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Prognosis of hepatocellular carcinoma expressing cytokeratin 19:Comparison with other liver cancers

World Journal of Gastroenterology 2012年第34期18卷 4751-4757页

作者： Jung Il Lee Jin-woo Lee Joon Mee Kim Ja kyung Kim Hyun Jung Chung Young Soo Kim Department of Internal Medicine School of MedicineInha UniversityIncheon 400-711South Korea Department of Pathology School of MedicineInha UniversityIncheon 400-711South Korea Department of Internal Medicine Yonsei University College of MedicineGangnam Severance HospitalSeoul 135-720South Korea

AIM:To investigate whether expressing biliary phenotype predicted poor outcome after the surgical treatment in primary liver cancers. METHODS:Out of 204 patients that underwent liver resection due to hepatocellular carcinoma (HCC), liver specimens of 70 patients with HCC were evaluated for biliary components by cytokeratin (CK) 19 immunostain (CK19 - HCC and CK19 + HCC). CK19 positivity was defined as membranous and/or cytoplasmic expression in ≥ 5% of tumor cells with moderate or strong intensity. Patients with other primary liver cancers, such as com- bined HCC and cholangiocarcinoma (cHCC-CC), intrahe- patic cholangiocarcinoma (ICC) who received curative liver resection, were also included in the study. Clinical characteristics of CK19-HCC and CK19 + HCC patients, including survival outcome after curative liver resection, were compared with that of cHCC-CC and ICC patients. RESULTS: The overall survival (OS) rate of CK19 - HCC(n = 49) after the curative surgical treatment was 90.7%, and 80.4% at 1 and 5 years after the resection. OS rate of CK19 + HCC (n = 21) was 74.3%, 28.9% and OS rate of cHCC-CC (n = 22) was 66.7%, 32.2% at 1 and 5 years after the surgery. For ICC (n = 19), 1 and 5-year-OS rate was 50.2% and 14.3% after the cura-tive resection. The OS rates of CK19 + HCC and cHCC-CC were significantly lower than that of CK19-HCC, but higher than the OS rate of ICC (P = 0.000). There was no statistically significant difference in OS rate between CK19 + HCC and cHCC-CC. The disease free survival (DFS) rate of CK19-HCC was 72.0% and 54.5% at 1 and 3 years after the surgical treatment. DFS rate of CK19 + HCC was 53.3%, 34.3% and DFS rate of cHCC- CC was 51.5%, 39.2% at 1 and 3 years after the resection. For ICC, 1 and 3-year-DFS rate was 28.0% and 14.0% after the curative resection. DFS rate of CK19-HCC was significantly higher than that of ICC (P = 0.017), but marginally higher than DFS rate of either CK19 + HCC or cHCC-CC (P = 0.097, P = 0.089, respec-tively).

关键词： Cytokeratin 19 Hepatocellular carcinoma Intrahepatic cholangiocarcinoma Liver cancers Hepa-tectomy

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Successful recanalization of chronic total occlusion of the superior mesenteric artery by transradial approach

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第8期11卷 627-630页

作者： woo Taek KIM Sung Gyun AHN Jun-Won LEE Joong kyung SUNG Seung Hwan LEE Junghan YOON Division of Cardiology Wonju College of MedicineYonsei University

It is a challenge to confirm chronic mesenteric ischemia(CMI) as a cause of gastrointestinal(GI) symptoms such as postprandial epigastric bloating,anorexia,and debilitating weight *** intervention for CMI has been gaining popularity because of the high morbidity associated with surgical ***,in EVI for superior mesenteric artery(SMA) occlusion,the transfemoral approach is limited by difficulty in coaxial alignment of the guiding catheter,which leads to insufficient back-up ***,we report on a 58-year-old male patient with chronic total occlusion of the SMA,which was successfully revascularized by endovascular intervention via the left radial *** endovascular therapy may be another treatment option for the treatment of CMI.

关键词： Transluminal angioplasty Radial artery Superior mesenteric artery Chronic mesenteric ischemia

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Arabidopsis thaliana RECEPTOR DEAD KINASE1 Functions as a Positive Regulator in Plant Responses to ABA

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Molecular Plant 2017年第2期10卷 223-243页

作者： Dhinesh Kumar Ritesh Kumar Dongwon Baek Tae-kyung Hyun woo Sik Chung Dae-Jin Yun Jae-Yean Kim Division of Applied Life Sciences Plant Molecular Biology and Biotechnology Research Center Gyeongsang National University Jinju 660-701 Korea Department of Industrial Plant Science and Technology Conege of Agricultural Life and Environmental Sciences Chungbuk National University Cheongju 28644Korea These authors contributed equally to this article.

