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Different Acupuncture Therapies for Postherpetic Neuralgia:An Overview of Systematic Reviews and Meta-analysis

Chinese Journal of Integrative Medicine 2025年第1期31卷 55-67页

作者： XIA Yun-fan SUN Ruo-han LI Shi-min WANG Yi-yi LI Rong-rong FANG Jian-qiao The Third Clinical Medical College of Zhejiang Chinese Medical University Hangzhou310000China Department of Rehabilitation Medicine Hangzhou Third People’s Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhou310000China Department of Acupuncture the Third Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310000China

Background: Postherpetic neuralgia(PHN) is the most common complication of herpes zoster infection and affects patients' quality of life. Acupuncture therapy is regarded as a competitive method of treatment for analgesia. Objective: To summarize evidence from systematic reviews(SRs) and evaluate the effectiveness and safety of different acupuncture therapies for treating PHN. Methods: Eight electronic databases were searched from their inception to August 5, 2022, including 4 international electronic databases(PubMed, EMBASE, the Cochrane Library, and Web of Science) and 4 Chinese databases(Chinese Biomedical Database, China National Knowledge Infrastructure, VIP Database and Wanfang Database).Methodological quality was assessed by A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2).The Risk of Bias in Systematic Review(ROBIS) tool was used to assess the risk of bias in SRs. Evidence level was assessed by the Grading of Recommendations Assessment, Development, and Evaluation(GRADE)approach. Results: Totally, 7 SRs were included, including 128 studies and 9,792 patients. In AMSTAR 2, most of the SRs were of low or critically low levels since they had more than 1 critical deficiency. In ROBIS, 1 SR(14.29%)was rated as high risk, and the other 6(85.71%) were rated as low risk. In the GRADE system, 9 outcomes(28.13%)were valued as high level, 5(15.63%) as moderate level, 1(3.13%) as low, and 17(53.13%) as very low. In the effectiveness of acupuncture therapy, the group "moxibustion vs. original medical treatment" [mean difference(MD)=–1.44, 95% confidence interval(CI): –1.80 to –1.08, I2=99%, P<0.00001] was of the highest heterogeneity and the group "bloodletting vs. original medical treatment"(MD=–2.80, 95% CI: –3.14 to –2.46, I2=0, P<0.00001)was of the lowest heterogeneity. Six SRs have reported the safety of their studies and no serious events were shown in the treatment and control groups. Conclusions: Acupuncture therapy seems to be effective in treating PH

关键词： acupuncture postherpetic neuralgia systematic review Chinese medicine

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Microplastics enhance the adsorption capacity of zinc oxide nanoparticles:Interactive mechanisms and influence factors

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Journal of Environmental Sciences 2025年第1期147卷 665-676页

作者： Weiping Xiong min Hu Siying He Yuhang Ye Yinping Xiang Haihao Peng Zhaomeng Chen Zhengyong Xu Honglin Zhang Weixiang Li Shudian Peng College of Environmental Science and Engineering Hunan University and Key Laboratory of Environmental Biology and Pollution Control(Hunan University)Ministry of EducationChangsha 410082China Hunan Boke Environmental Engineering Co.Ltd. Hengyang 421099China College of Environmental Protection and Safety Engineering University of South ChinaHengyang 421001China Hunan Modern Environmental Technology Co.Ltd. Changsha 410004China

Microplastics(MPs)are of particular concern due to their ubiquitous occurrence and propensity to interact and concentrate various waterborne contaminants from aqueous *** on the interaction and joint toxicity of MPs on engineered nanoparticles(ENPs)are exhaustive,but limited research on the effect of MPs on the properties of ENPs in multisolute ***,the effect of MPs on adsorption ability of ENPs to antibiotics was investigated for the first *** results demonstrated that MPs enhanced the adsorption affinity of ENPs to antibiotics and MPs before and after aging showed different effects on *** polyamide prevented aggregation of ZnONPs by introducing negative charges,whereas virgin polyamide affected ZnONPs with the help of electrostatic ***-IR and XPS analyses were used to probe the physicochemical interactions between ENPs and *** results showed no chemical interaction and electrostatic interactionwas the dominant force between ***,the adsorption rate of antibiotics positively correlated with pH and humic acid but exhibited a negative correlation with ionic *** study highlights that ENPs are highly capable of accumulating and transporting antibiotics in the presence of MPs,which could result in a widespread distribution of antibiotics and an expansion of their environmental risks and toxic effects on *** also improves our understanding of the mutual interaction of various co-existing contaminants in aqueous environments.

