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World Journal of Gastroenterology 2009年第18期15卷 2258-2264页

作者： Dongho Choi Hyo Won Lee kyung yul hur Jae Joon Kim Gyeong-Sin Park Si-Hyong Jang Young Soo Song Ki-Seok Jang Seung Sam Paik Department of Surgery College of MedicineSoonchunhyang University140-743 SeoulSouth Korea Department of Surgery Chi Hang Hospital140-741 SeoulSouth Korea Department of Pathology College of MedicineCatholic University137-040 SeoulSouth Korea Department of Pathology College of MedicineHanyang University133-790 SeoulSouth Korea

AIM:To verify that CD markers are available for detecting cancer stem cell populations and to evaluate their clinical significance in colon ***:Immunohistochemistry for CD133,CD24 and CD44 was performed on the tissue microarray of 523 colorectal *** records were reviewed and clinicopathological analysis was ***:In colorectal adenocarcinoma,128 of 523 cases(24.5%) were positive and 395 cases(75.5%) were negative for CD133 *** hundred and sixty-four of 523 cases(50.5%) were positive and 259 cases(49.5%) were negative for CD24 *** hundred and two of 523 cases(96%) were negative and 21 cases(4%) were positive for CD44 *** clinicopathological analysis,CD133 expression was present more in male patients(P = 0.002) and in advanced T stage cancer(P = 0.024).Correlation between CD24 expression and clinicopathological factors was seen in the degree of differentiation(P = 0.006).Correlation between CD44 expression and clinicopathological factors was seen in the tumor size(P = 0.001).Survival was not significantly related to CD133,CD24 and CD44 ***:CD markers were related to invasiveness and differentiation of colorectal ***,CD expression was not closely related to survival.

关键词： CD133 CD24 CD44 Colon cancer stemcells Colorectal adenocarcinoma

Effect of W/C ratio and cover thickness on polarization characteristics of embedded steel in mortar

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中国有色金属学会会刊：英文版 2009年第4期19卷 909-912页

作者： kyung-Man MOON Sung-yul LEE Myung-Hoon LEE Yun-Hae KIM Department of Mechanical and Material Engineering Korea Maritime University Department of Marine System Engineering Korea Maritime University

The effects of cover thickness and W/C(water-to-cement) ratio on polarization properties of embedded steel bar were investigated with electrochemical *** potentials shift to the noble direction with increasing the cover *** addition,when the cover thickness increasingly becomes thinner and thinner,effect of the W/C ratio on variation of corrosion potential increases as *** value at 100 kHz indicating the resistance of cover thickness increases with the decrement of W/C ratio as well as the increment of cover ***,in the case of W/C ratio at 0.6,impedance at 10 mHz shows the relatively larger value than that at W/C ratio of 0.4 or 0.5 in the range of cover thickness from 4 to 8 cm,which is probably expected that oxide film built up on the surface of steel bar due to strong alkali environment by hydration reaction with increasing W/C ratio is performed as the resistance *** is also observed that liquid junction potential tends to increase with decreasing W/C ratio.

关键词：保护层厚度嵌入式偏振特性钢筋砂浆覆盖厚度极化性能电化学方法

Brain-derived neurotrophic factor mediates macrophage migration inhibitory factor to protect neurons against oxygen-glucose deprivation

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Neural Regeneration Research 2020年第8期15卷 1483-1489页

作者： Su Hwan Bae Mi Ran Yoo Ye Yeong Kim In kyung Hong Mi Hee Kim Seung Hak Lee Dae yul Kim Department of Rehabilitation Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Asan Institute for Life Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea

Macrophage migration inhibitory factor(MIF)is a chemokine that plays an essential role in immune system *** studies suggested that MIF protects neurons in ischemic ***,few studies are reported on the role of MIF in neurological recovery after ischemic *** purpose of this study is to identify the molecular mechanism of neuroprotection mediated by *** neuroblastoma cells were incubated in Dulbecco’s modified Eagle’s medium under oxygen-glucose deprivation(OGD)for 4 hours and then returned to normal aerobic environment for reperfusion(OGD/R).30 ng/mL MIF recombinant(30 ng/mL)or ISO-1(MIF antagonist;50μM)was administered to human neuroblastoma *** cell cultures were assigned to one of four groups:control,OGD/R,OGD/R with MIF,OGD/R with *** viability was analyzed using WST-1 *** levels of brain-derived neurotrophic factor(BDNF),microtubule-associated protein 2(MAP2),Caspase-3,Bcl2,and Bax were detected by western blot assay and immunocytochemistry in each group to measure apoptotic ***-1 assay results revealed that compared to the OGD/R group,cell survival rate was significantly higher in the OGD/R with MIF group and lower in the OGD/R with ISO-1 *** blot assay and immunocytochemistry results revealed that expression levels of BDNF,Bcl2,and MAP2 were significantly higher,and expression levels of Caspase-3 and Bax were significantly lower in the MIF group than in the OGD/R *** levels of BDNF,Bcl2,and MAP2 were significantly lower,and expression levels of Caspase-3 and Bax were significantly higher in the ISO-1 group than in the OGD/R *** administration promoted neuronal cell survival and induced high expression levels of BDNF,MAP2,and Bcl2(anti-apoptosis)and low expression levels of Caspase-3 and Bax(pro-apoptosis)in an OGD/R *** results suggest that MIF administration is effective for inducing expression of BDNF and leads to neuroprotection of neuronal cells

关键词： apoptosis brain-derived neurotrophic factor hypoxia in vitro ischemic stroke macrophage migration inhibitory factor nerve regeneration neuroprotective effect reperfusion

Male metaplastic breast cancer with poor prognosis:A case report

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World Journal of Clinical Cases 2022年第15期10卷 4964-4970页

作者： Hyun yul Kim Seungju Lee Dong-il Kim Chang Shin Jung Jee Yeon Kim kyung Jin Nam Ki Seok Choo Youn Joo Jung Department of Surgery Pusan National University Yangsan HospitalPusan National University School of MedicineGyeongnam 50612South Korea Department of Pathology Pusan National University Yangsan HospitalPusan National University School of MedicineGyeongnam 50612South Korea Department of Radiology Pusan National University Yangsan HospitalPusan National University School of MedicineGyeongnam 50612South Korea

BACKGROUND Metaplastic breast cancer(MBC)is a rare subtype of breast *** constitute less than 1%of breast cancer cases and are much rarer in *** are few reports of MBC because of its ***,an aggressive type of cancer,is refractory to common treatment modalities of breast cancer and has a poor *** SUMMARY We report a case of MBC in a 78-year-old *** visited our clinic with a palpable mass on the left breast with no masses in the axillary *** had previously undergone robot-assisted laparoscopic radical prostatectomy for prostate cancer,but there was no family history of *** breast mass was visible on ultrasonography,mammography,and magnetic resonance imaging,and chest computed tomography revealed a lung mass in the posterior basal segment of the right lower *** patient was diagnosed with metaplastic carcinoma on core needle biopsy with lung *** mastectomy with sentinel lymph node biopsy and video-assisted segmentectomy of the right lung was ***,multiple metastases appeared 3 mo after surgery in the brain,chest,and abdomen,and the patient died 5 mo after the initial *** MBC is an aggressive and extremely rare breast cancer *** case reports are needed to determine the optimal treatment.

关键词： Breast neoplasm Male Triple-negative breast cancer Metaplastic breast cancer Adjuvant treatment Case report

Graphene platform for neural regenerative medicine

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Neural Regeneration Research 2016年第6期11卷 894-895页

作者： Tasneem Bouzid Alexander Sinitskii Jung yul Lim Department of Mechanical and Materials Engineering University of Nebraska-Lincoln Department of Chemistry University of Nebraska-Lincoln Graduate School of Dentistry Kyung Hee University

Graphene is a material composed of a single layer of carbon atoms arranged in a two-dimensional honeycomb lattice. The unique elec- trical, optical, thermal, and mechanical properties of graphene are extensively explo... 详细信息

关键词： Graphene platform for neural regenerative medicine NFL cell FAK RA

Material and mechanical factors:new strategy in cellular neurogenesis

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Neural Regeneration Research 2014年第20期9卷 1810-1813页

