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Nano-Micro Letters 2024年第5期16卷 214-230页

作者： Akromjon Akhmadjonov kyung taek bae Kang taek Lee Department of Mechanical Engineering KAISTDaejeon 34141Republic of Korea KAIST Graduate School of Green Growth and Sustainability Daejeon 34141Republic of Korea

The unique characteristics of nanofibers in rational electrode design enable effec-tive utilization and maximizing material properties for achieving highly efficient and sustainable CO_(2) reduction reactions( CO_(2)RRs)in solid oxide elec-trolysis cells(SOECs).However,practical appli-cation of nanofiber-based electrodes faces chal-lenges in establishing sufficient interfacial contact and adhesion with the dense *** tackle this challenge,a novel hybrid nanofiber electrode,La_(0.6)Sr_(0.4)Co_(0.15)Fe_(0.8)Pd_(0.05)O_(3-δ)(H-LSCFP),is developed by strategically incorporating low aspect ratio crushed LSCFP nanofibers into the excess porous interspace of a high aspect ratio LSCFP nanofiber framework synthesized via electrospinning *** consecutive treatment in 100% H_(2) and CO_(2) at 700°C,LSCFP nanofibers form a perovskite phase with in situ exsolved Co metal nanocatalysts and a high concentration of oxygen species on the surface,enhancing CO_(2) *** SOEC with the H-LSCFP electrode yielded an outstanding current density of 2.2 A cm^(-2) in CO_(2) at 800°C and 1.5 V,setting a new benchmark among reported nanofiber-based *** twinning of the H-LSCFP reveals improved contact adhesion and increased reaction sites for CO_(2)*** present work demonstrates a highly catalytically active and robust nanofiber-based fuel electrode with a hybrid structure,paving the way for further advancements and nanofiber applications in CO_(2)-SOECs.

关键词： Nanofibers Fuel electrodes Digital twinning CO_(2)reduction reaction Solid oxide electrolysis cells

Salt Tolerance in Rice: Focus on Mechanisms and Approaches

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Rice science 2017年第3期24卷 123-144页

作者： Inja Naga Bheema Lingeswara REDDY Beom-Ki KIM In-Sun YOON kyung-Hwan KIM taek-Ryoun KWON Genetic Engineering Division Department of Agricultural Biotechnology National Institute of Agricultural Sciences Rural Development Administration Jeonju-54874 South Korea

Salt tolerance is an important constrain for rice, which is generally categorized as a typical glycophyte. Soil salinity is one of the major constraints affecting rice production worldwide, especially in the coastal areas. Susceptibility or tolerance of rice plants to high salinity is a coordinated action of multiple stress responsive genes, which also interacts with other components of stress signal transduction pathways. Salt tolerant varieties can be produced by marker-assisted selection or genetic engineering by introducing salt-tolerance genes. In this review, we have updated on mechanisms and genes which can help in transferring of the salt tolerance into high-yielding rice varieties. We have focused on the need for integrating phenotyping, genomics, metabolic profiling and phenomics into transgenic and breeding approaches to develop high-yielding as well as salt tolerant rice varieties.

关键词： rice mechanism salinity salt tolerance yield gene protein

Formation of photo-reactive heterostructure from a multicomponent amorphous alloy with atomically random distribution

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Journal of Materials Science & Technology 2022年第14期109卷 245-253页

作者： Hae Jin Park Hee Jin Lee Tae kyung Kim Sung Hwan Hong Wei-Min Wang taek Jib Choi Ki Buem Kim Department of Nanotechnology and Advanced Materials Engineering Sejong University209 Neung dong-roGwangjin-guSeoul 05006Republic of Korea Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong UniversityJinan 250061China

In this study,metallic glass is designed tunable for promising functional applications via a facile and stable,one-step *** approach about alloy design and process is based on the unique properties of the Ti-Cu-Ni-Sn metallic glass that are afforded by the varying oxygen affinities of the four constituent *** metallic glass exhibits homogeneous nucleation of oxides and uniform formation of the various metal *** alloy design and hydrothermal synthesis to customize the metallic glasses are the most critical factors that determine the characteristics of the metal oxides and the resulting nanostructures and photoelectrode *** enables the desired element to be selectively grown via a facile single-step *** results provide a promising road map for the application of metallic glasses to photoelectrochemical(PEC)solar water splitting,as well as various other new possibilities.