关键词： Microplastics Engineered nanoparticles Adsorption Tetracycline

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Machine learning-based grayscale analyses for lithofacies identification of the Shahejie formation, Bohai Bay Basin, China

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Petroleum Science 2025年第1期22卷 42-54页

作者： Yu-Fan Wang Shang Xu Fang Hao Hui-min Liu Qin-Hong Hu Ke-Lai Xi Dong Yang National Key Laboratory of Deep Oil and Gas China University of Petroleum (East China) Shengli Oilfield Branch Company SINOPEC

It is of great significance to accurately and rapidly identify shale lithofacies in relation to the evaluation and prediction of sweet spots for shale oil and gas reservoirs. To address the problem of low resolution in logging curves, this study establishes a grayscale-phase model based on high-resolution grayscale curves using clustering analysis algorithms for shale lithofacies identification, working with the Shahejie Formation, Bohai Bay Basin, China. The grayscale phase is defined as the sum of absolute grayscale and relative amplitude as well as their features. The absolute grayscale is the absolute magnitude of the gray values and is utilized for evaluating the material composition(mineral composition + total organic carbon) of shale, while the relative amplitude is the difference between adjacent gray values and is used to identify the shale structure type. The research results show that the grayscale phase model can identify shale lithofacies well, and the accuracy and applicability of this model were verified by the fitting relationship between absolute grayscale and shale mineral composition, as well as corresponding relationships between relative amplitudes and laminae development in shales. Four lithofacies are identified in the target layer of the study area: massive mixed shale, laminated mixed shale, massive calcareous shale and laminated calcareous shale. This method can not only effectively characterize the material composition of shale, but also numerically characterize the development degree of shale laminae, and solve the problem that difficult to identify millimeter-scale laminae based on logging curves, which can provide technical support for shale lithofacies identification, sweet spot evaluation and prediction of complex continental lacustrine basins.

关键词： Shale Machine learning Absolute grayscale Relative amplitude Grayscale phase model Lithofacies identification

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C-X-C chemokine receptor type 5+CD8+T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferonalpha treatment

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World Journal of Gastroenterology 2025年第3期31卷 73-83页

作者： Zhen-Yu Xu Zhong-Shang Dai Guo-Zhong Gong min Zhang Department of Infectious Diseases Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Institute of Hepatology and Department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND C-X-C chemokine receptor type 5(CXCR5)^(+)CD8^(+)T cells represent a unique immune subset with dual roles,functioning as cytotoxic cells in persistent viral infections while promoting B cell *** their importance,the specific role of CXCR5^(+)CD8^(+)T cells in chronic hepatitis B(CHB),particularly during interferon-alpha(IFN-α)treatment,is not fully *** study aims to elucidate the relationship between CXCR5^(+)CD8^(+)T cells and sustained serologic response(SR)in patients undergoing 48 weeks of pegylated IFN-α(peg-IFN-α)treatment for *** To elucidate the relationship between CXCR5^(+)CD8^(+)T cells and sustained SR in patients undergoing 48 weeks of peg-IFN-αtreatment for *** This study enrolled 60 patients with hepatitis Be antigen(HBeAg)-positive CHB undergoing 48 weeks of peg-IFN-α*** were assessed for eligibility based on criteria such as persistent HBsAg-positive status for at least six months,HBeAb-negative,hepatitis B virus DNA levels exceeding 2×10^(4) copies/mL,and alanine aminotransferase(ALT)levels between 2 and 10 times the upper limit of *** samples were collected at baseline and at weeks 12,24,48,and a 24-week treatment-free follow-up(week 72)to measure serum interleukin(IL)-21 concentration via ELISA and to analyze CXCR5 and programmed death-ligand 1(PD-L1)expression on CD8^(+)T cells by flow cytometry,CXCR5 is a chemokine receptor that directs immune cells to specific tissues,while PD-L1 is a protein that regulates immune responses by inhibiting T cell *** Patients with CHB exhibited significantly lower levels of circulating CXCR5^(+)CD8^(+)T cells compared to healthy controls(Pminently expressed in patients who achieved sustained SR compared to non-SR(NSR).A significant correlation was observed between CXCR5 and PD-L1 expression(r=-0.189,P=0.002).However,there was no significant correlation between serum IL-21 level

