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The extract of the immature fruit of Poncirus trifoliata induces apoptosis in colorectal cancer cells via mitochondrial autophagy

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Food Science and Human Wellness 2020年第3期9卷 237-244页

作者： Sun-Young Kim Ho-Keun yi Bong-sik Yun Dae-Yeol Lee Pyung Han Hwang Hae-Ryong Park Min Sun Kim Research Institute of Clinical Medicine of Jeonbuk National University Biomedical Research Institute of Jeonbuk National University HospitalJeonju54907South Korea Department of Oral Biochemistry Institute of Oral BioscienceSchool of DentistryJeonbuk National UniversityJeonju54907South Korea Division of Biotechnology and Advanced Institute of Environment and Bioscience Jeonbuk National UniversityIksan-si54596South Korea Department of Pediatrics Jeonbuk National University Medical SchoolJeonju54907South Korea Department of Food Science and Biotechnology Kyungnam UniversityChangwon-si51767South Korea

The immature fruits of Poncirus trifoliate are used as a medicine for the treatment of gastrointestinal disorders,inflammation,and allergies in East ***,their effect on colon cancer cells remains *** investigated the effect of the immature fruit of *** extract on colorectal *** extract of the immature fruit of *** inhibited the proliferation of CT-26 cells compared with untreated cells and it induced autophagy and apoptosis through the protein kinase B/mammalian target of rapamycin and 5'-AMP-activated protein kinase *** number of autophagic vacuoles and autophage markers increased in response to the *** later time-points,apoptosis increased dose/*** CT-26 cells pre-treated a pan-caspase inhibitor prior to *** immature fruit extract treatment,we did not find any change in pro-caspase 3 and pro-PARP ***,in cells pre-treated autphage inhibitor,SQSTM1/p62 and LC3AB,pro-caspase 3 and pro-PARP levels did not *** results indicate the molecular mechanisms that the extract of the immature fruit of *** induces apoptosis in colorectal carcinoma cells by inducing mitochondrial *** this study,we provided a draft for further investigate the use of MEPT for colorectal cancer inhibition.

关键词： Anticancer Autophagy Apoptosis Mitochondria Poncirus trifoliata

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Analysis of Genetic and Biogeography Diversity of Korean Indigenous Wild Rocambole (<i>Allium monanthum</i>Max)

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American Journal of Plant Sciences 2013年第5期4卷 1054-1059页

作者： Gihwan yi kyung-Min Kim Division of Agroindustry & Farm Management Kyungpook National University Daegu South Korea Division of Plant Biosciences School of Plant Biosciences Kyungpook National University Daegu South Korea.

This study was conducted to obtain baseline data describing Allium monanthum Max. for breeding an elite cultivar. A. monanthum has recently become popular vegetable in Korea owing to its unique flavors and nutraceutical effects. The agronomic traits of 271 accessions of A. monanthum collected throughout Korea were evaluated in this study. Leaf width showed the greatest variation (0.1 to 25 mm) among traits evaluated, followed by leaf sheath length and number of cormlets. The average leaf sheath length and diameter, which are commonly used to evaluate quality in the market, were 1.29 cm and 0.3 cm. Some superior accessions had a leaf sheath length of >10 cm and diameter of >1.1 cm. The average weight of the cormlets ranged from 1 to 2 g;however, one accession weighed more than 4 g. The genetic diversity of A. monanthum calculated based on morphology and molecular distance was greater in Jeolla and Gyeoungsang provinces than Gyeonggi and Chungcheong provinces. Finally, seven elite accessions of A. monanthum were selected owing to their potential usefulness in future breeding projects.

关键词： Allium monanthum Indigenous Agronomic Traits Elite Lines Breeding

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Analysis of Low Amylose and Processability Fractured Endosperms Derived from Somatic Variation

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Food and Nutrition Sciences 2013年第6期4卷 21-27页

作者： Gihwan yi kyung Min Kim Department of Farm Management College of Agriculture & Life Science Kyungpook National University Gunwi-gun South Korea Division of Plant Biosciences School of Applied Biosciences College of Agriculture and Life Science Kyungpook National University Daegu South Korea.

