement, whirling process has been used in the manufacture of worm. Whirling process is a cutting process in which a series of cutting edges on the whirling ring remove material by turning over the rotating workpiece. In this study, cutting characteristics of the worm in whirling process has been analyzed. The undeformed chip models of front and side cutting edges were established. Using the undeformed chip models and DEFORM software, cutting force analyses are carried out. The calculated cutting force imposed on the tool is nearly the same as the sum of the forces calculated which are separately imposed on the front and side cutting edges.

关键词： Whirling process Undeformed chip model Cutting force DEFORM software

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Recurrence of gastric cancer in the jejunal stump after radical total gastrectomy

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World Journal of Gastrointestinal Surgery 2014年第4期6卷 74-76页

作者： Jong Han yoo Sang Hyuk Seo Min Sung An Tae Kwun Ha Kwang hee Kim Ki Beom Bae Chang Soo Choi Sang Hun Oh Young Kil Choi Department of Surgery Busan Paik HospitalInje University College of Medicine

This is a very rare case of the recurrence of gastric cancer in the jejunal stump after radical total gastrectomy with Roux-en-Y *** January 2008,a 65-year-old man underwent radical total gastrectomy with Roux-en-Y reconstruction for stageⅠB gastric cancer of the upper *** a follow-up in December2011,the patient had a recurrence of gastric cancer on gastroduodenal *** gastroduodenal fibroscopic biopsy specimens show a well-differentiated tubular *** tomography showed no lymphadenopathy or hepatic *** laparotomy,there was a tumor in the jejunal stump involving the pancreatic tail and ***,the patient underwent jejunal pouch resection,distal pancreatectomy and *** patient was diagnosed with gastric cancer on histopathological examination.

关键词： Gastric cancer Recurrence Jejunal stump

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Natural Variation in OsPRR37 Regulates Heading Date and Contributes to Rice Cultivation at a Wide Range of Latitudes

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Molecular Plant 2013年第6期6卷 1877-1888页

作者： Bon-Hyuk Koo Soo-Cheul yoo Joon-Woo Park Choon-Tak Kwon Byoung-Doo Lee Gynheung An Zhanying Zhang linjie Li Zichao Li Nam-Chon Paek Department of Plant Science Plant Genomics and Breeding Institute and Research Institute for Agriculture and Life Sciences Seoul National UniversitySeoul 151-921 Korea Department of Plant Systems Biotech and Crop Biotech Institute Kyung Hee University Yongin 446-701 Korea Key Lab of Crop Heterosis and Utilization of Ministry of Education and Beijing Key Lab of Crop Genetic Improvement China Agriculture UniversityBeijing 100193 China Institute of Green Bio Science and Technology Seoul National University Pyeongchang 232-916 Korea

Heading date and photoperiod sensitivity are fundamental traits that determine rice adaptation to a wide range of geographic environments. By quantitative trait locus （QTL） mapping and candidate gene analysis using whole- genome re-sequencing, we found that Oryza sativa Pseudo-Response Regulator37 （OsPRR37; hereafter PRR37） is respon- sible for the Early heading7-2 （EH7-2）/Heading date2 （Hd2） QTL which was identified from a cross of late-heading rice ＇Milyang23 （M23）＇ and early-heading rice ＇H143＇. H143 contains a missense mutation of an invariantly conserved amino acid in the CCT （CONSTANS, CO-like, and TOC1） domain of PRR37 protein. In the world rice collection, different types of nonfunctional PRR37 alleles were found in many European and Asian rice cultivars. Notably, the japonica varieties harboring nonfunctional alleles of both Ghd7/Hd4 and PRR37/Hd2 flower extremely early under natural long-day condi- tions, and are adapted to the northernmost regions of rice cultivation, up to 53~ N latitude. Genetic analysis revealed that the effects of PRR37 and Ghd7 alleles on heading date are additive, and PRR37 down-regulates Hd3a expression to suppress flowering under long-day conditions. Our results demonstrate that natural variations in PRR37/Hd2 and GhdT/ Hd4 have contributed to the expansion of rice cultivation to temperate and cooler regions.