关键词： C-X-C chemokine receptor type 5 Programmed death-ligand 1 Interleukin-21 Pegylated interferon-alpha Chronic hepatitis B

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Impact of Burial Dissolution on the Development of Ultradeep Fault-controlled Carbonate Reservoirs:Insights from High-temperature and High-pressure Dissolution Kinetic Simulation

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Acta Geologica Sinica(English Edition) 2025年第1期99卷 228-242页

作者： TAN Xiaolin ZENG Lianbo SHE min LI Hao MAO Zhe SONG Yichen YAO Yingtao WANG Junpeng LU Yuzhen National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing 102249China College of Geoscience China University of Petroleum(Beijing)Beijing 102249China PetroChina Hangzhou Institute of Geology Hangzhou 310023China Shenzhen Branch of CNOOC(China)Co. Ltd.Shenzhen 518000China

Burial dissolution is a critical diagenetic process influencing ultra-deep carbonate reservoir development and *** carbonate samples with different internal structures were prepared,and high-temperature and highpressure dissolution kinetic simulations were *** results demonstrate that the intensity of burial dissolution is controlled by temperature and pressure,while tectonic-fluid activity influences the development pattern of burial dissolution,ultimately determining the direction of its differential *** burial dissolution is likely to occur primarily at relatively shallow depths,significantly influencing reservoir formation,preservation,modification,and *** development of faults facilitates the maintenance of the intensity of burial *** maximum intensity of burial dissolution occurs at the tips and overlap zones of faults and intersections of multiple *** larger the scale of the faults,the more conducive it is to the development of burial *** dissolution fosters the formation of fault networks characterized by enhanced reservoir capacity and *** dissolution controlled by episodic tectonic-fluid activity is a plausible explanation for forming the Tarim Basin's ultra-deep fault-controlled“stringbead-like”reservoirs.

关键词： burial dissolution tectonic-fluid ultra-deep carbonate reservoirs high-temperature and high-pressure dissolution kinetic simulation

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ZIF-90-loaded DNAzyme-responsive PROTAC for the self-powered degradation of NF-κB

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Science China Chemistry 2025年第2期68卷 687-693页

作者： min Hou Liang Sun Tianyu Ren mingda Li Chao Hu Rong Liu Shuang Gu mingyan Jiang Jian-Hui Jiang Jianjun He College of Physics and Chemistry Hunan First Normal UniversityChangsha 410205China Hunan Provincial Key Laboratory of Animal Models and Molecular Medicine College of Biomedical SciencesCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Xiangtan Central Hospital Xiangtan 411199China

Transcription factors(TFs)play vital roles in regulating gene *** or mutated TFs are implicated in a wide array of diseases,highlighting their potential as drug ***,TFs are considered undruggable by conventional inhibitor-based *** recently emerged proteolysis targeting chimeras(PROTACs)have exhibited great potential in tackling *** particular,DNA-ligand chimeras that arm E3 ligase-recruiting ligands to TF-binding double-strand DNA represent a promising strategy for the targeted proteolysis of ***,we report a DNAzyme-inducible PROTAC(DzTAC)that selectively degrades NF-κB in a zinc ion-dependent *** further applied zinc-imidazolate metal–organic framework90(ZIF-90)to encapsulate DzTAC(ZIF-90@DzTAC),facilitating its delivery into cancer cells while self-supplying Zn2+via adenosine triphosphate(ATP)-triggered ZIF-90 ***,ZIF-90@DzTAC can enhance the treatment efficacy of doxorubicin-based chemotherapy in tumor-bearing *** developed DzTAC provides specific modulation over TF activity and opens an avenue for more functional nucleic acid-based control over targeted protein degradation.