Recently, improving eating quality and processing properties has become one of the most important objectives in japonica rice breeding programs in Korea. This study was carried out to determine the agronomy and physicochemical characteristics of the opaque endosperm rice "S-21-3-8" regenerated from seed-derived callus culture of a rice cultivar, "Ilpum". S3 generation of opaque endosperm mutants selected from pedigree breeding was used for analysis of agronomic and physicochemical traits. Genetic segregation was observed at the highest frequency among opaque endosperm mutants, being present in 85.7% (12/14 lines) of the entire opaque lines. However, the major agricultural characteristics and grain traits of "S-21-3-8" were similar to those of a donor cultivar, "Ilpum". "S-21-3-8" showed significantly lower (10.6%) amylose than those (17.7%) of "Ilpum" in brown rice, while the protein levels were similar to those of the donor plant. The grain hardness of "S-21-3-8" (1.67 kgf/mm2) was lower than that of "Ilpum" (1.97 kgf/mm2), resulting in a high flour-milling percentage. The loosely packed starch granules of "S-21-3-8" in the opaque endosperm were demonstrated by SEM analysis of cross-sectioned rice grains. The opaque endosperm mutants that were of somaclonal variations in the tissue culture will lead to improved eating quality and processing properties of rice.

关键词： Rice Opaque Endosperm Flour-Milling Starch Granules

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Hypothyroidism affects astrocyte and microglial morphology in type 2 diabetes

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Neural Regeneration Research 2013年第26期8卷 2458-2467页

作者： Sung Min Nam Yo Na Kim Dae Young Yoo Sun Shin yi Jung Hoon Choi In Koo Hwang Je kyung Seong Yeo Sung Yoon Department of Anatomy and Cell Biology College of Veterinary Medicine Research Institute for Veterinary Science Seoul National University Department of Biomedical Laboratory Science College of Biomedical Sciences Soonchunhyang University Department of Anatomy College of Veterinary Medicine Kangwon National University

In the present study, we investigated the effects of hypothyroidism on the morphology of astrocytes and microglia in the hippocampus of Zucker diabetic fatty rats and Zucker lean control rats. To induce hypothyroidism, Zucker lean control and Zucker diabetic fatty rats at 7 weeks of age orally received the vehicle or methimazole, an anti-thyroid drug, treatment for 5 weeks and were sacrificed at 12 weeks of age in all groups for blood chemistry and immunohistochemical staining. In the me- thimazole-treated Zucker lean control and Zucker diabetic fatty rats, the serum circulating triiodo- thyronine （T3） and thyroxine （＇I＂4） levels were significantly decreased compared to levels observed in the vehicle-treated Zucker lean control or Zucker diabetic fatty rats. This reduction was more prominent in the methimazole-treated Zucker diabetic fatty group. Glial fibrillary acidic protein im- munoreactive astrocytes and ionized calcium-binding adapter molecule 1 （Iba-1）-immunoreactive microglia in the Zucker lean control and Zucker diabetic fatty group were diffusely detected in the hippocampal CA1 region and dentate gyrus. There were no significant differences in the glial fibril- lary acidic protein and Iba-1 immunoreactivity in the CA1 region and dentate gyrus between Zucker lean control and Zucker diabetic fatty groups. However, in the methimazole-treated Zucker lean control and Zucker diabetic fatty groups, the processes of glial fibrillary acidic protein immunoreac- tive astrocytes and Iba-1 immunoreactive microglia, were significantly decreased in both the CA1 region and dentate gyrus compared to that in the vehicle-treated Zucker lean control and Zucker diabetic fatty groups. These results suggest that diabetes has no effect on the morphology of as- trocytes and microglia and that hypothyroidism during the onset of diabetes prominently reduces the processes of astrocytes and microglia.

关键词： neural regeneration astrocytes microglia diabetes hypothyroidism complications thyroid hormone obesity methimazole Zucker diabetic fatty rat grants-supported paper neuroregeneration

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Surgical outcome of pancreatic cancer using radical antegrade modular pancreatosplenectomy procedure

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World Journal of Gastroenterology 2012年第39期18卷 5595-5600页

作者： Ye Rim Chang Sung-sik Han Sang-Jae Park Seung Duk Lee Tae Suk Yoo Young-Kyu Kim Tae Hyun Kim Sang Myung Woo Woo Jin Lee Eun kyung Hong Department of Surgery Seoul National University HospitalSeoul 110-744South Korea Center for Liver Cancer National Cancer CenterGyeonggido 411-764South Korea