作者： Hillary Stoll Il Keun Kwon Jung yul Lim Department of Biological Systems Engineering University of Nebraska-LincolnLincolnNEUSA The Graduate School of Dentistry Kyung Hee UniversitySeoulKorea Department of Mechanical and Materials Engineering University of Nebraska-LincolnLincolnNEUSA

Since damaged neural circuits are not generally self-recovered, developing methods to stimulate neurogenesis is critically required. Most studies have examined the effects of soluble pharma- cological factors on the cellular neurogenesis. On the other hand, it is now recognized that the other extracellular factors, including material and mechanical cues, also have a strong potential to induce cellular neurogenesis. This article will review recent data on the material （chemical patterning, micro/nano-topography, carbon nanotube, graphene） and mechanical （static cue from substrate stiffness, dynamic cue from stretch and flow shear） stimulations of cellular neuro- genesis. These approaches may provide new neural regenerative medicine protocols. Scaffolding material templates capable of triggering cellular neurogenesis can be explored in the presence of neurogenesis-stimulatory mechanical environments, and also with conventional soluble factors, to enhance axonal growth and neural network formation in neural tissue engineering.

关键词： neural regenerative medicine cellular neurogenesis material cue mechanical factor soluble signal

Long-term pretreatment with proton pump inhibitor and Helicobacter pylori eradication rates

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World Journal of Gastroenterology 2014年第4期20卷 1061-1066页

作者： Seung Bae Yoon Jae Myung Park Jong-yul Lee Myong Ki Baeg Chul-Hyun Lim Jin Soo Kim Yu kyung Cho In Seok Lee Sang Woo Kim Myung-Gyu Choi Division of Gastroenterology Department of Internal Medicine College of Medicine The Catholic University of Korea

AIM: To investigate whether proton pump inhibitor (PPI) pretreatment influences Helicobacter pylori eradication rate.

关键词： Proton pump inhibitor Helicobacter pylori Urea breath test Antibiotics Drug resistance

Oncologic efficacy of gonadotropin-releasing hormone agonist in hormone receptor-positive very young breast cancer patients treated with neoadjuvant chemotherapy

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World Journal of Clinical Cases 2023年第27期11卷 6398-6406页

作者： Hee Jun Choi Jun Ho Lee Chang Shin Jung Jai Min Ryu Byung Joo Chae Se kyung Lee Jong Han Yu Seok Won Kim Seok Jin Nam Jeong Eon Lee Youn Joo Jung Hyun yul Kim Department of Surgery Samsung Changwon HospitalSungkyunkwan University School of MedicineChangwon 51353South Korea Division of Breast Surgery Department of SurgerySamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Department of Surgery Pusan National University Yangsan HospitalPusan National University School of MedicineGyeongnam 50612South Korea

BACKGROUND Breast cancer in young women has been shown to have an aggressive behavior and poor *** To evaluate the outcomes of young hormone receptor(HR)-positive patients with breast cancer treated with neoadjuvant chemotherapy(NAC),and the oncologic efficacy of gonadotropin-releasing hormone(GnRH)*** This retrospective study involved a prospectively enrolled *** included patients diagnosed with invasive breast cancer who were treated with NAC followed by curative surgery at the Samsung Medical Center and Samsung Changwon Hospital between January 2006 and December *** patients with HR-positive and human epidermal grow factor 2(HER2)-negative breast cancer,we analyzed the characteristics and oncology outcomes between the patients equal to or younger than 35 years and the patients older than 35 *** Among 431 patients with NAC and HR-positive/HER2-negative breast cancer,78 were 35 years old or younger,and 353 patients were older than 35 *** median follow-up was 71.0 *** was no statistically significant difference in disease free survival(DFS,P=0.565)and overall survival(P=0.820)between the patients equal to or younger than 35 years and the patients older than 35 *** two groups differed in that the GnRH agonist was used more frequently in the group of patients equal to or younger than 35 years than in the other group(52.4%vs 11.2%,P<0.001).Interestingly,for the DFS according to the GnRH agonist in the group of patients equal to or younger than 35 years,patients treated with the GnRH agonist had better DFS(P=0.037).CONCLUSION Administration of GnRH agonists might improve the DFS rate of HR-positive/HER2-negative breast cancer in the equal to or younger than 35 years group of patients with NAC.

关键词： Gonadotropin-releasing hormone Agonist Young Breast Cancer