Abscisic acid （ABA） is a major phytohormone involved in important stress-related and developmental plant processes. Membrane-delimited ABA signal transduction plays an important role in early ABA signaling, but the molecular mechanisms connecting core signaling components to the plasma membrane remain un- clear. Plants have evolved a large number of receptor-like kinases （RLKs） to modulate diverse biological processes by perceiving extracellular stimuli and activating downstream signaling responses. In this study, a putative leucine-rich repeat-RLK gene named RECEPTOR DEAD KINASE1 （AtRDK1） was identified and characterized in Arabidopsis thaliana. RDK1 promoter-GUS analysis revealed that RDK1 is expressed ubiq- uitously in the various tissues in Arabidopsis, and its expression is mainly induced by ABA. In the presence of ABA, RDKl-deficient rdkl-1 and rdkl-2 lines showed significant resistance in cotyledon greening and root growth, whereas RDKl-overexpressing lines showed enhanced sensitivity. Consistently, the expres- sion of ABA-responsive genes was significantly downregulated in rdkl mutant seedlings, which were also hypersensitive to drought stress with increased water loss. Interestingly, RDK1 was found to be an atypical kinase localized to the plasma membrane and did not require its kinase activity during ABA-mediated inhi- bition of seedling development. Accordingly, RDK1 interacted in the plasma membrane with type 2C protein phosphatase ABSClSIC ACID INSENSITIVE1 （ABI1）; this interaction was further enhanced by exogenous application of ABA, suggesting that RDKl-mediated recruitment of ABI1 onto the plasma membrane is important for ABA signaling. Taken together, these results reveal an important role for RDK1 in plant responses to abiotic stress conditions in an ABA-dependent manner.

关键词： ABA abiotic stress Arabidopsis atypical kinases protein phosphatases receptor-like kinases

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Clinical outcomes of self-expandable metal stents in palliation of malignant anastomotic strictures caused by recurrent gastric cancer

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World Journal of Gastroenterology 2009年第28期15卷 3523-3527页

作者： Yu kyung Cho Sang woo Kim Kwan woo Nam Jae Hyuck Chang Jae Myung Park Jeong-Jo Jeong In Seok Lee Myung-Gyu Choi In-Sik Chung Department of Internal Medicine The Catholic University of Korea

AIM： To examine the technical feasibility and clinical outcomes of the endoscopic insertion of a selfexpandable metal stent （SEMS） for the palliation of a malignant anastomotic stricture caused by recurrent gastric cancer. METHODS： The medical records of patients, who had obstructive symptoms caused by a malignant anastomotic stricture after gastric surgery and underwent endoscopic insertion of a SEMS from January 2001 to December 2007 at kangnam St Mary＇s Hospital, were reviewed retrospectively. RESULTS： Twenty patients （15 male, mean age 63 years） were included. The operations were a total gastrectomy with esophagojejunostomy （n = 12）, subtotal gastrectomy with Billroth-Ⅰ reconstruction （n = 2） and subtotal gastrectomy with Billroth- Ⅱ reconstruction （n = 8）. The technical and clinical success rates were 100% and 70%, respectively. A small bowel or colon stricture was the reason for a lack of improvement in symptoms in 4 patients. Two of these patients showed improvement in symptoms after another stent was placed. Stent reobstruction caused by tumor ingrowth or overgrowth occurred in 3 patients （15%） within 1 mo after stenting. Stent migration occurred with a covered stent in 3 patients who underwent a subtotal gastrectomy with Billroth-Ⅱ reconstruction. Two cases of partial stent migration were easily treated with a second stent or stent repositioning. The median stent patency was 56 d （range, 5-439 d）. The median survival was 83 d （range, 12-439 d）. CONCLUSION： Endoscopic insertion of a SEMS provides safe and effective palliation of a recurrent anastomotic stricture caused by gastric cancer, A meticulous evaluation of the presence of other strictures before inserting the stent is essential for symptom improvement.