AIM:To evaluate the surgical outcomes following radical antegrade modular pancreatosplenectomy (RAMPS) for pancreatic cancer. METHODS:Twenty-four patients underwent RAMPS with curative intent between January 2005 and June 2009 at the National Cancer Center, South Korea. Clinicopathologic data, including age, sex, operative findings, pathologic results, adjuvant therapy, postop-erative clinical course and follow-up data were retro-spectively collected and analyzed for this study. RESULTS:Twenty-one patients (87.5%) underwent distal pancreatectomy and 3 patients (12.5%) underwent total pancreatectomy using RAMPS. Nine patients (37.5%) underwent combined vessel resection, including 8 superior mesenteric-portal vein resections and 1 celiac axis resection. Two patients (8.3%) underwent combined resection of other organs, including the colon, stomach or duodenum. Negative tangential margins were achieved in 22 patients (91.7%). The mean tumor diameter for all patients was 4.09 ± 2.15 cm. The 2 patients with positive margins had a mean diameter of 7.25 cm. The mean number of retrieved lymph nodes was 20.92 ± 11.24 and the node positivity rate was 70.8%. The median survival of the 24 patients was 18.23 ± 6.02 mo. Patients with negative margins had a median survival of 21.80 ± 5.30 mo and those with positive margins had a median survival of 6.47 mo (P = 0.021). Nine patients (37.5%) had postoperative complications, but there were no postoperative mortalities. Pancreatic fistula occurred in 4 patients (16.7%):2 patients had a grade A fistula and 2 had a grade B fistula. On univariate analysis, histologic grade, positive tangential margin, pancreatic fistula and adjuvant therapy were significant prognostic factors for survival. CONCLUSION:RAMPS is a feasible procedure for achieving negative tangential margins in patients with carcinoma of the body and tail of the pancreas.

关键词： Carcinoma Pancreas Surgical resection Sur-vival Radical antegrade modular pancreatosplenectomy

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ARE THE SUMMER FRUIT TORTRIX, ADOXOPHYES ORANA, IN A WAY TO SPECIATION IN KOREA?

ARE THE SUMMER FRUIT TORTRIX, ADOXOPHYES ORANA, IN A WAY TO ...

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The ⅩⅤth International Plant Protection Congress

作者： BOO kyung Saeng KYEUNG sik Han Seoul National University School of Agricultural Biotechnology 441-744 Suwon Korea Dept.Urban Horticulture Shingu College 462-743 Seongnam Korea

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Nanomeshed Si nanomembranes

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npj Flexible Electronics 2019年第1期3卷 78-85页

作者： Xun Han kyung Jin Seo yi Qiang Zeping Li Sandra Vinnikova yiding Zhong Xuanyi Zhao Peijie Hao Shuodao Wang Hui Fang Department of Electrical and Computer Engineering Northeastern UniversityBostonMA 02115USA School of Mechanical and Aerospace Engineering Oklahoma State UniversityStillwaterOK 74074USA

One of the main challenges in stretchable electronics is to achieve high-performance stretchable semiconductors. Here, weintroduce an innovative concept of nanomeshed semiconductor nanomembrane which can be regarded almost as intrinsicallystretchable to conventional microelectronic layouts. By making a silicon film into homogeneous nanomeshes with spring-like nanotraces, we demonstrated a high electron mobility of 50 cm^(2)/V·s, and moderate stretchability with a one-time strain of 25% andcyclic strain of 14% after stretching for 1000 cycles, further improvable with optimized nanomesh designs. A simple analytic modelcovering both fractional material and trace sidewall surfaces well predicted the transport properties of the normally on siliconnanomesh transistors, enabling future design and optimizations. Besides potential applications in stretchable electronics, thissemiconductor nanomesh concept provides a new platform for materials engineering and is expected to yield a new family ofstretchable inorganic materials having tunable electronic and optoelectronic properties with customized nanostructures.