关键词： Metallic glass Alloy design Hydrothermal synthesis Metal oxide Water splitting

Bleeding after endoscopic papillectomy and its risk factors:A single center experience of 196 cases

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Hepatobiliary & Pancreatic Diseases International 2024年第6期23卷 613-619页

作者： Jin Ho Choi Won Chul Kim Joo kyung Park Jong Kyun Lee Kyu taek Lee Kwang Hyuck Lee Department of Medicine Division of GastroenterologySamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Korea

Background:Endoscopic papillectomy(EP)is an effective method to remove an ampulla of Vater(AoV)adenoma with minimal *** reviewed the clinical outcomes and prognosis of patients undergoing EP,including tumor recurrence and adverse ***:A total of 196 patients who underwent EP from January 2004 to December 2017 were *** information was collected through electronic medical records,and risk factors to predict postprocedural bleeding were analyzed using a multivariate logistic regression ***:A total of 93.9%patients(184/196)underwent complete *** the follow-up period,14.7%patients(27/184)experienced tumor recurrence,and two of seven surgically resected tumors were malignant.A total of 45.4%patients(89/196)experienced adverse events related to *** bleeding occurred in 16.3%of the patients(32/196),and they were all successfully treated with endoscopic hemostasis and conservative *** most frequent site of delayed bleeding was the distal end of the papillary orifice,and 56.3%(18/32)patients of delayed bleeding were classified as having mild severity,the others had moderate *** adenomatous polyposis(FAP)[odds ratio(OR)=3.80,95%confidence interval(CI):1.01-14.29;P<0.05]and male sex(OR=2.82,95%CI:1.04-7.63;P=0.04)showed statistical significance in predicting delayed post-EP ***:EP for AoV adenoma was a highly effective and safe *** risk of post-EP delayed bleeding was increased in patients with FAP syndrome and male patients,and post-EP bleeding occurred most commonly in the distal part of the AoV.

关键词： Ampullary neoplasm Endoscopic papillectomy Post-procedural bleeding Risk factor

Successful recanalization of chronic total occlusion of the superior mesenteric artery by transradial approach

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第8期11卷 627-630页

作者： Woo taek KIM Sung Gyun AHN Jun-Won LEE Joong kyung SUNG Seung Hwan LEE Junghan YOON Division of Cardiology Wonju College of MedicineYonsei University

It is a challenge to confirm chronic mesenteric ischemia(CMI) as a cause of gastrointestinal(GI) symptoms such as postprandial epigastric bloating,anorexia,and debilitating weight *** intervention for CMI has been gaining popularity because of the high morbidity associated with surgical ***,in EVI for superior mesenteric artery(SMA) occlusion,the transfemoral approach is limited by difficulty in coaxial alignment of the guiding catheter,which leads to insufficient back-up ***,we report on a 58-year-old male patient with chronic total occlusion of the SMA,which was successfully revascularized by endovascular intervention via the left radial *** endovascular therapy may be another treatment option for the treatment of CMI.

关键词： Transluminal angioplasty Radial artery Superior mesenteric artery Chronic mesenteric ischemia

Oxidative DNA damages by chemical exposures at work

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Advances in Bioscience and Biotechnology 2012年第7期3卷 957-971页

作者： kyung-taek Rim Occupational Safety and Health Research Institute Korea Occupational Safety and Health Agency Incheon Republic of Korea

Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a propensity for increased levels following toxic insult. Of the molecules subject to oxidative modification, DNA has received the greatest attention, with biomarkers of exposure and effect closest to validation. There are many chemicals in workplaces that could cause oxidative DNA damages such as carcinogens. This review concentrated on studies published between the years 2000 and 2012 that used to detect 8-oxodG in humans (workers), laboratory animals and in cell lines. Given the recent toxicological results from oxidative stress, it is important to review these studies to improve the current understanding of the oxidative DNA damages by chemical exposures at work. It also suggests that biomarkers may be responsible for understanding the role of oxidative DNA damage in disease, highlighting the need for further studies.

关键词： Oxidative DNA Damage Industrial Chemicals Chemoprevention Workers Health

Upconverting nanoparticle-containing erythrocyte-sized hemoglobin microgels that generate heat,oxygen and reactive oxygen species for suppressing hypoxic tumors

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Bioactive Materials 2023年第4期22卷 112-126页

作者： Hanju Kim Johyun Yoon Hwang kyung Kim Woo Tak Lee Nguyen Thi Nguyen Xuan Thien Le Eun-Hee Lee Eun Seong Lee kyung taek Oh Han-Gon Choi Yu Seok Youn School of Pharmacy Sungkyunkwan University2066 Seobu-roJangan-guSuwonGyeonggi-do16419Republic of Korea College of Pharmacy Korea University2511 Sejong-roSejong30019Republic of Korea Department of Biotechnology and Department of Biomedical-Chemical Engineering the Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do14662Republic of Korea College of Pharmacy Chung-Ang University84 Heukseok-roDongjak-guSeoul06974Republic of Korea College of Pharmacy Hanyang University55Hanyangdaehak-roSangnok-guAnsan15588Republic of Korea

Inspired by erythrocytes that contain oxygen-carrying hemoglobin(Hb)and that exhibit photo-driven activity,we introduce homogenous-sized erythrocyte-like Hb microgel(μGel)systems(5-6μm)that can(i)emit heat,(ii)supply oxygen,and(iii)generate reactive oxygen species(ROS;1O2)in response to near-infrared(NIR)laser *** μGels consist of Hb,bovine serum albumin(BSA),chlorin e6(Ce6)and erbium@lutetium upconverting nanoparticles(UCNPs;~35 nm)that effectively convert 808 nm NIR light to 660 nm visible *** Hb μGels are capable of releasing oxygen to help generate sufficient reactive oxygen species(^(1)O_(2))from UCNPs/Ce6 under severely hypoxic condition upon NIR stimulation for efficient photodynamic ***,the Hb μGels emit heat and increase surface temperature due to NIR light absorption by heme(iron protoporphyrin IX)and display photothermal *** changing the Hb/UCNP/Ce6 ratio and controlling the amount of NIR laser irradiation,it is possible to formulate bespoke Hb μGels with either photothermal or photodynamic activity or both in the context of combined therapeutic *** Hb μGels effectively suppress highly hypoxic 4T1 cell spheroid growth and xenograft mice tumors in vivo.