关键词： rice heading date quantitative trait locus natural variation Ghd7 OsPRR37.

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Comparative effectiveness of combined antiplatelet treatments in acute minor ischaemic stroke

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Stroke & Vascular Neurology 2022年第1期7卷 13-21页

作者： Shina Kim Joon-Tae Kim Ji Sung Lee Beom Joon Kim Jong-Moo Park Kyusik Kang Soo Joo Lee Jae Guk Kim Jae-Kwan Cha Dae-Hyun Kim Tai Hwan Park Sang-Soon Park kyung Bok Lee Jun Lee Keun-Sik Hong Yong-Jin Cho Hong-Kyun Park Byung-Chul Lee kyung-Ho Yu Mi Sun Oh Dong-Eog Kim Wi-Sun Ryu Jay Chol Choi Jee-Hyun Kwon Wook-Joo Kim Dong-Ick Shin Sung-Il Sohn Jeong-Ho Hong Man-Seok Park Kang-Ho Choi Ki-Hyun Cho Juneyoung Lee hee-Joon Bae Department of Neurology Chonnam National University HospitalChonnam National University Medical SchoolGwangjuKorea Clinical Research Center Asan Institute for Life SciencesAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Neurology Cerebrovascular CenterSeoul National University Bundang HospitalSeongnamKorea Department of Neurology Uijeongbu Eulji Medical CenterEulji University School of MedicineUijeongbu-siKorea Department of Neurology Nowon Eulji Medical CenterEulji UniversitySeoulKorea Department of Neurology Eulji University HospitalEulji UniversityDaejeonKorea Department of Neurology Dong-a UniversityBusanKorea Department of Neurology Seoul Medical CenterSeoulKorea Department of Neurology Soonchunhyang University HospitalSeoulKorea Department of Neurology Yeungnam University HospitalDaeguKorea Department of Neurology Inje University Ilsan Paik HospitalInje University College of MedicineGoyangKorea Department of Neurology Hallym University Sacred Heart HospitalAnyangKorea Department of Neurology Dongguk University Ilsan HospitalGoyangKorea Department of Neurology Jeju National University HospitalJeju National University School of MedicineJejuKorea Department of Neurology University of Ulsan College of MedicineUlsanKorea Department of Neurology Chungbuk National University HospitalCheongjuKorea Department of Neurology Keimyung University Dongsan Medical CenterDaeguKorea Department of Biostatistics Korea University College of MedicineSeoulKorea

Background No study has thoroughly compared the effectiveness of combined antiplatelet treatments(other than clopidogrel–aspirin)versus clopidogrel–aspirin or aspirin alone for early secondary prevention in acute ischaemic *** We identified patients with acute,minor,non-cardiogenic ischaemic stroke treated with aspirin alone,clopidogrel–aspirin or other combination *** scores considering the inverse probability of treatment weighting were used to adjust for baseline *** primary outcome was the composite of all strokes(ischaemic or haemorrhagic),myocardial infarction and all-cause mortality at 3 *** Among 12234 patients(male:61.9%;age:65.5±13 years)who met the eligibility criteria,aspirin,clopidogrel–aspirin and other combination treatments were administered in 52.2%,42.9%and 4.9%of patients,*** the crude analysis,the primary outcome event at 3 months occurred in 14.5%of the other combination group,14.4%of the aspirin group and 13.0%of the clopidogrel–aspirin *** the weighted Cox proportional hazards analysis,the 3-month primary outcome event occurred less frequently in the clopidogrel–aspirin group than in the other combination group(weighted HR:0.82(0.59–1.13)),while no association was found between the aspirin group(weighted HR:1.04(0.76–1.44))or other combination group and the 3-month primary *** Other combined antiplatelet treatment,compared with aspirin alone or clopidogrel–aspirin,was not associated with reduced risks of primary composite vascular events or recurrent stroke during the first 3 months after ***,the results suggest that other combination treatments,particularly the cilostazol-based combination,may not be effective alternatives for clopidogrel–aspirin to prevent early vascular events in patients with acute minor *** exploration in clinical trials will be needed.

关键词： prevention treatment alone

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