关键词： stretching inorganic fractional

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Automatic detection of teeth and dental treatment patterns on dental panoramic radiographs using deep neural networks

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Forensic Sciences Research 2022年第3期7卷 456-466页

作者： Hye-Ran Choi Thomhert Suprapto Siadari Jo-Eun Kim kyung-Hoe Huh Won-Jin yi Sam-Sun Lee Min-Suk Heo Department of Oral and Maxillofacial Radiology and Dental Research Institute School of DentistrySeoul National UniversitySeoulRepublic of Korea Artificial Intelligence Research Centre Digital Dental Hub IncorporationSeoulRepublic of Korea Department of Oral and Maxillofacial Radiology Seoul National University Dental HospitalSeoulRepublic of Korea

Disaster victim identification issues are especially critical and urgent after a large-scale *** aim of this study was to suggest an automatic detection of natural teeth and dental treatment patterns based on dental panoramic radiographs(DPRs)using deep learning to promote its applicability as human identifiers.A total of 1638 DPRs,of which the chronological age ranged from 20 to 49 years old,were collected from January 2000 to November *** dataset consisted of natural teeth,prostheses,teeth with root canal treatment,and *** detection of natural teeth and dental treatment patterns including the identification of teeth number was done with a pre-trained object detection network which was a convolutional neural network modified by *** objective metrics for the average precision were 99.1%for natural teeth,80.6%for prostheses,81.2%for treated root canals,and 96.8%for implants,*** values for the average recall were 99.6%,84.3%,89.2%,and 98.1%,in the same order,*** study showed outstanding performance of convolutional neural network using dental panoramic radiographs in automatically identifying teeth number and detecting natural teeth,prostheses,treated root canals,and implants.

关键词： Forensic sciences forensic odontology individual identification disaster victim identification radiography deep learning artificial intelligence

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Negative impact of sedation on esophagogastric junction evaluation during esophagogastroduodenoscopy

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World Journal of Gastroenterology 2014年第18期20卷 5527-5532页

作者： Eun Soo Kim Ho Young Lee Yoo Jin Lee Bo Ram Min Jae Hyuk Choi kyung sik Park Kwang Bum Cho Byoung Kuk Jang Woo Jin Chung Jae Seok Hwang Division of Gastroenterology and Hepatology Department of Internal MedicineKeimyung University School of MedicineDaegu 700-712South Korea

AIM: To compare the esophagogastric junction (EGJ) areas observed in sedated and non-sedated patients during esophagogastroduodenoscopy (EGD).

关键词： Esophagogastric junction Endoscopy Esophagus Propofol Midazolam

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Growth-promoting activity of Hominis Placenta extract on regenerating sciatic nerve

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Acta Pharmacologica Sinica 2006年第1期27卷 50-58页

作者： Tae-beom SEO In-sun HAN Jin-hwan YOON In-chan SEOL Yun-sik RIM Hyun-kyung JO Joung-jo AN Kwon-eui HONG Young-bae SEO Dong-hee KIM Seung-kiel PARK Deok-chun YANG Uk NAMGUNG Korea Department of Oriental Medicine.Daejeon University Daejeon 300-716Korea Korea Department of Biochemistry College of Medicine Chungnam National University.Daejeon 301-130Korea Korea

Aim:Extract of Hominis Placenta (HP) has been used in oriental medicine as anagent for improving physiological *** present study was conducted toinvestigate whether HP treatment in an experimental sciatic nerve injury animalmodel produces growth-promoting effects on regenerating peripheral nerve fibersafter ***:After HP was injected into a sciatic nerve injury site,changesin protein levels were analyzed in the regenerating nerve area by Western blottingand immunofluorescence staining *** quantitative assessment of ax-onal regeneration,a retrograde tracing technique was used to identify the neu-ronal cell bodies corresponding to regenerating axons,and the extent of neuriteoutgrowth in cultured dorsal root ganglia (DRG) sensory neurons prepared fromanimals that had experienced a sciatic nerve crush injury 7d before neuron collec-tion was ***:Induction levels of axonal growth-associated protein(GAP-43) in the injured sciatic nerves were elevated by HP *** treat-ment also upregulated cell division cycle 2 (Cdc2) protein levels in the distalstump of the injured sciatic *** Cdc2 protein was detected in Schwanncells,suggesting that Cdc2 kinase activity may be involved in the growth-promot-ing activity of regenerating axons via Schwann cell *** body mea-surement by retrograde tracing indicated that HP treatment produced significantincreases in regenerating motor ***,HP treatment of cultured DRGsensory neurons significantly increased neurite arborization and ***:HP promotes the regeneration of injured sciatic axons by upregulatingthe synthesis of regeneration-related protein factors such as GAP-43 and Cdc2.

关键词： hominis placenta axonal regeneration sciatic nerve GAP-43 protein Cyclindepend kinase 2

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