关键词： Stents Surgical anastomosis Stricture Endoscopic gastrointestinal surgery Stomach neoplasms

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Role of dietary gamma-aminobutyric acid in broiler chickens raised under high stocking density

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Animal Nutrition 2020年第3期6卷 293-304页

作者： Su-Been Jeong Yoo Bhin Kim Jeong-woo Lee Da-Hye Kim Byung-Hern Moon Hong-Hee Chang Yang-Ho Choi kyung-woo Lee Department of Animal Science and Technology Konkuk UniversitySeoul05029Republic of korea CellTech Co. Ltd.Chungbuk27622Republic of Korea Department of Animal Science Gyeongsang National Universityjinju52828Republic of Korea

The present study was conducted to evaluate the effects of dietary gamma-aminobutyric acid(GABA)in broiler chickens raised in high stocking density(HSD)on performance and physiological responses.A total of 900 male broiler chicks(Ross 308)at 1 d old were assigned in a 2×2 factorial arrangement to 4 treatments(10 replicates per treatment)with stocking density,7.5 birds/m^2(low stocking density;LSD)or 15 birds/m^2(HSD),and dietary GABA,0 or 100 mg/*** raised in HSD exhibited a decrease in body weight gain in all phases(P<0.05)and feed intake in starter and whole phases(P<0.01),and an increase in feed conversion ratio in the finisher phase(P<0.01)compared with LSD-raised ***,dietary GABA did not affect growth performance nor interacted with stocking density on production *** HSD *** increased relative liver weight on d 35 whereas dietary GABA increased relative liver weight and decreased relative bursa weight on d *** stocking density and dietary GABA affected yield and quality of breast and leg *** GABA increased(P<0.05)width of tibia on d 35 and interacted(P=0.054)with stocking density on breaking stocking density on d *** HSD *** group lowered(P<0.05)feather coverage *** interaction between stocking density and GABA on surface temperature of shank on d 21 was noted(P=0.024).Dietary GABA exhibited an opposite effect on the concentrations of cecal short-chain fatty acids depending on stocking density leading to a moderate to significant *** density decreased alpha-1-acid glycoprotein whereas dietary GABA decreased heterophil-to-lymphocyte ratio and corticosterone in blood or serum *** biochemical parameters were altered by stocking density or dietary *** is concluded that dietary GABA alleviated stress indices including corticosterone and heterophilto-lymphocyte ratio,but failed to reverse stocking density-induced growth depression.

关键词： Gamma-aminobutyric acid Stocking density Growth performance Stress indicator Broiler chicken

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Transmural penetration of sigmoid colon and rectum by retained surgical sponge after hysterectomy

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World Journal of Gastroenterology 2016年第10期22卷 3052-3055页

作者： woo Young Shin Chan Hyuk Im Sun Keun Choi Yun-Mee Choe kyung Rae Kim Department of Surgery Inha University HospitalInha University College of Medicine

Gossypiboma is a surgical sponge that is retained in the body after the operation. A 39-year-old female presented with vague lower abdominal pain, fever, and rectal discharge 15 mo after hysterectomy. The sponge remaining in the abdomen had no radiopaque marker. Therefore a series of radiographic evaluations was fruitless. The surgical sponge was found in the rectosigmoid colon on colonoscopy. The sponge penetrated the sigmoid colon and rectum transmurally, forming an opening on both sides. The patient underwent low anterior resection and was discharged without postoperative complications.

关键词： Gossypiboma Textiloma Retained foreign object Surgical sponge Radiopaque marker

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Paradoxical vocal fold motion masquerading as post-anesthetic respiratory distress:A case report

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World Journal of Clinical Cases 2023年第10期11卷 2349-2354页

作者： Jongyoon Baek Dae-Lim Jee Yoon Seok Choi Sang woo Kim Eun kyung Choi Department of Anesthesiology and Pain Medicine Yeungnam University College of MedicineDaegu 42415South Korea Department of Otorhinolaryngology-Head and Neck Surgery Yeungnam University College of MedicineDaegu 42415South Korea Department of Neurosurgery Yeungnam University College of MedicineDaegu 42415South Korea

BACKGROUND Functional vocal cord disorders can be a differential diagnosis for postoperative upper airway obstruction requiring urgent ***,this may be unfamiliar to anesthesiologists who would favor inappropriate airway intervention and increased *** SUMMARY A 61-year-old woman underwent cervical laminectomy,followed by laparoscopic cholecystectomy 10 mo *** adequate reversal of neuromuscular blockade,the patient experienced repetitive respiratory difficulty with inspiratory stridor after *** the second operation,the patient was diagnosed with paradoxical vocal fold motion(PVFM)by an otolaryngologist based on the clinical features and fiberoptic bronchoscopy results,and the patient was successfully *** PVFM should be considered a differential diagnosis if a patient presents with stridor after general anesthesia.