关键词： inducible proteolysis DNAzyme transcription factor ZIF-90 NF-κB

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Properties of the drip-line nucleus and mass relation of mirror nuclei

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Nuclear Science and Techniques 2025年第2期36卷 112-122页

作者： Meng-Ting Wan Li Ou min Liu Ning Wang College of Physics and Technology Guangxi Normal UniversityGuilin 541004China Guangxi Key Laboratory of Nuclear Physics and Technology Guangxi Normal UniversityGuilin 541004China

The isospin asymmetry and quadrupole deformation value of drip-line nuclei are investigated using the Weizsäcker-Skyrme nuclear mass *** observe that for heavy nuclei at the neutron drip line,the Coulomb energy heightened by an aug-mented charge could not be mitigated completely by symmetry energy because of isospin asymmetry saturation but is resisted complementally by strong nuclear *** positions of saltation for the difference in proton numbers between two neighboring nuclei at the neutron drip line,and the isospin asymmetry of the neutron drip-line nucleus as a function of the neutron number distinctly correspond to the known magic numbers,which can serve as a reference to verify the undeter-mined neutron magic *** fitting of the binding energy difference between mirror nuclei(BEDbMN),a set of Coulomb energy coefficients with greater accuracy is obtained.A high-precision description of the BEDbMN is useful for accurately determining the experimentally unknown mass of the nucleus close to the proton drip line if the mass of its mirror nucleus is measured experimentally.

关键词： Nuclear mass formula Drip-line nucleus Magic number Mirror nuclei Coulomb energy

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Impacts of near-M_(s)austempering treatment on microstructure evolution and bainitic transformation kinetics of a medium Mn steel

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Journal of Iron and Steel Research International 2025年第1期32卷 249-259页

作者： Yong-gang Yang Xin-yue Liu Rui-zhi Li Yu-lai Chen Hong-xiang Wu Guo-min Sun Zhen-li Mi National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing 100083China Technology Center Ningbo Iron&Steel Co.Ltd.Ningbo 315800ZhejiangChina

The microstructure evolution and bainitic transformation of an Fe-0.19C-4.03Mn-1.48Si steel subjected to near-M_(s)austempering treatment were systematically investigated by combining dilatometer,X-ray diffraction,and electron *** additional austempering treatments with isothermal temperatures above M_(s)were used as *** show that the incubation period for the bainitic transformation occurs when the medium Mn steel is treated with the austempering temperature above M_(s).However,when subjected to near-M_(s)isothermal treatment,the medium Mn steel does not show an incubation period and has the fastest bainitic transformation ***,the largest volume fraction of bainite with a value of 74.7%is obtained on the condition of near-M_(s)austempering treatment after cooling to room *** and microstructure evolution analysis indicates that the elimination of the incubation period and the fastest rate of bainitic transformation are related to the preformed *** advent of preformed martensite allows the specimen to generate more bainite in a limited *** bainitic ferrite nucleation at austenite grain boundaries and through autocatalysis at ferrite/austenite interfaces,a model is established to understand the kinetics of bainite formation and it can describe the nucleation rate of bainitic transformation well when compared to the experimental results.