关键词： Hemoglobin microgel Upconversion Photothermal therapy Photodynamic therapy Hypoxic tumors Oxygen-generation

STING-activating dendritic cell-targeted nanovaccines that evoke potent antigen cross-presentation for cancer immunotherapy

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Bioactive Materials 2024年第12期42卷 345-365页

作者： Nguyen Thi Nguyen Xuan Thien Le Woo Tak Lee Yong Taik Lim kyung taek Oh Eun Seong Lee Han-Gon Choi Yu Seok Youn School of Pharmacy Sungkyunkwan University2066 Seobu-roJangan-guSuwonGyeonggi-do16419Republic of Korea Department of Nano Engineering and School of Chemical Engineering Sungkyunkwan University2066 Seobu-roJangan-guSuwonGyeonggi-do16419Republic of Korea College of Pharmacy Chung-Ang University84 Heukseok-roDongjak-guSeoul06974Republic of Korea Department of Biotechnology and Department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do14662Republic of Korea College of Pharmacy Hanyang University55 Hanyangdaehak-roSangnok-guAnsan15588Republic of Korea

Recently,nanovaccine-based immunotherapy has been robustly investigated due to its potential in governing the immune response and generating long-term protective ***,the presentation of a tumor peptide-major histocompatibility complex to T lymphocytes is still a challenge that needs to be addressed for eliciting potent antitumor *** 1 conventional dendritic cell(cDC1)subset is of particular interest due to its pivotal contribution in the cross-presentation of exogenous antigens to CD8+T ***,the DC-derived nanovaccine(denoted as Si9GM)selectively targets cDC1s with marginal loss of premature antigen release for effective stimulator of interferon genes(STING)-mediated antigen *** marrow dendritic cell(BMDC)-derived membranes,conjugated to cDC1-specific antibody(αCLEC9A)and binding to tumor peptide(OVA257-264),are coated onto dendrimer-like polyethylenimine(PEI)-grafted silica *** molecular weight-cargos(αCLEC9A-OVA257-264 conjugates and 2′3′-cGAMP STING agonists)are loaded in hierarchical center-radial pores that enables lysosome escape for potent antigen-cross presentation and activates interferon type I,***,Si9GM vaccination leads to the upregulation of cytotoxic T cells,a reduction in tumor regulatory T cells(Tregs),M1/M2 macrophage polarization,and immune response that synergizes with αPD-1 immune checkpoint *** nanovaccine fulfills a dual role for both direct T cell activation as an artificial antigen-presenting cell and DC subset maturation,indicating its utility in clinical therapy and precision medicine.

关键词： DC-based nanovaccines Artificial antigen-presenting cells Type 1 conventional dendritic cells STING pathway activation Antigen cross-presentation

Risedronate Inhibition of Matrix Metalloproteinase-2 Expression in Osteosarcoma Cell Line

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中国肺癌杂志 2009年第6期12卷 664-665页

作者： Kim Yang kyung Sung taek JUNG taek Rim YOON The Brain Korea 21 Project Center for Biomedical Human Resources Department of Orthopaedic Surgery Chonnam National University Medical School

Background and objective Osteosarcoma is a high-malignant bone tumor and is the most frequent malignant bone tumor in children and adolescents. Significant proportions of the

关键词：肺癌恶性肿瘤炎症 β-七叶皂甙钠

Angiomyofibroblastoma of the vulva: A case report with literature review

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Case Reports in Clinical Medicine 2013年第3期2卷 221-224页

作者： Jung Ho Park Mi kyung Shin Maria Lee Sung taek Park Sung-Ho Park Hong-bae Kim Department of Obstetrics & Gynecology Hallym University Kangdong Sacred Heart Hospital Seoul Korea Department of Obstetrics & Gynecology Hallym University Kangnam Sacred Heart Hospital Seoul Korea Department of Pathology Hallym University Kangnam Sacred Heart Hospital Seoul Korea Hallym University Collage of Medicine Chuncheon Korea

Angiomyofibroblastoma (AMF) is a rare kind of soft tissue tumor that occurs predominantly in the vulva. Due to their location, clinicians often confuse AMF with Bartholin’s cyst or perineal hernia. Radiological evaluation is performed to rule out perineal hernia and invasive neoplasm. Like other benign mesenchymal tumors of vulva, AMF shows indolent behavior and rarely recurs after complete surgical excision.

关键词： Angiomyofibroblastoma Vulvar Neoplasm