关键词： Anesthesiology Vocal fold Paradoxical motion Postoperative respiratory distress Case report

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Strong contact coupling of neuronal growth cones with height-controlled vertical silicon nanocolumns

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Nano Research 2018年第5期11卷 2532-2543页

作者： Seong-Min Kim Seyeong Lee Dongyoon Kim Dong-Hee kang Kisuk Yang Seung-woo Cho Jin Seok Lee Insung S. Choi kyungtae kang Myung-Han Yoon School of Materials Science and Engineering Gwangju Institute of Science and Technology Gwongju 61005 Republic of Korea Department of Biotechnology Yonsei University 50 Yonsei-ro Seodaemun-gu Seoul 03722 Republic of Korea Department of Chemistry Sookmyung Women's University Seoul 04310 Republic of Korea Center for Cell-Encapsulation Research Department of Chemistry KAIST Daejeon 34141 Republic of Korea Department of Applied Chemistry Kyung Hee University Yongin Gyeonggi 17104 Republic of Korea

In this study, we report that height-controlled vertically etched silicon nano- column arrays （vSNAs） induce strong growth cone-to-substrate coupling and accelerate in vitro neurite development while preserving the essential features of initial neurite formation. Large-scale preparation of vSNAs with flat head morphology enabled the generation of well-controlled topographical stimulation without cellular impalement. A systematic analysis on topography- induced variations on cellular morphology and cytoskeletal dynamics was conducted. In addition, neurite development on the grid-patterned vSNAs exhibited preferential adhesion to the nanostructured region and outgrowth directionality. The arrangement of cytoskeletal proteins and the expression of a focal adhesion complex indicated that a strong coupling existed between the underlying nanocolumns and growth cones. Furthermore, the height-controlled nanocolumn substrates differentially modulated neurite polarization and elongation. Our findings provide an important insight into neuron-nanotopography interactions and their role in cell adhesion and neurite development.

关键词： vertical silicon nanostructures metal-assisted chemical etching primary hippocampal neurons neurite outgrowth cytoskeletal dynamics

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Microperimetry and spectral domain optical coherence tomography in myelinated retinal nerve fibers

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International Journal of Ophthalmology(English edition) 2016年第1期9卷 170-172页

作者： kyung Ho Lee Seong-woo Kim Soon-Sun Kwon Jaeryung Oh Kuhl Huh Department of Ophthalmology Korea University College of Medicine Biomedical Research Institute Seoul National University Bundang Hospital

Dear Sir,I write to present the correlation between microperimetric （MP） values and the density of myelinated retinal nerve fibers （MNFs） in optical coherence tomography （OCT） imaging.

关键词： Microperimetry and spectral domain optical coherence tomography in myelinated retinal nerve fibers OS Figure line

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Tailoring local structures of atomically dispersed copper sites for highly selective CO_(2) electroreduction

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Carbon Energy 2024年第4期6卷 79-90页

作者： kyung‐Jong Noh Byoung Joon Park Ying Wang Yejung Choi Sang‐Hoon You Yong‐Tae Kim Kug‐Seung Lee Jeong woo Han Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)PohangGyeongbukRepublic of Korea Department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH)PohangGyeongbukRepublic of Korea Pohang Accelerator Laboratory(PAL) Beamline DivisionPohangGyeongbukRepublic of Korea

Atomically‐dispersed copper sites coordinated with nitrogen‐doped carbon(Cu–N–C)can provide novel possibilities to enable highly selective and active electrochemical CO_(2) reduction ***,the construction of optimal local electronic structures for nitrogen‐coordinated Cu sites(Cu–N_(4))on carbon remains ***,we synthesized the Cu–N–C catalysts with atomically‐dispersed edge‐hosted Cu–N_(4) sites(Cu–N_(4)C_(8))located in a micropore between two graphitic sheets via a facile method to control the concentration of metal ***‐hosted Cu–N_(4)C_(8) catalysts outperformed the previously reported M–N–C catalysts for CO_(2)‐to‐CO conversion,achieving a maximum CO Faradaic efficiency(FECO)of 96%,a CO current density of–8.97 mA cm^(–2) at–0.8 V versus reversible hydrogen electrode(RHE),and over FECO of 90%from–0.6 to–1.0 V versus *** studies revealed that the micropore of the graphitic layer in edge‐hosted Cu–N_(4)C_(8) sites causes the d‐orbital energy level of the Cu atom to shift upward,which in return decreases the occupancy of antibonding states in the*COOH *** research suggests new insights into tailoring the locally coordinated structure of the electrocatalyst at the atomic scale to achieve highly selective electrocatalytic reactions.

关键词： atomic local structure density functional theory electrochemical CO_(2)reduction metal nitrogen‐doped carbon single‐atom catalyst

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