关键词： Medium manganese steel Bainitic transformation Microstructure Near-M_(s)austempering Transformation modeling

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Smartphone-assisted electrochemiluminescence imaging test strips towards dual-signal visualized and sensitive monitoring of aflatoxin B1 in corn samples

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Chinese Chemical Letters 2025年第1期36卷 464-468页

作者： Miao-Miao Chen min-Ling Zhang Xiao Song Jun Jiang Xiaoqian Tang Qi Zhang Xiuhua Zhang Peiwu Li Key Laboratory of Biology and Genetic Improvement of Oil Crops Ministry of Agriculture and Rural AffairsLaboratory of Risk Assessment for Oilseed Products(Wuhan)Quality Inspection and Test Center for Oilseed ProductsOil Crops Research InstituteChinese Academy of Agricultural SciencesWuhan 430062China Food Safety Research Institute Hubei UniversityWuhan 430062China Hubei Hongshan Laboratory Wuhan 430070China Xianghu Laboratory Hangzhou 311231China College of Chemistry and Chemical Engineering Hubei UniversityWuhan 430062China

Aflatoxins B1(AFB1)contamination in agro-food holds great threaten to human and animal *** test strips for rapid AFB1 visualized monitoring remains challenged by improvement of sensitivity and matrix interference *** this case,we developed a portable electrochemiluminescence(ECL)imaging test strip with dual-signal outputs for AFB1 quantification in corn ***@SiO_(2)@Au nanospheres were synthesized for bonding with anti-AFB1 antibody and then colorimetrical signal-reported on test line through the capillary flow at ***,ECL imaging signal of the constructed carbon-ink-based working electrode on polyvinyl chloride substrate of strips was exported under an applied potential of 1.25 *** whole ECL test strips not only endowed convenient colorimetric responses but guaranteed quick-witted ECL image distinguishment even at extremely low AFB1 *** detection limit of this ECL imaging-integrated mode was 10-fold lower than that of only colorimetric ***,satisfactory selectivity,reliability and practicability of the as-proposed ECL test strips were *** work offered a promising platform for on-site,accurate and sensitive detection of pollutants in foods.

关键词： Electrochemiluminescence imaging Test strips Nanomaterials Dual-signal outputs Aflatoxin B1 Food safety

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IL-22/IL-22R1 pathway enhances cholangiocarcinoma progression via ERK1/2 activation

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 246-269页

作者： Jin Zhou Jing-Rui Chen Jin-ming Li Shuang-Qing Han Xi-Yue Deng Zhong-min Li Wen Tong Chao Wang Yi Bai Ya-min Zhang The First Central Clinical School Tianjin Medical UniversityTianjin 300192China Department of Hepatobiliary and Pancreatic Surgery Tianjin Nankai HospitalTianjin 300070China Department of Hepatobiliary Surgery Tianjin First Central HospitalTianjin 300070China

BACKGROUND IL-22 plays a pivotal role in the processes of inflammation and tissue healing.,but its role in cholangiocarcinoma(CCA)remains *** study explored the IL-22/IL-22R1 pathway and its impact on CCA progression through the ERK1/2 signaling *** To determine the mechanism of the IL-22/IL-22R1 pathway in CCA and provide new directions for its clinical *** IL-22R1 expression was assessed in human and rat CCA tissues utilizing immunohistochemical techniques,Western blot analysis,and quantitative reverse transcription *** impact of IL-22 on CCA cells was assessed in vitro via tests for proliferation,migration,invasion,and apoptosis *** rat models of thioacetamide-induced CCA and subcutaneous xenografts in nude mice were used to assess the in vivo ***1/2 inhibitors were applied to elucidate the mechanistic role of the *** IL-22R1 was overexpressed in CCA cell lines and ***-22 treatment increased the phosphorylation of ERK1/2,promoting tumor cell proliferation,migration,invasion,and resistance to ***1/2 inhibition considerably reversed these effects both in vitro and in *** The IL-22/IL-22R1 axis promotes CCA progression by activating ERK1/2 *** this pathway with ERK1/2 inhibitors offers potential therapeutic strategies for CCA.

关键词： Cholangiocarcinoma IL-22 IL-22R1 ERK1/2 Cancer progression

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